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| 1 | Clinical importance of aspirin and clopidogrel resistance显示文摘Aspirin and clopidogrel are important components of medical therapy for patients with acute coronary syndromes, for those who received coronary artery stents and in the secondary prevention of ischaemic stroke. Despite their use, a significant number of patients experience recurrent adverse ischaemic events. Interindividual variability of platelet aggregation in response to these antiplatelet agents may be an explanation for some of these recurrent events, and small trials have linked 'aspirin and/or clopidogrel resistance', as measured by platelet function tests, to adverse events. We systematically reviewed all available evidence on the prevalence of aspirin/clopidogrel resistance, their possible risk factors and their association with clinical outcomes. We also identified articles showing possible treatments. After analyzing the data on different laboratory methods, we found that aspirin/clopidogrel resistance seems to be associated with poor clinical outcomes and there is currently no standardized or widely accepted definition of clopidogrel resistance. Therefore, we conclude that specific treatment recommendations are not established for patients who exhibit high platelet reactivity during aspirin/clopidogrel therapy or who have poor platelet inhibition by clopidogrel. | Gergely Feher Andrea Feher Gabriella Pusch Katalin Koltai Antal Tibold Beata Gasztonyi Elod Papp Laszlo Szapary Gabor Kesmarky Kalman Toth | 2010 | World Journal of Cardiology2010，2，7： | 36 |
| 2 | Striking elevation in incidence and prevalence of inflammatory bowel disease in a province of western Hungary between 1977-2001显示文摘AIM:An investigation into inflammatory bowel disease and colorectal cancer in Veszprem Province was conducted from 1977 to 2001.METHODS: Both hospital and outpatient records were collected and reviewed comprehensively. The majority of patients were followed up regularly.RESULTS:The population of the province was decreased from 386000 to 376000 during the period. Five hundred sixty new cases of ulcerative colitis (UC), 212 of Crohn's disease (CD), and 40 of indeterminate colitis (IC) were diagnosed. The incidence rates increased from 1.66 to 11.01 cases per 100 000 persons for UC, from 0.41 to 4.68 for CD and from 0.26 to 0.74 for IC. The prevalence rate at the end of 2001 was 142.6 for UC and 52.9 cases per 100 000 persons for CD. The peak onset age in UC patients was between 30 and 40 years, in CD between 20 and 30 years. A family history of IBD was present in 3.4% in UC and 9.9% in CD patients.Smoking increased the risk for CD (OR=1.94) while it decreased the risk for UC (OR=0.25). Twelve colorectal carcinomas were observed in this cohort, the cumulative colorectal cancer risk after 10 years in UC was 2%, after 20 years 8.8%, after 30 years 13.3%.CONCLUSION:The incidence and prevalence rates of IBD have increased steadily in Veszprem Province, now equivalent to that in Western European countries. Rapid increase in incidence rates supports a probable role for environmental factors. The rate of colorectal cancers in IBD is similar to that observed in Western countries. | Laszlo Lakatos Gabor Mester Zsuzsanna Erdelyi Mihaly Balogh Istvan Szipocs Gyorgy Kamaras Peter Laszlo Lakatos | 2004 | World Journal of Gastroenterology2004，10，3： | 17 |
| 3 | Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats显示文摘瞄准:决定 melatonin 预告的处理的效果并且在 L 精氨酸(L-Arg ) 的严厉上处理以后在老鼠的导致的试验性的胰腺炎。方法:男 Wistar 老鼠(25 ) 被划分成五个组。那些在 1h 的间隔在组 A 收到了 3.2g/kg 体重 L-Arg i.p 的二注射。在组麻省,老鼠与 50 mg/kg 体重 melatonin i.p 被对待在 L-Arg 管理以前的 30 min。在组 AM,在 L-Arg 被给以后,老鼠收到了 melatonin 1h 的一样的剂量。在组 M, melatonin 的单次量是以前描述了被管理。在组 C,对照动物收到了生理盐水注射 i.p 所有老鼠被给在第二 L-Arg 注射以后的 24 h。结果:引起严重引起坏死胰腺炎的 L-Arg 管理在浆液淀粉酶水平,胰腺的重量 / 身体重量比率(pw/bw ) ,胰腺的 IL-6 内容和 myeloperoxidase 由重要举起证实了活动,相对控制值。浆液淀粉酶水平的举起显著地在与仅仅与 L-Arg 注射的老鼠相比给 melatonin 追随者 L-Arg 的老鼠被减少。胰腺的抗氧化剂酶(Cu/Zn-superoxide 歧化酶(Cu/Zn-SOD ) 和过氧化氢酶(猫)) 的活动显著地被增加在胰腺炎以后的 24 h 感应。显著地在 L-Arg 之前给的 Melatonin 在独自与 L-Arg 对待的老鼠相对那减少了胰腺的猫活动。在肝, L-Arg 显著地每氧化水平,和谷胱甘肽过氧化物酶和 Cu/Zn-SOD 活动增加了类脂化合物,而 Mn 草皮活动作为与控制老鼠相比被减少。Melatonin 预告的处理阻止了这些变化。结论:Melatonin 是能在尖锐胰腺炎期间抵抗一些 L-Arg-induced 变化的一种抗氧化剂,并且可能因此在有尖锐引起坏死胰腺炎的病人的支持的治疗有用。 | Annamaria Szabolcs Russel J Reiter Tamas Letoha Peter Hegyi Gabor Papai Ilona Varga Katalin Jarmay Jozsef Kaszaki Reka Sari Zoltan Rakonczay Jr Janos Lonovics Tamas Takacs | 2006 | World Journal of Gastroenterology2006，12，2： | 13 |
| 4 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 5 | 时空交互视角下长三角城市群雾霾污染动态关联网络及协同治理研究显示文摘基于长三角26个城市2013~2018年空气质量指数日报数据,利用非格兰杰因果检验、复杂网络等方法,从时空交互视角分析了长三角城市群雾霾污染动态关联网络特征。结果发现:样本考察期长三角城市群总体雾霾污染指数及天数总体呈现下降趋势,冬季、春季及对应月份雾霾污染相对较重;长三角城市群雾霾污染空间网络相对稳定,各城市间都存在关联关系,整网关系紧密度逐年提升,但空间影响等级结构则渐趋松散;基于考察期污染指数均值及空间网络核心度的二维时空标准,可将长三角城市群细分为四种区别性治理类型。最后,提出长三角乃至全国城市群雾霾污染协同治理的相关对策与建议。 | 杨传明 Gabor Horvath | 2019 | 软科学2019，33，12： | 10 |
| 6 | Selection criteria for preoperative endoscopic retrograde cholangiopancreatography before laparoscopic cholecystectomy and endoscopic treatment of bile duct stones:Results of a retrospective,single center study between 1996-2002显示文摘AIM: The optimal treatment for bile duct stones (in terms of cost, complications and accuracy) is unclear. The aim of our study was to determine the predictive factors for preoperative endoscopic retrograde cholangiopancreatography (ERCP).METHODS: Patients undergoing preoperative ERCP (≤90 d before laparoscopic cholecystectomy) were evaluated in this retrospective study from the 1^st of January 1996 to the 31^st of December 2002. The indications for ERCP were elevated serum bilirubin, elevated liver function tests (LFT), dilated bile duct (≥8 mm) and/or stone at US examination, coexisting acute pancreatitis and/or acute pancreatitis or jaundice in patient's history. Suspected prognostic factors and the combination of factors were compared to the result of ERCRRESULTS: Two hundred and six preoperative ERCPs were performed during the observed period. The rate of successful cannulation for ERC was (97.1%). Bile duct stones were detected in 81 patients (39.3%), and successfully removed in 79 (97.5%). The number of prognostic factors correlated with the presence of bile duct stones. The positive predictive value for one prognostic factor was 1.2%, for two 43%,for three 72.5%, for four or more 91.4%.CONCLUSION: Based on our data preoperative ERCP is highly recommended in patients with three or more positive factors (high risk patients). In contrast, ERCP is not indicated in patients with zero or one factor (low risk patients).Preoperative ERCP should be offered to patients with two positive factors (moderate risk patients), however the practice should also be based on the local conditions (e.g.skill of the endoscopist, other diagnostic tools). | Laszlo Lakatos Gabor Mester Gyorgy Reti Attila Nagy Peter Laszlo Lakatos | 2004 | World Journal of Gastroenterology2004，10，23： | 10 |
| 7 | 取食转基因抗虫棉上的棉蚜对粉舞蛛存活和发育的影响显示文摘本文以转双价基因棉花SGK321、棉蚜Aphis gossypii和粉舞蛛Alopecosa pulverulenta为对象,研究了捕食转基因植物上的植食性害虫对多食性捕食性天敌的影响。结果表明,粉舞蛛可以猎食棉蚜,但单独捕食棉蚜不足以长期维持若蛛的生存和发育;与果蝇混合饲养,能显著提高若蛛存活率和体重。在猎物过量或数量不足的情况下,单独捕食转基因棉或常规棉上的棉蚜,若蛛的生存曲线和体重差异不显著。在猎物过量的条件下,用转基因棉上的棉蚜与果蝇混合饲养,若蛛的存活率显著高于用常规棉上的棉蚜与果蝇混合的处理;但这两种处理下,若蛛的体重差异不显著。在猎物数量不足的情况下,用转基因棉或常规棉上的棉蚜与果蝇混合饲养,若蛛的存活率和体重差异都不显著。可见,转双价基因棉花SGK321上的棉蚜对粉舞蛛的存活和发育没有显著的不利影响。 | 郭建英 Gabor L.LVEI 万方浩 韩召军 | 2006 | 昆虫学报2006，49，5： | 10 |
| 8 | Optimization and design of an aircraft's morphing wing-tip demonstrator for drag reduction at low speeds, Part II- Experimental validation using Infra-Red transition measurement from Wind Tunnel tests显示文摘In the present paper, an ‘in-house' genetic algorithm was numerically and experimentally validated. The genetic algorithm was applied to an optimization problem for improving the aerodynamic performances of an aircraft wing tip through upper surface morphing. The optimization was performed for 16 flight cases expressed in terms of various combinations of speeds, angles of attack and aileron deflections. The displacements resulted from the optimization were used during the wind tunnel tests of the wing tip demonstrator for the actuators control to change the upper surface shape of the wing. The results of the optimization of the flow behavior for the airfoil morphing upper-surface problem were validated with wind tunnel experimental transition results obtained with infra-red Thermography on the wing-tip demonstrator. The validation proved that the 2D numerical optimization using the ‘in-house' genetic algorithm was an appropriate tool in improving various aspects of a wing's aerodynamic performances. | Andreea Koreanschi Oliviu Sugar Gabor Joran Acotto Guillaume Brianchon Gregoire Portier Ruxandra Mihaela Botez Mahmoud Mamou Youssef Mebarki | 2017 | Chinese Journal of Aeronautics2017，30，1： | 10 |
| 9 | Digital Earth 2020:towards the vision for the next decade显示文摘This position paper is the outcome of a brainstorming workshop organised by the International Society for Digital Earth(ISDE)in Beijing in March 2011.It argues that the vision of Digital Earth(DE)put forward by Vice-President Al Gore 13 years ago needs to be re-evaluated in the light of the many developments in the fields of information technology,data infrastructures and earth observation that have taken place since.The paper identifies the main policy,scientific and societal drivers for the development of DE and illustrates the multi-faceted nature of a new vision of DE grounding it with a few examples of potential applications.Because no single organisation can on its own develop all the aspects of DE,it is essential to develop a series of collaborations at the global level to turn the vision outlined in this paper into reality. | Max Craglia Kees de Bie Davina Jackson Martino Pesaresi Gabor Remetey-Fulopp Changlin Wang Alessandro Annoni Ling Bian Fred Campbell Manfred Ehlers John van Genderen Michael Goodchild Huadong Guo Anthony Lewis Richard Simpson Andrew Skidmore Peter Woodgate | 2012 | International Journal of Digital Earth2012，5，1： | 8 |
| 10 | Density and Seasonal Dynamics of Bemisia tabaci(Gennadius) Mediterranean on Common Crops and Weeds Around Cotton Fields in Northern China显示文摘The density seasonal dynamics of Bemisia tabaci MED were evaluated over two years in a cotton-growing area in Langfang, Hebei Province, northern China on cotton(Gossypium hirsutum L.) and six other co-occurring common plants, common ragweed(Ambrosia artemisiifolia L.), piemarker(Abutilon theophrasti Medicus), sunflower(Helianthus annuus L.), sweet potato(Ipomoea batatas L.), soybean(Glycine max L.), and maize(Zea mays L.). The whitefly species identity was repeatedly tested and confirmed; seasonal dynamics on the various host plants were standardized by the quartile method. B. tabaci MED appeared on weeds(the common ragweed and piemarker) about 10 days earlier than on cotton, or the other cultivated plants. The peak population densities were observed over a span of 2 to 3 weeks on cotton, starting in early(2010) or mid-August(2011). The common ragweed growing adjacent to cotton supported the highest B. tabaci d ensities(no. on 100 cm2 leaf surface), 1 2-22 fold higher than on cotton itself. Sunflower supported more B. tabaci than the other plants, and about 1.5-2 fold higher than cotton did. Our results indicate that weeds(esp. the common ragweed) around cotton fields could increase the population density of B. tabaci MED on cotton, while sunflower could act as a trap crop for decreasing pest pressure on cotton. | ZHANG Xiao-ming YANG Nian-wan WAN Fang-hao Gabor L Lvei | 2014 | Journal of Integrative Agriculture2014，13，10： | 8 |
| 11 | Optimization and design of an aircraft's morphing wing-tip demonstrator for drag reduction at low speed, Part Ⅰ–Aerodynamic optimization using genetic, bee colony and gradient descent algorithms显示文摘In this paper, an ‘in-house' genetic algorithm is described and applied to an optimization problem for improving the aerodynamic performances of an aircraft wing tip through upper surface morphing. The algorithm's performances were studied from the convergence point of view, in accordance with design conditions. The algorithm was compared to two other optimization methods,namely the artificial bee colony and a gradient method, for two optimization objectives, and the results of the optimizations with each of the three methods were plotted on response surfaces obtained with the Monte Carlo method, to show that they were situated in the global optimum region. The optimization results for 16 wind tunnel test cases and 2 objective functions were presented. The 16 cases used for the optimizations were included in the experimental test plan for the morphing wing-tip demonstrator, and the results obtained using the displacements given by the optimizations were evaluated. | Andreea Koreanschi Oliviu Sugar Gabor Joran Acotto Guillaume Brianchon Gregoire Portier Ruxandra Mihaela Botez Mahmoud Mamou Youssef Mebarki | 2017 | Chinese Journal of Aeronautics2017，30，1： | 8 |
| 12 | Tube-nosed variations–a new species of the genus Murina(Chiroptera: Vespertilionidae) from China显示文摘DEAR EDITOR,During a survey in 2014,several tube-nosed bats(Vespertilionidae:Murininae:Murina)were collected in Sichuan Province.Based on morphological characters,these bats did not match any species previously recorded from China.Morphometric analyses and phylogenetic inference based on mitochondrial and nuclear gene sequences indicated that they represented a new species,named here as Murina jinchui sp.nov.Although the new species is presently known only from Wolong National Nature Reserve,it is unlikely to be a rare species in the area based on our capture frequencies. | Wen-Hua Yu Gabor Csorba Yi Wu | 2020 | Zoological Research2020，41，1： | 8 |
| 13 | A new non-linear vortex lattice method:Applications to wing aerodynamic optimizations显示文摘This paper presents a new non-linear formulation of the classical Vortex Lattice Method(VLM) approach for calculating the aerodynamic properties of lifting surfaces. The method accounts for the effects of viscosity, and due to its low computational cost, it represents a very good tool to perform rapid and accurate wing design and optimization procedures. The mathematical model is constructed by using two-dimensional viscous analyses of the wing span-wise sections,according to strip theory, and then coupling the strip viscous forces with the forces generated by the vortex rings distributed on the wing camber surface, calculated with a fully three-dimensional vortex lifting law. The numerical results obtained with the proposed method are validated with experimental data and show good agreement in predicting both the lift and pitching moment, as well as in predicting the wing drag. The method is applied to modifying the wing of an Unmanned Aerial System to increase its aerodynamic efficiency and to calculate the drag reductions obtained by an upper surface morphing technique for an adaptable regional aircraft wing. | Oliviu Sugar Gabor Andreea Koreanschi Ruxandra Mihaela Botez | 2016 | Chinese Journal of Aeronautics2016，29，5： | 6 |
| 14 | 电休克治疗用于精神分裂症的激越症状:随机对照试验的meta分析(英文)显示文摘背景:躁动在精神分裂症治疗中是一个重大挑战。电休克疗法(ECT)对各种精神疾病是一种快速、有效、和安全的治疗,但ECT对精神分裂症的躁动治疗的相关meta分析还尚未报道。目标:系统地评估单一使用ECT或ECT合并使用其他抗精神病药物(APs)的对精神分裂症的躁动治疗的有效性和安全性。方法:进行随机对照试验(RCT)的系统文献搜索。两名独立评估者筛选研究、提取结果数据与现有数据的安全性、进行质量评估和数据合成。采用建议、评估、开发、和评价的工作组等级(GRADE)来判断主要成果的证据的总体水平。结果:一共确定了中国有七个RCTs,包括ECT单一使用(4个RCTs有5个治疗组,n=240)和ECT-APs合并使用(3个RCTs,n=240)。研究对象平均年龄34.3(4.5)岁,平均治疗时间为4.3(3.1)周。所有7个RCTs非盲法,并且根据Jadad量表7项RCTs均被评为低质量。样本的Meta分析发现与APs单一治疗相比,单一使用ECT或ECT-APs合并使用阳性和阴性症状量表(PANSS)的躁动子因子评分改善均无显著性差异(ECT单一使用:weighted mean difference(WMD)=-0.90,95%confidence interval(CI):(-2.91,1.11),p=0.38;ECT-APs合并使用:WMD=-1.34,(95%CI:-4.07,1.39),p=0.33)。然而,PANSS总分(WMD=-7.13,I^2=0%,p=0.004)和兴奋子因子评分(WMD=-1.97,p<0.0001)、ECT治疗14天后的PANSS总分(WMD=-7.13,I^2=0%,p=0.004)和第7天和第14天的兴奋子因子评分(WMD=-1.97to-1.92,p=0.002 to 0.0001)均显示单一使用ECT优于APs单一治疗。ECT-APs合并治疗结束时(WMD=-10.40,p=0.03)和治疗后7天(WMD=-5.01,p=0.02)的PANSS总分显示均优于APs单药治疗。头痛(p=0.0001,number-needed-to-harm(NNH)=3,95%CI=2-4)是唯一的ECT单一治疗后不良反应,并且ECT单一治疗组比APs单药治疗发生的更频繁。根据GRADE方法,主要结果的证据水平被评为'非常低'(37.5%)和'低'(50%)。结论:基于中国7个RCTs合并的数据发现ECT单一治疗或ECT-APs合并治疗在精神分裂症患者的躁动治疗中并没有优势。然而,ECT单一治疗或ECT-APs合并治疗均与PANSS总分减低显著有关。需要高质量的RCTs验证目前的解释。 | 顾小静 郑伟 郭彤 Gabor S.Ungvari Helen F.K.CHiu 操小兰 CarlD'Arcy 孟祥飞 宁玉萍 项玉涛 | 2017 | 上海精神医学2017，29，1： | 6 |
| 15 | Corneal biomechanical data and biometric parameters measured with Scheimpflug-based devices on normal corneas显示文摘AIM: To analyze the correlations between ocular biomechanical and biometric data of the eye,measured by Scheimpflug-based devices on healthy subjects.METHODS: Three consecutive measurements were carried out using the corneal visualization Scheimpflug technology(Cor Vis ST) device on healthy eyes and the 10 device-specific parameters were recorded.Pentacam HR-derived parameters(corneal curvature radii on the anterior and posterior surfaces;apical pachymetry;corneal volume;corneal aberration data;depth,volume and angle of the anterior chamber) and axial length(AL) from IOLMaster were correlated with the 10 specific CorV is ST parameters.RESULTS: Measurements were conducted in 43 eyes of 43 volunteers(age 61.24±15.72y).The 10 specific Cor Vis ST data showed significant relationships with corneal curvature radii both on the anterior and posterior surface,pachymetric data,root mean square(RMS) data of lower-order aberrations,and posterior RMS of higher-order aberrations and spherical aberration of the posterior cornea.Anterior chamber depth showed a significant relationship,but there were no significant correlations between corneal volume,anterior chamber volume,mean chamber angle or AL and the 10 specific CorV is ST parameters.CONCLUSION: Cor Vis ST-generated parameters are influenced by corneal curvature radii,some corneal RMS data,but corneal volume,anterior chamber volume,chamber angle and AL have no correlation with the biomechan-ical parameters.The parameters measured by CorV is ST seem to refer mostly to corneal properties of the eye. | Gabor Nemeth Eszter Szalai Ziad Hassan Agnes Lipecz Zsuzsa Flasko Laszlo Modis | 2017 | International Journal of Ophthalmology(English edition)2017，10，2： | 6 |
| 16 | 精神分裂症患者自杀企图相关因素及其与生活质量的关系显示文摘目的分析中国精神科门诊精神分裂症患者的自杀企图发生率,并探索其相关因素和与生活质量的关系。方法对符合研究条件的250例平稳期精神分裂症患者的社会人口学资料、精神病性症状、药物锥体外系副作用和其生活质量进行调查,并应用多元Logistic回归分析探索其内在联系。结果多次住院和生理领域生活质量较低,与患者自杀企图的发生密切相关;阴性症状较重的精神分裂症患者出现自杀企图的可能性比较小。结论对于具有多次住院经历,并且生理领域生活质量较差的精神分裂症患者,要予以重视,重点预防其自杀企图的出现。 | 朱辉 项玉涛 Gabor S.Ungvari | 2008 | 中国康复理论与实践2008，14，6： | 5 |
| 17 | Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis显示文摘AIM To assess the prevalence of a panel of serologic markers that reflect gut barrier dysfunction in a mixed cohort of pediatric and adult primary sclerosing cholangitis(PSC) patients.METHODS Sera of 67 PSC patients [median age(range): 32(5-79) years, concomitant IBD: 67% and cirrhosis: 20%] were assayed for the presence of antibodies against to F-actin(AAA Ig A/Ig G) and gliadin(AGA Ig A/Ig G)] and for serum level of intestinal fatty acid-binding protein(I-FABP) by ELISA. Markers of lipopolysaccharide(LPS) exposure [LPS binding protein(LBP)] and various antimicrobial antibodies [anti-OMP Plus Ig A and endotoxin core Ig A antibody(Endo CAb)] were also determined. Poor disease outcome was defined as orthotopic liver transplantation and/or liver-related death during the follow-up [median: 99(14-106) mo]. One hundred and fifty-three healthy subjects(HCONT) and 172 ulcerative colitis(UC) patients were the controls. RESULTS A total of 28.4%, 28.0%, 9% and 20.9% of PSC patients were positive for AAA Ig A, AAA Ig G, AGA Ig A and AGA Ig G, respectively. Frequencies of AAA Ig A and AAA Ig G(P < 0.001, for both) and AGA Ig G(P = 0.01, for both) but not AGA Ig A were significantly higher compared to both of the HCONT and the UC groups. In survival analysis, AAA Ig A-positivity was revealed as an independent predictor of poor disease outcome after adjusting either for the presence of cirrhosis [HR = 5.15(1.27-20.86), P = 0.022 or for the Mayo risk score(HR = 4.24(0.99-18.21), P = 0.052]. AAA Ig A-positivity was significantly associated with higher frequency of antimicrobial antibodies(P < 0.001 for Endo Cab Ig A and P = 0.012 for anti-OMP Plus Ig A) and higher level of the enterocyte damage marker(median I-FABP_(AAA Ig A pos vs neg): 365 vs 166 pg/m L, P = 0.011), but not with serum LBP level. CONCLUSION Presence of Ig A type AAA identified PSC patients with progressive disease. Moreover, it is associated with enhanced mucosal immune response to various microbial antigens and enterocyte damage further highlighting the importance of the gut-liver interaction in PSC. | Tamas Tornai Eszter Palyu Zsuzsanna Vitalis Istvan Tornai David Tornai Peter Antal-Szalmas Gary L Norman Zakera Shums Gabor Veres Antal Dezsofi Gabriella Par Alajos Par Peter Orosz Ferenc Szalay Peter Laszlo Lakatos Maria Papp | 2017 | World Journal of Gastroenterology2017，23，29： | 5 |
| 18 | Adjunctive melatonin for tardive dyskinesia in patients with schizophrenia: a meta-analysis显示文摘背景:迟发性运动障碍(TD)的临床特征是异常不自主运动。TD具有严重的不可逆的致残性和社会功能损害。目的 :此荟萃分析基于随机对照试验(RCTs)文献系统评估褪黑素对精神分裂症患者迟发性运动障碍的临床疗效和安全性。方法 :两位独立评估者从以下数据库对相关的临床随机对照试验(RCT)文献进行检索(万方数据、中国知网(CNKI)、中国生物医学文摘数据库和PubM ed、PsycI NFO、Embase、Cochrane Library数据库),检索时间截止于2017年6月8日。以TD症状严重程度为主要结局指标,采用Rev Man 5.3版本进行统计分析,对RCTs的质量评估采用Cochrane风险评估偏倚和Jadad量表来评估各种偏倚的风险性。采用GRADE(Grades of Recommendation,Assessment,Development,and Evaluation)系统推荐分级方法对meta-分析结果的整体证据质量水平进行分级评价。结果 :最终筛选确定4个RCTs(n=130)。3个RCTs采用双盲法,1个RCT单盲,根据Cochrane风险评估偏倚和Jadad量表显示3个RCTs的疗效评估指标的证据质量被评定为'高质量'。与对照组相比,根据不自主运动量表(AIMS)评定褪黑素可改善TD严重程度(4个RCTs,n=130,加权平均差值(WMD):-1.52(95%CI:-3.24,0.20),p=0.08;I2=0%),但尚没有达到显著差异。根据等级方法,改善TD症状的meta分析结果的整体证据质量被评为'低',而关于不良反应和认知损害方面则数据太少。结论 :荟萃分析表明,褪黑素或可改善精神分裂症TD症状。但仍有待今后更高质量和更大样本的RCTs验证。 | 孙辰辉 郑伟 杨欣湖 蔡东滨 Chee H.NG Gabor S.UNGVARI 李海燕 吴玉洁 宁玉萍 项玉涛 | 2017 | 上海精神医学2017，29，3： | 5 |
| 19 | Seeing better-Evidence based recommendations onoptimizing colonoscopy adenoma detection rate显示文摘Colorectal cancer is one of the three most frequent causes of cancer deaths in men and women in Europe and North America. Diagnosis and resection of adenomas has convincingly demonstrated its utility in diminishing colorectal cancer incidence. Therefore, colonoscopy is now the gold standard for colorectal cancer screening. But it is also known that colonoscopy effectiveness varies among endoscopists. Among different quality indicators, the most used is the adenoma detection rate(ADR) which is the percentage of average-risk patients for colorectal cancer who are found to have at least one adenoma or adenocarcinoma during a screening colonoscopy. There is compelling evidence supporting an inverse correlation between ADR and interval colorectal cancer(cancer found after a screening colonoscopy). Many factors such as quality of precolonoscopy preparation, additional observers, manoeuvres with the endoscope(second view, retroflexion, water inflation rather than air), time spent during withdrawal, changes in patient position, foldflattener devices, new imaging or endoscopic modalities and use of intravenous or through the scope sprayed drugs, have been studied and developed with the aim of increasing the ADR. This reviews discusses these factors, and the current evidence, to 'see better' in the colon and optimize ADR. | Javier Aranda-Hernández Jason Hwang Gabor Kandel | 2016 | World Journal of Gastroenterology2016，22，5： | 5 |
| 20 | 抑郁症状快速评定量表自评版(QIDS-SR)应用于HBV相关肝脏疾病患者的心理测量学特性(英文)显示文摘背景:乙型肝炎病毒(HBV)感染伴发抑郁症是一种常见的现象。建立精确并且有时效的工具,用以评估HBV患者抑郁症状,对研究和临床实践是非常重要的。目的:这项研究测试了抑郁症状快速评定量表自评版(QIDS-SR)在乙型肝炎患者中使用的心理测量学特性。方法:这项研究招募了245名患有乙型肝炎病毒和相关肝病的抑郁症患者。采用蒙特玛莉抑郁评定量表(MADRS)和QIDS-SR评估抑郁症状的严重程度。结果:QIDS-SR的内部一致性((Cronbachα)为0.796.其总分与MADRS总分显著相关r=0.698,p<0.001)。探索性因素分析的QIDS-SR显示一维测量性能结论:QIDS-SR(中文版)在乙型肝炎患者中有良好的心理测量学特性,并且在评估临床抑郁症方面是有用的。 | 刘梅 王园园 赵景 郑素军 Gabor S.UNGVARI Chee H.NG 段钟平 项玉涛 | 2017 | 上海精神医学2017，29，1： | 5 |
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