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| 1 | 脊髓损伤神经学分类国际标准(2011年修订)显示文摘本手册内容为脊髓损伤神经学分类国际标准(ISNCSCI)第7版,该标准描述了脊髓损伤的查体方法(即国际标准查体方法)及美国脊髓损伤协会(ASIA)残损分级。基于世界各国脊髓损伤治疗和研究领域的临床医师和研究人员的意见、问题和建议,本标准对一些概念和表达进行了澄清和修订。关于ISNCSCI某些问题的澄清已经在最近发表的一些论文中进行详细阐述。另外,所做出的修订也尽可能与InSTeP培训项目保持一致。委员会对修订采取了审慎的态度,主要是考虑到重大修订应有循证学基础。 | American Spinal Injury Association International Spinal Cord Society 李建军 王方永(译) | 2011 | 中国康复理论与实践2011，17，10： | 401 |
| 2 | Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn’s disease显示文摘In 2018,the pan-Janus kinase(JAK)inhibitor tofacitinib was launched for the treatment of ulcerative colitis(UC).Although tofacitinib has proven efficacious in patients with active UC,it failed in patients with Crohn’s disease(CD).This finding strongly hints at a different contribution of JAK signaling in both entities.Here,we review the current knowledge on the interplay between the JAK/signal transducer and activator of transcription(STAT)pathway and inflammatory bowel diseases(IBD).In particular,we provide a detailed overview of the differences and similarities of JAK/STAT-signaling in UC and CD,highlight the impact of the JAK/STAT pathway in experimental colitis models and summarize the published evidence on JAK/STAT-signaling in immune cells of IBD as well as the genetic association between the JAK/STAT pathway and IBD.Finally,we describe novel treatment strategies targeting JAK/STAT inhibition in UC and CD and comment on the limitations and challenges of the new drug class. | Friederike Cordes Dirk Foell John Nik Ding Georg Varga Dominik Bettenworth | 2020 | World Journal of Gastroenterology2020，26，28： | 16 |
| 3 | Lymph node staging in colorectal cancer:Old controversies and recent advances显示文摘Outcome prediction based on tumor stage reflected by the American Joint Committee on Cancer(AJCC)/Union for International Cancer Control(UICC)tumor node metastasis(TNM)system is currently regarded as the strongest prognostic parameter for patients with colorectal cancer.For affected patients,the indication for adjuvant therapy is mainly guided by the presence of regional lymph node metastasis.In addition to the extent of surgical lymph node removal and the thoroughness of the pathologist in dissecting the resection specimen,several parameters that are related to the pathological work-up of the dissected nodes may affect the clinical significance of lymph node staging.These include changing definitions of lymph nodes,involved lymph nodes,and tumor deposits in different editions of the AJCC/UICC TNM system as well as the minimum number of nodes to be dissected.Methods to increase the lymph node yield in the fatty tissue include methylene blue injection and acetone compression.Outcome prediction based on the lymph node ratio,defined as the number of positive lymph nodes divided by the total number of retrieved nodes,may be superior to the absolute numbers of involved nodes.Extracapsular invasion has been identified as additional prognostic factor.Adding step sectioning and immunohistochemistry to the pathological work-up may result in higher accuracy of histological diagnosis.The clinical value of more recent technical advances,such as sentinel lymph node biopsy and molecular analysis of lymph nodes tissue still remains to be defined. | Annika Resch Cord Langner | 2013 | World Journal of Gastroenterology2013，19，46： | 14 |
| 4 | A Feasibility Study of FES Restoration of Elbow Movementsfor C5/C6 Quadriplegic Patients显示文摘This paper presents a feasibility study of restoration of elbow movements in C5/C6quadriplegic patientS by functional electrical stimulation (FES). A biomechanical model of thebiceps and triceps muscles and elbow joint is developed for computer simulation. A feedbackcontrol method is evaluated in the study for the static and dynamic responses. Results indicate thatit is possible to achieve extension control at the elbow joint with electrical stimulation of extensormuscle. These results may provide a plausible control method for controlling elbow extensionmovements in clinical application. | N. Lan J.C. Wang P. Lin and Y. Li(Dept. of Electrical Engineering, Tsinghua UniversityBeijing 100084, P. R. China)(Spinal Cord injury Unit, Charity HospitalChina Rehabilitation Research Center, Beijing 100077, P. R. China) | 1998 | Chinese Journal of Biomedical Engineering(English Edition)1998，7，3： | 6 |
| 5 | Cancer risk in IBD: How to diagnose and how to manage DALM and ALM显示文摘The risk of developing neoplasia leading to colorectal cancer is significantly increased in ulcerative colitis (UC) and most likely in Crohn's disease. Several endoscopic surveillance strategies have been implemented to identify these lesions. The main issue is that colitisassociated neoplasms often occurs in flat mucosa, often being detected on taking random biopsies rather than by identification of these lesions via endoscopic imaging. The standard diagnostic procedure in long lasting UC is to take four biopsies every 10 cm. Image enhancement methods, such as chromoendoscopy and virtual histology using endomicroscopy, have greatly im- proved neoplasia detection rates and may contribute toreduced random biopsies by taking targeted 'smart' biopsies. Chromoendoscopy may effectively be performed by experienced endoscopists for routine screening of UC patients. By contrast, endomicroscopy is often only available in selected specialized endoscopic centers. Importantly, advanced endoscopic imaging has the poten- tial to increase the detection rate of neoplasia whereas the interplay between endoscopic experience and interpretation of histological biopsy evaluation allows the physician to make a proper diagnosis and to find the appropriate therapeutic approach. Colitis-associated intraepithelial neoplasms may occur in flat mucosa of endoscopically normal appearance or may arise as dysplasia-associated lesion or mass (DALM), which may be indistinguishable from sporadic adenomas in healthy or non-colitis mucosa [adenoma-like mass (ALM)]. The aim of this review was to summarize endoscopic and histological characteristics of DALM and ALM in the context of therapeutic procedures. | Helmut Neumann Michael Vieth Cord Langner Markus F Neurath Jonas Mudter | 2011 | World Journal of Gastroenterology2011，17，27： | 6 |
| 6 | Magnetic and optical properties of NaGdF4:Nd^3+, Yb^3+, Tm^3+ nanocrystals with upconversion/downconversion luminescence from visible to the near-infrared second window显示文摘我们设计了并且综合 NaGdF <潜水艇class=“ a-plus-plus ”> 4 :Nd3+, Yb <啜class=“ a-plus-plus ”>3+, Tm <啜class=“ a-plus-plus ”>3+有联合双模式的 downconversion ( DC )和 upconversion ( UC )的磁性的 nanophosphors 在 800 nm 刺激之上的光致发光。六角形阶段的 NaGdF < 潜水艇 class= “ a-plus-plus ” > 4 :Nd3+, Yb < 啜 class= “ a-plus-plus ” >3+, Tm < 啜 class= “ a-plus-plus ” > 有一般水准的 3+ nanocrystals (NC ) 21 nm 的尺寸用一条 solvothermal 途径被综合。 Nd <啜class=“ a-plus-plus ”>3+, Yb <啜class=“ a-plus-plus ”>3+, Tm <啜class=“ a-plus-plus ”>3+做三元组的 NaGdF <潜水艇class=“ a-plus-plus ”> 4 NC 展出盖住的大量光致发光山峰一近红外线第一/第二扇窗户( 860900 , 1,000 ,和 1,060 nm ),并且可见排放包括蓝色( 475 nm ),绿色( 520 和 542 nm )和在在 800 nm 的刺激以后的黄( 587 nm )。在 Gd 上包含精力的循环的机制 < 啜 class= “ a-plus-plus ” > 是的 3+ sublattices 桥离子并且由起始的使活跃之物离子的最后的套住(Nd < 啜 class= “ a-plus-plus ” >3+) 被建议了。穿入深度研究显示 NIR 排放容易甚至在 10 公里的大织物厚度被检测。这些顺磁的 nanophosphors 在 20 kOe 和 1.2537 公里的纵的 relaxivity 价值表明 1.88 emu/g 的大磁化价值 < 啜 class= “ a-plus-plus ” > 1 ??( | Xianwen Zhang Zhi Zhao Xin Zhang David B. Cordes Brandon Weeks Bensheng Qiu Kailasnath Madanan Dhiraj Sardar Jharna Chaudhuri | 2015 | Nano Research2015，8，2： | 5 |
| 7 | Assessment of stricturing Crohn's disease:Current clinicalpractice and future avenues显示文摘Crohn's disease(CD) is a chronic remittent idiopathic disease. Although the early phase of the disease is commonly characterized by inflammation-driven symptoms, such as diarrhea, the frequency of fibrostenotic complications in patients with CD increases over the long-term course of the disease. This review presents the current diagnostic options for assessing CD-associated strictures. In addition to the endoscopic evaluation of CD strictures, this review summarizes the currently available imaging modalities, including ultrasound and cross-sectional imaging techniques. In addition to stricture detection, differentiating between the primarily inflammatory strictures and the predominantly fibrotic ones is essential for selecting the appropriate treatment strategy(anti-inflammatory medical treatment vs endoscopical or surgical approaches). Therefore, recent imaging advances, such as contrast-enhanced ultrasound and ultrasound elastography, contribute to the development of noninvasive non-radiating imaging of CD-associated strictures. Finally, novel magnetic resonance imaging techniques, such as diffusion-weighted, motility and magnetization transfer imaging, as well as 18F-FDG PET/CT, molecular imaging approaches and biomarkers, are critically reviewed with regard to their potential role in assessing stricturing CD. | Dominik Bettenworth Tobias M Nowacki Friederike Cordes Boris Buerke Frank Lenze | 2016 | World Journal of Gastroenterology2016，22，3： | 4 |
| 8 | Detection and characterization of murine colitis and carcinogenesis by molecularly targeted contrast-enhanced ultrasound显示文摘AIM To study mucosal addressin cellular adhesion molecule-1(MAd CAM-1) and vascular endothelial growth factor(VEGF)-targeted contrast enhanced ultrasound(CEUS) for the assessment of murine colitis and carcinogenesis. METHODS C57BL/6 mice were challenged with 3% dextran sodium-sulfate(DSS) for three, six or nine days to study the development of acute colitis. Ultrasound was performed with and without the addition of unspecific contrast agents. MAd CAM-1-targeted contrast agent was used to detect and quantify MAd CAM-1 expression. Inflammatory driven colorectal azoxymethane(AOM)/DSS-induced carcinogenesis was examined on day 42 and 84 using VEGF-targeted contrast agent. Highly specific tissue echogenicity was quantified using specialized software. Sonographic findings were correlated to tissue staining, western blot analysis and immunohistochemistry to quantify the degree of inflammation and stage of carcinogenesis. RESULTS Native ultrasound detected increased general bowel wall thickening that correlated with more progressed and more severe DSS-colitis(healthy mice: 0.3 mm ± 0.03 vs six days DSS: 0.5 mm ± 0.2 vs nine days DSS: 0.6 mm ± 0.2, P < 0.05). Moreover, these sonographic findings correlated well with clinical parameters such as weight loss(r2 = 0.74) and histological damage(r2 = 0.86)(P < 0.01). In acute DSS-induced murine colitis, CEUS targeted against MAd CAM-1 detected and differentiated stages of mild, moderate and severe colitis via calculation of mean pixel contrast intensity in decibel(9.6 d B ± 1.6 vs 12.9 d B ± 1.4 vs 18 d B ± 3.33, P < 0.05). Employing the AOM/DSSinduced carcinogenesis model, tumor development was monitored by CEUS targeted against VEGF and detected a significantly increased echogenicity in tumors as compared to adjacent healthy mucosa(healthy mucosa, 1.6 d B ± 1.4 vs 42 d, 18.2 d B ± 3.3 vs 84 d, 18.6 d B ± 4.9, P < 0.01). Tissue echogenicity strongly correlated with histological analysis and immunohistochemistry findings(VEGF-positive cells in 10 high power fields of healthy mucosa: 1 ± 1.2 vs 42 d after DSS start: 2.4 ± 1.6 vs 84 d after DSS start: 3.5 ± 1.3, P < 0.01). CONCLUSION Molecularly targeted CEUS is a highly specific and noninvasive imaging modality, which characterizes murine intestinal inflammation and carcinogenesis in vivo. | Markus Brückner Jan Heidemann Tobias M Nowacki Friederike Cordes Jorg Stypmann Philipp Lenz Faekah Gohar Andreas Lügering Dominik Bettenworth | 2017 | World Journal of Gastroenterology2017，23，16： | 4 |
| 9 | Combat lifesaver-trained, first-responder application of junctional tourniquets: A prospective, randomized,crossover trial显示文摘Background:Junctional hemorrhage surpassed extremity hemorrhage as the leading cause of preventable death after the resurgence of limb tourniquets during the recent conflicts in Afghanistan and Iraq.Junctional tourniquets(JTQs)were developed in response to this injury pattern.Published data for JTQ efficacy are limited and do not incorporate nonmedical,military first responders.We compared the time for effective placement and scores for device satisfaction between two different JTQs,stratified by combat lifesaver(CLS)and combat medics.Methods:We performed a prospective,randomized,crossover trial utilizing the SAM ’ Medical Junctional Tourniquet(SJT)and Junctional Emergency Treatment Tool(JETTTM).Investigators simple randomized CLS and combat medics to SJT or JETT for their first JTQ application on mannequins with penetrating inguinal injuries.Then,participants immediately placed the other JTQ on another casualty with the same injury.The primary outcome measured was time of successful applicatio n.Success was defined as proper JTQ placement and a pressu re reading of at least 180 mmHg.We compared outcomes between CLS and combat medics.Unsuccessful JTQ applications were excluded from the comparative analysis.Results:From June 2015 to August 2015,a total of 227 personnel(133 CLS and 94 combat medics)at Fort Hood,Texas,USA volunteered to participate in the study.Twenty-eight percent(38 of 133)of CLS and 40%(38 of 94)of combat medics placed both JTQs successfully,for a total of 152 applications(76 SJTs and 76 JETTs).We found a significant difference between applications of the JETT between the CLS and combat medics(92.0±37.7 s versus70.5±20.5 s,P=0.004).No other subg roup analyses,whether by device or user,demonstrated a sig nifica nt difference in application time.Both groups preferred the SJT over the JETT.CLS disagreed with combat medics that the JETT could be easily applied by one person(median 3.0[2.0,4.0]versus median 4.0[3.0,5.0];P=0.006).Conclusions:Overall,success rates for both the SJT and JETT were low.Improved training is needed to increase successful application of junctional tourniquets before widespread implementation.Combat lifesavers and combat medics prefer the SJT over the JETT. | Ismael Flecha Jason FNaylor Steven GSchauer Ryan ACurtis Cord WCunningham | 2019 | Military Medical Research2019，6，2： | 3 |
| 10 | Extent of Surgery Affects Survival for Papillary Thyroid Cancer显示文摘 | Karl Y. Bilimoria David J. Bentrem Clifford Y. Ko Andrew K. Stewart David P. Winchester Mark S. Talamonti Cord Sturgeon | 2007 | Annals of Surgery2007，，3： | 3 |
| 11 | Stable femtosecond X-rays with tunable polarization from a laser-driven accelerator显示文摘Technology based on high-peak-power lasers has the potential to provide compact and intense radiation sources for a wide range of innovative applications.In particular,electrons that are accelerated in the wakefield of an intense laser pulse oscillate around the propagation axis and emit X-rays.This betatron source,which essentially reproduces the principle of a synchrotron at the millimeter scale,provides bright radiation with femtosecond duration and high spatial coherence.However,despite its unique features,the usability of the betatron source has been constrained by its poor control and stability.In this article,we demonstrate the reliable production of X-ray beams with tunable polarization.Using ionization-induced injection in a gas mixture,the orbits of the relativistic electrons emitting the radiation are reproducible and controlled.We observe that both the signal and beam profile fluctuations are significantly reduced and that the beam pointing varies by less than a tenth of the beam divergence.The polarization ratio reaches 80%,and the polarization axis can easily be rotated.We anticipate a broad impact of the source,as its unprecedented performance opens the way for new applications. | Andreas Döpp Benoit Mahieu Agustin Lifschitz Cedric Thaury Antoine Doche Emilien Guillaume Gabriele Grittani Olle Lundh Martin Hansson Julien Gautier Michaela Kozlova Jean Philippe Goddet Pascal Rousseau Amar Tafzi Victor Malka Antoine Rousse Sebastien Corde Kim Ta Phuoc | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 12 | piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans显示文摘 | Alyson Ashe Alexandra Sapetschnig Eva-Maria Weick Jacinth Mitchell Marloes P. Bagijn Amy C. Cording Anna-Lisa Doebley Leonard D. Goldstein Nicolas J. Lehrbach Jérémie Le Pen Greta Pintacuda Aisa Sakaguchi Peter Sarkies Shawn Ahmed Eric A. Miska | 2012 | Cell2012，，1： | 2 |
| 13 | Guidelines for management of pediatric acute hyperextension spinal cord injury显示文摘Pediatric acute hyperextension spinal cord injury(SCI)named as PAHSCI by us,is a special type of thoracolumbar SCI without radiographic abnormality and highly related to back-bend in dance training,which has been increasingly reported.At present,it has become the leading cause of SCI in children,and brings a heavy social and economic burden.Both domestic and foreign academic institutions and dance education organizations lack a correct understanding of PAHSCI and relevant standards,specifications or guidelines.In order to provide standardized guidance,the expert team formulated this guideline based on the principles of science and practicability,starting from the diagnosis,differential diagnosis,etiology,admission evaluation,treatment,complications and prevention.This guideline puts forward 23 recommendations for 14 related issues. | Lian Zeng Yu-Long Wang Xian-Tao Shen Zhi-Cheng Zhang Gui-Xiong Huang Jamal Alshorman Tracy Boakye Serebour Charles H.Tator Tian-Sheng Sun Ying-Ze Zhang Xiao-Dong Guo on behalf of Chinese Orthopaedic Association,Spinal Cord Injury and Rehabilitation Group,Chinese Association of Rehabilitation Medicine,Group of Spinal Injury and Functional Reconstruction,Neuroregeneration&Neurorestoration Professional Committee,Association of Chinese Research Hospital,Sino-Canada Spinal and Spinal Cord Injury Center | 2023 | Chinese Journal of Traumatology2023，26，1： | 2 |
| 14 | Plasma MMP-2, MMP-9 and N-BNP in Long-Term Survivors Following Complicated Myocardial Infarction: Relation to Cardiac Magnetic Resonance Imaging Measures of Left Ventricular Structure and Function显示文摘 | Stein Orn Cord Manhenke Iain B. Squire Leong Ng Inder Anand Kenneth Dickstein | 2007 | Journal of Cardiac Failure2007，，10： | 2 |
| 15 | Perspectives on the clinical development of mmunotherapy in prostate cancer显示文摘 | Lisa M Cordes James L Gulley Ravi A Madan | 2018 | Asian Journal of Andrology2018，20，3： | 2 |
| 16 | Redox flow batteries-Concepts and chemistries for cost-effective energy storage显示文摘 | Matthaa Verena HOLLAND-CUNZ Faye CORDING Jochen FRIEDL Ulrich STIMMING | 2018 | Frontiers in Energy2018，12，2： | 2 |
| 17 | Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods显示文摘Neutralizing antibodies targeting the receptor-binding domain(RBD)of the SARS-CoV-2 spike(S)block severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)entry into cells via surface-expressed angiotensin-converting enzyme 2(ACE2).We used a surrogate virus neutralization test(sVNT)and SARS-CoV-2 S protein-pseudotyped vesicular stomatitis virus(VSV)vector-based neutralization assay(pVNT)to assess the degree to which serum antibodies from coronavirus disease 2019(COVID-19)convalescent patients interfere with the binding of SARS-CoV-2 S to ACE2.Both tests revealed neutralizing anti-SARS-CoV-2 S antibodies in the sera of ~90% of mildly and 100% of severely affected COVID-19 convalescent patients.Importantly,sVNT and pVNT results correlated strongly with each other and to the levels of anti-SARS-CoV-2 S1 IgG and IgA antibodies.Moreover,levels of neutralizing antibodies correlated with the duration and severity of clinical symptoms but not with patient age.Compared to pVNT,sVNT is less sophisticated and does not require any biosafety labs.Since this assay is also much faster and cheaper,sVNT will not only be important for evaluating the prevalence of neutralizing antibodies in a population but also for identifying promising plasma donors for successful passive antibody therapy. | Berislav Bosnjak Saskia Catherina Stein Stefanie Willenzon Anne Katrin Cordes Wolfram Puppe Gunter Bernhardt Inga Ravens Christiane Ritter Christian R.Schultze-Florey Nina Godecke Jorg Martens Hannah Kleine-Weber Markus Hoffmann Anne Cossmann Mustafa Yilmaz Isabelle Pink Marius M.Hoeper Georg M.N.Behrens Stefan Pohlm ann Rainer Blasczyk Thomas F.Schulz Reinhold Forster | 2021 | Cellular & Molecular Immunology2021，18，4： | 2 |
| 18 | Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo显示文摘 | Amelia Bartholomew Cord Sturgeon Mandy Siatskas Karen Ferrer Kevin McIntosh Sheila Patil Wayne Hardy Steve Devine David Ucker Robert Deans Annemarie Moseley Ronald Hoffman | 2002 | Experimental Hematology2002，，1： | 2 |
| 19 | Relationships between serum adipokines ,insulin levels, and bone densitY in girls with anorexia nervosa显示文摘 | Misra M Miller KK Cord J | 2007 | J Clin Endocrinol Metab2007，92，： | 1 |
| 20 | Integrated Control of Root and Crown Rot in Sugar Beet: Combined Effects of Cultivar, Crop Rotation, and Soil Tillage显示文摘 | Cord Buhre Christian Kluth Klaus Barcky Bemward M?rl?nder and Mark Varrelmann | 2009 | Plant Disease2009，93，2： | 1 |
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