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| 1 | Magnetic resonance imaging in breast cancer:A literature review and future perspectives显示文摘Early detection and diagnosis of breast cancer are essential for successful treatment. Currently mammography and ultrasound are the basic imaging techniques for the detection and localization of breast tumors. The low sensitivity and specificity of these imaging tools resulted in a demand for new imaging modalities and breast magnetic resonance imaging(MRI) has become increasingly important in the detection and delineation of breast cancer in daily practice. However, the clinical benefits of the use of pre-operative MRI in women with newly diagnosed breast cancer is still a matter of debate. The main additional diagnostic value of MRI relies on specific situations such as detecting multifocal, multicentric or contralateral disease unrecognized on conventional assessment(particularly in patients diagnosed with invasive lobular carcinoma), assessing the response to neoadjuvant chemotherapy, detection of cancer in dense breast tissue, recognition of an occult primary breast cancer in patients presenting with cancer metastasis in axillary lymph nodes, among others. Nevertheless, the development of new MRI technolo-gies such as diffusion-weighted imaging, proton spectroscopy and higher field strength 7.0 T imaging offer a new perspective in providing additional information in breast abnormalities. We conducted an expert literature review on the value of breast MRI in diagnosing and staging breast cancer, as well as the future potentials of new MRI technologies. | Gisela LG Menezes Floor M Knuttel Bertine L Stehouwer Ruud M Pijnappel Maurice AAJ van den Bosch | 2014 | World Journal of Clinical Oncology2014，5，2： | 25 |
| 2 | 成都平原蔬菜生产中灌溉水对农药渗漏的影响研究显示文摘针对成都平原蔬菜生产中大量施用农药、大量灌水的特点,首次在国内应用欧洲官方成熟的农药评估模型——PEARL模型,研究评估了成都平原当前蔬菜生产中的灌溉方式对两种不同特性农药的渗漏的影响。杀毒矾(土壤吸附力(KOM)为0 L/kg,半衰期(DT50)为80 d)在没有灌溉条件下,其渗出土体时的最大质量浓度是190μg.L-1,而有灌溉条件下其渗出质量浓度则可达523μg.L-1,是没有灌溉条件下的2.75倍。三唑磷(KOM为200 L.kg-1,DT50为60 d)在没有灌溉条件下,其渗出土体时的最大质量浓度是0.025μg.L-1,而有灌溉条件下其渗出质量浓度为0.13μg.L-1,比没有灌溉时提高了4.2倍。不管有没有灌溉三唑磷在该地区对地下水的污染风险都很小,而杀毒矾的风险则很高。因此,农药的化学特性是影响农药渗漏的最重要的因子。在蔬菜生产中应尽量选用被土壤吸附力强、半衰期短的农药,例如:三唑磷;农药在土壤中的移动载体是土壤水,不合理的灌溉会大大地加大农药淋溶,应当多使用微喷、滴灌等节水灌溉措施,减少使用漫灌等耗水多的原始灌溉方式。 | 林超文 陈一兵 黄晶晶 Rik van den Bosch Mechteld M.S.ter Horst | 2005 | 生态环境2005，14，5： | 12 |
| 3 | Effect of transjugular intrahepatic portosystemic shunt on pulmonary gas exchange in patients with portal hypertension and hepatopulmonary syndrome显示文摘AIM: To assess the impact of transjugular intrahepatic portosystemic shunt (TIPS) on pulmonary gas exchange and to evaluate the use of TIPS for the treatment of hepatopulmonary syndrome (HPS).METHODS: Seven patients, three of them with advanced HPS, in whom detailed pulmonary function tests were performed before and after TIPS placementat the University of Alabama Hospital and at the Hospital Clinic, Barcelona, were considered.RESULTS: TIPS patency was confirmed by hemodynamic evaluation. No changes in arterial blood gases were observed in the overall subset of patients. Transient arterial oxygenation improvement was observed in only one HPS patient, early after TIPS, but this was not sustained 4 mo later.CONCLUSION: TIPS neither improved nor worsened pulmonary gas exchange in patients with portal hypertension. This data does not support the use of TIPS as a specific treatment for HPS. However, it does reinforce the view that TIPS can be safely performed for the treatment of other complications of portal hypertension in patients with HPS. | Graciela Martínez-Pallí Britt B Drake Joan-Carles García-Pagán Joan-Albert Barberà Miguel R Arguedas Robert Rodriguez-Roisin Jaume Bosch Michael B Fallon | 2005 | World Journal of Gastroenterology2005，11，43： | 11 |
| 4 | Primary liver cancer: Worldwide incidence and trends显示文摘 | F.Xavier Bosch Josepa Ribes Mireia Díaz Ramon Cléries | 2004 | Gastroenterology2004，，5： | 10 |
| 5 | Liver cirrhosis显示文摘 | Emmanuel A Tsochatzis Jaime Bosch Andrew K Burroughs | 2014 | The Lancet2014，，： | 9 |
| 6 | 影像引导下乳腺癌的聚焦超声消融:现状、挑战及未来发展方向显示文摘影像引导下聚焦超声(FUS)消融为无创性操作,用于治疗良恶性乳腺肿瘤。可在实时超声或MRI引导下进行消融。过去20年第一阶段研究证实,在MRI或超声引导下进行乳腺肿瘤的FUS消融技术是可行且安全的。通过测量肿瘤完全坏死病例所占的比例。对FUS消融乳腺肿瘤的效果作一全面概述。肿瘤消融成功率为20%-100%,此范围取决于FUS系统的类型、成像技术、消融方法及病人的选择。目前还存在一些与乳腺肿瘤FUS消融相关的具体问题, | A.C.Schmitz D.Gianfelice B.L.Daniel W.P.Mali M.A.van den Bosch 秦乃姗 | 2008 | 国际医学放射学杂志2008，31，5： | 9 |
| 7 | Initiation of Programmed Cell Death in Self-Incompatibility: Role for Cytoskeleton Modifications and Several Caspase-Like Activities显示文摘规划房间死亡(PCD ) 是在优核质调整讨厌的房间的精确死亡的一个重要、通用的过程。在植物, PCD 的存在坚定地被建立了因为大约显示出在哺乳动物的系统涉及 apoptosis/PCD 的一十年,和许多部件在经历 PCD 的植物房间被发现。这里,我们从我们在 Papaver rhoeas 花粉在自我障碍反应表明 PCD 的参与的实验室考察工作。一个特定的 pollenpistil 相互作用的后果提供一个很整洁的方法破坏讨厌的自我的 PCD 的这利用,然而并非非自我花粉。我们讨论为几项象 caspase 一样活动的导致 SI 的激活提供证据的最近的数据并且建议 cytosol 的使发酸可以是在执行 PCD 的象 caspase 一样朊酶的激活的一个关键拐弯处点。我们也考察在发信号到调停 caspase 的 PCD 象 MAPK 的一样显示出肌动朊和微导管细胞骨架的参与的数据。在在发信号到 PCD 的这些各种各样的部件之间的潜在的连接被讨论。一起,这开始在一个单个房间系统造 PCD 的一幅图画,由一个 receptorligand 相互作用被触发。 | Maurice Bosch Natalie S. Poulter Sabina Vatovec Vernonica E. Franklin-Tong | 2008 | Molecular Plant2008，1，6： | 6 |
| 8 | Functional aspects on the pathophysiology of portal hypertension in cirrhosis显示文摘 | Juan-Carlos García-Pagán Jorge Gracia-Sancho Jaume Bosch | 2012 | Journal of Hepatology2012，，2： | 5 |
| 9 | Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases显示文摘Hepatocyte nuclear factor 4-alpha(HNF4α)is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs(pancreas,stomach,and intestine).In liver,HNF4αis best known for its role as a master regulator of liver-specific gene expression and essential for adult and fetal liver function.Dysregulation of HNF4αexpression has been associated with many human diseases such as ulcerative colitis,colon cancer,maturity-onset diabetes of the young,liver cirrhosis,and hepatocellular carcinoma.However,the precise role of HNF4αin the etiology of these human pathogenesis is not well understood.Limited information is known about the role of HNF4αisoforms in liver and gastrointestinal disease progression.There is,therefore,a critical need to know how disruption of the expression of these isoforms may impact on disease progression and phenotypes.In this review,we will update our current understanding on the role of HNF4αin human liver and gastrointestinal diseases.We further provide additional information on possible use of HNF4αas a target for potential therapeutic approaches. | Matthew M Yeh Dustin E Bosch Sayed S Daoud | 2019 | World Journal of Gastroenterology2019，25，30： | 5 |
| 10 | The effect of acupuncture on mood and working memory in patients with depression and schizophrenia显示文摘BACKGROUND: In patients with depression, as well as in patients with schizophrenia, both mood and working memory performance are often impaired. Both issues can only be addressed and improved with medication to some extent.OBJECTIVE: This study investigates the mood and the working memory performance in patients with depression or schizophrenia and whether acupuncture can improve these.DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: A pragmatic clinical trial design was used. The study was conducted in a psychiatric clinic. Fifty patients with depression and 50 with schizophrenia were randomly divided into an experimental and a waiting-list group. Additionally, 25 healthy control participants were included. Twelve weeks of individualized acupuncture treatment was used as the clinical intervention. MAIN OUTCOME MEASURES: All patients were tested before(T1) and after(T2) acupuncture treatment on a mood scale(Beck Depression Inventory-II, BDI-II), a simple working memory task(digit span), and a complex working memory task(letter-number sequencing); the healthy controls were tested at T1 only.RESULTS: Patients with depression scored worse than the others on the BDI-II, and patients with schizophrenia scored worse than the healthy controls. On the digit span, patients with schizophrenia did not differ from healthy controls whereas they scored worse of all on the letter-number sequencing. With respect to the acupuncture fi ndings, fi rst, the present study showed that the use of acupuncture to treat patients with schizophrenia was both practical and safe. Moreover, acupuncture had a positive effect on the BDI-II for the depression group, but acupuncture had no effect on the digit span and on the letternumber sequencing performance for the two clinical groups.CONCLUSION: The clinical improvement in patients with depression after acupuncture treatment was not accompanied by any signifi cant change in a simple working memory task or in a more complex working memory task; the same was true for the patients with schizophrenia. | Peggy Bosch Maurits van den Noort Sujung Yeo Sabina Lim Anton Coenen Gilles van Luijtelaar | 2015 | Journal of Integrative Medicine2015，13，6： | 5 |
| 11 | 浅谈戏剧表演应用于英语口语教学的意义 | 孙玲琪 William Adriaan Bosch | 2012 | 才智2012，0，2： | 4 |
| 12 | Molecular Tests for Colorectal Cancer Screening显示文摘 | Linda J.W. Bosch Beatriz Carvalho Remond J.A. Fijneman Connie R. Jimenez Herbert M. Pinedo Manon van Engeland Gerrit A. Meijer | 2011 | Clinical Colorectal Cancer2011，，1： | 4 |
| 13 | 雷米普利预防脑卒中:随机双盲试验显示文摘目的 :评价血管紧张素转换酶抑制剂 (ACEI)雷米普利 (ramipril)在脑卒中二级预防中的作用。试验设计 :随机对照 2× 2析因设计。组织 :19个国家的 2 67家医院。入选者 :92 97例患者 ,均有血管疾病或合并有一个危险因素的糖尿病患者 ,随访 4 5年。其为HOPE试验的一个组成部分。观察指标 :脑卒中 (有条件时 ,由CT或MRI证实 )、短暂脑缺血发作 (TIA)、认知功能障碍。在患者入选时、2年时及终点时记录血压。结果 :应用雷米普利使血压轻度下降 (平均收缩压降低 3 8mmHg,舒张压降低 2 8mmHg)。应用雷米普利组比安慰剂组脑卒中相对危险度下降 3 2 % (15 6比 2 2 6) ,致死性脑卒中下降 5 1%(17比 44 )。不管患者的基线血压水平高低、是否应用其他药物 ,以及有无脑卒中史、冠心病、外周动脉疾病、糖尿病或高血压 ,应用雷米普利受益是一致的。雷米普利组大脑认知或功能障碍者明显少于安慰剂组。结论 :雷米普利尽管使血压轻度降低 ,却使高危患者的脑卒中发生率明显下降。 | Jackie Bosch Salim Yusuf Janice Pogue Peter Sleight Eva Lonn Badrudin Rangoonwala Richard Davies Jan Ostergren Jeff Probstfield 高展 | 2002 | 英国医学杂志中文版2002，5，4： | 4 |
| 14 | The management of portal hypertension: Rational basis, available treatments and future options显示文摘 | Jaime Bosch Annalisa Berzigotti Juan Carlos Garcia-Pagan Juan G. Abraldes | 2008 | Journal of Hepatology2008，，： | 3 |
| 15 | Efficacy and Safety of Anticoagulation on Patients With Cirrhosis and Portal Vein Thrombosis显示文摘 | María Gabriela Delgado Susana Seijo Ismael Yepes Linette Achécar Maria Vega Catalina ángeles García–Criado Juan G. Abraldes Joaquín de la Pe?a Rafael Ba?ares Agustín Albillos Jaume Bosch Juan Carlos García–Pagán | 2012 | Clinical Gastroenterology and Hepatology2012，，7： | 3 |
| 16 | CXCR4表达可增强弥漫大B细胞淋巴瘤的播散能力并降低患者生存期显示文摘在一些血液系统恶性肿瘤中,趋化因子受体CXCR4与恶性B细胞的迁徙和转移有关。 CXCR4在血液系统肿瘤中过表达已经得到证实,但对弥漫大B细胞淋巴瘤( DLBCL)的作用尚不清楚。为此,作者采用DLBCL细胞系着重对体外细胞迁移和体内播散过程中CXCR4的作用进行研究,并评估94例DLBCL患者活检标本CXCR4表达的预后意义。 | Moreno M J Bosch R Dieguez-Gonzalez R 胡舜 余英豪 | 2015 | 临床与实验病理学杂志2015，31，10： | 3 |
| 17 | The AO/ASIF-proximal femoral nail (PFN): a new device for the treatment of unstable proximal femoral fractures显示文摘 | R.K.J Simmermacher A.M Bosch Chr Van der Werken | 1999 | Injury1999，，5： | 3 |
| 18 | Hepatic venous pressure gradient predicts development of hepatocellular carcinoma independently of severity of cirrhosis显示文摘 | Cristina Ripoll Roberto J. Groszmann Guadalupe Garcia-Tsao Jaime Bosch Norman Grace Andrew Burroughs Ramon Planas Angels Escorsell Juan Carlos Garcia-Pagan Robert Makuch David Patch Daniel S. Matloff | 2009 | Journal of Hepatology2009，，5： | 3 |
| 19 | 661 USE OF EARLY-TIPS FOR HIGH-RISK VARICEAL BLEEDING. RESULTS OF A POST-RCT SURVEILLANCE STUDY显示文摘 | M. Di Pascoli J.C. García-Pagan K. Caca W. Laleman C. Bureau B. Appenrodt A. Luca A. Zipprich J.G. Abraldes F. Nevens J.P. Vinel J. Bosch | 2012 | Journal of Hepatology2012，，： | 3 |
| 20 | Linoleic acid metabolic pathway allows for an efficient increase of intramuscular fat content in pigs显示文摘Background: Intramuscular fat(IMF) content is a relevant trait for high-quality meat products such as dry-cured ham,but increasing IMF has the undesirable correlated effect of decreasing lean growth.Thus,there is a need to find selection criteria for IMF independent from lean growth.In pigs,the proportion of linoleic(C18:2) and arachidonic(C20:4) acids decline with fat deposition and therefore they can be considered as indicators of fatness.The aim of this research was to estimate the genetic variation for C18:2 and C20:4 in IMF and their genetic correlations with IMF and lean growth traits,with the objective to assess their potential as specific biomarkers of IMF.The analysis was conducted using a full-pedigreed Duroc resource line with 91,448 records of body weight and backfat thickness(BT) at 180 days of age and 1371 records of fatty acid composition in the muscle gluteus medius.Results: The heritability estimates for C18:2 and C20:4 in IMF,whether expressed in absolute(mg/g of muscle) or in relative(mg/g of fatty acid) terms,as well as for their ratio(C20:4/C18:2),were high(> 0.40),revealing that the C18:2 to C20:4 pathway is subjected to substantial genetic influence.Litter effects were not negligible,with values ranging from8% to 15% of the phenotypic variance.The genetic correlations of C18:2 and C20:4 with IMF and BT were negative(-0.75 to-0.66,for IMF,and-0.64 to-0.36,for BT),if expressed in relative values,but almost null(-0.04 to 0.07),if expressed in absolute values,except for C18:2 with IMF,which was highly positive(0.88).The ratio of C20:4 to C18:2 also displayed a stronger genetic correlation with IMF(-0.59) than with BT(-0.10).Conclusions: The amount of C18:2 in muscle can be used as an IMF-specific biomarker.Selection for the absolute amount of C18:2 is expected to deliver a similar response outcome as selection for IMF at restrained BT.Further genetic analysis of the C18:2 metabolic pathway may provide new insights into differential fat deposition among adipose tissues and on candidate genes for molecular markers targeting specifically for one of them. | Sofia Gol Rayner Gonzalez-Prendes Lluis Bosch Marc Tor Josep Reixach Ramona N.Pena Joan Estany | 2019 | Journal of Animal Science and Biotechnology2019，10，3： | 3 |
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