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| 1 | 极高强度他汀治疗对冠状动脉粥样硬化消退的影响——ASTEROID试验显示文摘背景:以前的血管内超声(intravascular ultrasound,IVUS)试验证实,他汀治疗可减缓或阻止动脉粥样硬化的进展,但是迄今尚无应用动脉粥样斑块体积百分比(percent atheroma volume,PAV)证实粥样硬化消退的确切证据。PAV是最严格的评价病变进展和消退的IVUS测量指标。
目标:评价极高强度他汀治疗是否能逆转IVUS确定的冠状动脉粥样硬化。
设计和地点:于美国、加拿大、欧洲和澳大利亚53个社区和3级保健中心进行前瞻性开标盲法终点试验(A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden,ASTEROID)。应用马达驱动回撤IVUS评价基线和治疗24个月时冠状动脉粥样斑块负荷。每对基线和随访IVUS测量结果均进行盲法分析。
病例:从2002年11月到2003年10月,507例患者有基线IVUS检查结果,并接受至少1个剂量的研究药物。在24个月后,349例患者具有可用于评估的系列IVUS检查结果。
干预:所有患者均接受瑞舒伐他汀40ms/d强化治疗。
主要观测指标:预先设定了两个一级疗效指标:PAV变化和基线最严重病变10min节段动脉粥样斑块体积变化。二级疗效指标为整个动脉标准化总斑块体积的变化。结果:平均(SD)LDL—C水平由基线时的130.4(34.3)ms/dL降至60.8(20.0)ms/扎,平均下降了53.2%(P〈0.001)。平均(SD)HDL-C水平从基线时的43.1(11.1)ms/dL升至49.0(12.6)ms/dL,平均增加了14.7%(P〈0.001)。整个血管PAV平均(SD)变化为-0.98%(3.15%),中位数为-0.79%(97.5%CI,-1.21%~-0.53%)(与基线比较,P〈0.001)。最严重病变10min节段斑块体积平均(SD)变化为-6.1(10.1)mm^3,中位数为-5.6mm^3(97.5%CI,-6.8~-4.0mm^3)(与基线比较,P〈0.001)。总斑块体积变化中位数降低了6.8%,平均减少了-14.7(25.7)mm^3,中位数为-12.5mm^3(95%CI,-15.1~-10.5mm^3)(与基线比较,P〈0.001)。不良事件少见,与其他他汀试验相似。
结论:应用瑞舒伐他汀40ms/d进行极高强度他汀治疗可使LDL-C平均水平达到60.8ms/dL,使HDL—C增加14.7%。这导致所有3个预先设定的IVUS斑块负荷指标均显示动脉粥样硬化消退。因此,将LDL-C降至低于目前指南规定的水平,同时显著提高HDL-C,可以使冠心病患者动脉粥样硬化斑块消退。这些变化对临床预后的影响尚需进一步研究确定。 | Steven E. Nissen Stephen J. Nicholls Ilks Sipahi Peter Libby Joel S. Raichlen Christie M. Ballantyne Jean Davignon Raimund Erbel Jean Charles Fruchart Jean-Claude Tardif Paul Schoenhagen Tim Crowe Valerie Cain Kathy Wolski Marlene Coormastic E. Murat Tuzcu 仝其广(译) 王淑敏(译) 胡大一(校) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 341 |
| 2 | Neutrophil extracellular trap cell death requires both autophagy and superoxide generation显示文摘嗜中性的细胞外的陷井(网) 是能套住并且降级的细胞外的染色质结构微生物。他们从激活称为网络房间死亡,或 NETosis 的一个房间死亡程序的 neutrophils 产生。NETosis 的激活被显示了包含 NADPH oxidase 活动,原子信封的崩溃和大多数小粒膜,网的原子染色质和形成的 decondensation。我们报导在 phorbol,十四酸盐醋酸盐(PMA ) 刺激了 neutrophils,细胞内部的染色质 decondensation 和网形成跟随 autophagy 和 superoxide 生产,哪个被要求调停导致 PMA 的 NETosis 并且独立于对方发生。从有长期的 granulomatous 疾病的病人的 Neutrophils,缺乏 NADPH oxidase 活动,仍然展出导致 PMA 的 autophagy。相反地,导致 PMA 的 NADPH oxidase 活动没被 autophagy 的药理学抑制影响。有趣地,任何一个 autophagy 的抑制或 NADPH oxidase 阻止细胞内部的染色质 decondensation,它为 NETosis 和网形成是必要的,并且导致 apoptosis 的特点描绘的房间死亡。当 autophagy 或 NADPH oxidase 活动被阻止时,这些结果显示 apoptosis 可能为 NETosis 作为一个备份节目工作。 | Quinten Remij sen Tom Vanden Berghe Ellen Wirawan Bob Asselbergh Eef Parthoens Riet De Rycke Sam Noppen Michel Delforge Jean Wlllems Peter Vandenabeele | 2011 | Cell Research2011，21，2： | 46 |
| 3 | 轴向运动弦线的纵向振动及其控制显示文摘综述轴向运动弦线纵向振动及其控制问题的研究进展.多种工程系统如动力传送带、磁带、纸带、纺织纤维、带锯、空中缆车索道等均涉及轴向运动弦线的纵向振动.对线性模型而言,除早期结果外,总结了运动弦线的模态分析、具有复杂约束和耦合的运动弦线振动和运动弦线参数振动的近期研究.对非线性模型而言,提出了轴向运动弦线大幅纵向振动的运动微分方程,概述了离散化和直接近似解析分析、用黏弹性材料模型化阻尼机制和动力传输系统的耦合振动研究的新进展.讨论了轴向运动弦线振动主动控制的研究现状,包括能控性和能观性,控制分析的频域方法和能量方法,振动的自适应控制和非线性振动的控制.最后指出该研究方向今后需要研究的若干重要问题,包括运动弦线的非线性动力学行为、黏弹性运动弦线的振动、含运动弦线的混杂系统的控制和轴向运动弦线非线性振动的控制. | 陈立群 Jean W. Zu | 2001 | 力学进展2001，31，4： | 44 |
| 4 | Signaling Mechanisms in Pattern-Triggered Immunity (PTI)显示文摘在自然,植物常常不得不面对病原体攻击。然而,植物疾病很少由于主人植物拥有的有效免疫系统发生。病原体被开始所谓的被触发模式的豁免 PTI 和被触发受动器的豁免 ETI 的二个不同识别系统察觉,哪个被通常排斥病原体攻击的一套导致的辩护伴随。这里,我们讨论表明发生在 PTI 期间的小径的复杂网络,集中于激活 mitogen 的蛋白质 kinases 的参与。 | Jean Bigeard Jean Colcombet Heribert Hirt | 2015 | Molecular Plant2015，8，4： | 42 |
| 5 | 地塞米松玻璃体腔植入剂治疗中国患者视网膜静脉阻塞继发黄斑水肿的安全性和有效性:随机、假注射对照、多中心研究显示文摘目的 评估地塞米松玻璃体腔植入物(DEX)治疗中国患者视网膜静脉阻塞继发黄斑水肿(RVO-ME)的安全性和有效性.方法 为期6个月的随机、双盲、假注射对照、多中心、3期临床研究,此后接续为期2个月的开放标签的延展研究.视网膜分支(BRVO)或中央静脉阻塞(CRVO)患眼于基线时接受DEX植入(n=129)或假注射(n=130)治疗;治疗后6个月时,两组中满足再治疗标准的全部患眼均再次接受DEX植入治疗.有效性变量包括最佳矫正视力(BCVA)和黄斑中心凹视网膜厚度(CRT).BCVA检查采用早期治疗糖尿病视网膜病变研究组视力表进行.光相干断层扫描(OCT)检查采用德国Heidelberg公司Spectralis OCT仪或德国Zeiss公司Cirrus OCT仪进行.结果 治疗后6个月中(主要终点),DEX治疗组BCVA较基线提高≥15个字母的时间早于假注射组(P<0.001).治疗后第2个月时(效应峰值),DEX治疗组、假注射组BCVA较基线提高≥15个字母患者百分比分别为34.9%,11.5%.DEX治疗组、假注射组平均BCVA较基线分别提高(10.6±10.4)、(1.7±12.3)个字母;平均CRT分别较基线下降(407±212)、(62±224) μm (P<0.001).DEX治疗组CRVO、BRVO患眼治疗效果均优于假注射组.主要常见治疗相关不良事件为眼压升高,均可通过局部降眼压药物控制;无患者需要接受抗青光眼手术.结论 DEX治疗中国患者RVO-ME具有良好的安全性和显著的临床疗效;单次植入DEX较假注射可获得持续3-4个月的视力和解剖结构改善. | 黎晓新 王宁利 梁小玲 徐格致 Xiao-yan Li Jenny Jiao Jean Lou Yehia Hashad | 2018 | 中华眼底病杂志2018，34，3： | 41 |
| 6 | 可动式椎间盘镜技术治疗腰椎间盘突出症和椎管狭窄症显示文摘目的探讨可动式椎间盘镜技术治疗腰椎间盘突出症和腰椎管狭窄症的疗效。方法应用可动式椎间盘镜技术治疗腰椎间盘突出症130例、退变性椎管狭窄症60例、椎间盘突出合并椎管狭窄122例。26例有同一节段手术史。法国Bagatelle医院212例,均为单处开窗减压,双侧狭窄者潜行减压至对侧;天津医院100例,单处开窗82例、两处开窗14例、三处开窗3例、四处开窗1例,其中g例伴失稳者行镜下B-Twin椎体间融合术。根据Macnab评分标准评定疗效。结果术后随访1-24个月,平均12个月。法国Bagatelle医院单侧手术时间平均35min,双侧减压平均45min;术中出血量平均35ml;术中硬膜囊撕裂1例;术后当天下床活动,平均住院1.2d。疗效优191例,良15例,可6例;200例于术后3周内恢复原工作或生活。天津医院单处手术平均50min;术中出血量平均100ml;术中转开放手术2例,定位错误4例,神经根部分损伤2例,硬膜囊撕裂4例,切口浅表感染2例;术后1-3d下床活动,平均住院5d。疗效优80例,良15例,可5例。71例术后3周内恢复原工作或生活。结论可动式椎间盘镜手术器械可随意倾斜或摆动,使椎间盘切除手术操作更方便,减压彻底,效果优良。 | 徐宝山 Destandau Jean 夏群 吉宁 胡永成 张继东 苗军 周静 | 2009 | 中华骨科杂志2009，29，2： | 37 |
| 7 | 印度支那地块第三纪构造滑移与青藏高原岩石圈构造演化显示文摘印度支那地块于早第三纪至中新世发生大规模地向东南方向走滑,同时伴随着15°顺时针旋转。青藏高原及邻区晚自垩世以来的古地磁古构造及地质年代学研究新成果,说明青藏高原岩石圈的构造演化过程,即古新世初印度板块与欧亚大陆的南缘拉萨地块碰撞,至49 Ma左右印度与拉萨地块发生全面拼合,随着印度板块进一步向北挤压,从碰撞期至16 Ma,印度支那地块沿红河大型走滑断裂发生侧向滑移;印度与“欧亚大陆”之间的构造缩短通过岩右圈板块沿着大型走滑断裂系的挤出以及板块间的消减得到调整。青藏高原大规模的岩石圈构造缩短很可能始于中新世27 Ma左右沿着早期陆块间的接合带发生。一些事实还说明青藏高原的总体隆起很可能是通过10 Ma前后和3 Ma以后多期非均匀隆升形成的。 | 杨振宇 Jean Besse 孙知明 赵越 | 1998 | 地质学报1998，72，2： | 39 |
| 8 | 一种飞机图像目标多特征信息融合识别方法显示文摘提出了一种基于概率神经网络(Probabilistic neural networks,PNN)和DSmT推理(Dezert-Smarandache theory)的飞机图像目标多特征融合识别算法.针对提取的多个图像特征量,利用数据融合的思想对来自图像目标各个特征量提供的信息进行融合处理.首先,对图像进行二值化预处理,并提取Hu矩、归一化转动惯量、仿射不变矩、轮廓离散化参数和奇异值特征5个特征量;其次,针对DSmT理论中信度赋值构造困难的问题,利用PNN网络,构造目标识别率矩阵,通过目标识别率矩阵对证据源进行信度赋值;然后,用DSmT组合规则在决策级层进行融合,从而完成对飞机目标的识别;最后,在目标图像小畸变情形下,将本文提出的图像多特征信息融合方法和单一特征方法进行了对比测试实验,结果表明本文方法在同等条件下正确识别率得到了很大提高,同时达到实时性要求,而且具有有效拒判能力和目标图像尺寸不敏感性.即使在大畸变情况下,识别率也能达到89.3%. | 李新德 杨伟东 DEZERT Jean | 2012 | 自动化学报2012，38，8： | 32 |
| 9 | 有限元分析法确定Johson-Cook本构方程材料参数显示文摘采用反演法确定了马氏体不锈钢410的Johnson-Cook本构方程材料参数.剪切实验采用的剪切速率为1~5000s-1,温度为20~1000℃.有限元模拟在Abaqus软件平台上进行.采用Johnson-Cook模型,施加与实验相同的初始条件.通过Matlab非线性最小二乘法优化程序来调整有限元模型材料参数,找到合适值,使得模拟得到的力-位移曲线与实验得到曲线相吻合.结果表明,所得参数都能很好地代表不锈钢410在高温高变形速度下的流动特性,Johnson-Cook模型不能描述材料破坏阶段的行为特征. | 董菲 Guenael Germain Jean Lou Lebrun 李铸国 | 2011 | 上海交通大学学报2011，45，11： | 30 |
| 10 | 退化湿地生态系统的生态恢复与管理——以美国Hackensack湿地保护区为例显示文摘受城市化、工业化和地球温室效应等人类活动与自然因素的影响,美国Hackensack湿地保护区正面临着面积不断减少、景观破碎化、外来物种入侵、河水污染增加、盐碱化程度增加和范围扩大等生态胁迫。稳定湿地面积,重建湿地的复合景观,丰富生物多样性,恢复潮水的正常规律,减少水体污染,控制外来种的入侵与扩张,促进湿地原有植物的定居与扩增及原有植被的恢复是Hackensack湿地恢复的关键,也是恢复工程设计与实施的核心。退化湿地生态恢复的管理则以植被的生长、芦苇的扩散方式及动态、鱼类和蟹类的种群动态、鸟类的种类及其对生境地的利用情况对生态系统功能恢复状况进行生物检验,有效监控退化湿地生态系统的恢复动态,研究其恢复规律,进而采取相应的管理措施,科学调控生态恢复进程。 | 陈芳清 Jean Marie Hartman | 2004 | 自然资源学报2004，19，2： | 29 |
| 11 | 增强职业教育吸引力 欧洲的政策、理念与实践显示文摘欧洲国家通过欧洲共同市场和欧洲经济、货币联盟的建设,实现了经济上的一体化,并通过欧洲联盟(European Commission)走上了政治一体化的道路。同时,在欧洲职业培训发展中心等专门机构的组织和推动下,欧洲各国在职业教育与培训领域的合作也在不断深化。 | Johanna Lasonen Jean Gordon 李玉静 陈衍 | 2009 | 职业技术教育2009，30，12： | 26 |
| 12 | A Comparison of Carlin-type Gold Deposits:Guizhou Province,Golden Triangle,Southwest China,and Northern Nevada,USA显示文摘Several Au deposits in Guizhou Province,southwest China,described as being similar to the highly productive Carlin-type gold deposits in northern Nevada.USA,were examined to identify similarities and differences between the two districts.Samples were collected along transects from lowto high-grade rock,where possible,and fram stockpiles at the Shuiyindong,Zimudang,Taipingdong,Yata and Jinfeng(formerly Lannigou)deposits.Methods used to examine ore and alteration minerals included hand-sample description:reflectance spectroscopy using an ASD Terraspec spectrometer;analyses of hand samples by carbonate staining with Alizaren red and potassium ferricyanide;transmitted and reflected light petrography;chemical analyses,mineral identification,and imaging using a JEOL.JSM-5610 scanning electron microscope:and quantitative chemical analyses using a JEOL JXA-8900 electron probe microanalyzer.Geochemical analyses of hand samples for 52 elements were done by ALS Chemex.Results indicate both similarities and differences between the two districts.Both districts have similar geologic histories.and deposits at both locations appear to have formed as a result of similar tectonic events.though the district in southwest China lacks evidence of eoeval felsic igneous activity;however,the ore-stage minerals and the fluids that produced the minerals and deposits have some significant differences.The Nevada deposits were dominated by fluid-rock reaction in which host rock Fe was sulfidized to form Au-bearing pyrite.Although ore fluids sulfidized host rock Fe in the Cuizhou deposits.the timing of Fe metasomatism is unknown,so whether the deposits formed in response to sulfidation or pyritization is unclear.Fluid-rock reaction between an acidic,aqueous fluid and highly reactive calcareous rocks in Nevada caused extensive decarbonatization of host rocks,jasperoid replacemerit of carbonate minerals,and alteration of silty rock components to illite and kaolinite.In Guizhou,CO2-bearing ore fluids with temperatures and pressures approaching 100℃ and 500 bars greater than temperatures and pressures detemained for ore fluids in the Nevada deposits,deposited Aubearing pyrite.In examined Guizhou deposits these fluids carbonatized host rocks and farmed both replacement and open-space-filling ore.The fluids,which may have been immiscible,were sufficiently overpressured to fracture wall rocks and to create significant open space filled by vein quartz.While deposit architecture,tectonic setting,and host rocks in Guizhou are quite similar to northern Nevada,ore and alteration minerals suggest that ore-forming processes in examined Guizhou deposits have important similarities to processes associated with formation of orogenic Au systems.The Guizhou deposits display characteristics of both Carlin-type and orogenic systems,perhaps indicating formation at conditions somewhat intermediate to conditions for Carlin-type deposits and orogenic systems. | Jean S.CLlNE John L.MUNTEAN Xuexiang GU Yong XIA | 2013 | 地学前缘2013，20，1： | 23 |
| 13 | Advances in immunotherapy for treatment of lung cancer显示文摘Different approaches for treating lung cancer have been developed over time, including chemotherapy, radiotherapy and targeted therapies against activating mutations. Lately, better understanding of the role of the immunological system in tumor control has opened multiple doors to implement different strategies to enhance immune response against cancer cells. It is known that tumor cells elude immune response by several mechanisms. The development of monoclonal antibodies against the checkpoint inhibitor programmed cell death protein 1(PD-1) and its ligand(PD-L1), on T cells, has led to high activity in cancer patients with long lasting responses. Nivolumab, an anti PD-1 inhibitor, has been recently approved for the treatment of squamous cell lung cancer patients, given the survival advantage demonstrated in a phase III trial. Pembrolizumab, another anti PD-1 antibody, has received FDA breakthrough therapy designation for treatment of non-small cell lung cancer(NSCLC), supported by data from a phase I trial. Clinical trials with anti PD-1/PD-L1 antibodies in NSCLC have demonstrated very good tolerability and activity, with response rates around 20% and a median duration of response of 18 months. | Jean G.Bustamante Alvarez María González-Cao Niki Karachaliou Mariacarmela Santarpia Santiago Viteri Cristina Teixidó Rafael Rosell | 2015 | Cancer Biology & Medicine2015，12，3： | 22 |
| 14 | Stagnant lids and mantle overturns:Implications for Archaean tectonics, magmagenesis,crustal growth, mantle evolution, and the start of plate tectonics显示文摘The lower plate is the dominant agent in modern convergent margins characterized by active subduction,as negatively buoyant oceanic lithosphere sinks into the asthenosphere under its own weight.This is a strong plate-driving force because the slab-pull force is transmitted through the stiff sub-oceanic lithospheric mantle.As geological and geochemical data seem inconsistent with the existence of modernstyle ridges and arcs in the Archaean,a periodically-destabilized stagnant-lid crust system is proposed instead.Stagnant-lid intervals may correspond to periods of layered mantle convection where efficient cooling was restricted to the upper mantle,perturbing Earth's heat generation/loss balance,eventually triggering mantle overturns.Archaean basalts were derived from fertile mantle in overturn upwelling zones(OUZOs),which were larger and longer-lived than post-Archaean plumes.Early cratons/continents probably formed above OUZOs as large volumes of basalt and komatiite were delivered for protracted periods,allowing basal crustal cannibalism,garnetiferous crustal restite delamination,and coupled development of continental crust and sub-continental lithospheric mantle.Periodic mixing and rehomogenization during overturns retarded development of isotopically depleted MORB(mid-ocean ridge basalt)mantle.Only after the start of true subduction did sequestration of subducted slabs at the coremantle boundary lead to the development of the depleted MORB mantle source.During Archaean mantle overturns,pre-existing continents located above OUZOs would be strongly reworked;whereas OUZOdistal continents would drift in response to mantle currents.The leading edge of drifting Archaean continents would be convergent margins characterized by terrane accretion,imbrication,subcretion and anatexis of unsubductable oceanic lithosphere.As Earth cooled and the background oceanic lithosphere became denser and stiffer,there would be an increasing probability that oceanic crustal segments could founder in an organized way,producing a gradual evolution of pre-subduction convergent margins into modern-style active subduction systems around 2.5 Ga.Plate tectonics today is constituted of:(1)a continental drift system that started in the Early Archaean,driven by deep mantle currents pressing against the Archaean-age sub-continental lithospheric mantle keels that underlie Archaean cratons;(2)a subduction-driven system that started near the end of the Archaean. | Jean H.Bédard | 2018 | Geoscience Frontiers2018，9，1： | 21 |
| 15 | Comparison between endoscopic sclerotherapy and band ligation for hemostasis of acute variceal bleeding显示文摘AIM:To compare band ligation(BL) with endoscopic sclerotherapy(SCL) in patients admitted to an emergency unit for esophageal variceal rupture. METHODS:A prospective,randomized,single-center study without crossover was conducted.After endoscopic diagnosis of esophageal variceal rupture,patients were randomized into groups for SCL or BL treatment.Sclerotherapy was performed by ethanolamine oleate intravascular injection both above and below the rupture point,with a maximum volume of 20 mL.For BL patients,banding at the rupture point was attempted,followed by ligation of all variceal tissue of the distal esophagus.Primary outcomes for both groups were initial failure of bleeding control(5 d) ,early re-bleeding(5 d to 6 wk),and complications,including mortality.From May 2005 to May 2007,100 patients with variceal bleeding were enrolled in thestudy:50 SCL and 50 BL patients.No differences between groups were observed across gender,age,ChildPugh status,presence of shock at admission,mean hemoglobin levels,and variceal size. RESULTS:No differences were found between groups for bleeding control,early re-bleeding rates,complications,or mortality.After 6 wk,36(80%) SCL and 33(77 %) EBL patients were alive and free of bleeding.A statistically significant association between Child-Pugh status and mortality was found,with 16%mortality in Child A and B patients and 84%mortality in Child C patients(P<0.001) . CONCLUSION:Despite the limited number of patients included,our results suggest that SCL and BL are equally efficient for the control of acute variceal bleeding. | Gustavo Oliveira Luz Fauze Maluf-Filho Sérgio Eiji Matuguma Fábio Yuji Hondo Edson Ide Jeane Martins Melo Spencer Cheng Paulo Sakai | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，5： | 20 |
| 16 | 面向全球的护理领导力的四个要素——2014年美国磁性大会主题发言显示文摘本文根据2014年10月9日Jean Watson在美国德克萨斯州达拉斯市召开的美国磁性大会上的主题发言整理而来。旨在探索护士作为向全球提供服务的领导者,其领导力如何形成。Jean Watson认为新形势下的领导力由人文关怀、同情心和爱等核心价值观所指引,包括四个要素:批判、关爱、创造、改革。 | Jean Watson 陶珍晖 李君 邓俊 | 2015 | 中国护理管理2015，15，3： | 20 |
| 17 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 18 | Need of surveillance response systems to combat Ebola outbreaks and other emerging infectious diseases in African countries显示文摘There is growing concern in Sub-Saharan Africa about the spread of the Ebola virus disease(EVD),formerly known as Ebola haemorrhagic fever,and the public health burden that it ensues.Since 1976,there have been 885,343 suspected and laboratory confirmed cases of EVD and the disease has claimed 2,512 cases and 932 fatality in West Africa.There are certain requirements that must be met when responding to EVD outbreaks and this process could incur certain challenges.For the purposes of this paper,five have been identified:(i)the deficiency in the development and implementation of surveillance response systems against Ebola and others infectious disease outbreaks in Africa;(ii)the lack of education and knowledge resulting in an EVD outbreak triggering panic,anxiety,psychosocial trauma,isolation and dignity impounding,stigmatisation,community ostracism and resistance to associated socio-ecological and public health consequences;(iii)limited financial resources,human technical capacity and weak community and national health system operational plans for prevention and control responses,practices and management;(iv)inadequate leadership and coordination;and(v)the lack of development of new strategies,tools and approaches,such as improved diagnostics and novel therapies including vaccines which can assist in preventing,controlling and containing Ebola outbreaks as well as the spread of the disease.Hence,there is an urgent need to develop and implement an active early warning alert and surveillance response system for outbreak response and control of emerging infectious diseases.Understanding the unending risks of transmission dynamics and resurgence is essential in implementing rapid effective response interventions tailored to specific local settings and contexts.Therefore,the following actions are recommended:(i)national and regional inter-sectorial and trans-disciplinary surveillance response systems that include early warnings,as well as critical human resources development,must be quickly adopted by allied ministries and organisations in African countries in epidemic and pandemic responses;(ii)harnessing all stakeholders commitment and advocacy in sustained funding,collaboration,communication and networking including community participation to enhance a coordinated responses,as well as tracking and prompt case management to combat challenges;(iii)more research and development in new drug discovery and vaccines;and(iv)understanding the involvement of global health to promote the establishment of public health surveillance response systems with functions of early warning,as well as monitoring and evaluation in upholding research-action programmes and innovative interventions. | Ernest Tambo Emmanuel Chidiebere Ugwu Jeane Yonkeu Ngogang | 2014 | Infectious Diseases of Poverty2014，3，1： | 20 |
| 19 | 中国环境镉接触人群低骨密度及肾功能不全的研究显示文摘25年前,Ambio曾载文提出应警惕环境镉污染引起的健康效应。1998年在中国进行了这方面的研究,评价了因食用大米而接触镉人群的前臂骨密度(BMD)和肾功能,发现尿镉(CdU) 或血镉(CdB)高的绝经后妇女及血镉(CdB)高的男性,BMD均有所下降。在CdB或CdU与肾功能不全(视黄醇结合蛋白排泄增加)之间也发现了明显的、有统计学意义的剂量-效应关系及剂量-反应关系。第一次报道了日本以外的亚洲地区镉接触人群中存在骨不良效应。本文的意义在于阐明了亚洲的环境镉接触人群中仍存在着与肾和骨(镉的比较严重的有害效应)的联合效应,也讨论了一些欧洲镉接触人群的骨效应。 | Gunnar Nordberg 金泰廙 Alfred Bernard Sebastien Fierens Jean Pierre Buchet 叶葶葶 孔庆瑚 王洪复 | 2002 | AMBIO-人类环境杂志2002，31，6： | 19 |
| 20 | Organochlorine pesticides in soils under different land usage in the Taihu Lake region, China显示文摘地研究在泰胡·莱克区域被进行,到在在在 year1983.Thirteen organochlorine 杀虫剂( OCP )的这些物质的禁令以后的土壤的 revealthe organochlorine 杀虫剂集中的在 2004 的中国从稻地在土壤被分析,树土地 andfallow land.Total organochlorine 杀虫剂残余比 inuncultivated 休闲土地 soils.Among 在农业土壤是更高的所有杀虫剂,西格马 DDX ( DDD , DDE 和 DDT )为所有土壤样品有 highestconcentration ,变化 | WANG Fang JIANG Xin BIAN Yong-rong YAO Fen-xia GAO Hong-jian YU Gui-fen Jean Charles MUNCH Reiner SCHROLL | 2007 | Journal of Environmental Sciences2007，19，5： | 19 |
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