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    题名 作者 年代 出处 被引量
1Intelligent Manufacturing in the Context of Industry 4.0: A Review显示文摘Ray Y. Zhong Xun Xu Eberhard Klotz Stephen T. Newman 2017Engineering2017,3,5:130
2华蟾素治疗肝癌、肺癌、胰腺癌的Ⅰ期临床研究:初步报道显示文摘背景与目的:华蟾素目前广泛应用于肿瘤的治疗中,由于在80年代上市,未进行临床Ⅰ期研究,无法确定其最大耐受剂量。因此本文旨在观察华蟾素治疗肝细胞癌、肺癌和胰腺癌的最大耐受剂量和不良反应,同时评价治疗疗效。方法:Ⅲ、Ⅳ期肝细胞癌、非小细胞肺癌和胰腺癌接受华蟾素治疗,采用静脉滴注,连续14 d,21 d为一疗程。如果没有出现剂量限制性毒性,治疗将持续2个疗程。剂量递增的方案为:10、20、40、60、90和120 m l/(m2.d)。结果:入组15例患者(每个剂量组为3例)中,11例为肝癌,2例胰腺癌和2例肺癌。第五剂量组结束时没有发现剂量限制性毒性(DLT)。其中14例患者可评价疗效,6例(42.9%)为SD,8例(57.1%)为PD。在第一剂量组中,1例肝癌患者肿瘤缩小20%并维持11个月。结论:本研究最高剂量达到常规剂量的8倍,尚未出现剂量限制性毒性。部分患者获得了肿瘤缩小或稳定的疗效。孟志强 沈晔华 杨培英 Robert Newman 贝文英 张颖 葛勇前 Lorenzo Cohen Razelle Kurzrock 刘鲁明 2007中国癌症杂志2007,17,5:27
3中国初中生饮酒行为与其他健康危险行为的关系显示文摘目的探讨中国青少年自我报告的饮酒行为与其他健康危险行为之间的关系,为青少年健康行为干预提供依据。方法使用世界卫生组织网站公布的2003年中国全球学校学生健康状况调查数据,以SPSS13.0完成数据分析,采用χ2检验分析初中生饮酒行为与其他行为之间的关系。结果过去30d内发生饮酒行为的学生直接健康危险行为、其他健康危险行为、环境健康危险行为、心理健康危险行为发生的报告率更高,尤其是吸烟/被动吸烟、吸毒、逃课、斗殴、严重受伤、焦虑和有自杀计划行为,其OR值均在2.0以上。不同城市饮酒学生与非饮酒学生发生其他健康危险行为的类型基本相同。结论应充分考虑青少年饮酒行为的干预和预防教育。Teresa M.Merrick 张莹 田本淳 钱玲 Ian M Newman 2008中国学校卫生2008,29,5:14
4大学生饮酒模式调查分析显示文摘目的分析影响大学生饮酒模式的因素,针对饮酒教育及酒精政策提出建议。方法采用整群抽样方法,选择来自北京和郑州的530名大学生完成有效问卷调查。采用Epidata录入数据,SAS 12.0和R 2.7.2进行数据描述和分析。结果 74.5%的大学生在过去1年内饮过酒,啤酒是饮酒者的主要选择(85.9%),餐馆和家里是饮酒比较频繁的场所,饮用酒多来自同学/朋友及家庭成员提供,25.3%饮酒者并无特别原因饮酒,各有约1/5的饮酒者是出于社交目的或喜欢饮酒的感觉。认为'饮酒有助于社交'或'饮酒促进交流'者、父母及同学/朋友饮酒者、来自农村地区或小城镇者及吸烟者更容易发生饮酒行为(均P<0.05),男生大学生、规律饮酒者更容易遭遇强迫劝酒场面、更易发生醉酒(均P<0.05)。超过一半饮酒者出现酒后脸红、肌肉软弱无力等生理反应,饮酒对被调查大学生产生的社会心理影响依次是记忆丧失(23.9%)、宿醉(14.6%)、做了后悔的事(低于10%)等。结论目前大学生仍保持着一种低风险饮酒模式。大学生饮酒教育应提供关于饮酒利弊的科学信息,使其对饮酒保持一种现实的期望。应制定针对性酒精政策和教育鼓励和支持低风险且满足社交功能的饮酒模式,控制高风险饮酒模式。Newman IM Huang Zhaoqing Shell DF 钱玲 2014中国社会医学杂志2014,31,2:10
5Patients with irritable bowel syndrome-diarrhea have lower disease-specific quality of life than irritable bowel syndrome-constipation显示文摘AIM: To determine effect of irritable bowel syndrome(IBS) subtype on IBS-specific quality of life(QOL) questionnaire and its subscales.METHODS: We studied IBS patients visiting our functional gastroenterology disorder clinic at a tertiary care center of Unites States.IBS and IBS subtype were diagnosed using Rome-Ⅲ questionnaire.QOL was assessed using IBS-QOL questionnaire.IBSQOL assesses quality of life along eight subscales: dysphoria,interference with activities,body image,health worry,food avoidance,social reactions,sexual health,and effect on relationships.IBS-QOL and its subscales were both scored on a range of 0-100 with higher scores suggestive of better QOL.Results of overall IBS-QOL scores and subscale scores are expressed as means with 95%CI.We compared mean IBS-QOL score and its subscales among various IBSsubtypes.Analysis of variance(ANOVA) was used to compare the mean difference between more than two groups after controlling for age and gender.A posthoc analysis using Bonferroni correction was used only when P value for ANOVA was less than 0.05.RESULTS: Of 542 patients screened,243 had IBS as per Rome-Ⅲ criteria.IBS-mixed(IBS-M) was the most common IBS subtype(121 patients,49.8%) followed by IBS- diarrhea(IBS-D)(56 patients,23.1%),IBSconstipation(IBS-C)(54 patients,22.2%) and IBSunspecified(IBS-U)(12 patients,4.9%).Overall IBSQOL scores were significantly different among various IBS-subtypes(P = 0.01).IBS-QOL of patients with IBS-D(61.6,95%CI: 54.0-69.1) and IBS-M(63.0,95%CI: 58.1-68.0) was significantly lower than patients with IBS-C(74.5,95%CI: 66.9-82.1)(P = 0.03 and 0.02 respectively).IBS-D patients scored significantly lower than IBS-C on food avoidance(45.0,95%CI: 34.8-55.2 vs 61.1,95%CI: 50.8-71.3,P = 0.04) and interference with activity(59.6,95%CI: 51.4-67.7 vs 82.3,95%CI: 74.1-90.6,P < 0.001).IBS-M patients had more interference in their activities(61.6,95%CI: 56.3-66.9 vs 82.3,95%CI: 74.1-90.6,P = 0.001) and greater impact on their relationships(73.3,95%CI: 68.4-78.2 vs 84.7,95%CI: 77.2-92.2,P = 0.02) than IBS-C patients.Patients with IBS-M also scored significantly lower than IBS-C on food avoidance(47.2,95%CI: 40.7-53.7 vs 61.1,95%CI: 50.8-71.3,P = 0.04) and social reaction(66.1,95%CI: 61.1-71.1 vs 80.0,95%CI: 72.1-87.7,P = 0.005).CONCLUSION: IBS-D and IBS-M patients have lower IBS-QOL than IBS-C patients.Clinicians should recognize food avoidance,effects on daily activities and relationship problems in these patients.Prashant Singh Kyle Staller Kenneth Barshop Elaine Dai Jennifer Newman Sonia Yoon Shahar Castel Braden Kuo 2015World Journal of Gastroenterology2015,21,26:9
6Detecting community structure in networks显示文摘M. E. J. Newman 2004The European Physical Journal B2004,,2:7
7典型相关分析在中国青少年健康行为影响因素探讨中的应用显示文摘目的运用典型相关方法从多维度探讨几组中国青少年健康行为之间的相互关系。方法数据来自2003年全球学校学生健康状况调查——中国区(GSHS)。健康行为变量分为四组:健康行为、心理、其他个人行为和环境行为组。典型相关分析以SPSS13.0完成。结果不良心理状态主要由高水平的孤独、焦虑、有自杀想法、有自杀计划和抑郁来反映,健康行为主要由少吸烟、少饮酒、较少静坐行为和经常吃早餐来反映,其他不健康个人行为包括较少安全带使用、参与斗殴和旷课,而不良环境行为由较多被欺负、受到严重伤害和他人在面前吸烟决定。处于不良心理状态个体发生不健康行为的可能性越大,而暴露于不良环境行为越多者,其心理风险也越大。结论行为是一种多元变量,没有一个或一组心理或其他行为变量能够单独影响和解释中国青少年的健康行为。在进行这类因素的关联分析时,可更多地考虑应用典型相关分析方法。Teresa M. Merrick 张莹 Ian M Newman Duane Shell 钱玲 2008中国卫生统计2008,25,2:6
8Assessment of potential impacts to surface and subsurface water bodies due to longwall mining显示文摘Ground movements due to longwall mining operations have the potential to damage the hydrological balance within as well as outside the mine permit area in the form of increased surface ponding and changes to hydrogeological properties. Recently, the Office of Surface Mining, Reclamation and Enforcement(OSMRE) in the USA, has completed a public comment period on a newly proposed rule for the protection of streams and groundwater from adverse impacts of surface and underground mining operations(80 FR 44435). With increased community and regulatory focus on mining operations and their potential to adversely affect streams and groundwater, now there is a greater need for better prediction of the possible effects mining has on both surface and subsurface bodies of water. With mining induced stress and strain within the overburden correlated to changes in the hydrogeological properties of rock and soil, this paper investigates the evaluation of the hydrogeological system within the vicinity of an underground mining operation based on strain values calculated through a surface deformation prediction model. Through accurate modeling of the pre- and post-mining hydrogeological system, industry personnel can better depict mining induced effects on surface and subsurface bodies of water aiding in the optimization of underground extraction sequences while maintaining the integrity of water resources.Christopher Newman Zacharias Agioutantis Gabriel Boede Jimenez Leon 2017International Journal of Mining Science and Technology2017,27,1:6
9AHP-TOPSIS在瑜伽文胸舒适性主观评价中的应用显示文摘针对瑜伽文胸舒适性主观综合评判非量化、非系统化的问题,提出一种基于层次分析法(AHP)与逼近理想解排序法(TOPSIS)相结合的综合评判方法。从静态和动态因素分析影响瑜伽文胸舒适性的评判指标,运用AHP确定各评判指标的权重向量,并结合TOPSIS构建AHP-TOPSIS综合评判指标体系模型,计算出9款不同设计特征的瑜伽文胸综合优越度。结果显示:瑜伽文胸d9静态与动态的综合舒适性最优;d2、d8次之,d3综合舒适性最差。鲍正壮 周捷 鲁丹丹 LAU Newman 张俊 2021纺织高校基础科学学报2021,34,1:4
10Development of a new algorithm for implementing the edge effect offset for subsidence calculations显示文摘The surface deformation prediction system(SDPS) program has been developed as an engineering tool for the calculation of subsidence deformation indices through the implementation of various prediction methods.From basic user-defined input parameters, SDPS can determine subsidence indices, such as mining induced displacements, strains, tilt, etc., at any elevation between the seam and the horizontal or varying surface topography.A fundamental parameter in obtaining reliable ground deformation results is the determination of the edge effect offset.The value assigned to the edge effect offset corresponds to a virtual offsetting of boundary lines delineating the extracted panel to allow for roof cantilevering over the mined-out area.The objective of this paper is to describe the methods implemented in updating the edge effect offset algorithm within SDPS.Using proven geometric equations, the newly developed algorithm provides a more robust calculation of the offset boundary of the extracted panel for simplistic as well as more complex mining geometries.Given that an extracted panel is represented by a closed polyline, the new edge offset algorithm calculates a polyline offset into the extracted panel with respect to the user defined edge effect offset distance.Surface deformations are then calculated using this adjusted panel geometry.The Matlab program was utilized for development and testing of the new edge effect offset algorithm.After completing rigorous testing regimes, the new offset algorithm will be integrated into SDPS further increasing the speed and reliability of the program resulting in a retrospective increase in capability and flexibility.Joshua Hescock Christopher Newman Zach Agioutantis 2018International Journal of Mining Science and Technology2018,28,1:4
11透水混凝土路面砖路面的微生物学显示文摘因为透水路面砖系统(本文专指透水混凝土路面砖铺设的路面,两者可互换使用)能够滞留和降解路面上的碳氢化合物,而引起人们关注。试验研究证明:清除路面上油污的关键,是在路面砖上自然存在着微生物作用的结果。英国Formpave公司和Coventry大学的联合研究表明,一旦油污渗透至能滞留油污的坚固土工织物薄膜层上,则迅速成为某些微生物的食物源。油污经有氧细菌和真菌的代谢作用,转化为糖类成分,如葡萄糖。随着时间的推移,微生物数量逐渐增加,形成一个网络遍布在Inbitex土工布上,形成一层生物'膜',进一步改善了路面系统的过滤和净化功能。由于油污提供了大量食物源,会将较大的掠夺性生物,例如单细胞微生物和多细胞动物吸引到生物膜上。这些生物对保持土工织物的透水畅通等特性起到重要作用,也对降解油污的微生物体的连续存在起着关键作用。为了优化透水路面砖路面系统的功能,有必要了解用透水路面砖铺设路面系统是如何有利于环保的。A. P. Newman S. J. Coupe H. G. Smith T. Puehmeier P. Bond 崔玉忠(翻译) 刘黎(校核) 杜建东(校核) 2008建筑砌块与砌块建筑2008,,1:4
12A Lesion-Mimic Syntaxin Double Mutant in Arabidopsis Reveals Novel Complexity of Pathogen Defense Signaling显示文摘损害模仿 Arabidopsis 异种, syp121 syp122,组成地表示表明小径的水杨酸酸(SA ) 并且有低穿入抵抗到粉的霉真菌。损害模仿显型的基因分析在植物扩展了我们规划房间死亡(PCD ) 的理解。在 syp121 syp122 表明基因的 SA 的 Inactivation 仅仅部分救损害模仿显型,显示另外的防卫贡献 PCD。整个染色体 transcriptome 分析证实了那知道的导致 SA 的抄本,以及众多的其它病原体反应抄本,在 syntaxin 基因的 inactivation 以后是起来调整的。syp121 syp122 的 suppressor 异种分析表明 FMO1, ALD1,和 PAD4 为损害开发是重要的。EDS1, NDR1, RAR1,和 SGT1b 的变异的等位基因部分也救了损害模仿显型,建议那变异的 syntaxin 基因刺激 TIR-NB-LRR 和 CC-NB-LRR-type 电阻。syntaxin 两倍大美人加强了粉的导致霉的象 HR 一样回答。发信号的这要求的功能的 PAD4 然而并非功能的 SA。然而,发信号的 SA 加强了 PAD4 依赖的象 HR 一样反应。四倍的异种的分析建议 EDS5 和 SID2 授与分开的 SA 独立的发信号功能,并且那 FMO1 和 ALD1 调停 NPR1 依赖的 SA 独立的信号。这些研究加亮多重小径的贡献到防卫和点到他们的相互作用的复杂性。Ziguo Zhang Andrea Lenk Mats X. Andersson Torben Gjetting Carsten Pedersen Mads E. Nielsen Mari-Anne Newman Bi-Huei Hou Shauna C. Somerville Hans Thordal-Christensen 2008Molecular Plant2008,1,3:3
13Natural products: A continuing source of novel drug leads显示文摘Gordon M. Cragg David J. Newman 2013BBA - General Subjects2013,,6:3
14Renormalization group analysis of the small-world network model显示文摘M.E.J. Newman D.J. Watts 1999Physics Letters A1999,,4:3
15Development of a multiple level underground limestone mine from geology through mine planning显示文摘The development of a multiple level underground mine is a complex task in which geology,engineering,ground control,and unit operations are integrated into a single mine design.The components are interdependent and must function cohesively to ensure a profitable underground mining operation.To optimize reserve recovery,mine planning should begin from the lowest level and progress up.This limits any misjudgments or oversights of a given level affecting the underlying levels and ensures the ability to maximize recovery from each level.Mine planning should start with the exploration and characterization of the geologic setting.Once the reserve geology and quality is well understood,then mine planning can begin with respect to the following:(1)orientation of mine works with respect to horizontal stress;(2)access to the reserve;(3)determination of opening widths;(4)selection of back,floor horizons and pillar centers;(5)selection of development and secondary mining heights;(6)appropriate inter-burden thicknesses;and(7)examining the stability of the multiple level mine through numerical modeling.The multiple level mine design process and decisions are presented through a case history example.The theme is that there is one opportunity to'get it right'and many chances to overlook a small aspect within the design that will plague the mine throughout all levels and through the entirety of its operating life.Christopher Newman David Newman Robert Dupuy 2020International Journal of Mining Science and Technology2020,30,1:3
16Cdx 2 ectopic expression induces gastric intestinal metaplasia in transgenic mice显示文摘Debra G. Silberg Jessica Sullivan Eugene Kang Gary P. Swain Jennifer Moffett Newman J. Sund Sara D. Sackett Klaus H. Kaestner 2002Gastroenterology2002,,3:3
17设计紧凑的低杂散电感模块化变换器/逆变器系统显示文摘设计模块化的功率系统时,必须考虑到电磁兼容性的规定,低的杂散电感,高的保护标准以及非常低的成本。集成有最新IGBT技术的,电流从300A到1550A的,用于变换器和逆变器的大功率系统对于进行控制集成的那些公司是非常重要的。一些中小创新型公司目前已经在如功率计、榨糖厂以及无齿轮电梯等特殊领域展开业务。SEMIKRON模块化的功率系统完全能够满足交流电源大功率系统应用的要求。SEMIKRON开发的这种系统能够满足所有标准的要求,而且在集成时非常灵活。Paul Newman Norbert Pluschke 2006电源世界2006,,8:3
18Tracking domestic ducks:A novel approach for documenting poultry market chains in the context of avian influenza transmission显示文摘Agro-ecological conditions associated with the spread and persistence of highly pathogenic avian influenza(HPAI) are not well understood, but the trade of live poultry is suspected to be a major pathway. Although market chains of live bird trade have been studied through indirect means including interviews and questionnaires, direct methods have not been used to identify movements of individual poultry. To bridge the knowledge gap on quantitative movement and transportation of poultry, we introduced a novel approach for applying telemetry to document domestic duck movements from source farms at Poyang Lake, China. We deployed recently developed transmitters that record Global Positioning System(GPS) locations and send them through the Groupe Spécial Mobile(GSM) cellular telephone system. For the first time, we were able to track individually marked ducks from 3 to 396 km from their origin to other farms, distribution facilities, or live bird markets. Our proof of concept test showed that the use of GPS-GSM transmitters may provide direct, quantitative information to document the movement of poultry and reveal their market chains. Our findings provide an initial indication of the complexity of source-market network connectivity and highlight the great potential for futuretelemetry studies in poultry network analyses.Chang-Yong Choi John Y Takekawa XIONG Yue LIU Ying Martin Wikelski George Heine Diann J Prosser Scott H Newman John Edwards Fusheng Guo Xiangming Xiao 2016Journal of Integrative Agriculture2016,15,7:3
19心血管健康研究中血压轨迹与死亡率、心血管病事件和心力衰竭的关系显示文摘老年人的一般血压轨迹尚未明确,其与临床结局的关系也尚不确定。方法:本研究采用层次聚类分析法来确定心血管健康研究中4067参与者从0~7年重复测量血压值的血压轨迹。然后采用Cox比例风险回归模型评估每种血压轨迹聚类与全因死亡率、Smitson CC Scherzer R Shlipak MG Psaty BM Newman AB Sarnak MJ Odden MC Peralta CA 陈云 叶鹏 2018中华高血压杂志2018,26,2:3
20大学生对饮酒所致脸红反应社会学涵义的认知显示文摘目的了解大学生对饮酒所致脸红反应的理解,以及对饮酒脸红者的行为反应,为探讨饮酒所致脸红反应的遗传-环境联系提供线索。方法以自行设计的问卷对中国中部某大学医学院和教育学院的442名大学生进行匿名调查。以Epi Data 3.02录入数据,利用SPSS 13.0完成数据分析。结果71.0%的学生在过去一年里饮过酒。50.4%的学生认为脸红反应是表示脸红者不应再继续饮酒,有此认知的非饮酒学生和饮酒学生比例分别为63.6%和44.9%。55.4%的学生表示饮酒群体中的其他人将劝阻脸红者继续饮酒。针对饮酒场合中男生的脸红反应,41.9%的男生和49.2%的女生认为饮酒群体中的男生仍会鼓励男生脸红者继续饮更多的酒;如果出现脸红反应者是女生,此比例分别为7.8%和10.5%。结论大学生对饮酒所致脸红反应的社会学涵义缺乏正确认知,这种缺乏不仅影响其对脸红反应者、尤其是对不同性别脸红者的行为反应,而且有可能影响其自身的饮酒经历。张建国 Teresa MERRICK Ian NEWMAN 钱玲 2007中国健康教育2007,23,4:2
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