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| 1 | Regulatory T cells in cancer immunotherapy显示文摘表示 FOXP3 规章的 T (Treg ) 房间,对自我抗原压制异常有免疫力的反应,也压制反肿瘤免疫者反应。进肿瘤纸巾的很多 Treg 房间的渗入经常与差的预后被联系。正在积累 Treg 房间的移动能唤起并且提高反肿瘤免疫者反应的证据。然而, Treg 房间的全身的弄空可以并发地得到有害 autoimmunity。为没有 autoimmunity,唤起有效肿瘤免疫的一策略是明确地严重地指向区分的受动器 Treg 房间而非所有 FOXP3 + T 房间,因为受动器 Treg 房间是在肿瘤纸巾的占优势的房间类型。各种各样的房间表面分子包括象 CCR4 那样的 chemokine 受体,那被受动器 Treg 房间明确地表示能是弄空的候选人由特定的弄空房间的 monoclonal 抗体的受动器 Treg 房间。另外,受动器 Treg 房间的另外的免疫学的特征例如他们 CTLA-4,活跃增长,和 apoptosis 容易的趋势的高表达式,能被利用明确地控制他们的函数。例如, anti-CTLA-4 抗体可以杀死受动器 Treg 房间或稀释他们的镇压活动。这被希望指向的 Treg 房间的联合(例如,由减少 Treg 房间或 attenuating 他们在肿瘤纸巾的镇压活动) 与肿瘤特定的受动器 T 房间的激活(例如,由疫苗的癌症或有免疫力的检查点封锁) 将使当前的癌症免疫疗法更有效。 | Atsushi Tanaka Shimon Sakaguchi | 2017 | Cell Research2017，27，1： | 107 |
| 2 | Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases显示文摘Naturally arising regulatory CD4^+T(Treg)cells,which specifically express the transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface,are a T-cell subpopulation specialized for immune suppression,playing a key role in maintaining immunological self-tolerance and homeostasis.FoxP3 is required for Treg function,especially for its suppressive activity.However,FoxP3 expression per se is not necessary for Treg cell lineage commitment in the thymus and insufficient for full Treg-type gene expression in mature Treg cells.It is Treg-specific epigenetic changes such as CpG demethylation and histone modification that can confer a stable and heritable pattern of Treg type gene expression on developing Treg cells in a FoxP3-independent manner.Anomalies in the formation of Treg-specific epigenome,in particular,Treg-specific super-enhancers,which largely include Tregspecific DNA demethylated regions,are indeed able to cause autoimmune diseases in rodents.Furthermore,in humans,single nucleotide polymorphisms in Treg-specific DNA demethylated regions associated with Treg signature genes,such as IL2RA(CD25)and CTLA4,can affect the development and function of naive Treg cells rather than effector T cells.Such genetic variations are therefore causative of polygenic common autoimmune diseases including type 1 diabetes and rheumatoid arthritis via affecting endogenous natural Treg cells.These findings on the transcription factor network with FoxP3 at a key position as well as Tregspecific epigenetic landscape facilitate our understanding of Treg cell development and function,and can be exploited to prepare functionally stable FoxP3-expressing Treg cells from antigen-specific conventional T cells to treat autoimmune diseases. | Naganari Ohkura Shimon Sakaguchi | 2020 | Cell Research2020，30，6： | 29 |
| 3 | Improving recognition of hepatic perivascular epithelioid cell tumor:Case report and literature review显示文摘A 58-year-old man presented with the chief complaint of abdominal bloating and was incidentally found to have a liver tumor.As diagnostic imaging studies could not rule out malignancy,the patient underwent partial resection of segment 3 of the liver.The lesion pathologically showed eosinophilic proliferation,in addition to immunohistochemical positivity for human melanoma black 45 and Melan-A,thereby leading to the diagnosis of a hepatic perivascular epithelioid cell tumor(PEComa).A PEComa arising from the liver is relatively rare.Moreover,the name ‘PEComa' has not yet been widely recognized,and the same disease entity has been called epithelioid angiomyolipoma(EAML),further diminishing the recognition of PEComa.In addition,PEComa imaging findings mimic those of malignant liver tumors,and clinically,this tumor tends to enlarge.Therefore,a PEComa is difficult to diagnose.We conducted a systematic review of PEComa and EAML cases and discuss the results,including findings useful for differentiating perivascular epithelioid cell tumors from malignant liver tumors. | Toshiya Maebayashi Katsumi Abe Takuya Aizawa Masakuni Sakaguchi Naoya Ishibashi Osamu Abe Tadatoshi Takayama Hisashi Nakayama Shunichi Matsuoka Kazushige Nirei Hitomi Nakamura Masahiro Ogawa Masahiko Sugitani | 2015 | World Journal of Gastroenterology2015，21，17： | 20 |
| 4 | Usefulness of noninvasive transient elastography for assessment of liver fibrosis stage in chronic hepatitis C显示文摘AIM:To evaluate the method of noninvasive transient elastography for assessment of histological stage of liver fibrosis in patients with chronic hepatitis C (CHC). METHODS: Two hundred and thirty-seven patients with CHC were included in this study. Liver biopsy was performed under ultrasonography on 217 of the patients, excluding twenty with clear clinical evidence of liver cirrhosis. Fifty subjects without liver disease were enrolled as a control group (stage 0). Twenty- five patients with sustained virological response (SVR) to interferon (IFN) therapy were also enrolled. These patients underwent liver biopsy before IFN therapy. Examination of liver stiffness (LS) was performed by elastography. RESULTS: Medians (50% levels) of LS were 4.1 (3.5-4.9), 6.3 (4.8-8.5), 8.8 (6.8-12.0), 14.6 (10.5-18.6), and 22.2 (15.4-28.0), respectively, in the fibrosis stages 0-4 (P < 0.001). LS was significantly correlated with four serum fibrosis markers. LS values in patients with SVR were 3.8 (3.5-5.6), 5.2 (4.4-6.8), 6.8 (6.1-7.6), and 6.1 (3.6-7.9), respectively, in the fibrosis stages 1-4. In all stages, LS for patients with SVR was significantly lower than that for patients who did not undergo IFN therapy. LS was significantly correlated with serum concentrations of hyaluronic acid, type Ⅳ collagen, type Ⅳ collagen 7S, and type Ⅲ procollagen N peptide. CONCLUSION: LS correlated well with the histologicalstage of fibrosis. Changes in liver fibrosis stage may thus be estimated noninvasively using transient elastography. | Tadashi Takeda Takahiro Yasuda Yuji Nakayama Mika Nakaya Megumi Kimura Mariko Yamashita Ayumi Sawada Koji Abo Setsuko Takeda Hiroki Sakaguchi Susumu Shiomi Hitoshi Asai Shuichi Seki | 2006 | World Journal of Gastroenterology2006，12，48： | 16 |
| 5 | Bleeding after endoscopic submucosal dissection: Risk factors and preventive methods显示文摘Endoscopic submucosal dissection(ESD) has become widely accepted as a standard method of treatment for superficial gastrointestinal neoplasms because it enables en block resection even for large lesions or fibrotic lesions with minimal invasiveness, and decreases the local recurrence rate. Moreover, specimens resected in an en block fashion enable accurate histological assessment. Taking these factors into consideration, ESD seems to be more advantageous than conventional endoscopic mucosal resection(EMR), but the associated risks of perioperative adverse events are higher than in EMR. Bleeding after ESD is the most frequent among these adverse events. Although post-ESD bleeding can be controlled by endoscopic hemostasis in most cases, it may lead to serious conditions including hemorrhagic shock. Even with preventive methods including administration of acid secretion inhibitors and preventive hemostasis, post-ESD bleeding cannot be completely prevented. In addition high-risk cases for post-ESD bleeding, which include cases with the use of antithrombotic agents or which require large resection, are increasing. Although there have been many reports about associated risk factors and methods of preventing post-ESD bleeding, many issues remain unsolved. Therefore, in this review, we have overviewed risk factors and methods of preventing post-ESD bleeding from previous studies. Endoscopists should have sufficient knowledge of these risk factors and preventive methods when performing ESD. | Yosuke Kataoka Yosuke Tsuji Yoshiki Sakaguchi Chihiro Minatsuki Itsuko Asada-Hirayama Keiko Niimi Satoshi Ono Shinya Kodashima Nobutake Yamamichi Mitsuhiro Fujishiro Kazuhiko Koike | 2016 | World Journal of Gastroenterology2016，22，26： | 16 |
| 6 | Hemodynamic and morphologic changes of peripheral hepatic vasculature in cirrhotic liver disease: A preliminary study using contrast-enhanced coded phase inversion harmonic ultrasonography显示文摘AIM: To provide the useful information for the diagnosis of liver cirrhosis by observing the morphology of peripheral hepatic vessels and the hemodynamics of microbubble arrival time in these vessels.METHODS: Twenty-one subjects including 5 normal volunteers and 16 patients (liver cirrhosis, n=10;chronic hepatitis, n=6) were studied by contrast-enhanced coded phase inversion harmonic sonography (GE LOGIQ9 series) using a 6-8 MHz convex-arrayed wide-band transducer. The images of peripheral hepatic artery,portal and hepatic vein were observed in real-time for about 2 min after intravenous injection of Levovist. The time when microbubbles appeared in the peripheral vessels (microbubble arrival time) was also recorded. The morphologic changes of peripheral hepatic vasculature were classified as marked, slight, and no changes based on the regularity in caliber, course, ramification, and the delineation of vessels compared to normal subjects.RESULTS: The microbubble arrival time at peripheral artery, portal, and hepatic vein was shorter in cirrhotic patients than in chronic hepatitis patients and normal subjects. The marked, slight and no morphologic changes of peripheral hepatic vasculature found in 5 (5/6,83.3%), 1 (1/6, 16.7% ), and 0 (0/6, 0%) liver cirrhosis patients, respectively, and in 1 (1/10, 10%), 6 (6/10,60%), and 3 (3/10, 30%) chronic hepatitis patients,respectively. There was a significant difference between the two groups (P<0.001).CONCLUSION: Evaluation of the hemodynamics and morphology of peripheral hepatic vasculature by contrast-enhanced coded pulse inversion harmonic sonography can provide useful information for the diagnosis of liver cirrhosis. | Rong-Qin Zheng Bo Zhang Masatoshi Kudo Yasuhiro Sakaguchi | 2005 | World Journal of Gastroenterology2005，11，40： | 9 |
| 7 | Comparison of PPIs and H_2-receptor antagonists plus prokinetics for dysmotility-like dyspepsia显示文摘AIM:To compare efficacy of proton pump inhibitors(PPIs)with H2-receptor antagonists(H2RAs)plus prokinetics(Proks)for dysmotility-like symptoms in functional dyspepsia(FD).METHODS:Subjects were randomized to receive openlabel treatment with either rabeprazole 10 mg od(n= 57)or famotidine 10 mg bid plus mosapride 5 mg tid(n=57)for 4 wk.The primary efficacy endpoint was change(%)from baseline in total dysmotility-like dyspepsia symptom score.The secondary efficacy endpoint was patient satisfaction with treatment.RESULTS:The improvement in dysmotility-like dyspep-sia symptom score on day 28 was significantly greater in the rabeprazole group(22.5%±29.2%of baseline) than the famotidine+mosapride group(53.2%± 58.6%of baseline,P<0.0001).The superior benefit of rabeprazole treatment after 28 d was consistent regardless of Helicobacter pylori status.Significantly more subjects in the rabeprazole group were satisfied or very satisfied with treatment on day 28 than in the famotidine+mosapride group(87.7%vs 59.6%,P= 0.0012).Rabeprazole therapy was the only significant predictor of treatment response(P<0.0001),defined as a total symptom score improvement≥50%.CONCLUSION:PPI monotherapy improves dysmotility-like symptoms significantly better than H2RAs plus Proks,and should be the treatment of first choice for Japanese FD. | Masahiro Sakaguchi Miyuki Takao Yasuo Ohyama Hiroshi Oka Hiroshi Yamashita Takumi Fukuchi Kiyoshi Ashida Masahiro Murotani Masuyo Murotani Kazuo Majima Hiroshi Morikawa Takashi Hashimoto Keisuke Kiyota Hirohiko Esaki Kanji Amemoto Gouhei Isowa Fumiyuki Takao | 2012 | World Journal of Gastroenterology2012，18，13： | 8 |
| 8 | Endoscopic diagnosis for colorectal sessile serrated lesions显示文摘BACKGROUND Hyperplastic polyps are considered non-neoplastic, whereas sessile serrated lesions(SSLs) are precursors of cancer via the ‘‘serrated neoplastic pathway’’. The clinical features of SSLs are tumor size(> 5 mm), location in the proximal colon, coverage with abundant mucus called the ‘‘mucus cap’’, indistinct borders, and a cloud-like surface. The features in magnifying narrow-band imaging are varicose microvascular vessels and expanded crypt openings. However, accurate diagnosis is often difficult.AIM To develop a diagnostic score system for SSLs.METHODS We retrospectively reviewed consecutive patients who underwent endoscopic resection during colonoscopy at the Toyoshima endoscopy clinic. We collected data on serrated polyps diagnosed by endoscopic or pathological examination. The significant factors for the diagnosis of SSLs were assessed using logistic regression analysis. Each item that was significant in multivariate analysis was assigned 1 point, with the sum of these points defined as the endoscopic SSL diagnosis score. The optimal cut-off value of the endoscopic SSL diagnosis score was determined by receiver-operating characteristic curve analysis.RESULTS Among 1288 polyps that were endoscopically removed, we analyzed 232 diagnosed as serrated polyps by endoscopic or pathological examination. In the univariate analysis, the location(proximal colon), size(> 5 mm), mucus cap, indistinct borders, cloud-like surface, and varicose microvascular vessels were significantly associated with the diagnosis of SSLs. In the multivariate analysis, size(> 5 mm;P = 0.033), mucus cap(P = 0.005), and indistinct borders(P = 0.033) were independently associated with the diagnosis of SSLs. Size > 5 mm, mucus cap, and indistinct borders were assigned 1 point each and the sum of these points was defined as the endoscopic SSL diagnosis score. The receiver-operating characteristic curve analysis showed an optimal cut-off score of 3, which predicted pathological SSLs with 75% sensitivity, 80% specificity, and 78.4% accuracy. The pathological SSL rate for an endoscopic SSL diagnosis score of 3 was significantly higher than that for an endoscopic SSL diagnosis score of 0, 1, or 2(P < 0.001).CONCLUSION Size > 5 mm, mucus cap, and indistinct borders were significant endoscopic features for the diagnosis of SSLs. Serrated polyps with these three features should be removed during colonoscopy. | Toshihiro Nishizawa Shuntaro Yoshida Akira Toyoshima Tomoharu Yamada Yoshiki Sakaguchi Taiga Irako Hirotoshi Ebinuma Takanori Kanai Kazuhiko Koike Osamu Toyoshima | 2021 | World Journal of Gastroenterology2021，27，13： | 7 |
| 9 | Simultaneous Oxidization of NO_x and SO_2 by a New Non-thermal Plasma Reactor Enhanced by Catalyst and Additive显示文摘The non-thermal plasma as one of the most promising technologies for removingNO_x and SO_2 has attracted much attention.In this study,a new plasma reactor combined withcatalyst and additive was developed to effectively oxidize and remove NO_x and SO_2 in the fluegas.The experimental results showed that TiO_2 could improve the oxidation efficiency of SO_2 inthe case of applying plasma while having a negative effect on the oxidation process of NO andNO_x.With the addition of NH_3,the oxidation rates of NO_x,NO and SO_2 were slightly increased.However,the effect of adding NH_3 on NO_x oxidation was negative when the temperature wasabove 200℃. | Heejoon KIM 韩军 Yuhei SAKAGUCHI Wataru MINAMI | 2008 | Plasma Science and Technology2008，10，1： | 6 |
| 10 | Control of Secondary Flow in a Low Solidity Circular Cascade Diffuser显示文摘According to the previous experimental works on the low solidity circular cascade diffuser (LSD), a pressure recovery of a centrifugal blower was improved by the LSD significantly in a wide range of flow rate, and the pres-sure recovery was improved further by the LSD with a tandem cascade in comparison with the LSD with a sin-gle-row cascade. In the present study, the flow behavior in the LSD with the tandem cascade has been analyzed numerically by using the commercial CFD code of ANSYS-CFX12. It was shown clearly that the higher pressure recovery was achieved by applying the LSD with the tandem cascade, and the high pressure recovery is based on the high pressure rise in the vaneless space upstream of the LSD and the high blade loading of the front blade of the LSD. The high pressure recovery in the LSD could be achieved by controlling the flow separation on the suc-tion surface of the front blade and also on that of the rear blade due to formation of the favorable secondary flow and due to increase in mass flow passing through the slit section between the front and rear blades. | Daisaku Sakaguchi Takuji Fujii Hironobu Ueki Masahiro Ishida Hiroshi Hayami | 2012 | Journal of Thermal Science2012，21，4： | 5 |
| 11 | Sorbitol-based osmotic diarrhea:Possible causes and mechanism of prevention investigated in rats显示文摘AIM: To study the possible causes of sorbitol (S)-based diarrhea and its mechanism of reduction by rice gruel (RG) in cecectomized rats. METHODS: S was dissolved either in distilled water or in RG (50 g/L) and ingested as a single oral dose (1.2 g/kg body mass, containing 0.5 g/L phenol red as a re-covery marker) by S (control) and S + RG groups (n = 7), respectively. This dose is over the laxative dose for hu-mans. Animals were sacrificed exactly 1 h after dose in-gestion, without any access to drinking water. The whole gastro-intestinal tract was divided into seven segments and sampled to analyze the S and marker remaining in its contents.RESULTS: Gastric-emptying and intestinal transit were comparatively slower in the S + RG group. Also, the S absorption index in the 3rd and last quarter of the small intestine (24.85 ± 18.88% vs 0.0 ± 0.0% and 39.09 ± 32.75% vs 0.0 ± 0.0%, respectively, P < 0.05) was sig-nificantly higher in the S + RG group than in the control group. The S absorption index and the intestinal fluid volume are inversely related to each other. CONCLUSION: The intestinal mal-absorption of S is the main reason for S-based osmotic diarrhea. Where RG en-hanced the absorption of S through passive diffusion, the degree of diarrhea was reduced in cecectomized rats. | Md Shahidul Islam Ei Sakaguchi | 2006 | World Journal of Gastroenterology2006，12，47： | 4 |
| 12 | Flow Range Enhancement by Secondary Flow Effect in Low Solidity Circular Cascade Diffusers显示文摘High-pressure ratio and wide operating range are highly required for compressors and blowers. The technical issue of the design is achievement of suppression of flow separation at small flow rate without deteriorating the efficiency at design flow rate. A numerical simulation is very effective in design procedure, however, cost of the numerical simulation is generally high during the practical design process, and it is difficult to confirm the optimal design which is combined with many parameters. A multi-objective optimization technique is the idea that has been proposed for solving the problem in practical design process. In this study, a Low Solidity circular cascade Diffuser(LSD) in a centrifugal blower is successfully designed by means of multi-objective optimization technique. An optimization code with a meta-model assisted evolutionary algorithm is used with a commercial CFD code ANSYS-CFX. The optimization is aiming at improving the static pressure coefficient at design point and at low flow rate condition while constraining the slope of the lift coefficient curve. Moreover, a small tip clearance of the LSD blade was applied in order to activate and to stabilize the secondary flow effect at small flow rate condition. The optimized LSD blade has an extended operating range of 114 % towards smaller flow rate as compared to the baseline design without deteriorating the diffuser pressure recovery at design point. The diffuser pressure rise and operating flow range of the optimized LSD blade are experimentally verified by overall performance test. The detailed flow in the diffuser is also confirmed by means of a Particle Image Velocimeter. Secondary flow is clearly captured by PIV and it spreads to the whole area of LSD blade pitch. It is found that the optimized LSD blade shows good improvement of the blade loading in the whole operating range, while at small flow rate the flow separation on the LSD blade has been successfully suppressed by the secondary flow effect. | Daisaku Sakaguchi Min Thaw Tun Kanata Mizokoshi Daiki Kishikawa | 2014 | Journal of Thermal Science2014，23，4： | 4 |
| 13 | Gender differences of low-dose aspirin-associated gastroduodenal ulcer in Japanese patients显示文摘AIM:To clarify the gender differences about the clini-cal features and risk factors of low-dose aspirin (LDA) (81-100 mg daily)-associated peptic ulcer in Japanese patients.METHODS: There were 453 patients under treatment with LDA (298 males, 155 females) who underwent esophagogastroduodenoscopy at the Department of Gastroenterology and Hepatology of Hiratsuka City Hospital between January 2003 and December 2007. They had kept taking the LDA or started treatmentduring the study period and kept taking LDA during the whole period of observation. Of these, 119 patients (87 males, 32 females) were diagnosed as having LDA-associated peptic ulcer. We examined the clinical factors associated with LDA-associated peptic ulcer in both sexes.RESULTS: A history of peptic ulcer was found to be the risk factor for LDA-associated peptic ulcer common to both sexes. In female patients, age greater than 70 years (prevalence ORs 8.441, 95% CI: 1.797-33.649, P = 0.0069) was found to be another significant risk fac-tor, and the time to diagnosis as having LDA-associat-ed peptic ulcer by endoscopy was significantly shorter than that in the male patients (P = 0.0050). CONCLUSION: We demonstrated gender differences about the clinical features and risk factors of LDA-asso-ciated peptic ulcer. Special attention should be paid to aged female patients taking LDA. | Kazuhisa Okada Masahiko Inamori Kento Imajyo Hideyuki Chiba Takashi Nonaka Tadahiko Shiba Takashi Sakaguchi Kazuhiko Atsukawa Hisao Takahashi Etsuo Hoshino Atsushi Nakajima | 2010 | World Journal of Gastroenterology2010，16，15： | 4 |
| 14 | Identification of sources of lead in the atmosphere by chemical speciation using X-ray absorption near-edge structure(XANES) spectroscopy显示文摘Sources of Pb pollution in the local atmosphere together with Pb species, major ions, and heavy metal concentrations in a size-fractionated aerosol sample from Higashi-Hiroshima(Japan) have been determined by X-ray absorption near-edge structure(XANES) spectroscopy, ion chromatography, and ICP-MS/AES, respectively. About 80% of total Pb was concentrated in fine aerosol particles. Lead species in the coarse aerosol particles were PbC2O4, 2PbCO3·Pb(OH)2, and Pb(NO3)2, whereas Pb species in the fine aerosol particles were PbC2O4, PbSO4, and Pb(NO3)2. Chemical speciation and abundance data suggested that the source of Pb in the fine aerosol particles was different from that of the coarse ones. The dominant sources of Pb in the fine aerosol particles were judged to be fly ash from a municipal solid waste incinerator and heavy oil combustion. For the coarse aerosol particles, road dust was considered to be the main Pb source. In addition to Pb species, elemental concentrations in the aerosols were also determined. The results suggested that Pb species in size-fractionated aerosols can be used to identify the origin of aerosol particles in the atmosphere as an alternative to Pb isotope ratio measurement. | Kohei Sakata Aya Sakaguchi Masaharu Tanimizu Yuichi Takaku Yuka Yokoyama Yoshio Takahashi | 2014 | Journal of Environmental Sciences2014，26，2： | 4 |
| 15 | Development and Maintenance of Regulatory T cells显示文摘 | Naganari Ohkura Yohko Kitagawa Shimon Sakaguchi | 2013 | Immunity2013，，3： | 4 |
| 16 | Ultraslim endoscopy with flexible spectral imaging color enhancement for upper gastrointestinal neoplasms显示文摘AIM:To conduct a preliminary study on the effect of flexible spectral imaging color enhancement (FICE) used in combination with ultraslim endoscopy by focusing on the enhanced contrast between tumor and non-tumor lesions. METHODS: We examined 50 lesions of 40 patients with epithelial tumors of the upper gastrointestinal tract before endoscopic submucosal dissection using ultraslim endoscopy with conventional natural color imag ing and with FICE imaging. We retrospectively invest igated the effect of the use of FICE on endoscopic diagn osis in comparison with normal light. RESULTS: Visibility of the epithelial tumors of the upper gastrointestinal tract with FICE was superior to normal light in 54% of the observations and comparable to normal light in 46% of the observations. There was no lesion for which visibility with FICE was inferior to that with normal light. FICE visualized 69.6% of hyperemic lesions and 58.8% of discolored lesions better than conventional endoscopy with natural color imaging. FICE sign if icantly improved the visibility of lesions with hyp ere mia or discoloration compared with normocolored lesions. CONCLUSION: This study suggests that the use of FICE would improve the ability of ultraslim endoscopy to detect epithelial tumors of the upper gastrointestinal tract. | Yukari Tanioka Hideo Yanai Eiki Sakaguchi | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，1： | 4 |
| 17 | Regulatory T Cells and Immune Tolerance显示文摘 | Shimon Sakaguchi Tomoyuki Yamaguchi Takashi Nomura Masahiro Ono | 2008 | Cell2008，，5： | 4 |
| 18 | Memory consolidation during sleep and adult hippocampal neurogenesis显示文摘In anticipation of the massive burden of neurodegenerative disease within super-aged societies, great efforts have been made to utilize neural stem and progenitor cells for regenerative medicine. The capacity of intrinsic neural stem and progenitor cells to regenerate damaged brain tissue remains unclear, due in part to the lack of knowledge about how these newly born neurons integrate into functional circuitry. As sizable integration of adult-born neurons naturally occurs in the dentate gyrus region of the hippocampus, clarifying the mechanisms of this process could provide insights for applying neural stem and progenitor cells in clinical settings. There is convincing evidence of functional correlations between adult-born neurons and memory consolidation and sleep; therefore, we describe some new advances that were left untouched in our recent review. | Iyo Koyanagi Katherine G.Akers Pablo Vergara Sakthivel Srinivasan Takeshi Sakurai Masanori Sakaguchi | 2019 | Neural Regeneration Research2019，14，1： | 4 |
| 19 | Best mix of primary energy resources by renewable energy and fossil fuel with CCS in view of security,stability and sustainability——A vision on hydrogen supply chain by organic chemical hydride method显示文摘The best mix scenario by renewable energy and fossil fuel with or without CCS(Carbon Dioxide Capture and Storage) would be a solution to compromise Greenhouse Gases emission issue caused by carbon dioxide(CO2),and depletion of crude oil and natural gas reserves.As fossil fuel with pre-combustion CCS means hydrogen manufacturing and also hydrogen can be produced via electrolysis with renewable energy,it is desirable to establish transportation and storage systems of hydrogen as a clean energy.In this paper a vision on Hydrogen Supply Chain by Organic Chemical Hydride(OCH) Method as well as comparison of CCS configuration are discussed. | Junichi SAKAGUCHI | 2010 | Science China(Technological Sciences)2010，53，1： | 4 |
| 20 | Noise Characteristics of Centrifugal Blower with Low Solidity Cascade Diffuser(Noise Reduction by means of Small Groove Located at LSD Blade Leading Tip)显示文摘This paper deals with the effect of the blade tip-groove of the low solidity cascade diffuser (LSD) on the blowercharacteristic and the noise generated by the LSD. The small grooves were set up at the root and/or tip near theleading edge of the LSD blade. In order to clarify the mechanism of noise increase due to LSD and also to reducethe noise, the relationships between the noise increase based on the LSD, the LSD performance and the secondaryflow formed additionally by the tip-groove were investigated experimentally as well as numerically, especiallyanalyzing flow behaviors in the LSD in view points of flow separation on the suction surface of the LSD bladeand the secondary flow on the side walls. By reducing the stagnation region smaller near the root and/or tip of theLSD blade leading edge, the secondary flow behavior changes remarkably around the LSD blade, as a result, thenoise level and the blower characteristics vary. It can be concluded that, by means of a small tip-groove locatedonly at the shroud side near the LSD blade leading edge, the noise generated by the LSD can be reduced withoutdeteriorations of the LSD performance and the blower characteristics as well. | Tengen MURAKAMI Masahiro ISHIDA Daisaku SAKAGUCHI Yu KOBA | 2009 | Journal of Thermal Science2009，18，4： | 3 |
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