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| 1 | The immune tolerant phase of chronic HBV infection: new perspectives on an old concept显示文摘长期的肝炎 B 病毒(HBV ) 感染通过强烈与耐心的年龄被联系的不同疾病阶段进行。所谓的免疫者容忍(信息技术) 阶段代表感染的古典早阶段;它与 HBV 复制的高水平和肝发炎的临床的符号的缺乏被联系。HBV 感染的这个阶段是否也与免疫学的被联系, “ 展示; tolerance' 最近被质问了。这里,我们考察数据那争论有免疫力的忍耐的这个概念然后建议发生在 CHB 感染的这个早阶段期间的 immunopathological 事件的其他的解释。 | Antonio Bertoletti Patrick T Kennedy | 2015 | Cellular & Molecular Immunology2015，12，3： | 36 |
| 2 | Hepatitis B-specific T helper cell responses in uninfected infants born to HBsAg^(+)/HBeAg^(-) mothers显示文摘Vertically transmitted hepatitis B virus(HBV)usually causes chronic infection.While combined active–passive immunoprophylaxis in neonates of hepatitis B surface antigen-positive(HBsAg1)mothers at birth prevents vertical transmission,it is not yet clear whether neonates encounter the virus or its products in the absence of hepatitis B e antigen(HBeAg).This study was undertaken to investigate HBV antigen-specific T-cell responses in vaccinated neonates of HBsAg1/HBeAg2 mothers.Blood was collected from 46 HBsAg1 mothers and their neonates(subjects)as well as 24 age-matched controls.All neonates of HBsAg1 mothers received appropriate immunoprophylaxis,and HBsAg and hepatitis B surface antibody(anti-HBs)antibody titers were determined after completion of the vaccination course.Peripheral blood mononuclear cells(PBMCs)from infants at birth,1 and 6 months of age were stimulated with recombinant HBsAg,hepatitis B core antigen(HBcAg)and mitogen,and interferon(IFN)-c concentrations were determined by ELISA.HBsAg-induced production of IL-2,IL-5,IL-6 and IL-10 was assessed using a cytometric bead array kit on cells from 6-month-old neonates post-vaccination.All neonates were HBsAg2 and responded to vaccination.Increased IFN-c production following HBcAg stimulation was seen in 30.4%of neonates born to HBsAg1/HBeAg2 mothers.Subjects demonstrated significantly higher IL-2 production post-HBsAg stimulation,whereas IL-5,IL-6 and IL-10 cytokine responses were not significantly different.Almost one-third of uninfected neonates developed viral antigen-induced IFN-c production,suggesting that they had been exposed to virions or viral derivatives.This encounter,however,did not impair their T-cell responses to vaccination. | Lemonica Koumbi Antonio Bertoletti Vassiliki Anastasiadou Maria Machaira Winnie Goh Nikolaos G Papadopoulos Dimitris A Kafetzis Vassiliki Papaevangelou | 2010 | Cellular & Molecular Immunology2010，7，6： | 4 |
| 3 | Incubation Phase of Acute Hepatitis B in Man: Dynamic of Cellular Immune Mechanisms显示文摘 | George J.M. Webster Stephanie Reignat Mala K. Maini Simon A. Whalley Graham S. Ogg Abigail King David Brown Peter L. Amlot Roger Williams Diego Vergani Geoffrey M. Dusheiko Antonio Bertoletti | 2000 | Hepatology2000，，5： | 4 |
| 4 | Overview of the special issue on HBV immunity显示文摘 | Antonio Bertoletti Fu-Sheng Wang | 2015 | Cellular & Molecular Immunology2015，12，3： | 3 |
| 5 | SARS-CoV-2-specific T cells in infection and vaccination显示文摘During viral infections,antibodies and T cells act together to prevent pathogen spread and remove virus-infected cells.Virusspecific adaptive immunity can,however,also trigger pathological processes characterized by localized or systemic inflammatory events.The protective and/or pathological role of virus-specific T cells in SARS-CoV-2 infection has been the focus of many studies in COVID-19 patients and in vaccinated individuals.Here,we review the works that have elucidated the function of SARS-CoV-2-specific T cells in patients and in vaccinated individuals.Understanding whether SARS-CoV-2-specific T cells are more linked to protection or pathogenesis is pivotal to define future therapeutic and prophylactic strategies to manage the current pandemic. | Antonio Bertoletti Nina Le Bert Martin Qui Anthony T.Tan | 2021 | Cellular & Molecular Immunology2021，18，10： | 3 |
| 6 | Preserved T-Cell Function in Children and Young Adults With Immune-Tolerant Chronic Hepatitis B显示文摘 | Patrick T.F. Kennedy Elena Sandalova Juandy Jo Upkar Gill Ines Ushiro–Lumb Anthony T. Tan Sandhia Naik Graham R. Foster Antonio Bertoletti | 2012 | Gastroenterology2012，，3： | 2 |
| 7 | Different cytokine profiles of intraphepatic T cells in chronic hepatitis B and hepatitis C virus infections显示文摘 | Bertoletti A D'Elios MM Boni C | | 0，，： | 2 |
| 8 | Control or persistence of hepatitis B virus: the critical role of initial host-virus interactions显示文摘 | Webster G J Bertoletti A | 2002 | Immunol Cell Biol2002，80，1： | 2 |
| 9 | Bronchoscopic cryotherapy treatment of isolated endoluminal typical earcinoid tumor 显示文摘 | Bertoletti L Elleuch R Kaczmarek D | 2006 | Chest2006，130，5： | 1 |
| 10 | Role of hepatitis B virus specific cytotoxie T cells in liver damage and viral control显示文摘 | Bertoletti A MainiM Williams R | 2003 | J Antivial Research2003，60，： | 1 |
| 11 | Bronchoscopic cryotherapy treatmentof isolated endoluminal typical carcinoid tumor显示文摘 | Bertoletti L Elleuch R Kaczmarek D | 2006 | Chest2006，130，5： | 1 |
| 12 | The immune response during hepatitis B virus infection 显示文摘 | Bertoletti A Gehring AJ | 2006 | J Gen Viro12006，87，6： | 1 |
| 13 | Protection or damage : a dual role for the virus specific cytotoxin T lymphocyte response in hepatitis B and C infection? 显示文摘 | Bertoletti A Maini MK | 2000 | Curr Opin Microbiol2000，3，4： | 1 |
| 14 | Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B显示文摘 | Boni C Bertoletti A Penna A | | 0，，： | 1 |
| 15 | Kinetics of the immune response during HBV and HCV infection显示文摘 | Antonio Bertoletti Carlo Ferrari | 2003 | Hepatology2003，，1： | 1 |
| 16 | Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: New perspectives for immune therapy显示文摘 | Carolina Boni Amalia Penna Graham S. Ogg Antonio Bertoletti Massimo Pilli Cristina Cavallo Albertina Cavalli Simona Urbani Richard Boehme Ruggero Panebianco Franco Fiaccadori Carlo Ferrari | 2001 | Hepatology2001，，4： | 1 |
| 17 | Kinetics of the immune response during HBV and HCV infection 显示文摘 | Bertoletti A Ferrari C | 2003 | Hepatology2003，38，： | 1 |
| 18 | Control or persistence of hepatitis B virus: The critical role of initial host-virus interactions显示文摘 | Webster GJM Bertoletti A | 2002 | Immunol Cell Biology2002，80，： | 1 |
| 19 | Natural variants of cytotoxic epitopes are T-cell receptor antaganists for antiviral cytotoxic T cell显示文摘 | Bertoletti A Sette A Chisari FV | 1994 | Nature1994，369，6479： | 1 |
| 20 | Innate and adaptive immune respon- ses in chronic hepatitis B virus infections,, towards restora- tion of immune control of viral infection显示文摘 | Bertoletti A Ferrari C | 2011 | Gut2011，，： | 1 |
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