|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Different antibiotic susceptibility between antrum and corpus of the stomach,a possible reason for treatment failure of Helicobacter pylori infection显示文摘AIM:To assess whether antibiotic resistance varies between the antrum and corpus of the stomach of patients that are either Helicobacter pylori(H.pylori)therapy-naive or pre-treated.METHODS:H.pylori strains were isolated from antrum and corpus biopsies from 66 patients that received a diagnostic gastroduodenoscopy for variant clinical indications.Antimicrobial susceptibility to amoxicillin,clarithromycin,tetracycline,metronidazole,levofloxacin and rifabutin was tested with the E-test method on IsoSensitest agar with 10 vol%defibrinated horse blood.In patients with a different antibiotic susceptibility pattern between the isolates from the antrum and corpus,DNA fingerprinting via random amplified polymorphic DNA analysis was performed to detect differences among DNA patterns of H.pylori isolates.RESULTS:Primary,secondary and tertiary resistance to clarithromycin was 6.9%,53.8%and 83.3%,retrospectively.Metronidazole and levofloxacin resistance also increased according to the number of previous treatments(17.2%,69.2%,83.3%;13.8%,23.1%,33.3%).Tertiary resistance to rifabutin was detected in12.5%of patients.In none of the 66 patients a resistance against amoxicillin or tetracycline was detectable.Discordant antibiotic susceptibility between antrum and corpus isolates for different antibiotics was seen in 15.2%(10/66)of the patients.Two out of those ten patients were naive to any H.pylori antibiotic treatment.The remaining eight patients previously received at least one eradication therapy.DNA fingerprinting analysis revealed no substantial differences among DNA patterns between antrum and corpus isolates in the majority of patients suggesting an infection with a single H.pylori strain.CONCLUSION:Different antibiotic susceptibility between antrum and corpus biopsies is a common phenomenon and a possible explanation for treatment failure.Resistant H.pylori strains may be missed if just one biopsy from one anatomic site of the stomach is taken for H.pylori susceptibility testing. | Michael Selgrad Ina Tammer Cosima Langner Jan Bornschein Julia Mei?le Arne Kandulski Mariya Varbanova Thomas Wex Dirk Schlüter Peter Malfertheiner | 2014 | World Journal of Gastroenterology2014，20，43： | 10 |
| 2 | Silicon and silicon nitride photonic circuits for spectroscopic sensing on-a-chip [Invited]显示文摘There is a rapidly growing demand to use silicon and silicon nitride(Si3N4) integrated photonics for sensing applications, ranging from refractive index to spectroscopic sensing. By making use of advanced CMOS technology,complex miniaturized circuits can be easily realized on a large scale and at a low cost covering visible to mid-IR wavelengths. In this paper we present our recent work on the development of silicon and Si3N4-based photonic integrated circuits for various spectroscopic sensing applications. We report our findings on waveguide-based absorption, and Raman and surface enhanced Raman spectroscopy. Finally we report on-chip spectrometers and on-chip broadband light sources covering very near-IR to mid-IR wavelengths to realize fully integrated spectroscopic systems on a chip. | Ananth Z.Subramanian Eva Ryckeboer Ashim Dhakal Frédéric Peyskens Aditya Malik Bart Kuyken Haolan Zhao Shibnath Pathak Alfonso Ruocco Andreas De Groote Pieter Wuytens Daan Martens Francois Leo Weiqiang Xie Utsav Deepak Dave Muhammad Muneeb Pol Van Dorpe Joris Van Campenhout Wim Bogaerts Peter Bienstman Nicolas Le Thomas Dries Van Thourhout Zeger Hens Gunther Roelkens Roel Baets | 2015 | Photonics Research2015，3，5： | 7 |
| 3 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 4 | 动脉瘤性蛛网膜下腔出血患者的重症监护处理:神经危重症监护学会多学科共识会议的推荐意见显示文摘蛛网膜下腔出血(subarachnoidhemorrhage,SAH)是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏,使得治疗方法各异,可供选择的指导意见不多。现有的指南主要强调危险因素、预防、自然史以及再出血的预防,很少涉及SAH患者的重症监护问题。美国神经危重症监护学会组织了一次国际性多学科共识会议来探讨SAH的重症监护处理。根据发表的文章和研究领域,此次会议召集了来自欧洲和北美地区的神经重症监护科、神经外科、神经内科、介入神经放射科和神经麻醉科方面的专家。根据临床经验和制定实践指南方面的经验,选择4名经验丰富的神经重症监护专家组成评判委员会。应用推荐分级的评估、制定与评价(GradesofRecommendationsAssessment,DevelopmentandEvaluation,GRADE)系统进行文献回顾,结合参会者的经验、评判委员会的审评以及文献讨论产生推荐意见。应用GRADE系统制定推荐意见,其制定原则不仅强调研究资料的质量,而且还重视利弊权衡与实践转化。对SAH患者日常处理过程中面临的所有问题均提供指导和推荐意见,即使缺乏高质量的证据。 | Michael N. Diringer Thomas P. Bleck J. Claude Hemphill David Menon Lori Shutter Paul Vespa Nicolas Bruder E. Sander Connolly Jr Giuseppe Citerio Daryl Gress Daniel Hanggi Brian L. Hoh Giuseppe Lanzino Peter Le Roux Alejandro Rabinstein, Erich Schmut zhard Nino Stocchetti Jose I. Suarez Miriam Tresgiari Ming-Yuan Tseng Mervyn D. I. Vergouwen Stefan Wolf Gregory Zip fel 田飞(译) 宿 英英(译) | 2013 | 国际脑血管病杂志2013，21，5： | 5 |
| 5 | Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans显示文摘 | Enrico Brunetti Peter Kern Dominique Angèle Vuitton | 2009 | Acta Tropica2009，，1： | 4 |
| 6 | FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer显示文摘Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers. | Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti | 2016 | World Journal of Gastroenterology2016，22，31： | 4 |
| 7 | Polyphase Filter Banks for Embedded Sample Rate Changes in Digital Radio Front-Ends显示文摘This paper presents efficient processing engines for software-defined radio (SDR) front-ends. These engines, based on a polyphase channelizer, perform arbitrary sample-rate changes, frequency selection, and bandwidth control. This paper presents an M-path polyphase filter bank based on a modified N-path polyphase filter. Such a system allows resampling by arbitrary ratios while performing baseband aliasing from center frequencies at Nyquist zones that are not multiples of the output sample rate. This resampling technique is based on sliding cyclic data load interacting with cyclic-shifted coefficients. A non-maximally-decimated polyphase filter bank (where the number of data loads is not equal to the number of M subfilters) processes M subfilters in a time period that is less than or greater than the M data loads. A polyphase filter bank with five different resampling modes is used as a case study for embedded resampling in SDR front-ends. These modes are (i) maximally decimated, (ii) under-decimated, (iii) over-decimated, and combined up- and down-sampling with (iv) single stride length, and (v) multiple stride lengths. These modes can be used to obtain any required rational sampling rate change in an SDR front-end based on a polyphase channelizer. They can also be used for translation to and from arbitrary center frequencies that are unrelated to the output sample rates. | Mehmood Awan Yannick Le Moullec Peter Koch Fred Harris | 2011 | ZTE Communications2011，9，4： | 3 |
| 8 | World Gastroenterology Organisation Global Guidelines: Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis显示文摘 | Douglas R. LaBrecque Zaigham Abbas Frank Anania Peter Ferenci Aamir G. Khan Khean-Lee Goh Saeed S. Hamid Vasily Isakov Maribel Lizarzabal Manuel M. Pe?aranda Juan F.R. Ramos Shiv Sarin Davor Stimac Alan B.R. Thomson Muhammed Umar Justus Krabshuis Anton Le | 2014 | Journal of Clinical Gastroenterology2014，，6： | 3 |
| 9 | Hardware Architecture of Polyphase Filter Banks Performing Embedded Resampling for Software-Defined Radio Front-Ends显示文摘In this paper, we describe resource-efficient hardware architectures for software-defined radio (SDR) front-ends. These architectures are made efficient by using a polyphase channelizer that performs arbitrary sample rate changes, frequency selection, and bandwidth control. We discuss area, time, and power optimization for field programmable gate array (FPGA) based architectures in an M -path polyphase filter bank with modified N -path polyphase filter. Such systems allow resampling by arbitrary ratios while simultaneously performing baseband aliasing from center frequencies at Nyquist zones that are not multiples of the output sample rate. A non-maximally decimated polyphase filter bank, where the number of data loads is not equal to the number of M subfilters, processes M subfilters in a time period that is either less than or greater than the M data-load's time period. We present a load-process architecture (LPA) and a runtime architecture (RA) (based on serial polyphase structure) which have different scheduling. In LPA, N subfilters are loaded, and then M subfilters are processed at a clock rate that is a multiple of the input data rate. This is necessary to meet the output time constraint of the down-sampled data. In RA, M subfilters processes are efficiently scheduled within N data-load time while simultaneously loading N subfilters. This requires reduced clock rates compared with LPA, and potentially less power is consumed. A polyphase filter bank that uses different resampling factors for maximally decimated, under-decimated, over-decimated, and combined up- and down-sampled scenarios is used as a case study, and an analysis of area, time, and power for their FPGA architectures is given. For resource-optimized SDR front-ends, RA is superior for reducing operating clock rates and dynamic power consumption. RA is also superior for reducing area resources, except when indices are pre-stored in LUTs. | Mehmood Awan Yannick Le Moullec Peter Koch Fred Harris | 2012 | ZTE Communications2012，10，1： | 3 |
| 10 | piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans显示文摘 | Alyson Ashe Alexandra Sapetschnig Eva-Maria Weick Jacinth Mitchell Marloes P. Bagijn Amy C. Cording Anna-Lisa Doebley Leonard D. Goldstein Nicolas J. Lehrbach Jérémie Le Pen Greta Pintacuda Aisa Sakaguchi Peter Sarkies Shawn Ahmed Eric A. Miska | 2012 | Cell2012，，1： | 2 |
| 11 | A Lethally Irradiated Allogeneic Granulocyte-Macrophage Colony Stimulating Factor-Secreting Tumor Vaccine for Pancreatic Adenocarcinoma: A Phase II Trial of Safety, Efficacy, and Immune Activation显示文摘 | Lutz Eric Charles J. Yeo Keith D. Lillemoe Barbara Biedrzycki Barry Kobrin Joseph Herman Elizabeth Sugar Steven Piantadosi John L. Cameron Sara Solt Beth Onners Irena Tartakovsky Miri Choi Rajni Sharma Peter B. Illei Hruban Ralph H. Ross A. Abrams Dung Le | 2011 | Annals of Surgery2011，，2： | 2 |
| 12 | Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans显示文摘 | Enrico Brunetti Peter Kern Dominique Angèle Vuitton | 2009 | Acta Tropica2009，，1： | 2 |
| 13 | Canonical Workflows to Make Data FAlR显示文摘The FAIR principles have been accepted globally as guidelines for improving data-driven science and data management practices,yet the incentives for researchers to change their practices are presently weak.In addition,data-driven science has been slow to embrace workflow technology despite clear evidence of recurring practices.To overcome these challenges,the Canonical Workflow Frameworks for Research(CWFR)initiative suggests a large-scale introduction of self-documenting workflow scripts to automate recurring processes or fragments thereof.This standardised approach,with FAIR Digital Objects as anchors,will be a significant milestone in the transition to FAIR data without adding additional load onto the researchers who stand to benefit most from it.This paper describes the CWFR approach and the activities of the CWFR initiative over the course of the last year or so,highlights several projects that hold promise for the CWFR approaches,including Galaxy,Jupyter Notebook,and RO Crate,and concludes with an assessment of the state of the field and the challenges ahead. | Peter Wittenburg Alex Hardisty Yann Le Franc Amirpasha Mozaffari Limor Peer Nikolay A.Skvortsov Zhiming Zhao Alessandro Spinuso | 2022 | Data Intelligence2022，4，2： | 2 |
| 14 | 白内障的发展及其相关危险因素视力损害调查项目显示文摘目的:评估澳大利亚居民白内障的发展及其相关危险因素。
方法:对在维多利亚9个随机抽取的城区共3721个参加者做调查,进行全面的标准化的访谈和眼科检查作基线纪录及5年随访。根据Wilmer白内障分级系统对晶体混浊进行临床分级并照相。皮质性、核性、后囊下性白内障分别观察其发展和其相关危险因素。白内障发展的危险因素包括不同的社会人口统计,饮食。遗传性,医药干预和眼部特征。危险因素分析用单一和多元logistic回归法。 | Bickol N. Mukesh Anhchuong Le Peter N. Dimitrov Shazia Ahmed Hugh R. Taylor Catherine A. McCarty 刘亮(译) | 2006 | 美国医学会眼科杂志(中文版)2006，18，4： | 2 |
| 15 | Functional studies of mesenchymal stem cells derived from adult human adipose tissue显示文摘 | Andrea Dicker Katarina Le Blanc Gaby ?str?m Vanessa van Harmelen Cecilia G?therstr?m Lennart Blomqvist Peter Arner Mikael Rydén | 2005 | Experimental Cell Research2005，，2： | 2 |
| 16 | Scent of dying cell:The role of attraction signals in the clearance of apoptotic cells and its immunological consequences显示文摘 | Munoz LE Peter C Herrman M | 2010 | Autoimmun Rev2010，9，6： | 1 |
| 17 | Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a T H 2-skewed immune response显示文摘 | Stephanie T. Yerkovich Marjut Roponen Miranda E. Smith Kathy McKenna Anthony Bosco Lily S. Subrata Emilie Mamessier Matthew E. Wikstr?m Peter Le Souef Peter D. Sly Patrick G. Holt John W. Upham | 2009 | The Journal of Allergy and Clinical Immunology2009，，1： | 1 |
| 18 | Rapid growth in CO2 emissions after the 2008-2009 global financial crisis 显示文摘 | Peters G P Marland G Le Quere C | 2012 | Nature Climate Change2012，2，： | 1 |
| 19 | High Prognostic Impact of Flow Cytometric Minimal Residual Disease Detection in Acute Myeloid Leukemia: Data From the HOVON/SAKK AML 42A Study显示文摘 | Monique Terwijn Wim L.J. van Putten Angèle Kelder Vincent H.J. van der Velden Rik A. Brooimans Thomas Pabst Johan Maertens Nancy Boeckx Georgine E. de Greef Peter J.M. Valk Frank W.M.B. Preijers Peter C. Huijgens Angelika M. Dr?ger Urs Schanz Mojca Jongen | 2013 | Journal of Clinical Oncology2013，，31： | 1 |
| 20 | <ce:link locator='fx1'/> Pain in Chronic Pancreatitis: The Role of Reorganization in the Central Nervous System显示文摘 | Georg Dimcevski Saber A.K. Sami Peter Funch–Jensen Domenica Le Pera Massimiliano Valeriani Lars Arendt–Nielsen Asbj?rn M. Drewes | 2007 | Gastroenterology2007，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员