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| 1 | TGF-β-induced epithelial to mesenchymal transition显示文摘在开发期间并且在不同形态基因的事件的上下文,上皮的房间经历对间充质的转变或 transdifferentiation (EMT ) 上皮的叫的一个过程。在这个过程,房间失去他们的上皮的特征,包括他们的极性和专业化房间房间接触,并且获得迁移的行为,甚至在遥远的地点,允许他们移动离开他们的上皮的房间社区并且集成到包围织物。EMT 在开发期间说明区别粘性并且被另一进程补充,打电话对上皮的转变间充质(相遇) 。当在开发期间是一个不可分的过程时, EMT 也在病理学的条件下面被概括,显著地在纤维变性并且在癌的侵略和转移。因此, EMT 在肿瘤前进被看作重要的步。发信号的 TGF- 尾被显示了在 EMT 起一个重要作用。事实上,在文化把 TGF- 尾加到上皮的房间是在各种各样的上皮的房间导致 EMT 的一个方便方法。尽管更不描绘的、上皮的粘性能被 TGF- 也调整,尾 - 联系了骨头形态基因的蛋白质(BMP ) ,和 BMP 被显示了导致 EMT 或相遇取决于发展上下文。在这评论,我们将响应 TGF- 尾讨论 EMT 的正式就职,并且集中于内在的发信号和抄写机制。 | Jian Xu Samy Lamouille Rik Derynck | 2009 | Cell Research2009，19，2： | 218 |
| 2 | The unique structural and functional features of CXCL12显示文摘The CXC chemokine CXCL12 is an important factor in physiological and pathological processes, includingembryogenesis, hematopoiesis, angiogenesis and inflammation, because it activates and/or induces migration ofhematopoietic progenitor and stem cells, endothelial cells and most leukocytes. Therefore, CXCL12 activity istightly regulated at multiple levels. CXCL12 has the unique property of existing in six splice variants in humans,each having a specific tissue distribution and in vivo activity. Controlled splice variant transcription and mRNAstability determine the CXCL12 expression profile. CXCL12 fulfills its functions in homeostatic and pathologicalconditions by interacting with its receptors CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3(ACKR3) and by binding to glycosaminoglycans (GAGs) in tissues and on the endothelium to allow a properpresentation to passing leukocytes. Homodimerizaton and heterodimerization of CXCL12 and its receptors can altertheir signaling activity, as exemplified by the synergy between CXCL12 and other chemokines in leukocyte migrationassays. Receptor binding may also initiate CXCL12 internalization and its subsequent removal from theenvironment. Furthermore, CXCL12 activity is regulated by posttranslational modifications. Proteolytic removal ofNH2- or COOH-terminal amino acids, citrullination of arginine residues by peptidyl arginine deiminases or nitrationof tyrosine residues reduce CXCL12 activity. This review summarizes the interactions of CXCL12 with the cellularenvironment and discusses the different levels of CXCL12 activity regulation. | Rik Janssens Sofie Struyf Paul Proost | 2018 | Cellular & Molecular Immunology2018，15，4： | 28 |
| 3 | 成都平原蔬菜生产中灌溉水对农药渗漏的影响研究显示文摘针对成都平原蔬菜生产中大量施用农药、大量灌水的特点,首次在国内应用欧洲官方成熟的农药评估模型——PEARL模型,研究评估了成都平原当前蔬菜生产中的灌溉方式对两种不同特性农药的渗漏的影响。杀毒矾(土壤吸附力(KOM)为0 L/kg,半衰期(DT50)为80 d)在没有灌溉条件下,其渗出土体时的最大质量浓度是190μg.L-1,而有灌溉条件下其渗出质量浓度则可达523μg.L-1,是没有灌溉条件下的2.75倍。三唑磷(KOM为200 L.kg-1,DT50为60 d)在没有灌溉条件下,其渗出土体时的最大质量浓度是0.025μg.L-1,而有灌溉条件下其渗出质量浓度为0.13μg.L-1,比没有灌溉时提高了4.2倍。不管有没有灌溉三唑磷在该地区对地下水的污染风险都很小,而杀毒矾的风险则很高。因此,农药的化学特性是影响农药渗漏的最重要的因子。在蔬菜生产中应尽量选用被土壤吸附力强、半衰期短的农药,例如:三唑磷;农药在土壤中的移动载体是土壤水,不合理的灌溉会大大地加大农药淋溶,应当多使用微喷、滴灌等节水灌溉措施,减少使用漫灌等耗水多的原始灌溉方式。 | 林超文 陈一兵 黄晶晶 Rik van den Bosch Mechteld M.S.ter Horst | 2005 | 生态环境2005，14，5： | 12 |
| 4 | Live Cell Imaging with R-GEC01 Sheds Light on fig22- and Chitin-Induced Transient [Ca2+]cyt Patterns in Arabidopsis显示文摘细胞内部的 Ca 2+ transients 在触发的联系病原体的分子的模式(PAMP ) 期间是发信号的串联的不可分的部分在植物的免疫。然而,我们导致 PAMP 的 Ca 2+ 信号的空间分发的知识是有限的。房间的调查 -- 并且表明 processesrequires 的 Ca 2+-dependent 的织物特定的性质万用的 Ca 2+ reportersthat 能提取空间信息从细胞并且 subcellular 结构,以及从整个纸巾随着时间的过去从秒的经期到小时。空间的基于荧光的记者盖子 botha 女人和时间的范围,它理想地做他们适合学习在生活房间发信号的 Ca 2+ 。在这研究,我们比较了二个基于荧光的 Ca 2+ 传感器:Förster 回声精力转移(烦恼) 基于的记者黄 cameleon NES-YC3.6 和基于紧张的传感器 R-GECO1。我们证明 R-GECO1 响应几刺激与 ratiometric NES-YC3.6 相比展出一个显著地增加的信号变化。由于它的优异敏感, R-GECO1 能在细胞的规模上报导导致 flg22 、导致几丁质的 Ca 2+ 信号,它允许鉴定定义[Ca 2+] cyt 摆动在表皮并且响应真菌的 elicitor 几丁质的警卫房间。而且,我们发现在根的导致 flg22 、导致几丁质的 Ca 2+ 信号从延伸地区开始。 | Nana F. Keinath Rainer Waadt Rik Brugman Julian I. Schroeder Guido Grossmann Karin Schumacher Melanie Krebs | 2015 | Molecular Plant2015，8，8： | 4 |
| 5 | 九区控制(诊断法电解控制)在神火铝电200kA电解槽上的应用显示文摘电流效率和电能消耗是铝电解生产中最重要的指标。因此 ,对全世界的铝厂来说提高电流效率的同时降低电耗成为一个挑战性课题。一项全新的热量和物质平衡控制模型 (称之为 9区控制模型 ) ,首次在河南神火铝电公司2 0 0kA电解槽上进行试验。通过六个多月的试验 ,9区控制有效地稳定了电解生产过程 ,降低了温度波动 ,使电流效率提高了 1 .0 4% ,直流电耗降低了 1 74kWh/t-Al。 | 边友康 郑凤章 黄琦 张兵胜 韩洪流 Peter White Renuka Rodrigo Rik Kelchtermans 戴军 姚世焕 | 2005 | 轻金属2005，，1： | 4 |
| 6 | A Roadmap toward Engineered Nitrogen-Fixing Nodule Symbiosis显示文摘In the late 19th century,it was discovered that legumes can establish a root nodule endosymbiosis with nitrogen-fixing rhizobia.Soon after,the question was raised whether it is possible to transfer this trait to non-leguminous crops.In the past century,an ever-increasing amount of knowledge provided unique insights into the cellular,molecular,and genetic processes controlling this endosymbiosis.In addition,recent phylogenomic studies uncovered several genes that evolved to function specifically to control nodule formation and bacterial infection.However,despite this massive body of knowledge,the long-standing objective to engineer the nitrogen-fixing nodulation trait on nonleguminous crop plants has not been achieved yet.In this review,the unsolved questions and engineering strategies toward nitrogen-fixing nodulation in non-legume plants are discussed and highlighted. | Rik Huisman Rene Geurts | 2020 | Plant Communications2020，1，1： | 4 |
| 7 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 8 | TGF-β signaling and epithelial–mesenchymal transition in cancer progression显示文摘 | Yoko Katsuno Samy Lamouille Rik Derynck | 2013 | Current Opinion in Oncology2013，，1： | 3 |
| 9 | SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS显示文摘 | Xin-Hua Feng Rik Derynck | 2005 | Annual Review of Cell and Developmental Biology2005，，： | 3 |
| 10 | A Fluorescent Alternative to the Synthetic Strigolactone GR24显示文摘Strigolactones 最近被含有在未葬、地下在更高的植物的发展小径。在 vitro 并且在 vivo 便于 strigolactones 的分子、化学的性质,我们发展了一荧光灯 strigolactone 分子, CISA-1,经由一篇小说综合了柔韧的方法, high-yielding,和使用的简单开始的材料。我们证明 CISA-1 穿上大量已知的 strigolactone 活动和进一步的报告一偶然在是为 strigolactone 类似物的严峻的生物活动的一个高度敏感、快速的方法的 Arabidopsis 的 rooting 试金。在这 rooting 试金和广泛地使用的 Orobanche 萌芽试金, CISA-1 比通常测试的 GR24 显示出更强壮的生物活动。CISA-1 和 GR24 在禁止是同等地有效的在 Arabidopsis 开花期茎分叉。在两分叉并且偶然 rooting 试金,我们也证明那项 CISA-1 活动依赖于最大 strigolactone 发信号小径。在水甲醇答案, CISA-1 在附近三方面比 GR24 更稳定,它可以贡献在各种各样的生物测试观察的增加的活动。 | Amanda Rasmussen Thomas Heugebaert Cedrick Matthys Rik Van Deun Francois-Didier Boyer1 Sofie Goormachtig Christian Stevens Danny Geelen | 2013 | Molecular Plant2013，6，1： | 3 |
| 11 | Rhizobium Lipo-chitooligosaccharide Signaling Triggers Accumulation of Cytokinins in Medicago truncatula Roots显示文摘 | Arjan van Zeijl Rik H.M. Op den Camp Eva E. Deinum Tatsiana Charnikhova Henk Franssen Huub J.M. Op den Camp Harro Bouwmeester Wouter Kohlen Ton Bisseling Rene Geurts | 2015 | Molecular Plant2015，8，8： | 3 |
| 12 | Mapping theArabidopsis Metabolic Landscape by Untargeted Metabolomics at Different Environmental Conditions显示文摘新陈代谢的染色体宽的协会研究(mGWAS ) ,因此,代谢物层次被认为是特点,帮助能解开新陈代谢的网络的基因基础。309 Arabidopsis 就职的一个总数在二个独立环境条件(控制和应力) 下面被种并且使遭到到介绍的 untargeted LC-MS-based metabolomic;获得的吸水的代谢物的层次在 GWAS 被使用。我们为超过 3000 半极的代谢物的 two-condition-based GWAS 导致了 123 高度解决的代谢物的察觉量的特点 loci ?(p 1.0E-08 ) 。有趣地,不同地,从在 Arabidopsis 主要代谢物,趋于被很多小效果的 loci 控制,的自然变化,我们在发现几个学生大效果的 loci 控制第二等的代谢物的变化的小效果的 loci 的一个广阔数字。two-condition-based GWAS 被集成用一个时间功课压力实验与导出网络的代谢物抄本关联跟随。通过这条综合途径,我们选择了在结构的基因和代谢物之间的 70 个关键候选人协会,并且试验性地验证了八个新奇协会,他们中的二个在二环境的出现微分基因规定学习了。我们表明联合有 time-course-derived 网络的基于 metabolomics 的 GWAS 两个都为识别代谢物基因协会在不同不能生活的环境下面执行了的大规模 untargeted 的力量,提供进 Arabidopsis 的新陈代谢的风景的新奇全球卓见。 | Si Wu Takayuki Tohge Alvaro Cuadros-lnostroza Hao Tong Hezi Tenenboim Rik Kooke Michael Meret Joost B. Keurentjes Zoran Nikoloski Alisdair R. Fernie Lothar Willmitzer Yariv Brotman | 2018 | Molecular Plant2018，11，1： | 3 |
| 13 | TGFβ receptor signaling 显示文摘 | Rik D Xin-Hua F | 1997 | Biochimica et Biophysica Acta1997，1333，： | 2 |
| 14 | The consequences of uncertainties in land use, climate and vegetation responses on the terrestrial carbon显示文摘The IPCC SRES narratives were implemented in IMAGE 2.2 to evaluate thefuture condition of the climate system (including the biosphere). A series of scenario experiments was used to assess possible ranges in emissions and concentrations of greenhouse gases, climate change and impacts. These experiments focussed on the role of the terrestrial carbon cycle. The experiments show that the SRES narratives dominate human emissions and not natural processes. In contrary, atmospheric CO2 concentration strongly differs between the experiments. Atmospheric CO2 concentrations range for A1B from 714 to 1009 ppmv CO2 in 2100. The spread of this range is comparable with the full SRES range as implemented in IMAGE 2.2 (515-895 μmol/mol CO2). The most important negative and positive feedback processes in IMAGE 2.2 on the build-up of CO2 concentrations are CO2 fertilisation and soil respiration respectively. Indirect effects of these processes furtherchange land-use patterns, deforestation rates and alter the natural C fluxes. The cumulative effects of these changes have a pronounced influence on the final CO2 concentrations. Our scenario experiments highlight the importance of a proper parameterisation of feedback processes, C-cycle and land use in determining the future states of the climate system. | Rik Leemans Bas Eickhout Bart Strengers Lex Bouwman Michiel Schaeffer | 2002 | Science China(Life Sciences)2002，45，z1： | 2 |
| 15 | Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: An international consensus显示文摘 | Lasse R. Braathen Rolf-Markus Szeimies Nicole Basset-Seguin Robert Bissonnette Peter Foley David Pariser Rik Roelandts Ann-Marie Wennberg Colin A. Morton | 2007 | Journal of the American Academy of Dermatology2007，，： | 2 |
| 16 | Visual attention during brand choice: The impact of time pressure and task motivation显示文摘 | Rik Pieters Luk Warlop | 1999 | International Journal of Research in Marketing1999，，1： | 2 |
| 17 | A spatially explicit and quantitative vulnerability assessment of ecosystem service change in Europe显示文摘 | Marc J. Metzger Dagmar Schr?ter Rik Leemans Wolfgang Cramer | 2008 | Regional Environmental Change2008，，3： | 2 |
| 18 | 1977~1997:文化建筑20年显示文摘在法国,20世纪产生了一系列新奇又切合实际的创造,涉及到各种各样的学科.从吉马尔设计的地铁入口到协和式飞机,从柯布西埃到斯塔尔克,从米其林指南到雪铁龙DS19型汽车,从佩里昂设计的家具到塔隆的高速火车车厢,从南锡学校到'原始'风格,从拉利克的花瓶到萃萃们(Tsé Tsé)设计的花瓶,在这一个世纪里,法国不断地将设计调节成一面'世纪的镜子'. | Gilles de Bure Rik Gadella 傅杰 | 2004 | 国外城市规划2004，19，5： | 2 |
| 19 | The causes of land-use and land-cover change: moving beyond the myths显示文摘 | Eric F. Lambin B.L. Turner Helmut J. Geist Samuel B. Agbola Arild Angelsen John W. Bruce Oliver T. Coomes Rodolfo Dirzo Günther Fischer Carl Folke P.S. George Katherine Homewood Jacques Imbernon Rik Leemans Xiubin Li Emilio F. Moran Michael Mortimore P.S. | 2001 | Global Environmental Change2001，，4： | 2 |
| 20 | 简易转速测量系统设计显示文摘介绍了一种基于定时器的转速测量系统的设计与开发。使用直流电动机的转轴来测量其转速,定时器IC 555用于不稳定模式。使用数字存储示波器(DSO)测量的定时器输出波形的频率几乎与转轴的转速成线性比例,而这个转速又与外部输入电压水平的变化成线性关系,由此得到了定时器输出波形频率与转速之间的线性关系。该系统的主要优点是线性输入-输出,体积小,便于携带且成本低。 | Akash Kumar Anindya Debnath Antar Banik Kabirul Islam Mondal Partha Pratim Biswas Rik Bhattacharyya T K Maiti | 2020 | Journal of Measurement Science and Instrumentation2020，11，2： | 2 |
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