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| 1 | Increased ΤGF-β3 in primary biliary cirrhosis: An abnormality related to pathogenesis?显示文摘AIM: To investigate the transforming growth factor-β (TGF-β) isoforms in the peripheral and hepatic venous blood of primary biliary cirrhosis (PBC) patients. METHODS: We examined TGF-β1, TGF-β2 and TGF-β3 (enzyme-linked immunosorbent assay), in 27 stage Ⅳ PBC patients (27 peripheral and 15 hepatic vein sera), 35 early (Ⅰ-Ⅱ) PBC and 60 healthy controls. As disease controls 28 hepatitis C virus (HCV) cirrhosis (28 peripheral and 17 hepatic vein serum), 44 chronic HCV hepatitis and 38 HCV-related hepatocellular carcinomas were included. We also tested liver tissue by immunohistochemistry to identify localization of TGF isoforms. RESULTS: TGF-β1 was significantly decreased in all cirrhotics (PBC Ⅲ-Ⅳ: median 13.4 ng/mL; range, 7.4-26.2, HCV cirrhosis: 11.6 ng/mL; range, 5.0-33.8), compared to controls (30.9 ng/mL; range, 20.9-37.8). TGF-β2 was increased in viral cirrhosis but not in PBC and chronic hepatitis. TGF-β3 (47.2 pg/mL; range, 27.0-79.7 in healthy controls) was increased in early and late PBC (Ⅰ-Ⅱ: 94.3 pg/mL; range, 41.5-358.6; Ⅲ-Ⅳ: 152.8 pg/mL; range, 60.4-361.2; P < 0.001) and decreased in viral cirrhosis (37.4 pg/mL; range, 13.3-84.0; P < 0.05). Hepatic vein TGF-β levels were analogous to those in peripheral blood. Immunohistochemistry identified all isoforms in portal tract lymphocytes, sinusoidal cells and cholangiocytes. TGF-β3 was additionally overexpressed in hepatocytes in PBC patients. CONCLUSION: The serum profile of TGF-β isoforms is different in cirrhotics. Increased TGF-β3 is characteristic of PBC. These findings may be related to the immunological abnormalities of PBC. | Argyro Voumvouraki Mairi Koulentaki Maria Tzardi Ourania Sfakianaki Penelope Manousou George Notas Elias Kouroumalis | 2010 | World Journal of Gastroenterology2010，16，40： | 4 |
| 2 | Exploring Educator Values Alignment Strategies in an Intervention Context: The Emergence of the Beacon Strategy显示文摘Purpose:The purpose of this paper is to explore whether the four value alignment strategies available to educators(Scaffolding,Balancing,Intervention,and Refuge)previously identified in the mathematics education literature comprehensively capture educator value alignment strategies in an in terve ntion con text.Design/Approach/Methods:To this end,we analyse semi-structured interview data with two teacher-leaders involved in the Getting Ready in Numeracy(G.R.I.N.)intervention program through a value alignment lens.Findings:We ascertain that a fifth strategy,the Beacon strategy,is needed to describe the range of value alignment strategies employed by educators in the GRI.N.program.The Beacon strategy involves the educator digging in and reasserting their expectations until the student behaves in a manner that aligns with the educator's values.In part it invoIves the educator being able to recognize their own values and clearly communicating these values to students.O rigin al ity/Value:This article further explores strategies that educators have at their disposal for aligning their values with those of their students.The uncovering of the Beacon strategy is particularly valuable as it suggests that educators could be purposefully pursuing value alignment even when they do not appear to take any active steps to move further towards their students'sets of values. | Penelope Kalogeropoulos James Anthony Russo Philip Clarkson | 2021 | ECNU Review of Education2021，4，2： | 3 |
| 3 | Expression of Transforming Growth Factor-β1 by Pancreatic Stellate Cells and Its Implications for Matrix Secretion and Turnover in Chronic Pancreatitis显示文摘 | Fanny Wai-Tsing Shek Robert Christopher Benyon Fiona Mairi Walker Peter Raymond McCrudden Sylvia Lin Foon Pender Elizabeth Jean Williams Penelope Ann Johnson Colin David Johnson Adrian Calvin Bateman David Roger Fine John Peter Iredale | 2002 | The American Journal of Pathology2002，，5： | 2 |
| 4 | Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments显示文摘Lycopene is a naturally occurring red carotenoid compound that is found in watermelon.Lycopene has antioxidant properties.Lycopene content,sugar content and hollowheart resistance are subject to significant genotype×environment interaction(G×E),which makes breeding for these fruit quality traits difficult.The objectives of this study were to(i)evaluate the influence of years and locations on lycopene content,sugar content and hollowheart resistance for a set of watermelon genotypes,and(ii)identify genotypes with high stability for lycopene,sugar,and hollowheart resistance.A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated,multi-harvest trials.Lycopene was tested in a subset of 10 genotypes.Data were analyzed using univariate and multivariate stability statistics(BLUP-GGE biplot)using SASGxE and RGxE programs.There were strong effects of environment as well as G×E interaction on watermelon quality traits.On the basis of stability measures,genotypes were classified as stable or unstable for each quality trait.'Crimson Sweet'is an inbred line with high quality trait performance as well as trait stability.'Stone Mountain','Tom Watson','Crimson Sweet'and'Minilee'were among the best genotypes for lycopene content,sugar content and hollowheart resistance.We developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality traits.The chart will assist in choosing parents for improvement of watermelon cultivars.See http://gffzz783b6e01a04243c3hwk59f5op0wb969f9.ffgz.tsg.suse.edu.cn/cucurbit/wmelon/wmelonmain.html. | Mahendra Dia Todd C Wehner Penelope Perkins-Veazie Richard Hassell Daniel S Price George E Boyhan Stephen M Olson Stephen R King Angela R Davis Gregory E Tolla Jerome Bernier Benito Juarez | 2016 | Horticulture Research2016，3，1： | 2 |
| 5 | Interruptions in healthcare:theoretical views显示文摘 | Tobias G Penelope S | | 0，，05： | 1 |
| 6 | Does Aspirin Have a Role in Venous Thromboembolism Prophylaxis in Total Knee Arthroplasty Patients?显示文摘 | Kevin J. Bozic Thomas P. Vail Penelope S. Pekow Judith H. Maselli Peter K. Lindenauer Andrew D. Auerbach | 2010 | The Journal of Arthroplasty2010，，7： | 1 |
| 7 | Prepregnancy body mass index, gestational weight gain, and risk of hypertensive pregnancy among Latina women显示文摘 | Renée Turzanski Fortner Penelope Pekow Caren G. Solomon Glenn Markenson Lisa Chasan-Taber | 2009 | American Journal of Obstetrics and Gynecology2009，，2： | 1 |
| 8 | Patterning self-assembledmonolayers显示文摘 | Rachel K Smith Penelope ALewis Paul S Weiss | 2004 | Progress in surface science2004，，75： | 1 |
| 9 | Haze-active protein and polyphenolics in apple juice assessed by turbidity显示文摘 | SIEBERT K J PENELOPE Y L | 1997 | J of Food Science1997，62，： | 1 |
| 10 | The impact of sexual abuse on female development: Lessons from a multigenerational, longitudinal research study显示文摘 | Penelope K. Trickett Jennie G. Noll Frank W. Putnam | 2011 | Development and Psychopathology2011，，2： | 1 |
| 11 | Physiological responses of cabbage to incipient copper toxicity显示文摘 | Penelope A R Helen C H Kenneth L S | 1989 | J Amer Soc Hor Sci1989，114，1： | 1 |
| 12 | NCIC CTG IND.190 Phase I Trial of Dalotuzumab (MK-0646) in Combination with Cisplatin and Etoposide in Extensive-Stage Small-Cell Lung Cancer显示文摘 | Peter M. Ellis Frances A. Shepherd Scott A. Laurie Glenwood D. Goss Martin Olivo Jean Powers Lesley Seymour Penelope A. Bradbury | 2014 | Journal of Thoracic Oncology2014，，3： | 1 |
| 13 | Haze-active and polyphenols in apple juice assessed by turbidimetry显示文摘 | PENELOPE Y L | 1997 | J Food Sci1997，62，1： | 1 |
| 14 | Haze-active protein and polyphenolics in apple juice assessed by turbidity显示文摘 | Siebert K J Penelope Y L | 1997 | J of Food Science1997，62，： | 1 |
| 15 | Synthesis,structures and hypoxia-selective cytotoxicity of cobalt ( Ⅲ )complexes containing tridentate amine and nitrogen mustard ligands显示文摘 | DAVID C WARE PENELOPE J BROTHERS | 2000 | J Chem Soc Dalton Trans2000，，： | 1 |
| 16 | Haze-active protein and polyphenols in apple juice assessed by turbidimetry显示文摘 | Karl J Siebert Penelope Y Lynn | 1997 | J Food Science1997，62，1： | 1 |
| 17 | Efficacy and side effects of praziquantel against Schistosoma mansoni in a community of western C?te d’Ivoire显示文摘 | Giovanna Raso Eliézer K N'Goran Abale Toty Anne Luginbühl Cynthia A Adjoua Norbert T Tian-Bi Isaac I Bogoch Penelope Vounatsou Marcel Tanner Jürg Utzinger | 2003 | Transactions of the Royal Society of Tropical Medicine and Hygiene2003，，1： | 1 |
| 18 | Serum HE4 as a prognostic marker in endometrial cancer — A population based study显示文摘 | Donal J. Brennan Andreas Hackethal Alex M. Metcalf Jermaine Coward Kaltin Ferguson Martin K. Oehler Michael A. Quinn Monika Janda Yee Leung Michael Freemantle Penelope M. Webb Amanda B. Spurdle Andreas Obermair | 2014 | Gynecologic Oncology2014，，1： | 1 |
| 19 | Creating and sustaining trust in virtual teams显示文摘 | Penelope Sue Greenberg Ralph H. Greenberg Yvonne Lederer Antonucci | 2007 | Business Horizons2007，，4： | 1 |
| 20 | Digoxin显示文摘 | Penelope R Foss B Benezra SA | 1980 | Anal Pro- files Drug Subt1980，9，： | 1 |
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