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| 1 | Multisciplinary management of patients with liver metastasis from colorectal cancer显示文摘Colorectal cancer(CRC) is one of the leading causes of cancer-related death. Surgery, radiotherapy and chemotherapy have been till now the main therapeutic strategies for disease control and improvement of the overall survival. Twenty-five per cent(25%) of CRC patients have clinically detectable liver metastases at the initial diagnosis and approximately 50% develop liver metastases during their disease course. Twentythirty per cent(20%-30%) are CRC patients with metastases confined to the liver. Some years ago various studies showed a curative potential for liver metastases resection. For this reason some authors proposed the conversion of unresectable liver metastases to resectable to achieve cure. Since those results were published, a lot of regimens have been studied for resectability potential. Better results could be obtained by the combination of chemotherapy with targeted drugs, such as anti-VEGF and antiEGFR monoclonal antibodies. However an accurate selection for patients to treat with these regimens and to operate for liver metastases is mandatory to reduce the risk of complications. A multidisciplinary team approach represents the best way for a proper patient management. The team needs to include surgeons, oncologists, diagnostic and interventional radiologists with expertise in hepatobiliary disease, molecular pathologists, and clinical nurse specialists. This review summarizes the most important findings on surgery and systemic treatment of CRC-related liver metastases. | Kathleen De Greef Christian Rolfo Antonio Russo Thiery Chapelle Giuseppe Bronte Francesco Passiglia Andreia Coelho Konstantinos Papadimitriou Marc Peeters | 2016 | World Journal of Gastroenterology2016，22，32： | 22 |
| 2 | 超高效液相色谱-飞行时间质谱快速分析人参根中的皂甙化合物显示文摘建立了超高效液相色谱-飞行时间质谱快速分析人参根部提取物中的皂甙类化合物的方法。色谱柱为HSST3超高效液相色谱柱(100 mm×2.1 mm,1.8μm);以15 mmol/L甲酸铵水溶液-乙腈为流动相,采用二元梯度洗脱的方式对人参主根的皂甙提取物进行分离。基于待测目标物的多级质谱碎片离子、精确质量等信息,结合9种人参皂甙标准化合物的多级质谱碎片离子质谱图,共鉴定出人参主根提取物中27种皂甙类化合物。在确定的条件下,以9种人参皂甙标样为研究对象,进行了全面的方法学考察,发现它们的线性范围分别为0.33~9.00 mg/L(Rg1),0.11~9.00 mg/L(Re),0.02~2.00 mg/L(Rf),0.07~6.00 mg/L(Rg2),0.04~3.00 mg/L(Rb1,Rb3),0.22~6.00 mg/L(Rc),0.04~9.00 mg/L(Rb2,Rd);在中等加标浓度时,经内标物峰面积校正的9种皂甙标准化合物的峰面积的相对标准偏差(RSD)不高于11.3%;低、中、高3个质量浓度加标水平的回收率范围分别为90%~100%、98%~104%及96%~103%;最低检出限为3.5~18.5μg/L。该方法具有高分辨、快捷、简便、可靠等特点,并成功地应用于分析同一产地、不同生长时间的人参干燥主根中皂甙的差异。可以预计此方法可进一步应用于各种人参原料和制品中皂甙的快速测定。 | 胡春秀 孔宏伟 朱超 魏恒 Thomas HANKEMEIER Jan van der GREEF 王梅 许国旺 | 2011 | 色谱2011，29，6： | 14 |
| 3 | Comparative Transcriptional Profiling and Preliminary Study on Heterosis Mechanism of Super-Hybrid Rice显示文摘杂种优势比也是从二父母表演的后代改善了的生物现象和优异性能生来的父母线。混合米饭是在利用杂种优势的庄稼的最成功的 apotheoses 之一。由基因表示(半自动地面防空系统)的连续分析 F1 超级混血儿的米饭 Liangyou-2186 和它的父母介绍的 Transcriptional 表明 1183 差别表示了基因( DG ),在哪个之中 DG 被发现显著地在象光合作用和碳固定那样的小径充实,并且大多数涉及碳固定小径的关键基因在 F1 混合米饭展出了起来调整的表示。而且,相应的酶的增加的分解代谢的活动和光合的效率也被检测,它联合了显示那碳固定可能在 F1 混血儿,和力量被提高在超级混血儿的米饭与收益活力和杂种优势被联系。由有收益相关的量的特点 loci (QTL ) 的相关 DG,在微分基因表示和 phenotypic 变化之间的一种潜在的关系也被发现。另外,当以前在 Arabidopsis 报导了,包含生理节奏节奏、轻的发信号的小径的一个规章的网络也被发现,它建议如此的一个网络可能也与在混合米饭的杂种优势是相关的。总的来说,现在的学习为理解在米饭位于杂种优势下面的分子的机制提供另一个看法。 | Gui-Sheng Song Hong-Li Zhai Yong-Gang Peng Lei Zhang Gang Wei Xiao- Ying Chen Yu-Guo Xiao Lili Wang Yue-Jun Chen Bin Wu Bin Chen Yu Zhang Hua Chen Xiu-Jing Feng Wan-Kui Gong Yao Liu Zhi-Jie Yin Feng Wang Guo-Zhen Liu Hong-Lin Xu Xiao-Li Wei Xiao-Ling Zhao Pieter B.F. Ouwerkerk Thomas Hankemeier Theo Reijmers Rob van der Heijden Cong-Ming Lu Mei Wang Jan van der Greef Zhen Zhu | 2010 | Molecular Plant2010，3，6： | 12 |
| 4 | HPLC/LTQ-FTMS用于白参中的丙二酰基人参皂苷的研究显示文摘在15mM甲酸铵作为流动相添加剂条件下,采用HPLC/LTQ-FTMS实现了白参样品中酸性人参皂苷的优化分离。根据高分辨质谱、多级质谱信息,结合保留规律验证,在白参萃取液中共检测和识别了八种丙二酰基人参皂苷,包括丙二酰基人参皂苷Rg1、Re、Rf、Rb1、Rc、Rb2、Rb3和Rd。 | 孔宏伟 王梅 Rob van der Heijden Jan van der Greef Thomas Hankemeier 许国旺 | 2009 | 世界科学技术-中医药现代化2009，11，1： | 5 |
| 5 | Prediction of delayed graft function using different scoring algorithms: A single-center experience显示文摘AIM To compare the performance of 3 published delayed graftfunction(DGF) calculators that compute the theoretical risk of DGF for each patient.METHODS This single-center,retrospective study included 247 consecutive kidney transplants from a deceased donor.These kidney transplantations were performed at our institution between January 2003 and December 2012.We compared the occurrence of observed DGF in our cohort with the predicted DGF according to three different published calculators. The accuracy of the calculators was evaluated by means of the c-index(receiver operating characteristic curve).RESULTS DGF occurred in 15.3% of the transplants under study.The c index of the Irish calculator provided an area under the curve(AUC) of 0.69 indicating an acceptable level of prediction,in contrast to the poor performance of the Jeldres nomogram(AUC = 0.54) and the Chapal nomogram(AUC = 0.51). With the Irish algorithm the predicted DGF risk and the observed DGF probabilities were close. The mean calculated DGF risk was significantly different between DGF-positive and DGF-negative subjects(P < 0.0001). However,at the level of the individual patient the calculated risk of DGF overlapped very widely with ranges from 10% to 51% for recipients with DGF and from 4% to 56% for those without DGF.The sensitivity,specificity and positive predictive value of a calculated DGF risk ≥ 30% with the Irish nomogram were 32%,91% and 38%. CONCLUSION Predictive models for DGF after kidney transplantation are performant in the population in which they were derived,but less so in external validations. | Magda Michalak Kristien Wouters Erik Fransen Rachel Hellemans Amaryllis H Van Craenenbroeck Marie M Couttenye Bart Bracke Dirk K Ysebaert Vera Hartman Kathleen De Greef Thiery Chapelle Geert Roeyen Gerda Van Beeumen Marie-Paule Emonds Daniel Abramowicz Jean-Louis Bosmans | 2017 | World Journal of Transplantation2017，7，5： | 3 |
| 6 | Biochemical studies in relation to the possible germination regulatory role of naturally occurring coumarin and phenolics显示文摘 | Van-Sumere C F Cottenie J Greef J D | 1972 | Receni Advances in Phtochem1972，，4： | 1 |
| 7 | Laminin-l-induced migration of multiple myeloma cells involves the high-affinity 67KD laminin receptor显示文摘 | Vande BI Vanderkerken K De Greef C | 2001 | Br J Cancer2001，85，9： | 1 |
| 8 | The stimulating effect of a harsh environment on the bacteriocin activity by Enterococcus faecium RZS C5 and dependency on the environmental stress factor used显示文摘 | Leroy F Vankrunkelsven S De Greef J | 2003 | Food Microbiol2003，83，1： | 1 |
| 9 | Effect of immunosuppression on damage,leukocyte infiltration,and regeneration after severe warm ischemia/reperfusion renal injury显示文摘 | Ysebaert D K De Greef K E Vercauteren S R | 2003 | Kidney Int2003，64，3： | 1 |
| 10 | Identification of intact glucosinolates using direct coupling of high-performance liquid chromatography with continuous-flow flit fast atom bombardment tandem mass spectrometry 显示文摘 | Kokkonen P Van der Greef J Niessen W | 1991 | Biol Mass Spectrom1991，20，5： | 1 |
| 11 | A class of decomposable poverty measures显示文摘 | Foster J Greef J Thorbecke E | | 0，，52： | 1 |
| 12 | High Prognostic Impact of Flow Cytometric Minimal Residual Disease Detection in Acute Myeloid Leukemia: Data From the HOVON/SAKK AML 42A Study显示文摘 | Monique Terwijn Wim L.J. van Putten Angèle Kelder Vincent H.J. van der Velden Rik A. Brooimans Thomas Pabst Johan Maertens Nancy Boeckx Georgine E. de Greef Peter J.M. Valk Frank W.M.B. Preijers Peter C. Huijgens Angelika M. Dr?ger Urs Schanz Mojca Jongen | 2013 | Journal of Clinical Oncology2013，，31： | 1 |
| 13 | Exposure-Response Analysis in Patients With Schizophrenia to Assess the Effect of Asenapine on QTc Prolongation显示文摘 | Sunny Chapel Matt M. Hutmacher George Haig Howard Bockbrader Rik de Greef Sheldon H. Preskorn Richard L. Lalonde | 2009 | Journal of Clinical Pharmacology2009，，： | 1 |
| 14 | Proteome analysis of the medicinal plant Catharanthus roseus 显示文摘 | Jacobs DI Gaspari M van der Greef J | 2005 | Planta2005，221，5： | 1 |
| 15 | T cells as mediators in renal ischemia/reperfusion injury显示文摘 | Ysebaert D K De Greef K E De Beuf A | 2004 | Kidney Int2004，66，2： | 1 |
| 16 | A chimaeric ribonuclease-inhibitor gene restores fertility to male sterile plants显示文摘 | Mariani C Gosele V De Bluckeleer M De Block M Robert B Goldberg De Greef W Leemans J | 1992 | Nature1992，357，6： | 1 |
| 17 | The effects of acute and chronic exercise on inflammatory markers in children and adultswith a chronic inflammatory disease:a systematic review显示文摘 | Ploeger HE Takken T De Greef MH | 2009 | Exerc Immunol Rev2009，15，1： | 1 |
| 18 | Separation and identification of intact glucosinolates using direct coupling of high-performance liquid chromatography with frit to fast-atom bombardment mass spectrometry 显示文摘 | Kokkonen P Van der Greef J Niessen W | 1989 | Rapid Commun Mass Spectrom1989，3，4： | 1 |
| 19 | Treatment of cow's milk protein allergy显示文摘 | Vandenplas Y De Greef E Devreker T | 2014 | Pediatr Gastroenterol Hepatol Nutr2014，17，1： | 1 |
| 20 | The effects of a low-to-moderate intensity pre-conditioning exercise prograrmne linked with exercise counselling for sedentary haemodialysis patients in The Netherlands: results of a randomized clinical trial 显示文摘 | van Vilsteren MC de Greef MH Huisman RM | 2005 | N ephrol Dial Transplant2005，20，1： | 1 |
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