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| 1 | Transplantation of primary and reversibly immortalized human liver cells and other gene therapies in acute liver failure and decompensated chronic liver disease显示文摘Studies performed in experimental small animalswith hepatic-based metabolic disorders but nostructural liver disease,including Gunn andanalbuminaemic rats and rabbits with inherited low-density lipoprotein receptor deficiency,have shownthat up to 95% of hepatocytes transplanted into thespleen or liver remain in these sites,withimprovement in metabolic function | Stephen M.Riordan Roger Williams | 2000 | World Journal of Gastroenterology2000，6，5： | 13 |
| 2 | A New Infrared Atmospheric Sounding Interferometer Channel Selection and Assessment of Its Impact on Met Office NWP Forecasts显示文摘A new set of Infrared Atmospheric Sounding Interferometer(IASI) channels was re-selected from 314 EUMETSAT channels.In selecting channels,we calculated the impact of the individually added channel on the improvement in the analysis outputs from a one-dimensional variational analysis(1D-Var) for the Unified Model(UM) data assimilation system at the Met Office,using the channel score index(CSI) as a figure of merit.Then,200 channels were selected in order by counting each individual channel's CSI contribution.Compared with the operationally used 183 channels for the UM at the Met Office,the new set shares 149 channels,while the other 51 channels are new.Also examined is the selection from the entropy reduction method with the same 1D-Var approach.Results suggest that channel selection can be made in a more objective fashion using the proposed CSI method.This is because the most important channels can be selected across the whole IASI observation spectrum.In the experimental trial runs using the UM global assimilation system,the new channels had an overall neutral impact in terms of improvement in forecasts,as compared with results from the operational channels.However,upper-tropospheric moist biases shown in the control run with operational channels were significantly reduced in the experimental trial with the newly selected channels.The reduction of moist biases was mainly due to the additional water vapor channels,which are sensitive to the upper-tropospheric water vapor. | Young-Chan Noh Byung-Ju Sohn Yoonjae Kim Sangwon Joo William Bell Roger Saunders | 2017 | Advances in Atmospheric Sciences2017，34，11： | 6 |
| 3 | Transition from wavelets to ripples in a laboratory flume with a diverging channel显示文摘An experimental investigation on the initiation and development of bed forms on a bed of fine silica sand was conducted under alluvial flow conditions in a laboratory flume with a diverging channel. The main aims of the study were to assess: i) the steepness of bed forms in the transition stage of development; and ii) the threshold height of wavelets (ηt) that triggered the start of ripple development. Detailed bed profile measurements were carried out using an acoustic Doppler probe, traversed longitudinally over the sediment bed at various experimentation times. The bed form dimensions were extracted from such bed profile records and analysed for the wavelet, transition and equilibrium stages. It was found that the steepness of ripples in the transition and equilibrium stages were similar, confirming predictions of previous mathematical model simulations. A lognormal distribution fitted the wavelet length data. The wavelet threshold height was estimated as ηt≈ 7 mm, or y+ ≈ 80 in wall units. Such a height magnitude suggested that ripple development could be triggered by the wavelets reaching the outer flow zone of a turbulent boundary layer. The ηt value obtained corresponded generally to the intersection point between two predictive equations for bed form dimensions. A formulation was developed to predict ηt as a function of the sediment grain size, which was confirmed for the fine sand used in this study. | William B. RAUEN Binliang LIN Roger A. FALCONER | 2008 | International Journal of Sediment Research2008，23，1： | 5 |
| 4 | Heart Disease and Stroke Statistics—2013 Update: A Report From the American Heart Association显示文摘 | Alan S. Go Dariush Mozaffarian Véronique L. Roger Emelia J. Benjamin Jarett D. Berry William B. Borden Dawn M. Bravata Shifan Dai Earl S. Ford Caroline S. Fox Sheila Franco Heather J. Fullerton Cathleen Gillespie Susan M. Hailpern John A. Heit Virginia J. | 2013 | Circulation2013，，1： | 5 |
| 5 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 6 | Executive Summary: Heart Disease and Stroke Statistics—2013 Update: A Report From the American Heart Association显示文摘 | Alan S. Go Dariush Mozaffarian Véronique L. Roger Emelia J. Benjamin Jarett D. Berry William B. Borden Dawn M. Bravata Shifan Dai Earl S. Ford Caroline S. Fox Sheila Franco Heather J. Fullerton Cathleen Gillespie Susan M. Hailpern John A. Heit Virginia J. | 2013 | Circulation2013，，1： | 4 |
| 7 | Incubation Phase of Acute Hepatitis B in Man: Dynamic of Cellular Immune Mechanisms显示文摘 | George J.M. Webster Stephanie Reignat Mala K. Maini Simon A. Whalley Graham S. Ogg Abigail King David Brown Peter L. Amlot Roger Williams Diego Vergani Geoffrey M. Dusheiko Antonio Bertoletti | 2000 | Hepatology2000，，5： | 4 |
| 8 | Single vs dual(en bloc) kidney transplants from donors ≤ 5 years of age: A single center experience显示文摘AIM: To compare outcomes between single and dual en bloc(EB) kidney transplants(KT) from small pediatric donors. METHODS: Monocentric nonprospective review of KTs from pediatric donors ≤ 5 years of age. Dual EB KT was defined as keeping both donor kidneys attached tothe inferior vena cava and aorta, which were then used as venous and arterial conduits for the subsequent transplant into a single recipient. Donor age was less useful than either donor weight or kidney size in decision-making for kidney utilization as kidneys from donors < 8 kg or kidneys < 6 cm in length were not transplanted. Post-transplant management strategies were standardized in all patients.RESULTS: From 2002-2015, 59 KTs were performed including 34 dual EB and 25 single KTs. Mean age of donors(17 mo vs 38 mo, P < 0.001), mean weight(11.0 kg vs 17.4 kg, P = 0.046) and male donors(50% vs 84%, P = 0.01) were lower in the dual EB compared to the single KT group, respectively. Mean cold ischemia time(21 h), kidney donor profile index(KDPI; 73% vs 62%) and levels of serum creatinine(SCr, 0.37 mg/d L vs 0.49 mg/d L, all P = NS) were comparable in the dual EB and single KT groups, respectively. Actuarial graft and patient survival rates at 5-years follow-up were comparable. There was one case of thrombosis resulting in graft loss in each group. Delayed graft function incidence(12% dual EB vs 20% single KT, P = NS) was slightly lower in dual EB KT recipients. Initial duration of hospital stay(mean 5.4 d vs 5.6 d) and the one-year incidences of acute rejection(6% vs 16%), operative complications(3% vs 4%), and major infection were comparable in the dual EB and single KT groups, respectively(all P = NS). Mean 12 mo SCr and abbreviated MDRD levels were 1.17 mg/d L vs 1.35 mg/d L and 72.5 m L/min per 1.73 m^2 vs 60.5 m L/min per 1.73 m^2(both P = NS) in the dual EB and single KT groups, respectively. CONCLUSION: By transplanting kidneys from young pediatric donors into adult recipients, one can effectively expand the limited donor pool and achieve excellent medium-term outcomes. | Yousef Al-Shraideh Umar Farooq Hany El-Hennawy Alan C Farney Amudha Palanisamy Jeffrey Rogers Giuseppe Orlando Muhammad Khan Amber Reeves-Daniel William Doares Scott Kaczmorski Michael D Gautreaux Samy S Iskandar Gloria Hairston Elizabeth Brim Margaret Mangus Robert J Stratta | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 9 | The Systemic Inflammatory Response Syndrome in Acute Liver Failure显示文摘 | Nancy Rolando Jim Wade Milagros Davalos Julia Wendon John Philpott-Howard Roger Williams | 2000 | Hepatology2000，，4： | 3 |
| 10 | Outcomes after percutaneous reduction and fixation of proximal humeral fractures显示文摘 | Jay D. Keener Brad O. Parsons Evan L. Flatow Kenneth Rogers Gerald R. Williams Leesa M. Galatz | 2007 | Journal of Shoulder and Elbow Surgery2007，，3： | 3 |
| 11 | The Systemic Inflammatory Response Syndrome in Acute Liver Failure显示文摘 | Nancy Rolando Jim Wade Milagros Davalos Julia Wendon John Philpott-Howard Roger Williams | 2000 | Hepatology2000，，4： | 3 |
| 12 | Expression of Transforming Growth Factor-β1 by Pancreatic Stellate Cells and Its Implications for Matrix Secretion and Turnover in Chronic Pancreatitis显示文摘 | Fanny Wai-Tsing Shek Robert Christopher Benyon Fiona Mairi Walker Peter Raymond McCrudden Sylvia Lin Foon Pender Elizabeth Jean Williams Penelope Ann Johnson Colin David Johnson Adrian Calvin Bateman David Roger Fine John Peter Iredale | 2002 | The American Journal of Pathology2002，，5： | 2 |
| 13 | Inhibitors of hepatic DNA synthesis in fulminant hepatic failure显示文摘 | Dr. Robin D. Hughes PhD Haruki Yamada MD Christopher D. Gove PhD Roger Williams MD | 1991 | Digestive Diseases and Sciences1991，，6： | 2 |
| 14 | Executive Summary: Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association显示文摘 | Véronique L. Roger Alan S. Go Donald M. Lloyd-Jones Emelia J. Benjamin Jarett D. Berry William B. Borden Dawn M. Bravata Shifan Dai Earl S. Ford Caroline S. Fox Heather J. Fullerton Cathleen Gillespie Susan M. Hailpern John A. Heit Virginia J. Howard Bret | 2012 | Circulation2012，，1： | 2 |
| 15 | Bacterial and Fungal Infection in Acute Liver Failure显示文摘 | Nancy Rolando John Philpott-Howard Roger Williams | 1996 | Semin Liver Dis1996，，04： | 2 |
| 16 | Lessons from look-back in acute liver failure? A single centre experience of 3300 patients显示文摘 | William Bernal Anna Hyyrylainen Amit Gera Vinod K. Audimoolam Mark J.W. McPhail Georg Auzinger Mohammed Rela Nigel Heaton John G. O’Grady Julia Wendon Roger Williams | 2013 | Journal of Hepatology2013，，1： | 2 |
| 17 | Blockade of PD1 and TIM3 Restores Innate and Adaptive Immunity in Patients with Acute Alcoholic Hepatitis显示文摘 | Lee J.L. Markwick Antonio Riva Jennifer M. Ryan Helen Cooksley Elena Palma Tom H. Tranah Godhev K. Manakkat Vijay Nikhil Vergis Mark Thursz Alex Evans Gavin Wright Sarah Tarff John O’Grady Roger Williams Debbie L. Shawcross Shilpa Chokshi | 2014 | Gastroenterology2014，，： | 2 |
| 18 | Sarcopenia: An Undiagnosed Condition in Older Adults. Current Consensus Definition: Prevalence, Etiology, and Consequences. International Working Group on Sarcopenia显示文摘 | Roger A. Fielding Bruno Vellas William J. Evans Shalender Bhasin John E. Morley Anne B. Newman Gabor Abellan van Kan Sandrine Andrieu Juergen Bauer Denis Breuille Tommy Cederholm Julie Chandler Capucine De Meynard Lorenzo Donini Tamara Harris Aimo Kannt F | 2011 | Journal of the American Medical Directors Association2011，，4： | 2 |
| 19 | Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome显示文摘 | Roy Freeman Wouter Wieling Felicia B. Axelrod David G. Benditt Eduardo Benarroch Italo Biaggioni William P. Cheshire Thomas Chelimsky Pietro Cortelli Christopher H. Gibbons David S. Goldstein Roger Hainsworth Max J. Hilz Giris Jacob Horacio Kaufmann Jens | 2011 | Autonomic Neuroscience: Basic and Clinical2011，，1： | 2 |
| 20 | Screening immigrants for tuberculosis—why not for HBV infection?显示文摘 | Roger Williams Andrew P Holt | 2013 | The Lancet2013，，9884： | 2 |
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