|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Different antibiotic susceptibility between antrum and corpus of the stomach,a possible reason for treatment failure of Helicobacter pylori infection显示文摘AIM:To assess whether antibiotic resistance varies between the antrum and corpus of the stomach of patients that are either Helicobacter pylori(H.pylori)therapy-naive or pre-treated.METHODS:H.pylori strains were isolated from antrum and corpus biopsies from 66 patients that received a diagnostic gastroduodenoscopy for variant clinical indications.Antimicrobial susceptibility to amoxicillin,clarithromycin,tetracycline,metronidazole,levofloxacin and rifabutin was tested with the E-test method on IsoSensitest agar with 10 vol%defibrinated horse blood.In patients with a different antibiotic susceptibility pattern between the isolates from the antrum and corpus,DNA fingerprinting via random amplified polymorphic DNA analysis was performed to detect differences among DNA patterns of H.pylori isolates.RESULTS:Primary,secondary and tertiary resistance to clarithromycin was 6.9%,53.8%and 83.3%,retrospectively.Metronidazole and levofloxacin resistance also increased according to the number of previous treatments(17.2%,69.2%,83.3%;13.8%,23.1%,33.3%).Tertiary resistance to rifabutin was detected in12.5%of patients.In none of the 66 patients a resistance against amoxicillin or tetracycline was detectable.Discordant antibiotic susceptibility between antrum and corpus isolates for different antibiotics was seen in 15.2%(10/66)of the patients.Two out of those ten patients were naive to any H.pylori antibiotic treatment.The remaining eight patients previously received at least one eradication therapy.DNA fingerprinting analysis revealed no substantial differences among DNA patterns between antrum and corpus isolates in the majority of patients suggesting an infection with a single H.pylori strain.CONCLUSION:Different antibiotic susceptibility between antrum and corpus biopsies is a common phenomenon and a possible explanation for treatment failure.Resistant H.pylori strains may be missed if just one biopsy from one anatomic site of the stomach is taken for H.pylori susceptibility testing. | Michael Selgrad Ina Tammer Cosima Langner Jan Bornschein Julia Mei?le Arne Kandulski Mariya Varbanova Thomas Wex Dirk Schlüter Peter Malfertheiner | 2014 | World Journal of Gastroenterology2014，20，43： | 10 |
| 2 | Serological assessment of gastric mucosal atrophy in gastric cancer显示文摘 | Jan Bornschein Michael Selgrad Thomas Wex et : | 2012 | BMC Gastroenterology2012，12，10： | 1 |
| 3 | Antibiotic susceptibility of Helicobacter pylori in central Germany and its relationship with the number of eradication therapies显示文摘 | Michael Selgrad Julia Meile Jan Bornschein Arne Kandulski Cosima Langner Mariya Varbanova Thomas Wex Ina Tammer Dirk Schlüter Peter Malfertheiner | 2013 | European Journal of Gastroenterology & Hepatology2013，，11： | 1 |
| 4 | HER2 status in gastroesophageal cancer: a tissue microarray study of 1040 cases显示文摘 | Rocco Cappellesso Matteo Fassan Esther Hanspeter Jan Bornschein Emanuele S.G. d’Amore Lucia V. Cuorvo Guido Mazzoleni Mattia Barbareschi Marco Pizzi Vincenza Guzzardo Peter Malfertheiner Marjan Micev Maria Guido Luciano Giacomelli Vladislav V. Tsukanov Vi | 2015 | Human Pathology2015，，5： | 1 |
| 5 | H. pylori Infection Is a Key Risk Factor for Proximal Gastric Cancer显示文摘 | Jan Bornschein Michael Selgrad Maren Warnecke Doerthe Kuester Thomas Wex Peter Malfertheiner | 2010 | Digestive Diseases and Sciences2010，，11： | 1 |
| 6 | A Frequent Toll‐Like Receptor 1 Gene Polymorphism Affects NK ‐ and T‐cell IFN ‐γ Production and is Associated with Helicobacter pylori ‐induced Gastric Disease显示文摘 | Chin‐An Yang Carmen Scheibenbogen Sandra Bauer Christoph Kleinle Thomas Wex Jan Bornschein Peter Malfertheiner Stephan Hellmig Ralf R. Schumann Lutz Hamann | 2012 | Helicobacter2012，，1： | 1 |
| 7 | Antibiotic susceptibility of Helicobacter pylori in central Germany and its relationship with the number of eradication therapies显示文摘 | Michael Selgrad Julia Meile Jan Bornschein Arne Kandulski Cosima Langner Mariya Varbanova Thomas Wex Ina Tammer Dirk Schlüter Peter Malfertheiner | 2013 | European Journal of Gastroenterology & Hepatology2013，，11： | 1 |
| 8 | A Frequent Toll‐Like Receptor 1 Gene Polymorphism Affects NK ‐ and T‐cell IFN ‐γ Production and is Associated with Helicobacter pylori ‐induced Gastric Disease显示文摘 | Chin‐An Yang Carmen Scheibenbogen Sandra Bauer Christoph Kleinle Thomas Wex Jan Bornschein Peter Malfertheiner Stephan Hellmig Ralf R. Schumann Lutz Hamann | 2012 | Helicobacter2012，，1： | 1 |
| 9 | 1047 Efficacy of an Investigational Recombinant Antigen Based Vaccine Against a CagA H. pylori Infectious Challenge in Healthy Volunteers显示文摘 | Peter Malfertheiner Michael Selgrad Thomas Wex Jan Bornschein Emanuela Palla Giuseppe Del Giudice David Graham Penny M. Heaton | 2012 | Gastroenterology2012，，5： | 1 |
| 10 | Helicobacter pylori but not gastrin is associated with the development of colonic neoplasms显示文摘 | Michael Selgrad Jan Bornschein Arne Kandulski Carla Hille Jochen Weigt Albert Roessner Thomas Wex Peter Malfertheiner | 2014 | Int. J. Cancer2014，，5： | 1 |
| 11 | A Frequent Toll‐Like Receptor 1 Gene Polymorphism Affects NK ‐ and T‐cell IFN ‐γ Production and is Associated with Helicobacter pylori ‐induced Gastric Disease显示文摘 | Chin‐An Yang Carmen Scheibenbogen Sandra Bauer Christoph Kleinle Thomas Wex Jan Bornschein Peter Malfertheiner Stephan Hellmig Ralf R. Schumann Lutz Hamann | 2012 | Helicobacter2012，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员