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| 1 | 美国国立神经疾病和卒中研究所-加拿大卒中网血管性认知障碍统一标准显示文摘背景和目的:1/3的个体会罹患卒中和(或)痴呆,而且,除卒中或痴呆外,2倍于此数的人会出现认知障碍。常用的卒中量表并不能评价认知功能,而痴呆的诊断标准则集中在认知障碍的晚期阶段,且在很大程度上偏向Alzheimer病(AD)的诊断。尚缺乏普遍公认的标准用于识别和描述存在认知障碍的个体,尤其是在早期阶段,而且特别是与血管因素有关的认知障碍或血管性认知障碍。方法:美国国立神经疾病和卒中研究所(MINDS)与加拿大卒中网(CSN)召集临床诊断、流行病学、神经心理学、脑影像学、神经病理学、试验模型、生物标记物、遗传学和临床试验方面的研究人员,为血管性认知障碍的描述和研究推荐一些最低限度的常用的临床和研究标准。结果:将这些讨论的结果发表于此。结论:一个统一标准的制定代表着使用、确认和改进过程中的第一步。使用相同的标准将有助于在认知障碍的早期阶段识别患者,使不同的研究具有可比性,并且通过整合知识来加速研究进展的步伐。 | Vladimir Hachinski Costantino Iadecola Ron C.Petersen Monique M.Breteler David L.Nyenhuis Sandra E.Black William J.Powers Charles DeCarli Jose G.Merino Raj N.Kalaria Harry V.Vinters David M.Holtzman Gary A.Rosenberg Martin Dichgans John R.Marler Gabrielle G.Leblanc 李焰生(译) 俞羚(译) 高枚春(译) 张静芳(译) 熊昕丽(译) 邹静(译) 林岩(译) 潘元美(译) | 2007 | 国际脑血管病杂志2007，15，1： | 63 |
| 2 | Adverse events with bismuth salts for Helicobacter pylori eradication:Systematic review and meta-analysis显示文摘AIM: To assess the safety of bismuth used in Helico- bacter pylori (H pylori) eradication therapy regimens. METHODS: We conducted a systematic review and meta-analysis. MEDLINE and EMBASE were searched (up to October 2007) to identify randomised controlled tri- als comparing bismuth with placebo or no treatment, or bismuth salts in combination with antibiotics as part of eradication therapy with the same dose and duration of antibiotics alone or, in combination, with acid suppres- sion. Total numbers of adverse events were recorded. Data were pooled and expressed as relative risks with 95% confidence intervals (CI). RESULTS: We identified 35 randomised controlled tri- als containing 4763 patients. There were no serious adverse events occurring with bismuth therapy. There was no statistically significant difference detected in total adverse events with bismuth [relative risk (RR) = 1.01; 95% CI: 0.87-1.16], specific individual adverse events, with the exception of dark stools (RR = 5.06; 95% CI: 1.59-16.12), or adverse events leading to withdrawal of therapy (RR = 0.86; 95% CI: 0.54-1.37). CONCLUSION: Bismuth for the treatment of H pylori is safe and well-tolerated. The only adverse event oc- curring significantly more commonly was dark stools. | Alexander C Ford Peter Malfertheiner Monique Giguère José Santana Mostafizur Khan Paul Moayyedi | 2008 | World Journal of Gastroenterology2008，14，48： | 62 |
| 3 | Prostate cancer screening in Europe and Asia显示文摘Prostate cancer(PCa)is the second most common cancer among men worldwide and even ranks first in Europe.Although Asia is known as the region with the lowest PCa incidence,it has been rising rapidly over the last 20 years mostly due to the introduction of prostate-specific antigen(PSA)testing.Randomized PCa screening studies in Europe show a mortality reduction in favor of PSA-based screening but coincide with high proportions of unnecessary biopsies,overdiagnosis and subsequent overtreatment.Conclusive data on the value of PSA-based screening and hence the balance between harms and benefits in Asia is still lacking.Because of known racial variations,Asian countries should not directly apply the European screening models.Like in the western world also in Asia,new predictive markers,tools and risk stratification strategies hold great potential to improve the early detection of PCa and to reduce the worldwide existing negative aspects of PSA-based PCa screening. | Kai Zhang Chris H.Bangma Monique J.Roobol | 2017 | Asian Journal of Urology2017，4，2： | 15 |
| 4 | Direct ex vivo analysis of dendritic cells in patients with hepatocellular carcinoma显示文摘瞄准:与肝细胞癌(HCC ) 从病人分析树枝状的房间(DC ) 的显型和功能以便在这疾病理解他们的角色。方法:骨髓的的树枝状的房间在 HCC 病人的外部血被枚举。从外部血的天真、刺激的骨髓的的树枝状的房间上的 CD80, CD83, CD86 和 HLA 医生表示被分析。骨髓的的树枝状的房间从外部血被孤立,他们的功能被测试。吞噬作用用 FITC 葡聚糖祷告被分析,肽特殊刺激,在多形核白细胞 dI:dC 之上刺激 allogeneic T 房间和 cytokines 的分泌物的能力被测试。结果:骨髓的的树枝状的房间与 HCC 在病人被减少。在 CD80, CD83, CD86 和 HLA 医生表示的差别都没从 HCC 病人和健康控制在天真、刺激的骨髓的的树枝状的房间上被发现。肽 specific T 房间的正常吞噬作用或刺激与一个损害 allo-stimulatory 能力和减少的 IL-12 分泌物相对照被观察。结论:在病人的 mDCs 的损害 IL-12 生产能导致建议指导治疗可以提高的那 IL-12 的天真的 T 房间的一个损害 stimulatory 能力在 HCC 病人的肿瘤 specific 免疫者回答。 | Lars A Ormandy Anatol Frber Tobias Cantz Susanne Petrykowska Heiner Wedemeyer Monique Hrning Frank Lehner Michael P Manns Firouzeh Korangy Tim F Greten | 2006 | World Journal of Gastroenterology2006，12，20： | 12 |
| 5 | 主要人参皂甙的分布和比例及人参产品的质量控制显示文摘采用反相高效液相色谱法,对150多种西洋参、人参及三七的根、叶及其产品进行了分析。以8种主要的人参皂甙Rg,Re,Rf,Rb1,Rc,Rb2,Rg2和Rd作为对照品,来评价人参及其产品的质量,这8种人参皂甙的分布及其比例在对人参及其商品的定性、定量分析方面具有显著的意义。本文首次提出了单体皂甙的含量比率这一有价值的数据在人参品种及不同用药部位鉴定方面的有效性。 | Ma Yuanchun Luo Mai Lynn Malley Monique Doucet(Celex Laboratories Inc., Atholville Industrial Park, 77 Comeau St.,P. O. Box 428,Atholville,New Brunswick CANADA EOK 1A0) | 1996 | 中国药物化学杂志1996，6，1： | 12 |
| 6 | Genetic and epigenetic changes associated with cholangiocarcinoma:From DNA methylation to microRNAs显示文摘Cholangiocarcinomas are malignant epithelial liver tumors arising from the intra- and extra-hepatic bile ducts. Little is known about the molecular development of this disease, and very few effective treatment options are available. Thus, prognosis is poor. Genetic and epigenetic changes play an integral role in the neoplastic transformation of human cells to their malignant counterparts. This review summarizes some of the more prevalent genetic alterations (by microRNA expression) and epigenetic changes (hypermethylation of specific gene promoters) that are thought to contribute to the carcinogenic process in cholangiocarcinoma. | Monique Stutes Steven Tran Sharon DeMorrow | 2007 | World Journal of Gastroenterology2007，13，48： | 11 |
| 7 | Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C显示文摘 | Laurent Castéra Julien Vergniol Juliette Foucher Brigitte Le Bail Elise Chanteloup Maud Haaser Monique Darriet Patrice Couzigou Victor de Lédinghen | 2005 | Gastroenterology2005，，2： | 8 |
| 8 | DYNAMIC RESOURCE ALLOCATION FOR EFFICIENT PATIENT SCHEDULING: A DATA-DRIVEN APPROACH显示文摘有效职员 rostering 并且遇见门诊病人需求的耐心的安排是一项很复杂、动态的任务。由于受欢迎的变化和专家可获得性,专家分配一定很灵活、非近视。医药专家典型地在亚专门化被限制,服务几个病人组织并且是在对诊所和操作空间的耐心的访问的链的关键资源(或) 。克服一个近视看法一次离开安排的约会,当分配关键资源到不同的耐心的组时,我们通过耐心的约会的链探讨耐心的流动。我们在场到花名同活动和病人的专家的自动分配的一条新、数据驱动的算法的途径组织。由他们的很自然,简化数学模型不能捕获对被建模的系统特征的复杂性。在我们的途径,到他们的日常活动的专家的分配对过去和现在的关键资源可获得性,以及到过去的资源分配灵活、应答。在花名同活动的可变性活跃地被最小化,以便提高供应链流动。与用实验数据的申请盒子的分离事件的模拟,我们说明我们的途径怎么改进耐心的服务水平(SL,病人的百分比服务了在时间上) 象一样等待时间(天) ,没有在资源能力的变化。 | Monique Bakker Kwok-Leung Tsui | 2017 | Journal of Systems Science and Systems Engineering2017，26，4： | 8 |
| 9 | Methods of computed tomography screening and management of lung cancer in Tianjin: design of a population-based cohort study显示文摘Objective: European lung cancer screening studies using computed tomography(CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time(VDT) is more specific for early lung cancer detection than a diameter-based protocol. However, whether this also applies to a Chinese population is unclear. The aim of this study is to compare the diagnostic performance of a volume-based protocol with a diameter-based protocol for lung cancer detection and optimize the nodule management criteria for a Chinese population.Methods: This study has a population-based, prospective cohort design and includes 4000 participants from the Hexi district of Tianjin, China. Participants will undergo low-dose chest CT at baseline and after 1 year. Initially, detected lung nodules will be evaluated for diameter and managed according to a routine diameter-based protocol(Clinical Practice Guideline in Oncology for Lung Cancer Screening, Version 2.2018). Subsequently, lung nodules will be evaluated for volume and management will be simulated according to a volume-based protocol and VDT(a European lung nodule management protocol). Participants will be followed up for 4 years to evaluate lung cancer incidence and mortality. The primary outcome is the diagnostic performance of the European volume-based protocol compared to diameter-based management regarding lung nodules detected using low-dose CT.Results: The diagnostic performance of volume-and diameter-based management for lung nodules in a Chinese population will be estimated and compared.Conclusions: Through the study, we expect to improve the management of lung nodules and early detection of lung cancer in Chinese populations. | Yihui Du Yingru Zhao Grigory Sidorenkov Geertruida H.de Bock Xiaonan Cui Yubei Huang Monique D.Dorrius Mieneke Rook Harry J.M.Groen Marjolein A.Heuvelmans Rozemarijn Vliegenthart Kexin Chen Xueqian Xie Shiyuan Liu Matthijs Oudkerk Zhaoxiang Ye | 2019 | Cancer Biology & Medicine2019，16，1： | 7 |
| 10 | PSA-based prostate cancer screening: the role of active surveillance and informed and shared decision making显示文摘自从在 1960 年代描述前列腺特定的抗原(PSA ) 的鉴定的第一份出版物,许多进步被取得了。PSA 测试从是变化了开始,到也是的一个监视工具用作一个诊断工具。随着时间的过去,测试重重地由于它敏感和特性的缺乏被辩论了。然而,直到现在, PSA 测试仍然是为察觉的唯一的 biomarker 并且前列腺癌症监视。为前列腺癌症的基于 PSA 的屏蔽与与随后的 overtreatment 的不必要的测试和 overdiagnosis 的一个高比例被联系。在为前列腺癌症屏蔽的早年里,举起的高率是很重要的。然而,随着时间的过去,基于 PSA 的屏蔽上的意见向明智的选择的观点变了。现在,不道德没有他们,屏蔽人知道 PSA 测试,以及一种明智的选择与更好耐心的结果有关的事实的利弊被认为。当屏蔽研究的三个学生的结果被介绍了,屏蔽的缺点正在变得更好理解,现在通知了选择正在变得更相关。 | Lionne D F Venderbos Monique J Roobol | 2011 | Asian Journal of Andrology2011，13，2： | 6 |
| 11 | 基于智能手机应用的中国学龄儿童及其家庭成员减盐健康教育(AppSalt):平行、整群随机对照研究显示文摘目的探讨基于智能手机应用的健康教育能否降低学龄儿童及其家庭成员的盐摄入量。设计平行、整群随机对照试验,将学校随机分配到干预组或对照组(1∶1)。背景从2018年9月15日至2019年12月27日,在中国北部、中部和南部3个省份纳入54所小学。参与者592名小学3年级儿童[每所学校约11名儿童,其中308名(52.0%)男孩;平均年龄8.58岁(标准差0.41)],以及1184名成年家庭成员[其中551名(46.5%)男性;平均年龄45.80岁(12.87)]。干预在手机应用程序的支持下,对干预组中的儿童进行关于减盐的健康教育,并布置家庭作业,以带动全家参与减盐的相关活动。主要结局测量干预组和对照组在第12个月随访时盐摄入量(通过24小时尿钠排泄量测量)改变值的差值。结果基线调查后,来自27所学校的297名儿童和594名成年家庭成员被分配到干预组,另外27所学校的295名儿童和590名成年家庭成员被分配到对照组。在试验期间,由于儿童转到另一所学校或成年家庭成员无法参加随访评估,27名(4.6%)儿童和112名(9.5%)成年人失去随访。干预组其余287名儿童和546名成人,以及对照组的278名儿童和526名成人完成了12个月的随访评估。干预组儿童基线时的平均盐摄入量为5.5[标准差(SD)1.9]g/天,干预组成人10.0(SD 3.5)g/天,对照组儿童5.6(SD 2.1)g/天,成人10.0(SD 3.6)g/天。在研究期间,干预组和对照组儿童的盐摄入量均有所增加,但干预组增加的幅度较小[调整混杂偏倚变量后平均干预效果为-0.25 g/天,95%可信区间(CI):-0.61~0.12;P=0.18]。干预组和对照组成人的盐摄入量均有所下降,但干预组的盐摄入量变化更大(平均效果-0.82 g/天,-1.24~-0.40;P<0.001)。对儿童收缩压的平均效果为-0.76 mmHg(-2.37~0.86;P=0.36),成人为-1.64 mmHg(-3.01~-0.27;P=0.02)。结论采用儿童带动家长的方式,基于手机应用程序的健康教育可有效降低成人的盐摄入量和收缩压,但对儿童的效果并不显著。这种新颖的方法有可能被更大规模地推广,但在此之前方案需要进一步加强,才能减少包括学童在内的人群盐摄入量。试验注册中国临床试验注册ChiCTR1800017553。 | Feng J He 张普洪 骆蓉 李园 孙悦文 陈凤格 赵昱红 赵伟 李道西 陈航 吴田勇 周思远 刘宇 李贤 何静 Changqiong Wang Monique Tan Jing Song Graham A MacGregor | 2022 | 英国医学杂志中文版2022，25，9： | 5 |
| 12 | Clinical characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer hospital显示文摘Objectives:To evaluate the characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer hospital.Methods:Patients with pulmonary nodules 4–25 mm in diameter detected via computed tomography(CT)in 2013 were consecutively included.The analysis was restricted to patients with a histological nodule diagnosis or a 2-year follow-up period without nodule growth confirming benign disease.Patient information was collected from hospital records.Results:Among the 314 nodules examined in 299 patients,212(67.5%)nodules in 206(68.9%)patients were malignant.Compared to benign nodules,malignant nodules were larger(18.0 mm vs.12.5 mm,P<0.001),more often partly solid(16.0%vs.4.7%,P<0.001)and more often spiculated(72.2%vs.41.2%,P<0.001),with higher density in contrast-enhanced CT(67.0 HU vs.57.5 HU,P=0.015).Final diagnosis was based on surgery in 232 out of 314(73.9%)nodules,166 of which were identified as malignant[30(18.1%)stage III or IV]and 66 as benign.In 36 nodules(11.5%),diagnosis was confirmed by biopsy and the remainder verified based on stability of nodule size at follow-up imaging(n=46,14.6%).Among 65 nodules subjected to gene(EGFR)mutation analyses,28(43.1%)cases(EGFR19 n=13;EGFR21 n=15)were identified as EGFR mutant and 37(56.9%)as EGFR wild-type.Prior to surgery,the majority of patients[n=194(83.6%)]received a contrast-enhanced CT scan for staging of both malignant[n=140(84.3%)]and benign[n=54(81.8%)]nodules.Usage of positron emission tomography(PET)-CT was relatively uncommon[n=38(16.4%)].Conclusions:CT-derived nodule assessment assists in diagnosis of small to intermediate-sized malignant pulmonary nodules.Currently,contrast-enhanced CT is commonly used as the sole diagnostic confirmation technique for pre-surgical staging,often resulting in surgery for late-stage disease and unnecessary surgery in cases of benign nodules. | Xiaonan Cui Daiwei Han Marjolein AHeuvelmans Yihui Du Yingru Zhao Lei Zhang Harry JMGroen Geertruida Hde Bock Monique DDorrius Matthijs Oudkerk Rozemarijn Vliegenthart Zhaoxiang Ye | 2020 | Cancer Biology & Medicine2020，17，1： | 5 |
| 13 | 巴黎地下空间计划——重点发展复合式基础设施的远大前景显示文摘通过介绍巴黎地下空间网络规划的现状、发展方向以及目前所遇到的问题 ,阐述了城市地下空间网络建设必须走复合式、标准化的道路 ,为城市地下空间利用提供了有益的经验。 | Monique LABBE | 2004 | 地下空间2004，24，3： | 5 |
| 14 | Nutritional and vitamin status in patients with neuroendocrine neoplasms显示文摘Symptoms of gastroenteropancreatic located neuroendocrine neoplasms(GEPNENs) are often related to food intake and manifest as abdominal pain or diarrhoea which can influence patients nutritional status. Malnutrition is common in cancer patients and influences quality of life, treatment options and survival but is also present in up to 40% of patients with GEP-NENs. As part of malnutrition there are often deficiencies in fat-soluble vitamins, mainly vitamin D. Little knowledge exists on trace elements. Several factors influence the development of malnutrition such as size and localisation of the primary tumour as well as metastases, side effects from treatment but also hormone production of the tumour itself. One of the main influencing factors leading to malnutrition is diarrhoea which leads to dehydration and electrolyte disturbances. Treatment of diarrhoea should be guided by its cause. Screening for malnutrition should be part of routine care in every GEP-NEN patient. Multidisciplinary treatment including dietician support is necessary for all malnourished patients with GEP-NENs. | Dominique SVM Clement Margot ET Tesselaar Monique E van Leerdam Rajaventhan Srirajaskanthan John K Ramage | 2019 | World Journal of Gastroenterology2019，25，10： | 4 |
| 15 | Alb4 of Arabidopsis Promotes Assembly and Stabilization of a Non Chlorophyll-Binding Photosynthetic Complex, the CF1CF0-ATP Synthase显示文摘 | Monique Benz Thomas Bals Irene Luise Gugel Markus Piotrowski Andreas Kuhn Danja Schunemann Jurgen Soll Elisabeth Ankele | 2009 | Molecular Plant2009，2，6： | 4 |
| 16 | Identification of Early Nuclear Target Genes of Plastidial Redox Signals that Trigger the Long- Term Response of Arabidopsis to Light Quality Sh∽ts显示文摘自然照明条件是高度可变的并且因为他们的无柄的生活方式,植物在细胞、分子的水平被强迫到 acclimate 到他们。在轻紧张或质量的变化在减小 / 氧化(氧化还原作用) 导致变化为包括光合作用和新陈代谢的功能、结构的调整的补偿环境适应回答充当一个扳机的光合的电子链的状态。如此的回答在原子核和细胞器在植物基因表示包括控制氧化还原作用的变化。这里,我们在模型有机体 Arabidopsis thaliana 的原子核为早调整氧化还原作用的基因(尔格) 的鉴定描述策略显著地回答 30 或在在光合的电子运输链的一个减小信号的产生以后的 60min。由把野类型的植物的反应与环境适应异种 stn7 的作比较,我们能明确地识别尔格。结果为 mitochondrial 电子运输链, tetrapyrrole 生合成,糖类新陈代谢,和发信号的类脂化合物合成包括基因在不同原子基因组上揭示叶绿体氧化还原作用信号的重要影响。这些表示侧面与响应光合的电子 transportby 的减小观察的那些清楚地不同高轻的处理。因此,识别的尔格对在光合的电子运输的氧化还原作用不平衡唯一并且然后被使用分析潜在的氧化还原作用应答的 cis 元素, trans 因素,和 chromosomal 规章的热点。数据识别一个新奇氧化还原作用应答的元素并且在在 epigenetic 进程上指向氧化还原作用信号的崭新的影响的 transcriptional 和 chromosomal 层次显示广泛的氧化还原作用控制。 | Lars Dietzel Christine Glaeer Monique Liebers Stefan Hiekel Florence Courtois Olaf Czarneckit Hagen Schlicke Yan Zubo Thomas Borner Klaus Mayer Bernhard Grimm Thomas Pfannschmidt | 2015 | Molecular Plant2015，8，8： | 4 |
| 17 | Is breast conservative surgery a reasonable option in multifocal or multicentric tumors?显示文摘The incidence of multifocal(MF) and multicentric(MC) carcinomas varies widely among clinical studies,depending on definitions and methods for pathological sampling.Magnetic resonance imaging is increasingly used because it can help identify additional and conventionally occult tumors with high sensitivity.However,false positive lesions might incorrectly influence treatment decisions.Therefore,preoperative biopsies must be performed to avoid unnecessary surgery.Most studies have shown higher lymph node involvement rates in MF/MC tumors than in unifocal tumors.However,the rate of local recurrences is usually low after breast conservative treatment(BCT) of MC/MF tumors.It has been suggested that BCT is a reasonable option for MC/MF tumors in women aged 50-69 years,with small tumors and absence of extensive ductal carcinoma in situ.A metaanalysis showed an apparent decreased overall survival in MC/MF tumors but data are controversial.Surgery should achieve both acceptable cosmetic results and negative margins,which requires thorough preoperative radiological workup and localization of lesions.Boost radiotherapy techniques must be evaluated since double boosts might result in increased toxicity,namely fibrosis.In conclusion,BCT is feasible in selected patients with MC/MF but the choice of surgery must be discussed in a multidisciplinary team comprising at least radiologists,surgeons and radiotherapists. | Gilles Houvenaeghel Agnès Tallet Aurélie Jalaguier-Coudray Monique Cohen Marie Bannier Camille Jauffret-Fara Eric Lambaudie | 2016 | World Journal of Clinical Oncology2016，7，2： | 4 |
| 18 | Prevalence and prognosis of synchronous colorectal cancer: A Dutch population-based study显示文摘 | Sanna A. Mulder Ries Kranse Ronald A. Damhuis Johannes H.W. de Wilt Rob J.Th. Ouwendijk Ernst J. Kuipers Monique E. van Leerdam | 2011 | Cancer Epidemiology2011，，5： | 3 |
| 19 | Biofilm architecture: An emerging synthetic biology target显示文摘Synthetic biologists are exploiting biofilms as an effective mechanism for producing various outputs.Metabolic optimization has become commonplace as a method of maximizing system output.In addition to production pathways,the biofilm itself contributes to the efficacy of production.The purpose of this review is to highlight opportunities that might be leveraged to further enhance production in preexisting biofilm production systems.These opportunities may be used with previously established production systems as a method of improving system efficiency further.This may be accomplished through the reduction in the cost of establishing and maintaining biofilms,and maintenance of the enhancement of product yield per unit of time,per unit of area,or per unit of required input. | Stephen J.Kassinger Monique L.van Hoek | 2020 | Synthetic and Systems Biotechnology2020，5，1： | 3 |
| 20 | Adenoma detection with cap-assisted colonoscopy versus regular colonoscopy: a randomised controlled trial显示文摘 | Thomas R de Wijkerslooth Esther M Stoop Patrick M Bossuyt Elisabeth M H Mathus-Vliegen Jan Dees Kristien M A J Tytgat Monique E van Leerdam Paul Fockens Ernst J Kuipers Evelien Dekker | 2012 | Gut2012，，10： | 3 |
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