|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Wnt/b-catenin signaling plays an ever-expanding role in stem cell self-renewal,tumorigenesis and cancer chemoresistance显示文摘Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell polarity.The role of Wnt signaling in controlling cell proliferation and stem cell self-renewal is primarily carried out through the canonical pathway,which is the best-characterized the multiple Wnt signaling branches.The past 10 years has seen a rapid expansion in our understanding of the complexity of this pathway,as many new components of Wnt signaling have been identified and linked to signaling regulation,stem cell functions,and adult tissue homeostasis.Additionally,a substantial body of evidence links Wnt signaling to tumorigenesis of cancer types and implicates it in the development of cancer drug resistance.Thus,a better understanding of the mechanisms by which dysregulation of Wnt signaling precedes the development and progression of human cancer may hasten the development of pathway inhibitors to augment current therapy.This review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and disease.We begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness,tumorigenesis,and cancer drug resistance.Ultimately,we hope to present an organized collection of evidence implicating Wnt signaling in tumorigenesis and chemoresistance to facilitate the pursuit of Wnt pathway modulators that may improve outcomes of cancers in which Wnt signaling contributes to aggressive disease and/or treatment resistance. | Maryam K.Mohammed Connie Shao Jing Wang Qiang Wei Xin Wang Zachary Collier Shengli Tang Hao Liu Fugui Zhang Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Lewis L.Shi Aravind Athiviraham Tong-Chuan He Michael J.Lee | 2016 | Genes & Diseases2016，3，1： | 70 |
| 2 | Histone deacetylase inhibitor trichostatin A induced caspase-independent apoptosis in human gastric cancer cell显示文摘背景 Histone deacetylase 禁止者( HDACI )被报导了在房间一直不是的胃的癌症上在 trichostatin A ( TSA )的癌症 cells.The 效果导致 apoptosis 很好, characterized.This 学习被瞄准在人的胃的癌症 SGC-7901 cells.Methods 上探索 TSA 的效果和机制房间与 TSA 被对待并且由房间增长试金,西方的污点, TUNEL 试金, isothiocyanate ( FITC )与 Annexin V 结合了的由荧光黄的流动 cytometry 并且 PI 染色分析了, | WU Zhi-qun ZHANG Rui Connie Chao ZHANG Ji-feng ZHANG Yuan-qiang | 2007 | Chinese Medical Journal2007，，23： | 20 |
| 3 | 中国香港双语儿童初步阅读能力与语音、文字加工关系的研究显示文摘采用音节检测、短时言语记忆、快速命名等语音加工任务和汉字、字母、数字等方向加工任务,探讨语音和文字加工在儿童初步阅读中的作用,116名6岁左右的香港双语儿童参加了测试。结果表明:语音加工能力是跨语言的比较稳定的因素,是预测汉语和英语阅读的较好指标;文字加工具有特异性,即汉字方向加工只能预测汉语阅读,字母方向加工则预测英语阅读。 | 钟毅平 Catherine Mcbride-Chang Connie Suk-Han Ho | 2002 | 心理科学2002，25，2： | 17 |
| 4 | 长链脂肪乳剂及中/长链脂肪乳剂水解速率的比较研究显示文摘目的 :比较长链脂肪乳剂、物理混合的中 /长链脂肪乳剂及结构脂肪乳剂的水解速率。 方法 :应用 1 1 4 C甘油棕榈酸标记的长链三酰甘油 (LCT)和 2 ,3 3 H甘油辛酸标记的中链三酰甘油 (MCT) ,分别标记Intralipid ,Lipo fundin及Structolipid ,在体外添加缓冲液、脂蛋白酯酶和肝酯酶后 ,置 37℃温箱中水浴、孵育。采用气相色谱仪测定核素标记的各种脂肪酸及三酰甘油浓度 ,游离脂肪酸浓度用放射性核素扫描计数测定 ,通过计算培养液中1 4 C标记的长链脂肪酸及3 H标记的中链脂肪酸分别在1 4 C标记LCT及3 H标记MCT中的比例 ,来计算三种脂肪乳剂的水解率。 结果 :物理混合的中 /长链脂肪乳剂及结构脂肪乳剂的水解程度明显高于长链脂肪乳剂 ,差异有统计学意义。物理混合的中 /长链脂肪乳剂水解程度高于结构脂肪乳剂 ,但在水解程度及水解速度上却无统计学差异。 结论 :物理混合的中 | 吴国豪 Connie Jarstrand Jorgen Nordenstrom | 2002 | 肠外与肠内营养2002，9，1： | 13 |
| 5 | 晚期卵巢癌、输卵管癌及原发性腹膜癌腹腔镜肿瘤细胞减灭术的安全性及有效性研究显示文摘目的总结晚期卵巢癌、输卵管癌和腹膜癌患者行腹腔镜初次或间歇性肿瘤细胞减灭术的临床经验。方法回顾分析接受腹腔镜肿瘤细胞减灭术的晚期卵巢癌(FIGOⅡc期以上)、输卵管癌和原发性腹膜癌患者临床资料。结果 32名患者接受腹腔镜评估手术。17例接受全腹腔镜肿瘤细胞减灭术,其中88.2%为满意的肿瘤细胞减灭术;11例腹腔镜评估后转开腹肿瘤细胞减灭术,其中72.7%为满意的肿瘤细胞减灭术;4例仅进行活检和(或)姑息手术。腹腔镜组平均随访时间19.7月9,例无瘤生存6,例带瘤生存2,例因肿瘤死亡。开腹组平均随访时间25.8月,3例无瘤生存,5例带瘤生存,3例因肿瘤死亡。腹腔镜组术中失血量较少,术后住院时间较短(P=0.008和P=0.03),但手术时间及并发症发生率与开腹组相比无统计学差异。中位复发时间,腹腔镜组为31.7月,开腹组为21.5个月(P=0.3)。结论对于经过精心挑选的晚期卵巢癌、输卵管癌和原发性腹膜癌病例,采用腹腔镜进行诊断、分期和肿瘤细胞减灭术,在技术上是可行的。 | 李萌 熊光武 Farr R.Nezhat Shaghayegh M.DeNoble Connie S.Liu Jennifer E.Cho Douglas N.Brown Linus Chuang Herbert Gretz Prakash Saharia | 2012 | 中国微创外科杂志2012，12，2： | 11 |
| 6 | Nrf2抗氧化损伤通路在CCl_4所致小鼠肝毒性中的保护作用(英文)显示文摘目的观察核转录相关因子2(nuclear factor erythroid 2-related factor 2,Nrf2)抗氧化损伤通路对四氯化碳(CCl4)所致小鼠肝毒性的保护作用。方法选取Nrf2-null、Wild-type、Keap1-KD、Keap1-HKO小鼠,按基因型分为4组,分别给予40 mg/kg CCl4腹腔注射,腹腔注射生理盐水(10 m L/kg)作对照,16 h后收集血浆和肝组织样本,检测血中谷丙转氨酶(alanine transaminase,ALT)和乳酸脱氢酶(lactic dehydrogenase,LDH)活性以及肝组织中丙二醛(malondialdehyde,MDA)含量;HE染色观察肝组织病理学变化,Real-time PCR和Western blot法检测相关基因表达。结果 CCl4增加Nrf2-null组和Wild-type组血中ALT、LDH活性及肝组织MDA含量,同时造成肝组织病理损伤,而在Keap1-KD组和Keap1-HKO组影响不明显;Nrf2因子靶基因(Nqo1和Gclc)在CCl4的诱导表达逐渐增高(顺序为Nrf2-null、Wild-type、Keap1-KD、Keap1-HKO),继而使炎症因子、内质网应激基因、细胞凋亡基因、细胞坏死基因的表达(m KC、MIP-2、IL-1β、TNFα、Gadd45、Chop10、Bax、Caspase 3、Mcl、Noxa)按Nrf2-null、Wild-type、Keap1-KD、Keap1-HKO顺序逐渐下降。结论 Nrf2因子激活保护CCl4所致小鼠肝损伤反应。 | 陆远富 Connie Wu 刘杰 Curtis Dean Klaassen | 2015 | 遵义医学院学报2015，38，1： | 11 |
| 7 | Impacts of climate gradients on the vegetation phenology of major land use types in Central Asia (1981-2008)显示文摘土地的时间系列关于植被生长模式的表面物候学(LSP ) 数据提议卓见。他们能被利用陆地表面部件的时间、光谱的反射性质产生。Interannual 和季节的 LSP 数据为理解并且预言一个生态系统的反应到生来、人为的驱动程序引起的变化是重要的。这研究在中亚检验在陆上的物候学和 28 年气候动力学之间的时间空间的变化模式和相互作用。长期(1981-2008 ) 象成长季节和植被生产率的开始,山峰和长度预定那样的 LSP 记录从遥远地察觉到的植被新鲜数据被导出。模式被分析在地区性的规模识别并且描绘气候司机的影响。我们探索了在 phenological 和降水之间的关系,为三的温度变量概括了暴露于地区性的干旱事件和加强的土地和水资源使用的 decadelong 的陆地使用类型:rainfed 农业,灌溉农业,和非农业。决定是否并且 LSP 动力学怎么与气候模式被联系,在这二个变量之间的一系列简单线性回归分析被执行。三个陆地使用班越过中亚显示出唯一的 phenological 回答到气候变化。大多数 phenological 反应变量被显示断然被相关到降水并且否定地相关到温度。影响所有三个陆地使用班的 phenological 回答的最实质的气候变量是春天温度政体。这些结果显示更高的温度将引起更早、更长的成长季节的那未来[出版摘要] | Jahan KARIYEVA Willem J.D. van LEEUWEN Connie A. WOODHOUSE | 2012 | Frontiers of Earth Science2012，6，2： | 10 |
| 8 | Antimicrobial activity of green tea extract against isolates of methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa显示文摘Objective:To evaluate antibacterial activity of the Indonesian water soluble green tea extract,Camellia sinensis,against clinical isolates of methicillin-resistantStaphylococcus aureus (S.aureus)(MRSA)and multi-drug resistant Pseudomonas aeruginosa(MDR-P.aeruginosa).Methods:Antimicrobial activity of green tea extract was determined by the disc diffusion method and the minimum inhibitory concentration(MIC)was determined by the twofold serial broth dilutions method.The tested bacteria using in this study were the standard strains and multi-drug resistant clinical isolates of S.aureus and P.aeruginosa,obtained from Laboratory of Clinical Microbiology,Faculty of Medicine,University of Indonesia.Results:The results showed that the inhibition zone diameter of green tea extracts forS.aureus ATCC 25923 and MRSA were(18.970依0.287)mm,and(19.130依0.250)mm respectively.While the inhibition zone diameter forP.aeruginosa ATCC 27853 and MDR-P.aeruginosawere(17.550依0.393)mm and(17.670依0.398)mm respectively.The MIC of green tea extracts againstS.aureus ATCC 25923 and MRSA were 400μg/mL and 400μg/mL,respectively,whereas the MIC for P.aeruginosa ATCC 27853 and MDR-P.aeruginosawere 800μg/mL,and 800μg/mL,respectively.Conclusions:Camellia sinensisleaves extract could be useful in combating emerging drug-resistance caused by MRSA andP.aeruginosa. | Maksum Radji Rafael Adi Agustama Berna Elya Conny Riana Tjampakasari | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，8： | 8 |
| 9 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 10 | 铅胁迫对黄瓜幼苗叶片蛋白质的影响显示文摘黄瓜幼苗经不同质量浓度铅处理后,叶片中可溶性蛋白质含量均发生了明显的变化.100 mg/L铅处理时,黄瓜幼苗叶片中可溶性蛋白质含量高于对照值,且随处理时间的延长,与对照比增加的值逐渐减少;500 mg/L和900 mg/L铅处理的叶片中可溶性蛋白质含量随着处理时间的延长表现为下降趋势,并且铅质量浓度越高,随着处理时间的延长,蛋白质含量下降量增加.不同质量浓度铅处理不同时期黄瓜幼苗叶片可溶性蛋白质组分的变化在谱带数和表达量上有明显的差异. | 刘素纯 萧浪涛 廖柏寒 Annie Zhu jiang Connie Lo | 2006 | 湖南农业大学学报(自然科学版)2006，32，2： | 6 |
| 11 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 12 | Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline显示文摘 | Michael F. Holick Neil C. Binkley Heike A. Bischoff-Ferrari Catherine M. Gordon David A. Hanley Robert P. Heaney M. Hassan Murad Connie M. Weaver | 2011 | The Journal of Clinical Endocrinology & Metabolism2011，，7： | 5 |
| 13 | Mdm proteins: critical regulators of embryogenesis and hornoeostasis显示文摘 | Sydney M. Moyer Connie A. Larsson Guillermina Lozano | 2017 | Journal of Molecular Cell Biology2017，9，1： | 5 |
| 14 | 中国青少年人群的峰值骨量:充足钙摄入的重要性显示文摘在生命早期阶段达到较高的峰值骨量和强度对于降低未来发生骨质疏松症或降低骨量的风险至关重要。种族和性别等遗传因素在很大程度上影响了峰值骨量的差异性和达到峰值骨量的时机。一般而言,与白种人相比,亚洲人的面积骨矿物质密度较低,并且达到峰值骨量的时间更早。在不同生活方式的影响因素中,有强有力的证据表明饮食中钙摄入和体育锻炼对骨骼累积具有积极作用。研究表明,各个年龄段中国人的钙摄入量都远低于建议的摄入量。为了能够达到其遗传潜能的峰值骨量和骨强度,强烈建议中国人群通过促进饮食摄入和(或)服用补充剂来获得足够的钙和维生素D摄入,尤其是中国青少年群体。 | 曹思思 Weaver M Connie 贺晓燕 洪帆 | 2020 | 中华内分泌代谢杂志2020，36，6： | 5 |
| 15 | Mechanistic links between gut microbial community dynamics, microbial functions and metabolic health显示文摘Gut microbes comprise a high density, biologically active community that lies at the interface of an animal with its nutritional environment. Consequently their activity profoundly influences many aspects of the physiology and metabolism of the host animal. A range of microbial structural components and metabolites directly interact with host intestinal cells and tissues to influence nutrient uptake and epithelial health. Endocrine, neuronal and lymphoid cells in the gut also integrate signals from these microbial factors to influence systemic responses. Dysregulation of these host-microbe interactions is now recognised as a major risk factor in the development of metabolic dysfunction. This is a two-way process and understanding the factors that tip host-microbiome homeostasis over to dysbiosis requires greater appreciation of the host feedbacks that contribute to regulation of microbial community composition. To date, numerous studies have employed taxonomic profiling approaches to explore the links between microbial composition and host outcomes(especially obesity and its comorbidities), but inconsistent host-microbe associations have been reported. Available data indicates multiple factors have contributed to discrepancies between studies. These include the high level of functional redundancy in host-microbiome interactions combined with individual variation in microbiome composition; differences in study design, diet composition and host system between studies; and inherent limitations to the resolution of r RNA-based community profiling. Accounting for these factors allows for recognition of the common microbial and host factors driving community composition and development of dysbiosis on high fat diets. New therapeutic intervention options are now emerging. | Connie WY Ha Yan Y Lam Andrew J Holmes | 2014 | World Journal of Gastroenterology2014，20，44： | 4 |
| 16 | Molecular Tests for Colorectal Cancer Screening显示文摘 | Linda J.W. Bosch Beatriz Carvalho Remond J.A. Fijneman Connie R. Jimenez Herbert M. Pinedo Manon van Engeland Gerrit A. Meijer | 2011 | Clinical Colorectal Cancer2011，，1： | 4 |
| 17 | Practice Guidelines for Management of the Difficult Airway: An Updated Report by the American Society of Anesthesiologists Task Force on Management of the Difficult Airway显示文摘 | Jeffrey L. Apfelbaum Carin A. Hagberg Robert A. Caplan Casey D. Blitt Richard T. Connis David G. Nickinovich Carin A. Hagberg Robert A. Caplan Jonathan L. Benumof Frederic A. Berry Casey D. Blitt Robert H. Bode Frederick W. Cheney Richard T. Connis Orin F | 2013 | Anesthesiology2013，，2： | 4 |
| 18 | Metronomic chemotherapy for non-metastatic triple negative breast cancer: Selection is the key显示文摘Triple negative breast cancer(TNBC) accounts for 15%-20% of all breast cancer, and is still defined as what it is not. Currently, TNBC is the only type of breast cancer for which there are no approved targeted therapies and maximum tolerated dose chemotherapy with taxanes and anthracycline-containing regimens is still the standard of care in both the neoadjuvant and adjuvant settings. In the last years, metronomic chemotherapy(MC) is being explored as an alternative to improve outcomes in TNBC. In the neoadjuvant setting, purely metronomic and hybrid approaches have been developed with the objective of increasing complete pathologic response(p CR) and prolonging disease free survival. These regimens proved to be very effective achieving pC R rates between 47%-60%, but at the cost of great toxicity. In the adjuvant setting, MC is used to intensify adjuvant chemotherapy and, more promisingly, as maintenance therapy for high-risk patients, especially those with no pC R after neoadjuvant chemotherapy. Considering the dismal prognosis of TNBC, any strategy that potentially improves outcomes, specially being the oral agents broadly available and inexpensive, should be considered and certainly warrants further exploration. Finally, the benefit of MC needs to be validated in properly designed clinical trials were the selection of the population is the key. | Connie Rabanal Rossana Ruiz Silvia Neciosup Henry Gomez | 2017 | World Journal of Clinical Oncology2017，8，6： | 4 |
| 19 | Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury显示文摘 | Yumiko Imai Keiji Kuba G. Greg Neely Rubina Yaghubian-Malhami Thomas Perkmann Geert van Loo Maria Ermolaeva Ruud Veldhuizen Y.H. Connie Leung Hongliang Wang Haolin Liu Yang Sun Manolis Pasparakis Manfred Kopf Christin Mech Sina Bavari J.S. Malik Peiris Ar | 2008 | Cell2008，，2： | 4 |
| 20 | 肠外营养时不同脂肪乳剂对粒细胞功能的影响显示文摘目的 比较静脉输注长链及中长链脂肪乳剂时对粒细胞功能的影响。 方法 选择18位健康志愿者进行前瞻性随机交叉对照研究 ,连续输注MCT/LCT或LCT(TG :0 .15 g·kg-1·h-1) ,在研究前及输注中 2h、4h及 2 4h分别抽血提取多核白细胞作趋向性、自发游动、吞噬能力、杀菌率及吞噬过程中氧化代谢测定。 结果 静脉输注脂肪乳剂时多核白细胞的趋向性和自发游动能力无明显改变 (P >0 .0 5 ) ,但多核白细胞的吞噬及杀菌能力下降 (P <0 .0 5 ) ,两种脂肪乳剂之间无统计学差异 (P >0 .0 5 )。静脉输注脂肪乳剂可明显抑制NBT值 (P <0 .0 5 ) ,且LCT的抑制程度要大于MCT/LCT(P <0 .0 5 )。 结论 静脉输注脂肪乳剂可影响粒细胞吞噬、杀菌及氧化代谢能力 ,但对粒细胞的趋向性及自发游动能力无明显影响。长链及中 /长链脂肪乳剂在对粒细胞功能的影响上无明显差异。 | 吴国豪 Connie Jarstrand Jorgen Nordenstrom | 2001 | 中国临床营养杂志2001，9，4： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员