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| 1 | 北京教学医院普通外科住院患者营养风险、营养不足、超重、肥胖及营养支持状况显示文摘目的调查北京教学医院普通外科住院患者人院和入院2周(或出院)时营养风险、营养不足、超重、肥胖和营养支持的状况。方法采用定点连续抽样,选择2007年3月至6月在北京3家教学医院普通外科住院患者进行营养风险筛查,使用营养风险筛查2002(NRS2002)于患者入院和入院2周(或出院)时实施,并调查患者2周内(或至出院时)的营养支持状况,分析营养风险和营养支持之间的关系。NRS200293分为有营养风险,体重指数(BMI)〈18.5kg/m2并结合患者临床情况判定为营养不足。结果300例入选者中,有297例完成筛查,NRS2002适用率为99.0%。入院时总营养风险发生率为30.0%,营养不足、超重和肥胖的发生率分别为8.1%、38.3%和9.4%。存在营养风险和无营养风险患者的营养支持率分别为62.2%和19.O%。在接受腹部大手术的患者中,有营养风险和无营养风险患者的营养支持率分别为71.6%和43.2%。入院和入院2周(或出院)时的总营养风险发生率分别为30.0%和35.8%,两者相比差异无统计学意义(x2=2.271,P=0.132)。结论NRS2002适用于普通外科住院患者的营养筛查。临床营养支持在普通外科得到了充分重视,但临床上存在肠外、肠内营养的不合理应用。住院期间未观察到患者营养风险发生率的变化. | 梁晓坤 蒋朱明 Marie T. Nolan 于康 陈伟 吴欣娟 张海燕 郑一宁 刘华平 Jens Kondrup | 2009 | 中华临床营养杂志2009，17，2： | 42 |
| 2 | Transition-metal doped edge sites in vertically aligned MoS2 catalysts for enhanced hydrogen evolution显示文摘为象氢进化反应那样的电气化学的反应的高度活跃、便宜的催化剂(她的) 为有效精力的发展是关键的变换和存储技术。理论模拟在揭示在材料和他们的催化活动的电子结构之间的关联是有帮助的,并且指导改进催化剂的预言和发展。然而,在精确地设计需要的原子地点的困难在做在试验性、理论的结果之间的直接比较导致挑战。在瞬间 < 潜水艇 class= “ a-plus-plus ” > 2 , 而薹是惰性的,瞬间边被表明了为她活跃。用一条计算基于描述符的途径,我们预言由合并转变金属原子(Fe,公司, Ni,或 Cu ) ,薹地点应该也成为她活跃。垂直地站的、终止边的瞬间 < 潜水艇 class= “ a-plus-plus ” > 2 nanofilms 为验证这些预言提供一个明确的模型系统。转变金属做了瞬间 < 潜水艇 class= “ a-plus-plus ” > 2 nanofilms 表演交换水流密度由的增加至少双重,与理论计算一致。这个工作为由把倡导者合并到特别原子地点改进电气化学的催化剂,并且为使用明确的系统以便理解提升效果的起源开创进一步的机会。 | Haotian Wang Charlie Tsai Desheng Kong Karen Chan Frank Abild-Pedersen Jens K. Norskov Yi Cui | 2015 | Nano Research2015，8，2： | 41 |
| 3 | 营养支持对有营养风险胃肠病患者临床结局的影响以及成本-效果比初步探讨:275例前瞻性队列研究显示文摘目的研究营养支持对有营养风险的胃肠病患者的临床结局影响,并初步收集成本一效果有关信息,对成本一效果比进行初步探讨。方法本研究为前瞻性队列研究设计,采用定点连续抽样,随访记录研究对象整个住院期间的营养支持应用情况、感染性并发症发病和治疗情况、住院天数等方面信息,并收集研究对象住院期间营养支持的直接费用、并发症的诊断和治疗费用。用多因素统计分析方法评估营养支持对感染性并发症的影响。将“无感染性并发症患者比例”作为效果指标,对肠内营养、肠外营养、肠内和肠外联合营养及无营养支持的4个队列进行成本-效果比的初步探讨。结果对有营养风险的患者,接受营养支持群体与未接受营养支持群体相比感染性并发症发病率显著降低(6.8%比19.6%,X^2=9.0,P=0.003),但住院总费用增高(P=0.0001)。肠外营养、肠内营养、肠外营养一肠内营养联合应用以及未使用营养支持队列,经多因素调整后的成本分别是5635、1212、5220和1339元,而“无感染性并发症患者比例”分别是92.3%、96.4%、91.9%和80.4%。肠外营养、肠内营养和肠外营养.肠内营养支持与无营养支持队列相比,增量成本效果比分别为36101、-794及33748元。结论对有营养风险的胃肠病患者接受营养支持有助于改善患者结局。由于本研究收集成本一效果比有关数据的范围不够,无法通过“广义估计方程”对可能影响结果的因素进行调整,其结果不符合卫生经济学的全面要求,不能直接引用。本初步结果尚需收集更多成本一效果比方面数据的临床研究来校正和补充。 | 王艳 蒋朱明 Jens Kondrup 王杨 Marie Nolan 钱家鸣 于康 | 2013 | 中华临床营养杂志2013，21，6： | 37 |
| 4 | 62 kaBP以来湖光岩玛珥湖沉积物有机碳同位素记录及古气候环境意义显示文摘湖光岩玛珥湖HUG B孔岩心记录了62kaBP以来的古气候、古环境变化信息。全岩有机碳同位素组成(δ13CTOC)分析表明,62kaBP以来δ13CTOC值变化比较明显,其变化范围为-28.5‰~-15.5‰。结合孢粉和有机地球化学指标进行综合分析,湖光岩玛珥湖δ13CTOC变化曲线可划分为6个演化阶段:62~58和48~40.5kaBP两个时段的δ13CTOC值偏负,沉积物中有机质主要来源于热带—亚热带地区的陆生C3森林植被,反映了温暖潮湿的气候环境;58~48和40.5~17.2kaBP期间δ13CTOC值明显偏正,沉积物中有机质主要源自C4草本植物,反映了湖光岩地区有效降水量减少、干旱程度增加导致湖光岩玛珥湖湖面下降,大量C4草本植物生长在暴露的湖滨岸;17.2~4kaBP时段内δ13CTOC值尽管存在更加频繁的波动,但总体呈现逐渐偏负的趋势,反映了暖湿和冷干气候多次交替但总体上逐渐变暖、变湿的气候环境;4kaBP以来δ13CTOC值存在逐渐偏正的趋势,虽然不排除人类活动的影响,但很可能反映了干旱程度的再次增加。综合分析表明,有效降水量(降水量-蒸发量)是控制湖光岩玛珥湖地区C3/C4植物相对生物量变化的主导因素。湖光岩玛珥湖有机碳同位素的研究结果支持区域气候环境而不是大气CO2浓度变化是末期冰期以来热带低纬度地区C3/C4植被相对生物量变化的主要原因。 | 刘强 顾兆炎 刘嘉麒 游海涛 吕厚远 储国强 祁向雷 Jorg F W Negendank Jens Mingram Georg Schettler | 2005 | 海洋地质与第四纪地质2005，25，2： | 34 |
| 5 | Petawatt and exawatt class lasers worldwide显示文摘In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development. | Colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang Hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christopher Spindloe Sándor Szatmári Raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel | 2019 | High Power Laser Science and Engineering2019，7，3： | 33 |
| 6 | 急性胰腺炎的外科治疗显示文摘 | Hans Guenther Beger Bettina Rau Rainer Isenmann Jens Mayer 刘斌 吴在德 | 2001 | 中华外科杂志2001，39，4： | 28 |
| 7 | 电离层GPS掩星观测改正TEC反演方法显示文摘电离层掩星观测中,当低轨卫星(LEO)轨道高度较低时,轨道以上的电离层电子总含量(TEC)对掩星反演的影响不能忽略.目前,一般采用指数函数等外推方法来处理该问题,对反演结果可能引起较大误差.为提高电离层掩星反演精度,本文研究利用LEO处于非掩星一侧GPS观测数据的改正TEC新反演方法.用三维射线追踪程序计算出电离层掩星观测模拟数据,分别应用改正TEC方法和外推方法进行反演,将反演结果与所用模式值进行比较.结果表明:对于轨道高度约800km的GPS MET掩星模拟数据,外推方法和改正TEC方法反演结果都与模式值基本一致;对于轨道高度约400km的CHAMP掩星模拟数据,外推方法误差较大,改正TEC方法反演结果与模式值相符得较好.将改正TEC方法应用于GPS MET实测数据的反演,取得了合理的结果.这些说明,改正TEC算法是一种有效的电离层掩星反演方法,尤其是对于轨道较低的LEO的电离层掩星观测反演特别有用. | 吴小成 胡雄 张训械 Jens Wickert | 2006 | 地球物理学报2006，49，2： | 25 |
| 8 | Global leaf nitrogen and phosphorus stoichiometry and their scaling exponent显示文摘Leaf nitrogen(N) and phosphorus(P) concentrations constrain photosynthetic and metabolic processes,growth and the productivity of plants. Their stoichiometry and scaling relationships regulate the allocation of N and P from subcellular to organism, and even ecosystem levels, and are crucial to the modelling of plant growth and nutrient cycles in terrestrial ecosystems. Prior work has revealed a general biogeographic pattern of leaf N and P stoichiometric relationships and shown that leaf N scales roughly as two-thirds the power of P. However, determining whether and how leaf N and P stoichiometries, especially their scaling exponents, change with functional groups and environmental conditions requires further verification. In this study, we compiled a global data set and documented the global leaf N and P concentrations and the N:P ratios by functional group, climate zone and continent. The global overall mean leaf N and P concentrations were 18.9 mg g^(-1) and 1.2 mg g^(-1), respectively, with significantly higher concentrations in herbaceous than woody plants(21.72 mg g^(-1) vs. 18.22 mg g^(-1) for N; and 1.64 mg g^(-1) vs. 1.10 mg g^(-1) for P). Both leaf N and P showed higher concentrations at high latitudes than low latitudes. Among six continents, Europe had the highest N and P concentrations(20.79 and 1.54 mg g^(-1)) and Oceania had the smallest values(10.01 and 0.46 mg g^(-1)). These numerical values may be used as a basis for the comparison of other individual studies. Further, we found that the scaling exponent varied significantly across different functional groups,latitudinal zones, ecoregions and sites. The exponents of herbaceous and woody plants were 0.659 and0.705, respectively, with significant latitudinal patterns decreasing from tropical to temperate to boreal zones. At sites with a sample size ≥10, the values fluctuated from 0.366 to 1.928, with an average of 0.841.Several factors including the intrinsic attributes of different life forms, P-related growth rates and relative nutrient availability of soils likely account for the inconstant exponents of leaf N vs. P scaling relationships. | Di Tian Zhengbing Yan Karl J.Niklas Wenxuan Han Jens Kattge Peter B.Reich Yongkai Luo Yahan Chen Zhiyao Tang Huifeng Hu Ian J.Wright Bernhard Schmid Jingyun Fang | 2018 | National Science Review2018，5，5： | 24 |
| 9 | 基于响应面模型的区域大气污染控制辅助决策工具研发显示文摘基于CMAQ模型结果,利用高维克里金插值算法,建立了排放控制因子与污染物环境浓度的响应面模型(RSM),实现了大气污染可控源排放与复合污染水平的实时函数响应.研究结果显示,RSM对PM2.5的预测结果与CMAQ实际模拟结果的误差在容许范围内(最大误差小于0.20μg.m-3,3.89%).基于所建立的RSM,开发了RSM-VAT区域大气污染控制可视化辅助决策工具.使用RSM-VAT对美国8个典型城市的PM2.5污染状况进行了控制情景分析,通过'可视化展示'和'图表分析'二大模块,输出不同控制情景下的环境污染物浓度的实时响应图、可视化展示和数据分析图表等结果. | 劳苑雯 朱云 Carey Jang Che Jen Lin 邢佳 陈志润 谢俊平 王书肖 Joshua Fu | 2012 | 环境科学学报2012，32，8： | 20 |
| 10 | Male reproductive organs are at risk from environmental hazards显示文摘具有从一个环境观点的兴趣的男繁殖混乱包括性机能障碍,不孕, cryptorchidism, hypospadias 和阴囊的癌症。几份报告经过 50 年在一些时间时期期间建议衰退精子计数和一些区域的这些繁殖混乱的增加。除了阴囊的癌症,这条证据是偶然的并且需要小心的解释。然而,男细菌线是到电离的损坏效果的最敏感的纸巾之一放射,辐射热和很多已知的有毒物。到目前为止职业的危险是为损害男繁殖功能的最好记录的风险因素并且包括物理暴露(辐射热,电离放射,高频率电磁的放射),化学暴露(一些溶剂作为碳二硫化物和乙烯乙二醇醚,一些杀虫剂作为 dibromochloropropane , ethylendibromide 和 DDT/DDE ,是的一些重金属无机的铅和水银)并且工作过程象金属焊接那样。在支流国家的改进工作条件戏剧性地减少了已知的危险工作地点暴露,但是在更少的支流国家的百万个工人在从繁殖有毒物的风险。到在食谱的 biopersistent 污染物质的环境低级暴露可以提出的新数据表演风险到在世界的所有部分的人。为另外的有毒物,证据仅仅是暗示的,在结论能被得出以前,进一步的评估被需要。是否作为是在场的在的 phthalates, bisphenol A 和硼加重很多工业并且消费者产品必要风险尚待被证实。一样适用于 psychosocial stressors 和手机的使用。最后,有数据,显示胎儿的睾丸的特别危险到有毒物鈥攆o r 例子母亲的烟草吸烟。在男繁殖毒性应该被探讨的地方,时间来了在生活很早包括暴露形成完全新的角度。 | Jens Peter Bonde | 2010 | Asian Journal of Andrology2010，12，2： | 19 |
| 11 | Value of three-dimensional reconstructions in pancreatic carcinoma using multidetector CT:Initial results显示文摘AIM:To evaluate the use of three-dimensional imaging of pancreatic carcinoma using multidetector computed tomography(CT)in a prospective study.METHODS:Ten patients with suspected pancreatic tumors were examined prospectively using multidetec-tor CT(Somatom Sensation 16,Siemens,Erlangen,Germany).The images were evaluated for the pres-ence of a pancreatic carcinoma and invasion of the peripancreatic vessels and surrounding organs.Using the isotropic CT data sets,a three-dimensional image was created with automatic vascular analysis and semi-automatic segmentation of the organs and pancreatic tumor by a radiologist.The CT examinations and the three-dimensional images were presented to the sur-geon directly before and during the patient's operation using the Medical Imaging Interaction Toolkit-based software 'ReLiver'.Immediately after surgery,the value of the two images was judged by the surgeon.The operation and the histological results served as the gold standard.RESULTS:Nine patients had a pancreatic carcinoma(all pT3),and one patient had a serous cystadenoma.One tumor inf iltrated the superior mesenteric vein.The inf iltration was correctly evaluated.All carcinomas were resectable.In comparison to the CT image with axial and coronal reconstructions,the three-dimensional image was judged by the surgeons as better for operation planning and consistently described as useful.CONCLUSION:A 3D-image of the pancreas repre-sents an invaluable aid to the surgeon.However,the 3D-software must be further developed in order to be integrated into daily clinical routine. | Miriam Klauβ Max Schbinger Ivo Wolf Jens Werner Hans-Peter Meinzer Hans-Ulrich Kauczor Lars Grenacher | 2009 | World Journal of Gastroenterology2009，15，46： | 16 |
| 12 | Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound显示文摘AIM:To evaluate whether contrast enhanced ultrasound(CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer.METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal cancer underwent CEUS before treatment(CEUS date 1) and before the second(CEUS date 2) and fourth(CEUS date 3) cycle of bevacizumab based chemotherapy.Three parameters [PEAK,Time to peak(TTP) and RISE RATE]were correlated with radiological response.RESULTS:For neoadjuvant purpose a reduction of tumour mass was required to assume clinical response.Based on these response criteria there was a significant(P < 0.001) correlation in TTP between metastases of responders(9.08 s) and non-responders(14.76 s) archived on CEUS date 1.By calculating a standardized quotient(metastases divided by normal liver tissue) we were able to define a cut off,predicting response with a sensitivity of 92.3 % and a specificity of 100 %.To reflect a palliative intention only those patients with progressive disease were classified as non-responders.In this stetting TTP was also significantly(P < 0.01) different between responders and non-responders.In contrast,Peak and Rise rate did not show any significant difference between responder and non-responder.CONCLUSION:CEUS might serve as a surrogate marker to predict treatment response in patients with metastasized colorectal cancer who receive antiangiogenic therapy. | Ramin Schirin-Sokhan Ron Winograd Christoph Roderburg Jhenee Bubenzer Nicole Cabral do ó Dorothee Guggenberger Hartmut Hecker Christian Trautwein Jens J W Tischendorf | 2012 | World Journal of Gastroenterology2012，18，6： | 16 |
| 13 | Yb-doped large-pitch fibres: effective single-mode operation based on higher-order mode delocalisation显示文摘Rare earth-doped fibres are a diode-pumped,solid-state laser architecture that is highly scalable in average power.The performance of pulsed fibre laser systems is restricted due to nonlinear effects.Hence,fibre designs that allow for very large mode areas at high average powers with diffraction-limited beam quality are of enormous interest.Ytterbium-doped,rod-type,large-pitch fibres(LPF)enable extreme fibre dimensions,i.e.,effective single-mode fibres with mode sizes exceeding 100 times the wavelength of the guided radiation,by exploiting the novel concept of delocalisation of higher-order transverse modes.The non-resonant nature of the operating principle makes LPF suitable for high power extraction.This design allows for an unparalleled level of performance in pulsed fibre lasers. | Jens Limpert Fabian Stutzki Florian Jansen Hans-Jurgen Otto Tino Eidam Cesar Jauregui Andreas Tunnermann | 2012 | Light(Science & Applications)2012，1，1： | 16 |
| 14 | Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology显示文摘AIM: To examine the vitamin D status in patients with alcoholic cirrhosis compared to those with primary biliary cirrhosis. METHODS: Our retrospective case series comprised 89 patients with alcoholic cirrhosis and 34 patients with primary biliary cirrhosis who visited our outpatient clinic in 2005 and underwent a serum vitamin D status assessment. RESULTS: Among the patients with alcoholic cirrhosis, 85% had serum vitamin D levels below 50 nmol/L and 55% had levels below 25 nmol/L, as compared to 60% and 16% of the patients with primary biliary cirrhosis, respectively (P < 0.001). In both groups, serum vitamin D levels decreased with increasing liver disease severity, as determined by the Child-Pugh score. CONCLUSION: Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology, with lower levels of vitamin D in alcoholic cirrhosis than in primary biliary cirrhosis. | Mikkel Malham SΦren Peter JΦrgensen Peter Ott JΦrgen Agnholt Hendrik Vilstrup Mette Borre Jens F Dahlerup | 2011 | World Journal of Gastroenterology2011，17，7： | 15 |
| 15 | 呈现科研数据知识库:re3data.org注册机制显示文摘科研人员在钻研科研问题与分享科研数据的过程中,需要某种基础设施来确保数据最大程度的获取性、稳定性和可用性。这类基础设施可以统称为科研数据知识库(Research Data Repository,RDR)。自2012年启动的re3data.org项目,主要从事科研数据知识库的登记注册,以及为科研人员、科研资助组织、图书馆和出版商等提供有关异构科研数据知识库的全景概述。截至2013年7月,已有400个科研数据知识库向re3data.org登记,其中288个采用re3data.org的信息图标,以协助科研人员遴选合适的知识库,并且存储与重用他们的数据。这篇论文描绘异构RDR的全景,表述机构的、学科的、跨学科的以及项目专业的RDR类型。深入描述re3data.org的特性,以及这套注册系统如何协助科研人员分辨适合存储和搜索科研数据的知识库。 | Heinz Pampel Paul Vierkant Frank Scholze Roland Bertelmann Maxi Kindling Jens Klump Hans-Jürgen Goebelbecker Jens Gundlach Peter Schirmbacher Uwe Dierolf 顾立平 | 2014 | 现代图书情报技术2014，，3： | 15 |
| 16 | Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease显示文摘AIM To investigate the effect of a low-FODMAP diet on irritable bowel syndrome(IBS)-like symptoms in patients with inflammatory bowel disease(IBD).METHODS This was a randomised controlled open-label trial of patients with IBD in remission or with mild-to-moderate disease and coexisting IBS-like symptoms(Rome III) randomly assigned to a Low-FODMAP diet(LFD) or a normal diet(ND) for 6 wk between June 2012 andDecember 2013. Patients completed the IBS symptom severity system(IBS-SSS) and short IBD quality of life questionnaire(SIBDQ) at weeks 0 and 6. The primary end-point was response rates(at least 50-point reduction) in IBS-SSS at week 6 between groups; secondary end-point was the impact on quality of life. RESULTS Eighty-nine patients, 67(75%) women, median age 40, range 20-70 years were randomised: 44 to LFD group and 45 to ND, from which 78 patients completed the study period and were included in the final analysis(37 LFD and 41 ND). There was a significantly larger proportion of responders in the LFD group(n = 30, 81%) than in the ND group(n = 19, 46%);(OR = 5.30; 95%CI: 1.81-15.55, P < 0.01). At week 6, the LFD group showed a significantly lower median IBSSSS(median 115; inter-quartile range [IQR] 33-169) than ND group(median 170, IQR 91-288), P = 0.02. Furthermore, the LFD group had a significantly greater increase in SIBDQ(median 60, IQR 51-65) than the ND group(median 50, IQR 39-60), P < 0.01.CONCLUSION In a prospective study, a low-FODMAP diet reduced IBS-like symptoms and increased quality of life in patients with IBD in remission. | Natalia Pedersen Dorit Vedel Ankersen Maria Felding Henrik Wachmann Zsuzsanna Végh Line Molzen Johan Burisch Jens Rikardt Andersen Pia Munkholm | 2017 | World Journal of Gastroenterology2017，23，18： | 15 |
| 17 | Upper gastrointestinal sensory-motor dysfunction in diabetes mellitus显示文摘胃肠(官方补给) 感觉马达的畸形在有糖尿病的病人是普通的并且可以包含官方补给的道的任何部分。畸形经常是无临床症状的,并且幸好,严重、威胁生活的问题仅仅很少发生。在糖尿病的反常上面的官方补给的感觉马达的功能的致病不完全地被理解并且是最可能的起源多因素。糖尿病的自治神经病以及糖尿病的尖锐非最优的控制被显示了损害官方补给的马达和感觉功能。词法并且官方补给的墙的机械改变在糖尿病的持续时间期间开发的简历,并且可以贡献马达和感觉机能障碍。在感觉的这评论和活动性,在糖尿病的上面的官方补给的道的混乱被讨论;并且与感觉马达的机能障碍有关的机械改变也是的词法变化和简历探讨了。 | Jingbo Zhao Jens Brφndum Frφkjaer Asbjφrn Mohr Drewes Niels Ejskjaer | 2006 | World Journal of Gastroenterology2006，12，18： | 15 |
| 18 | Diagnostic criteria for acute liver failure due to Wilson disease显示文摘AIM: To describe the diagnostic criteria for acute liver failure due to Wilson disease (WD), which is an uncommon cause of acute liver failure (ALF). METHODS: We compared findings of patients presenting with ALF due to WD to those with ALF of other etiologies. RESULTS: Previously described criteria, such as low alkaline phosphatase activity, ratio of low alkaline phosphatase to total bilirubin or ratio of high aspartate aminotransferase (AST) to alanine aminotransferase (ALT), failed to identify patients with ALF due to WD. There were significant differences in low ALT and AST activities (53 ± 43 vs 1982 ± 938, P < 0.0001 and 87 ± 44 vs 2756 ± 2941, P = 0.037, respectively), low choline esterase activity (1.79 ± 1.2 vs 4.30 ± 1.2, P = 0.009), high urine copper concentrations (93.4 ± 144.0 vs 3.5 ± 1.8, P = 0.001) and low hemoglobin (7.0 ± 2.2 vs 12.6 ± 1.8, P < 0.0001) in patients with ALF caused by WD as compared with other etiologies. Interestingly, 4 of 7 patients with ALF due to WD survived without liver transplantation. CONCLUSION: In ALF, these criteria can help establish a diagnosis of WD. Where applicable, slit- lamp examination for presence of Kayser-Fleischer rings and liver biopsy for determination of hepatic copper concentration still remain important for the diagnosis of ALF due to WD. The need for liver transplantation should be evaluated carefully as the prognosis is not necessarily fatal. | Christoph Eisenbach Olivia Sieg Wolfgang Stremmel Jens Encke Uta Merle | 2007 | World Journal of Gastroenterology2007，13，11： | 14 |
| 19 | Extrahepatic complications to cirrhosis and portal hypertension: Haemodynamic and homeostatic aspects显示文摘In addition to complications relating to the liver, patients with cirrhosis and portal hypertension develop extrahepatic functional disturbances of multiple organ systems. This can be considered a multiple organ failure that involves the heart, lungs, kidneys, the immune systems, and other organ systems. Progressive fibrosis of the liver and subsequent metabolic impairment leads to a systemic and splanchnic arteriolar vasodilatation. This affects both the haemodynamic and functional homeostasis of many organs and largely determines the course of the disease. With the progression of the disease, the circulation becomes hyperdynamic with cardiac, pulmonary as well as renal consequences for dysfunction and reduced survival. Infections and a changed cardiac function known as cirrhotic cardiomyopathy may be involved in further aggravation of other complications such as renal failure precipitatingthe hepatorenal syndrome.Patients with end-stage liver disease and related complications as for example the hepatopulmonary syndrome can only radically be treated by liver transplantation.As a bridge to this treatment,knowledge on the mechanisms of the pathophysiology of complications is essential for the choice of vasoactive drugs,antibiotics,drugs with specific effects on fibrogenesis and inflammation,and drugs that target specific receptors. | S?ren M?ller Jens H Henriksen Flemming Bendtsen | 2014 | World Journal of Gastroenterology2014，20，42： | 14 |
| 20 | 经支气管超声引导针吸活检在肺癌纵隔分期和胸腔内病变诊断中的应用显示文摘既往研究显示,经支气管超声引导针吸活检(endobronchial ultrasound-guided transbronchial needle aspiration, EBUS-TBNA)是一项微创技术,可用于肺癌患者的纵隔分期、胸腔内病变的诊断、不明原因淋巴结肿大的诊断以及非小细胞肺癌(non-small cell lung cancer, NSCLC)新辅助化疗后的纵隔再分期。本综述旨在关注EBUS在NSCLC纵隔分期中的作用,以及EBUS在进一步评估通过常规检查仍诊断未明的胸腔内病变中的应用。总之,就NSCLC患者纵隔分期而言,由于EBUS的诊断敏感性和特异性均较高,其为纵隔镜检查的有效替代,亦可用于疑似胸腔病变的活检,且不会给患者带来任何并发症风险。 | Jens ECKARDT Peter B.LICHT 南娟(译) 丁燕(译) 刘谦(校) | 2010 | 中国肺癌杂志2010，13，5： | 13 |
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