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| 1 | Ivabradine in the treatment of systolic heart failure- A systematic review and meta-analysis显示文摘AIM To perform a systematic-review and meta-analysis to compare outcomes of ivabradine combined with betablocker to beta-blocker alone in heart failure with reduced ejection fraction(HFr EF).METHODS We searched PubM ed, Cochrane, EMBASE, CINAHL and Web of Science for trials comparing ivabradine + betablocker to beta-blocker alone in HFr EF. We performed a systematic-review and meta-analysis of published literature. Primary end-point was combined end point of cardiac death and hospitalization for heart failure.RESULTS Six studies with 17671 patients were included. Mean follow-up was 8.7 ± 7.9 mo. Combined end-point of heart failure readmission and cardiovascular death was better in ivabradine + beta-blocker group compared to beta-blocker alone(RR: 0.93, 95%CI: 0.79-1.09, P = 0.354). Mean difference(MD) in heart rate was higher in the ivabradine + beta-blocker group(MD: 6.14, 95%CI: 3.80-8.48, P < 0.001). There was no difference in all cause mortality(RR: 0.98, 95%CI: 0.89-1.07, P = 0.609), cardiovascular mortality(RR: 0.99, 95%CI: 0.86-1.15, P = 0.908) or heart failure hospitalization(RR: 0.87, 95%CI: 0.68-1.11, P = 0.271). CONCLUSION From the available clinical trials, ivabradine + betablocker resulted in a significantly greater reduction in HRcoupled with improvement in combined end-point of heart failure readmission and cardiovascular death but with no improvement in all cause or cardiovascular mortality. Given the limited evidence, further randomized controlled trials are essential before widespread clinical application of ivabradine + beta-blocker is advocated for HFrEF. | Mahesh Anantha Narayanan Yogesh NV Reddy Janani Baskaran Abhishek Deshmukh David G Benditt Ganesh Raveendran | 2017 | World Journal of Cardiology2017，9，2： | 5 |
| 2 | Expression of apolipoprotein serum amyloid A mRNA in hjman atherosclerotic lesions and cultured vascular cells:implications for serum amyloid A显示文摘 | Meek RL Urieli Shoval S Benditt EP | 1994 | Proc Natl Acad Sci USA1994，91，： | 2 |
| 3 | Surgical left atrial appendage occlusion during cardiac surgery: A systematic review and meta-analysis显示文摘AIM To evaluate the safety and efficacy of surgical left atrial appendage occlusion(s-LAAO) during concomitant cardiac surgery.METHODS We performed a comprehensive literature search through May 31 st 2018 for all eligible studies comparing s-LAAO vs no occlusion in patients undergoing cardiac surgery. Clinical outcomes during follow-up included: embolic events, stroke, all-cause mortality, atrial fibrillation(AF), reoperation for bleeding and postoperative complications. We further stratified the analysis based on propensity matched studies and AF predominance.RESULTS Twelve studies(n = 40107) met the inclusion criteria.s-LAAO was associated with lower risk of embolic events(OR: 0.63, 95%CI: 0.53-0.76; P < 0.001) and stroke(OR: 0.68, 95%CI: 0.57-0.82; P < 0.0001).Stratified analysis demonstrated this association was more prominent in the AF predominant strata. There was no significant difference in the incidence risk of allcause mortality, AF, and reoperation for bleeding and postoperative complications.CONCLUSION Concomitant s-LAAO during cardiac surgery was associated with lower risk of follow-up thromboembolic events and stroke, especially in those with AF without significant increase in adverse events. Further randomized trials to evaluate long-term benefits of s-LAAO are warranted. | Varunsiri Atti Mahesh Anantha-Narayanan Mohit K Turagam Scott Koerber Sunil Rao Juan FViles-Gonzalez Rakesh MSuri Poonam Velagapudi Dhanunjaya Lakkireddy David G Benditt | 2018 | World Journal of Cardiology2018，10，11： | 2 |
| 4 | Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome显示文摘 | Roy Freeman Wouter Wieling Felicia B. Axelrod David G. Benditt Eduardo Benarroch Italo Biaggioni William P. Cheshire Thomas Chelimsky Pietro Cortelli Christopher H. Gibbons David S. Goldstein Roger Hainsworth Max J. Hilz Giris Jacob Horacio Kaufmann Jens | 2011 | Autonomic Neuroscience: Basic and Clinical2011，，1： | 2 |
| 5 | ESC Guidelines on management ( diagnosis and treatment ) of syncope-update 2004 显示文摘 | Brignole M Alboni P Benditt D | 2004 | Europace2004，6，： | 1 |
| 6 | Effect of cough on heart rate and blood pressure in patients with ' Cough syncope' 显示文摘 | Benditt DG Samniah N Pham S | 2005 | Heart Rhythm2005，2，8： | 1 |
| 7 | Guidelines on management (diagnosis and treatment) of syncope显示文摘 | Brignole M Alboni P Benditt D | 2001 | Eur Heart J2001，22，： | 1 |
| 8 | Expression of apoti- poprotein serum amytoid A mRNA in human atheroselerotie le- sions and cultured vascular cells:Implications for serum amyloid A function显示文摘 | Meek RL Urieli- Shoval S Benditt EP | 1994 | Proc Natl Aead Sci USA1994，，91： | 1 |
| 9 | Tilt tabl e testing for assessing syncope显示文摘 | Benditt DG Ferguson DW Grubb BP | 1996 | J Am Coll Cardiol1996，28，1： | 1 |
| 10 | Amyloid protein SAA is an apoprotein of mouse plasma high density lipoprotein显示文摘 | Benditt EP Eriksen N Hanson RH | 1979 | Proc Natl Acad Sci USA1979，76，8： | 1 |
| 11 | Guidelines on management (diagnosis and treatment) of syncope - update 2004 executive summary 显示文摘 | Brignole M Alboni P Benditt DG | 2004 | Eur Heart J2004，25，22： | 1 |
| 12 | Maximal inspiratory pressures and dimensions of the diaphragm显示文摘 | Mccool FD Conomos P Benditt JO | 1997 | Am J Respin Crlt Care Med1997，155，： | 1 |
| 13 | Guidelines on management (diagnosis and treatment) of syncope显示文摘 | Brignole M Alboni P Benditt D | 2001 | Eur Heart J2001，22，15： | 1 |
| 14 | Guidelines on management (diagnosis and treatment) of syncope-update 2004 显示文摘 | Brignole M Alboni P Benditt D | 2004 | Europace2004，6，6： | 1 |
| 15 | Air leaking through the mouth during nocturnal nasal ventilation: effect on sleep quality显示文摘 | Meyer TJ Pressman MR Benditt J | 1997 | Sleep1997，20，7： | 1 |
| 16 | Expression of apolipoprotein serum amyloid A mRNA in human atherosclerotic lesions and cultured vascular cells: implications for serum amyloid A function显示文摘 | Meek RL Urieli-Shoval S Benditt EP | 1994 | Proc Natl Acad Sci USA1994，91，8： | 1 |
| 17 | Expression of apolipoprotein serum amyloid A mRNA in human atherosclerotic lesions and cultured vascular cells:implications for serum amyloid A function显示文摘 | Meek RL Urieli-Shoval S Benditt EP | 1994 | Proc Natl Acad Sci U S A1994，91，8： | 1 |
| 18 | Safety and efficacy of median stemotomy versus video-assisted thoracic surgery for lung volume reduction surgery显示文摘 | Mckenna R J Jr Benditt J O DeCamp M | 2004 | J Thorac Cardiovasc Surg2004，127，： | 1 |
| 19 | Long-Term Follow-Up of Permanent Transvenous Pacing Systems Preserved During Tricuspid Valve Replacement显示文摘 | J. Ernesto Molina Connie L. Roberts David G. Benditt | 2010 | The Annals of Thoracic Surgery2010，，1： | 1 |
| 20 | Oxygen therapy in chronic obstructive pulmonary disease 显示文摘 | Kim V Benditt JO Wise RA | 2008 | Proc Am Thorac Soc2008，5，4： | 1 |
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