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| 1 | Weaning stress and gastrointestinal barrier development:Implications for lifelong gut health in pigs显示文摘The gastrointestinal(GI) barrier serves a critical role in survival and overall health of animals and humans. Several layers of barrier defense mechanisms are provided by the epithelial, immune and enteric nervous systems. Together they act in concert to control normal gut functions(e.g., digestion,absorption, secretion, immunity, etc.) whereas at the same time provide a barrier from the hostile conditions in the luminal environment. Breakdown of these critical GI functions is a central pathophysiological mechanism in the most serious GI disorders in pigs. This review will focus on the development and functional properties of the GI barrier in pigs and how common early life production stressors, such as weaning, can alter immediate and long-term barrier function and disease susceptibility.Specific stress-related pathophysiological mechanisms responsible for driving GI barrier dysfunction induced by weaning and the implications to animal health and performance will be discussed. | Adam J.Moeser Calvin S.Pohl Mrigendra Rajput | 2017 | Animal Nutrition2017，，4： | 33 |
| 2 | 乙型肝炎病毒母婴传播及其阻断研究的现状与存在问题显示文摘HBV可经血液、母婴、性接触等多种途径传播,其中母婴传播是我国HBV传播的主要途径之一.乙型肝炎母婴阻断是指通过产前、产时,产后采取一系列措施对新生儿进行保护以减少感染HBV机会的方法.近年来,HBV的母婴阻断取得了较好效果,总体阻断成功率约在90%以上,但仍有一定的失败率,在相关机制、方案优化等方面仍面临一些亟待解决的问题. | 邹怀宾 陈煜 张华 段钟平 李杰 庄辉 梁晓峰 Calvin Q.Pan | 2010 | 中华肝脏病杂志2010，18，7： | 18 |
| 3 | Current recommendations of managing HBV infection in preconception or pregnancy显示文摘肝炎 B 仍然是肝硬化, hepatocellular 癌和世界范围的肝移植的一个领先的原因。长期的肝炎 B 的管理在怀孕期间是挑战性的。尽管 immunoprophylaxis 为对有长期的肝炎 B 感染的母亲出生的婴儿是广泛地可得到的,到婴儿的肝炎 B 的传播仍然 perinatally 发生。新兴的数据在开始第三个三个月在建议抗病毒的治疗的那开始高度, viremic 母亲能在他们的婴儿阻止 immunoprophylaxis 失败。lamivudine, telbivudine 和 tenofovir 通常是安全的在怀孕期间被过去常的可得到的药安全数据表演。以便最小化胎儿的暴露到抗病毒的药,抗病毒的治疗应该与肝硬化,高肝炎 B 病毒的负担,或优先的历史 immunoprophylaxis 失败在怀孕期间被限制到病人的一个选择的组。选任的凯撒的节可以减少 perinatal 传播的风险。为为怀孕或在怀孕的早舞台计划的那些女性,在产科医生, gastroenterologist,和主要照顾医生之中的通讯和后续是重要的。在这篇文章,我们以前将考察肝炎 B 感染的特征,在期间并且在怀孕以后;增加 mother-tochild 传播的风险因素;抗病毒的药使用上的安全数据在怀孕期间;并且在选择情况中的凯撒的节的潜在的角色。 | James S. Park Calvin Pan | 2014 | Frontiers of Medicine2014，8，2： | 17 |
| 4 | Beclin 1-Vps34 complex architecture: Understanding the nuts and bolts of therapeutic targets显示文摘Autophagy 是由毁坏并且再循环细胞内部的内容帮助细胞的动态平衡的维护的一条重要 lysosomal 降级小径。autophagy 的 Dysregulation 被连接到越来越多的人的疾病。Beclin 1-Vps34 蛋白质蛋白质相互作用网络为 autophagy 规定是批评的并且对细胞的正直因此必要。特别地经由 Beclin 1-Vps34 建筑群的行动的调整, autophagy 的操作被认为一条有希望的线路与 autophagy 相关的疾病作斗争。这里,我们在核心部件和 Beclin 1-Vps34 建筑群的结构的建筑学上总结最近的调查结果,并且怎么这些调查结果提供珍贵卓见进位于这些建筑群并且为设计治疗学的策略的多重函数下面的分子的机制。 | Deanna H. Morris Calvin K. Yip Yi Shi Brian T. Chait Qing Jun Wang | 2015 | Frontiers in Biology2015，10，5： | 17 |
| 5 | 基于遗传算法的变密度条件下地下水模拟优化模型显示文摘将遗传算法和变密度地下水流及溶质运移模拟程序SEAWAT耦合起来,开发了一个新的用于地下水模拟优化管理的通用程序——SWTGA。以求解变密度条件下地下水优化管理问题,从而为地下水管理决策者提供科学依据和技术支持。设计SWTGA时,建立了适用于变密度条件下地下水优化管理常见问题的目标函数的一般形式,同时设定了常用的约束条件。最后将SWTGA程序应用于一个理想滨海含水层中地下水开采方案的优化设计,寻优之后获得了最佳开采方案,与未优化开采方案的对比显示优化结果合理可行,验证了SWTGA模拟优化程序的有效性和可靠性。 | 林锦 郑春苗 吴剑锋 Calvin C.Chien | 2007 | 水利学报2007，38，10： | 15 |
| 6 | 粉体表面改性技术改善中药浸膏粉流动性的研究显示文摘该研究应用粉体表面改性技术改善中药浸膏粉的流动性。应用Comil粉碎整粒机,将1%的纳米Si O2对7种中药浸膏粉进行表面改性处理。采用粉体流动性测试仪,比较改性处理前后各浸膏粉的流动性变化,利用扫描电镜(SEM)观察各浸膏粉的微观表面形态变化,借助显微镜测定并比较各浸膏粉的粒径分布变化,并对改性前后的浸膏粉进行吸湿性研究。结果表明,表面改性处理后,各浸膏粉的休止角、抹刀角、压缩度、黏附度均明显降低,流动性指数增加,流动性得到显著性提高,以葛根浸膏粉和大黄浸膏粉改善最为显著,扫描电镜观察显示改性后的浸膏粉表面均附着有纳米Si O2,而改性前后的浸膏粉的粒径和吸湿性均无明显变化。该技术可为改善中药浸膏粉流动性提供新的解决途径。 | 余艳宏 陆文亮 李佳佳 Changquan Calvin Sun 周群 | 2014 | 中国中药杂志2014，39，23： | 12 |
| 7 | A review of the geomechanics aspects of a double fatality coal burst at Austar Colliery in NSW,Australia in April 2014显示文摘A coal burst occurred on 15 April, 2014 at the Austar Coal Mine, located west of Newcastle, NSW,Australia. The burst resulted in fatal injuries to two men working as part of the mining crew at the development face. At the time, a continuous miner was being used to mine a longwall development gate road through heavily structured coal, at a depth of approximately 550 m. A number of pre-cursor bumps had occurred on previous shifts, emanating from the coal ribs of the roadway, in proximity to the coal face.This paper reviews the geological, geotechnical and mining conditions and circumstances leading up to the coal burst event; and presents and discusses the available evidence and possible interpretations relating to the geomechanical behaviour mechanisms that may have been critical factors in this incident. The paper also discusses some key technical and operational considerations of ground support systems and mining practices and strategies needed for operating in such conditions in the future. | Hebblewhite Bruce Calvin Jim | 2017 | International Journal of Mining Science and Technology2017，27，1： | 11 |
| 8 | A meta-analysis of D1 versus D2 lymph node dissection显示文摘 | Rajini Seevaratnam Alina Bocicariu Roberta Cardoso Alyson Mahar Alex Kiss Lucy Helyer Calvin Law Natalie Coburn | 2012 | Gastric Cancer2012，，1： | 7 |
| 9 | Response to endoscopic therapy for biliary anastomotic strictures in deceased versus living donor liver transplantation显示文摘BACKGROUND:Endoscopic therapy has been successful in the management of biliary complications after both deceased donor liver transplantation(DDLT) and living donor liver transplantation(LDLT).LDLT is thought to be associated with higher rates of biliary complications,but there are few studies comparing the success of endoscopic management of anastomotic strictures between the two groups.This study aims to compare our experience in the endoscopic management of anastomotic strictures in DDLT versus LDLT.METHODS:This is a retrospective database review of all liver transplant patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) after liver transplantation.The frequency of anastomotic stricture and the time to develop and to resolve anastomotic stricture were compared between DDLT and LDLT.The response of anastomotic stricture to endoscopic therapy was also analyzed.RESULTS:A total of 362 patients underwent liver transplantation between 2003 and 2011,with 125 requiring ERCP to manage biliary complications.Thirty-three(9.9%) cases of DDLT and 8(27.6%) of LDLT(P=0.01) were found to have anastomotic stricture.When comparing DDLT and LDLT,there was no difference in the mean time to the development of anastomotic strictures(98±17 vs 172±65 days,P=0.11),likelihood of response to ERCP [22(66.7%) vs 6(75.0%),P=0.69],mean time to the resolution of anastomotic strictures(268±77 vs 125±37 days,P=0.34),and the number of ERCPs required to achieve resolution(3.9±0.4 vs 4.7±0.9,P=0.38).CONCLUSIONS:Endoscopic therapy is effective in the majority of biliary complications relating to liver transplantation.Anastomotic strictures occur more frequently in LDLT compared with DDLT,with equivalent endoscopic treatment response and outcomes for both groups. | Calvin HY Chan Fergal Donnellan Michael F Byrne Alan Coss Mazhar Haque Holly Wiesenger Charles H Scudamore Urs P Steinbrecher Alan A Weiss Eric M Yoshida | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 7 |
| 10 | Phenylphthalazines as small-molecule inhibitors of urea transporter UT-B and their binding model显示文摘瞄准:脲 transporters (UT ) 是明确地搬运脲的 transmembrane 蛋白质的一个家庭。没有影响电解质平衡, UT 禁止者施加利尿的活动。这研究的目的是发现新奇 UT 禁止者并且决定抑制 mechanism.Methods:主要屏蔽脲 transporter B (UT-B ) 禁止的活动用老鼠红血球细胞溶解在许多 10 000 个多样的小分子被进行试金。在与 1-phenylamino-4-phenylphthalazin 的核心结构发现成功以后, 160 类似物的 UT-B 禁止的活动与散布试金的一盏站流动灯被检验,他们的结构活动关系(SAR ) 被分析。抑制机制是进一步的在 silico assays.Results 使用调查: phenylphthalazine 混合物 PU 1424,化学上说出5-(4-(( 4-methoxyphenyl )氨基) phthalazin-1-yl )有 IC 50的 -2-methylbenzene 硫安类药剂,显示出的有势力 UT-B 抑制活动,禁止的人和鼠标 UT-B-mediated 脲运输 0.02 和 0.69 μ 珍视; mol/L ,分别地并且在更高的集中施加了100% UT-B 抑制。复合 PU 1424 没在缺乏 UT-B 的老鼠红血球影响膜脲运输。结构活动分析表明与在在 R2 位置的 R4 和酸性硫酸基的酰胺的 methoxyl 组一起的类似物在 UT-B 上展出了最高的力量抑制活动。而且,在 silico,试金验证了 R4 和 R2 在 UT-B.Conclusion 上类似物界限放到 UT-B 有约束力的衣袋和施加的抑制活动:复合 PU1424 与在 submicromolar 范围的 IC 50 是人和老鼠 UT-B 的一个新奇禁止者。它的有约束力的地点被定位在那么 UT-B 结构的地点。 | Jian-hua RAN Min LI Weng-leong TOU Tian-luo LEI Hong ZHOU Calvin Yu-Chian CHEN Bao-xue YANG | 2016 | Acta Pharmacologica Sinica2016，37，7： | 6 |
| 11 | A systematic review of the accuracy and indications for diagnostic laparoscopy prior to curative-intent resection of gastric cancer显示文摘 | Pierre-Anthony Leake Roberta Cardoso Rajini Seevaratnam Laercio Lourenco Lucy Helyer Alyson Mahar Calvin Law Natalie G. Coburn | 2012 | Gastric Cancer2012，，1： | 5 |
| 12 | 代偿期丙型肝炎肝硬化患者抗病毒治疗的临床研究显示文摘目的通过回顾性研究代偿期丙型肝炎肝硬化患者,探讨抗病毒治疗对肝硬化进展的影响并寻找肝硬化进展的预测因素。方法将2004年至2015年就诊的代偿期丙型肝炎肝硬化患者分为3组:治疗后获得持续病毒学应答(SVR)组、未获得SVR(NSVR)组和未治疗组。通过分析对比伴或不伴肝硬化进展的患者基线特征,寻找肝硬化进展预测因素;同时研究血小板计数、脾脏大小、终末期肝病模型(MELD)评分、序贯器官衰竭评估(SOFA)评分及Child-Turotte-Pugh(CTP)评分的改变,对比3组肝癌发生率。据资料不同分别采用One-Way ANOVA检验、Kruskal-Wallis H检验、两样本t检验、χ^2检验、多因素logistic回归分析。结果共纳入89例代偿期肝硬化患者,42例接受干扰素联合利巴韦林抗病毒治疗(30例接受聚乙二醇干扰素仅和12例接受普通干扰素),47例未接受任何抗病毒治疗。在接受干扰素联合利巴韦林抗病毒治疗患者中,20例获得SVR,22例未获得SVR。与基线值相比较,SVR组和NSVR组血小板计数分别增加(44.93±32.66)×10^9/L和(9.73±28.83)×10^9/L,未治疗组血小板计数下降(19.76±54.5)×10^9/L,三组血小板计数的改变差异有统计学意义(F=14.731,P〈0.001);SVR组脾脏缩小(0.91±1.09)cm,而NSVR组及未治疗组脾脏分别增大(0.20±0.84)cm和(1.11±1.69)cm,三组脾脏变化差异有统计学意义(F=14.943,P〈0.001);而三组MELD评分、SOFA评分及CTP评分的变化无明显差异(P〉0.05)。SVR组、NSVR组和未治疗组进展为肝癌的患者例数分别为1例(5.00%)、5例(22.73%)和6例(12.77%),差异有统计学意义(χ^2=13.787,P=0.001)。单因素分析提示SVR、HCVRNA、总胆红素、白蛋白是疾病进展的预测因素,多因素logistic回归分析提示SVR及总胆红素是疾病进展的预测因素。结论干扰素联合利巴韦林治疗代偿期丙型肝炎肝硬化的临床疗效确切,具有较好的近期和远期疗效。 | 谢志伟 李剑萍 关玉娟 张霞意 郭凤霞 陈彬彬 Calvin Q. Pan | 2017 | 中华肝脏病杂志2017，25，11： | 4 |
| 13 | Similar efficacy and safety of tenofovir in Asians and non-Asians with chronic hepatitis B显示文摘AIM:To compare the efficacy and safety of tenofovir disoproxil fumarate(TDF)in Asian and non-Asian chronic hepatitis B(CHB)patients.METHODS:The efficacy and safety of the initial 48wk of treatment with TDF was compared in a posthoc analysis of combined data from 217 Asians and299 non-Asians included in Studies 102 and 103and a post-approval,open-label trial(Study 123).Patient groups were compared according to baseline hepatitis B e antigen(HBe Ag)status and viral load.The main outcome measures included the proportion of patients who achieved a hepatitis B virus(HBV)DNA level<400 copies/m L at Week 48 of treatment.Secondary measures included:HBV DNA and alanine aminotransaminase(ALT)levels over time;proportion of patients with normal ALT levels;proportion of patients with HBe Ag loss/seroconversion and proportion of patients with hepatitis B surface antigen loss/seroconversion;changes in liver histology.Safety and tolerability were evaluated by the occurrence of adverse events(AEs),serious AEs,laboratory abnormalities,discontinuation of the study drug due to AEs,or death.The primary efficacy and safety analysis set included all patients who were randomly assigned to treatment and received at least one dose of study drug.RESULTS:At week 48,similar proportions of Asians and non-Asians reached HBV DNA<400 copies/m L(96%of Asian and 97%of non-Asian patients with HBe Ag-negative CHB and 83%of Asian and 79%of non-Asian patients with HBe Ag-positive CHB had HBV DNA)and normal ALT(78%of Asian and 81%of nonAsian patients with HBe Ag-negative CHB and 71%of Asian and 74%of non-Asian patients with HBe Agpositive CHB had normal ALT).On-treatment HBV DNA decline rates were similar between Asians and nonAsians regardless of baseline HBe Ag status and viralload.HBV DNA decline during the first four weeks was2.9 log10 copies/m L in HBe Ag-negative Asians and nonAsians,and in HBe Ag-positive non-Asians,and 3.1log10 copies/m L in HBe Ag-positive Asians.HBe Ag loss and seroconversion was achieved in 14%of Asians vs 26%and 24%,respectively,in non-Asians.Liver histology improved in 77.2%of Asians and 71.5%of non-Asians.No resistance to TDF developed.No renal safety signals were observed.CONCLUSION:TDF demonstrated similar viral suppression,normalization of ALT,improvements in liver fibrosis,and no detectable resistance in Asian and non-Asian patients regardless of baseline HBe Ag status. | Calvin Q Pan Sing Chan Huy Trinh Alan Yao Ho Bae Lillian Lou | 2015 | World Journal of Gastroenterology2015，21，18： | 4 |
| 14 | Vascular endothelial growth factor: Biology and therapeutic applications显示文摘 | Quoc T. Ho Calvin J. Kuo | 2007 | International Journal of Biochemistry and Cell Biology2007，，7： | 3 |
| 15 | A systematic review and meta-analysis of the utility of EUS for preoperative staging for gastric cancer显示文摘 | Roberta Cardoso Natalie Coburn Rajini Seevaratnam Rinku Sutradhar Laercio Gomes Lourenco Alyson Mahar Calvin Law Elaine Yong Jill Tinmouth | 2012 | Gastric Cancer2012，，1： | 3 |
| 16 | A classification system for tableting behaviors of binary powder mixtures显示文摘The ability to predict tableting properties of a powder mixture from individual components is of both fundamental and practical importance to the efficient formulation development of tablet products. A common tableting classification system(TCS) of binary powder mixtures facilitates the systematic development of new knowledge in this direction. Based on the dependence of tablet tensile strength on weight fraction in a binary mixture,three main types of tableting behavior are identified. Each type is further divided to arrive at a total of 15 sub-classes. The proposed classification system lays a framework for a better understanding of powder interactions during compaction. Potential applications and limitations of this classification system are discussed. | Changquan Calvin Sun | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，4： | 3 |
| 17 | Ileal Pouch Anal Anastomosis: Analysis of Outcome and Quality of Life in 3707 Patients显示文摘 | Victor Warren Fazio Ravi P. Kiran Feza H. Remzi John Calvin Coffey Helen Mary Heneghan Hasan Tarik Kirat Elena Manilich Bo Shen Sean T. Martin | 2013 | Annals of Surgery2013，，4： | 3 |
| 18 | Defining Surgical Quality in Gastric Cancer: A RAND/UCLA Appropriateness Study显示文摘 | Savtaj Brar Calvin Law Robin McLeod Lucy Helyer Carol Swallow Lawrence Paszat Rajini Seevaratnam Roberta Cardoso Matthew Dixon Alyson Mahar Laercio G. Lourenco Lavanya Yohanathan Alina Bocicariu Tanios Bekaii-Saab Ian Chau Neal Church Daniel Coit Christop | 2013 | Journal of the American College of Surgeons2013，，2： | 3 |
| 19 | How useful is preoperative imaging for tumor, node, metastasis (TNM) staging of gastric cancer? A meta-analysis显示文摘 | Rajini Seevaratnam Roberta Cardoso Caitlin Mcgregor Laercio Lourenco Alyson Mahar Rinku Sutradhar Calvin Law Lawrence Paszat Natalie Coburn | 2012 | Gastric Cancer2012，，1： | 3 |
| 20 | Expression of Transforming Growth Factor-β1 by Pancreatic Stellate Cells and Its Implications for Matrix Secretion and Turnover in Chronic Pancreatitis显示文摘 | Fanny Wai-Tsing Shek Robert Christopher Benyon Fiona Mairi Walker Peter Raymond McCrudden Sylvia Lin Foon Pender Elizabeth Jean Williams Penelope Ann Johnson Colin David Johnson Adrian Calvin Bateman David Roger Fine John Peter Iredale | 2002 | The American Journal of Pathology2002，，5： | 2 |
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