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| 1 | Metabolic syndrome as a risk factor for gallstone disease显示文摘AIM: To establish an association between the presence of metabolic syndrome and the development of gallstone disease.METHOIDS: We carried out a cross-sectional study in a check-up unit in a university hospital in Mexico City. We enrolled 245 subjects, comprising 65 subjects with gallstones (36 women, 29 men) and 180 controls (79women and 101 men without gallstones). Body mass index, waist circumference, blood pressure, plasma insulin, and serum lipids and lipoproteins levels were measured. Insulin resistance was calculated by homeostasis model assessment. Unconditional logistic regressionanalysis (univariate and multivariate) was used to calculate the risk of gallstone disease associated with the presence of at least three of the criteria (Adult Treatment Panel Ⅲ). Analyses were adjusted for age and sex.RESULTS: Among 245 subjects, metabolic syndrome was present in 40% of gallstone disease subjects, compared with 17.2% of the controls, adjusted by age and gender (odds ratio (OR) = 2.79; 95%CI, 1.46-5.33; P = 0.002),a dose-dependent effect was observed with each component of metabolic syndrome (OR = 2.36, 95%CI, 0.72-7.71;P = 0.16 with one component and OR = 5.54, 95%CI,1.35-22.74; P = 0.02 with four components of metabolic syndrome). Homeostasis model assessment was significantly associated with gallstone disease (adjusted OR = 2.25;95%CI, 1.08-4.69; P = 0.03).CONCLUSION: We conclude that as for cardiovascular disease and diabetes mellitus, gallstone disease appears to be strongly associated with metabolic syndrome. | Nahum Méndez-Sánchez Norberto C. Chavez-Tapia Daniel Motola-Kuba Karla Sanchez-Lara Guadalupe Ponciano-Rodríguez Héctor Baptista Martha H. Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，11： | 32 |
| 2 | 在 hilar cholangiocarcinoma 的外科的切除术的原则显示文摘 The aim of this article is to describe the surgical techniques for the treatment of hilar cholangiocarcinoma(HC).Resection with microscopically negative margin(R0) is the only way to cure patients with HC.Today,resection of the caudate lobe and part of segment Ⅳ,combined with a right or left hepatectomy,bile duct resection,lymphadenectomy of the hepatic hilum and sometimes vascular resection,is the standard surgical procedure for HC.Intraoperative frozen-section examination of proximal and distal biliary margins is necessary to confirm the suitability of resection.Although lymphadenectomy probably has little direct effect on survival,inaccurate staging information may influence post resection treatment recommendations.Aggressive venous and arterial resections should be undertaken in selected cases to achieve a R0 resection.The concept of 'no-touch proposed' in 1999 by Neuhaus et al combine an extended right hepatectomy with systematic portal vein resection and caudate lobectomy avoiding hilar dissection and possible intraoperative microscopic dissemination of cancer cells.More recently minor liver resections have been proposed for treatment of HC.As the hilar bifurcation of the bile ducts is near to liver segments Ⅳ,Ⅴ and Ⅰ,adequate liver resection of these segments together with the bile ducts can result in cure. | Emilio Ramos | 2013 | World Journal of Gastrointestinal Oncology2013，5，7： | 21 |
| 3 | 国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南显示文摘腹腔镜胃袖状切除术(1aparoscopic sleeve gastrectomy,LSG)系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显,逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25~26日, | 苏远涛 徐安安 朱江帆 Diaz AA Arvidsson D Baker RS Basso N Bellanger D Boza C El Mourad H France M Gagner M Galvao-Neto M Higa KD Himpens J Hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M Nguyen NT Nocca D Prager G Pomp A Ramos AC Rosenthal RJ Shah S Vix M Wittgrove A Zundel N | 2013 | 中国微创外科杂志2013，13，9： | 12 |
| 4 | Serum leptin levels and insulin resistance are associated with gallstone disease in overweight subjects显示文摘AIM: To establish an association between the serum leptin levels and the development of gallstone disease (GD).METHODS: We carried out a non-matched case-controlled study in a university hospital in Mexico City. Two hundred and eighty-seven subjects were included: 97 cases with gallstones and 190 controls. Body mass index (BMI), fasting plasma leptin, insulin, serum lipid, and lipoprotein levels were measured. Insulin resistance was calculated by homeostasis model assessment (HOMA-IR). Unconditional logistic regression analysis (univariate and multivariate)stratified by BMI was used to calculate the risk of GD.RESULTS: The multivariate conditional regression analysis revealed a model for those patients with BMI <30. The selected variables in the model were HOMA-IR index with OR = 1.31, P= 0.02 and leptin higher than median with OR = 2.11, P= 0.05. In the stratum of BMI ≥30, we did not find a useful model.CONCLUSION: We concluded that insulin resistance and the development of GD appears to be associated with serum leptin levels in subjects with overweight, but not in obese subjects with similar metabolic profiles. | Nahum Méndez-Sánchez Luisa B Bermejo-Martínez Yolanda Vi(n|~)als Norberto C Chavez-Tapia Irina Vander Graff Guadalupe Ponciano-Rodríguez Martha H Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，39： | 11 |
| 5 | 面向微系统的介电泳力微纳粒子操控研究显示文摘微系统中低浓度微纳粒子的操控技术亟需改进和完善,介电泳(dielectrophoresis)在这一领域具有很大的潜力.以介电泳基本原理分析为基础,推导了介电泳力的复数表达式.综合分析了影响传统介电泳力和行波介电泳力的主要因素,并建立星型电极和平行电极阵列的二维理论模型,分别作为传统介电泳力和行波介电泳力的微纳粒子操控结构.设置相应的边界条件,利用实部、虚部耦合求解的方法,仿真计算两种电极上的介电泳力分布规律,为实验提供参数依据.以传统介电泳力为基础,利用星型电极进行微纳粒子收集实验;以行波介电泳力为基础,利用平行电极阵列进行微纳粒子的提升与定向驱动实验.对比分析可知,实验与理论以及仿真分析具有较好的一致性.结果表明,微系统中利用介电泳力能够有效地对微纳粒子进行相关操控. | 任玉坤 敖宏瑞 顾建忠 姜洪源 Anfonio Ramos | 2009 | 物理学报2009，58，11： | 10 |
| 6 | Repression of the Auxin Response Pathway Increases Arabidopsis Susceptibility to Necrotrophic Fungi显示文摘在植物,到 necrotrophic 病原体的抵抗取决于在不同荷尔蒙系统之间的相互影响,例如水杨酸调整的那些酸(SA ) , jasmonic 酸(JA ) ,乙烯,和 abscisic 酸。由 SA 小径发信号的植物生长素的压抑最近被显示贡献抗菌剂抵抗。这里,我们表明表明在刺激植物生长素的 SCF (Skp1CullinF 盒子) ubiquitination 小径展览有缺点的异种 axr1, axr2,和 axr6 的那 Arabidopsis 植物生长素增加的危险性到 necrotrophic 真菌 Plectosphaerella cucumerina 和 Botrytis cinerea。另外,被 SCF-ubiquitin/proteasome 机械通常为移动指向的植物生长素 transcriptional 抑压者 AXR3 的稳定发生在 P 之上。cucumerina 感染。植物生长素运输或 proteasome 功能的药理学抑制各作为在非对待的植物生长素反应异种损害野类型的植物的 necrotroph 抵抗到类似的程度。这些结果建议植物生长素发信号为到 necrotrophic 真菌 P 的抵抗是重要的。cucumerina 和 B。cinerea。SGT1b (编码 HSP90/HSC70 合作女伴的二 Arabidopsis SGT1 基因之一) 在某些抵抗(R) 基因调节到 biotrophic 病原体的植物生长素和 JA 回答和抵抗支持 SCF E3-ubiquitin ligase 建筑群的功能。我们发现 sgt1b 异种对 P 同样抵抗。是的 cucumerina 野类型的植物。相反地, auxin/SCF 发信号异种在到 obligate biotrophic oomycete 的被触发 RPP4 的抵抗是不妥协的, Hyaloperonospora parasitica。因此,在到 oomycetes 的 R 调节基因的抵抗的 SGT1b 的占优势的行动看起来在除帮助 SCF E3-ubiquitin ligases 以外的一个地点。然而, sgt1b axr1 的基因添加在到 H 的危险性的两倍异种。一旦 plantpathogen 相容性被建立, parasitica 建议调停 SCF 的 ubiquitination 贡献限制 biotrophic 病原体殖民。 | Francisco Llorente Paul M usksktt Andrea Sanchez-Vallet Gemma Lopez Brisa Ramos Clara Sanchez-Rodriguez Lucia Jorda Jane Parker Antonio Molina | 2008 | Molecular Plant2008，1，3： | 8 |
| 7 | Value of a newly sequenced bacterial genome显示文摘Next-generation sequencing(NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft(partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the 'scientific value' of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information. | Eudes GV Barbosa Flavia F Aburjaile Rommel TJ Ramos Adriana R Carneiro Yves Le Loir Jan Baumbach Anderson Miyoshi Artur Silva Vasco Azevedo | 2014 | World Journal of Biological Chemistry2014，5，2： | 7 |
| 8 | Clinical characteristics and surgical treatment of schwannomas of the esophagus and stomach: A case series and systematic review显示文摘BACKGROUND Gastrointestinal schwannomas are slow-growing benign mesenchymal neoplasms that originate from Schwann cells of the nerve sheath of Auerbach′s plexus or less frequently from Meissner′s plexus.The main differential diagnosis of gastric schwannomas are the gastrointestinal stromal tumors(GISTs),which are classified by their immunohistochemistry.The treatment of choice for gastric schwannomas is surgery where laparoscopy plays an important role.Wedge resection,subtotal or total gastrectomy can be done.In its counterpart,esophageal schwannomas are benign tumors of the esophagus that are very uncommon since they comprise less than 2%of all esophageal tumors.The main differential diagnosis is the leiomyoma which corresponds to the most common benign esophageal tumor,followed by GIST.The treatment consists on tumoral enucleation or esophagectomy.AIM To review the available literature about gastrointestinal schwannomas;especially lesions from de stomach and esophagus,including diagnosis,treatment,and follow up,as well as,reporting our institutional experience.METHODS A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes guidelines.The following databases were used for reviewing process:Pub Med,Ovid,MEDLINE,and Scopus.Only English language manuscripts were included.All gastrointestinal schwannomas specifically located in the esophagus and stomach were included.Cases that did not report long-term follow-up were excluded.RESULTS Gastric localization showed a higher prevalence in both,the literature review and our institution:94.95%(n=317)and 83%(n=5)respectively.With a follow-up with disease-free survival greater than 36 mo in most cases:62.01%(n=80)vs66.66%(n=4).In both groups,the median size was>4.1 cm.Surgical treatment is curative in most cases CONCLUSION Schwannoma must be taken into account in the differential diagnosis of gastrointestinal mesenchymal tumors.It has a good prognosis,and most are benign.A disease-free survival of more than 36 mo can be achieved by surgery. | Jesús Morales-Maza Francisco Ulises Pastor-Sifuentes Germán E Sánchez-Morales Emilio Sanchez-Garcia Ramos Oscar Santes Uriel Clemente-Gutiérrez Adriana Simoneta Pimienta-Ibarra Heriberto Medina-Franco | 2019 | World Journal of Gastrointestinal Oncology2019，11，9： | 7 |
| 9 | 交流电渗驱动机理及流速计算显示文摘在阐述电极极化机制的基础上说明了交流电渗流的形成过程;通过建立非对称电极等效电路和理论模型,获得了交流电渗流微泵的流速的计算公式;通过分析,解释了对称电极虽然能产生局部电渗流但不能形成流速的现象。研究结果为进一步分析和研究交流电渗流微泵提供了理论基础。 | 姜洪源 闫宝森 杨胡坤 Ramos Antonio | 2007 | 中国机械工程2007，18，14： | 7 |
| 10 | Reduction of NO by CO using Pd–CeTb and Pd–CeZr catalysts supported on SiO_2 and La_2O_3–Al_2O_3显示文摘The catalytic activity of Pd catalysts supported on Ce0.73Tb0.27 O x/Si O2, Ce0.6Zr0.4O x/Si O2,Ce0.73Tb0.27 O x/La2O3–Al2O3and Ce0.6Zr0.4O x/La2O3–Al2O3was studied using the reduction of NO by CO. The catalysts were characterized by X-ray fluorescence, surface area, X-ray diffraction, temperature-programmed reduction, CO chemisorption and oxygen storage capacity. Temperature-programmed reduction results indicated that Tb or Zr incorporation improves the reducibility and oxygen storage capacity. CO chemisorption data suggested the presence of large Pd O particles due to the low CO/Pd ratio. No significant differences were obtained in light off temperatures(T Light off) for all Pd catalysts and the most active was1.5%Pd/Ce0.6Zr0.4O x/Si O2. | Victor Ferrer Dora Finol Roger Solano Alexander Moronta Miguel Ramos | 2015 | Journal of Environmental Sciences2015，27，1： | 7 |
| 11 | Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation显示文摘BACKGROUND The impact of perioperative blood transfusion on short-and long-term outcomes in pediatric living donor liver transplantation(PLDLT)must still be ascertained,mainly among young children.Clinical and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver transplantation.AIM To determine whether transfusion is associated with early and late postoperative complications and mortality in small patients undergoing PLDLT.METHODS We evaluated the effects of perioperative transfusion on postoperative complications in recipients up to 20 kg of body weight,submitted to PLDLT.A total of 240 patients were retrospectively allocated into two groups according to postoperative complications:Minor complications(n=109)and major complications(n=131).Multiple logistic regression analysis identified the volume of perioperative packed red blood cells(RBC)transfusion as the only independent risk factor for major postoperative complications.The receiver operating characteristic curve was drawn to identify the optimal volume of the perioperative RBC transfusion related to the presence of major postoperative complications,defining a cutoff point of 27.5 mL/kg.Subsequently,patients were reallocated to a low-volume transfusion group(LTr;n=103,RBC≤27.5 mL/kg)and a high-volume transfusion group(HTr;n=137,RBC>27.5 mL/kg)so that the outcome could be analyzed.RESULTS High-volume transfusion was associated with an increased number of major complications and mortality during hospitalization up to a 10-year follow-up period.During a short-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and bleeding complications,with a decrease in rejection complications compared to the LTr.Over a long-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and minor neoplastic complications,with a decrease in rejection complications.Additionally,Cox hazard regression found that high-volume RBC transfusion increased the mortality risk by 3.031-fold compared to low-volume transfusion.The Kaplan-Meier survival curves of the studied groups were compared using log-rank tests and the analysis showed significantly decreased graft survival,but with no impact in patient survival related to major complications.On the other hand,there was a significant decrease in both graft and patient survival,with high-volume RBC transfusion.CONCLUSION Transfusion of RBC volume higher than 27.5 mL/kg during the perioperative period is associated with a significant increase in short-and long-term postoperative morbidity and mortality after PLDLT. | Karina Gordon Estela Regina Ramos Figueira Joel Avancini Rocha-Filho Luiz Antonio Mondadori Eduardo Henrique Giroud Joaquim Joao Seda-Neto Eduardo Antunes da Fonseca Renata Pereira Sustovitch Pugliese Agustin Moscoso Vintimilla Jose Otavio Costa Auler Jr Maria Jose Carvalho Carmona Luiz Augusto Carneiro D'Alburquerque | 2021 | World Journal of Gastroenterology2021，27，12： | 6 |
| 12 | 行波电渗微流体驱动理论模型与实验显示文摘为了研究行波电渗(TWEO)微流体驱动,在封闭的微通道内建立了TWEO微流体驱动模型,并进行了仿真和实验研究。根据TWEO驱动原理,分别建立了封闭通道内TWEO微流体驱动电场及流场的数学模型,并对电场及流场问题进行了求解,流场的仿真结果说明了实验测量通道高度2/3处速度的合理性。最后,分析了实验和仿真结果并确定了容抗比例系数。实验及仿真结果表明:电导率分别为1.5 mS/m7、.7 mS/m1、6.9 S/m的KCl溶液的容抗比例系数分别为0.05、0.035、0.025,而且电导率与容抗比例系数呈线性关系。结果为进一步研究TWEO及其应用提供了理论基础及实验方法。 | 姜洪源 杨胡坤 敖宏瑞 RAMOS Antonio | 2009 | 光学精密工程2009，17，5： | 5 |
| 13 | 交流电渗微泵理论模型与数值仿真显示文摘通过交流电渗流的产生机制及对非对称电极交流电渗微泵驱动原理的分析,建立了交流电渗微泵的物理模型和数学模型.根据微通道内电势分布满足Laplace方程,确定了交流电渗微泵微通道内电势及电场分布.并且利用设定的微通道内流场的边界条件,对Navier-Storks方程进行了数值仿真计算,获得了微通道内电渗流流场,分析表明其仿真计算与实验结果具有较好的一致性.从而验证了交流电渗微泵理论模型的正确性,为进一步研究和分析非对称电极交流电渗微泵提供了理论工具和仿真手段. | 姜洪源 杨胡坤 闫辉 RAMOS Antonio | 2007 | 哈尔滨工程大学学报2007，28，12： | 5 |
| 14 | 3-D AVO分析和模拟用于煤层气储层的裂缝探测显示文摘近几年来,振幅随炮检距变化(AVO)分析已经成功地用于预测储层性质和流体含量,在某些情况下,能提供气—水界面、气—油界面的空间位置。在这篇文章中,我们证明,3-D,AVO方法也可用于描述裂缝性储层的性质。给出裂缝密度变化的空间位置。在新墨西哥州San Juan盆地的Cedar Hill矿区Fruitland组地层的裂缝性煤层中生产甲烷气因为煤层缺乏原生渗透率,裂缝的存在则是生产甲烷气的决定性因素。为了有助于描述煤层的储层性质,在这块地区采用的是3-D多分量地震勘探。本次研究中,多分量数据体的叠前F波振幅资料用来圈定煤层气储层中大泊松比差异(或高裂缝密度)的区域边界。而震源-接收点方位分选则用于检测煤层裂缝系统引起的方位各向异性的优选方向、两种模拟方法(使用射线追踪和反射率)预测裂缝性煤层带对角度有关的P波反射率的影响对水平层状地层模型建立了合成共中心点(CMP)道集,模型所用的弹性参数取自声波测井和密度测井。由各向异性模拟方法模拟煤层中裂缝密度的变化。与砂岩—煤层界面有关的大声阻抗差异决定了P波反射率响应。对于计算模型来说,这些差异的影响远远超过各向异性差异的影响。由3—D数据体得到的9个大面元的地震AVO分析证实了模型的预测,具有AVO截距的范围指示低速煤层可能与应力释放带有关。具有AVO梯度的范围辨别大泊松比差异的煤层带,并因而识别煤层气储层中的高密度裂缝带。3-D AVO成果和储层泊松比变化图结合这些响应生成包括断裂程度和其可能的应力条件的储层图件。震源接收点方位分选被用于测定煤层裂缝系统引起的方位各向异性的优选方向。 | Antonio C. B. Ramos Thomas L. Davis 赵岩 | 1999 | 国外油气勘探1999，11，1： | 5 |
| 15 | Understanding plant drought resistance in a Mediterranean coastal sand dune ecosystem:differences between native and exotic invasive species显示文摘Aims Mediterranean coastal dunes are habitats of great conservation interest,with a distinctive and rich flora.In the last century,Acacia spp.,native from Australia,have been introduced in Portugal,with the objective of stabilizing sand dunes,and since have become dominant in numerous sand dune habitats.This invasion process led to the reduction of native plant species richness,changed soil characteristics and modified habitat’s microclimatic char-acteristics.The aim of this research was to typify and compare,in Mediterranean sand dune ecosystems,the ecophysiological responses to drought of Helichrysum italicum and Corema album,two native species,and Acacia longifolia,an exotic invasive spe-cies.We addressed the following specific objectives:(i)to com-pare water relations and water use efficiencies,(ii)to evaluate water stress,(iii)to assess water use strategies and water sources used by plants and(iv)to evaluate the morphological adaptations at leaf and phyllode level.Methods In order to obtain an integrative view of ecophysiological patterns,water relations and performance measuring methods have been applied:predawn(ψPD)and midday(ψMD)water potential,chloro-phyll a fluorescence,oxygen isotopic composition of xylem,rain and groundwater(δ18O)and leaf carbon isotopic discrimination(Δ13C).The leaf characteristics of the three species,as well as the histochemistry of non-glandular trichome cell walls,were also studied to identify morpho-traits related to drought resistance.Important Findings The results support our initial hypothesis:although A.longifolia clearly possesses a degree of resistance to water stress,such ability is provided by a different water strategy,when compared to native species.Natives relied on morphological adaptations to restrict water loss,whereas the invasive species adjusted the water uptake as a way to balance their limited ability of restricting water loss.We corroborate that woody native species(i)have a conservative water-saving strategy and minor seasonal variations relative to invasive species,(ii)use enriched water sources during drought periods,indicating different water sources and root systems com-paring with invasive species and(iii)present drought leaf morpho-functional adaptations related with limiting water loss.Comparing the physiological performance of invasive and native species can offer causal explanations for the relative success of alien plant invasions on sand dunes ecosystems. | Cristina Antunes Ana Júlia Pereira Patrícia Fernandes Margarida Ramos Lia Ascensão Otília Correia Cristina Máguas | 2018 | Journal of Plant Ecology2018，11，1： | 4 |
| 16 | 桑叶黄酮对49~56周龄蛋鸡生产性能、器官指数和生殖激素的影响显示文摘试验旨在研究桑叶黄酮对蛋鸡生产性能、器官指数及繁殖激素水平的影响,并初步探讨日粮中桑叶黄酮的适宜添加量。选取49~56周龄海兰褐蛋鸡240只,随机分为5组(每组4个重复,每个重复12只),各组间产蛋率差异不显著,对照组饲喂基础日粮,试验组在日粮中分别添加10、50、100、200 mg/kg桑叶黄酮提取物。预试期1周,正试期8周。试验期间测定产蛋性能、饲料转化率,试验第8周屠宰测定器官指数和生殖激素水平。结果表明:与对照组相比,日粮中添加桑叶黄酮后对产蛋率、蛋重、料蛋比和平均日耗料均无显著影响,但可以提高产蛋率,以10 mg/kg添加水平产蛋率最高;添加桑叶黄酮对内脏器官无显著影响,但均可降低腹脂率;添加10、50 mg/kg桑叶黄酮均可增加十二指肠长度(P<0.05);添加10、50 mg/kg桑叶黄酮可提高排卵后卵泡数量,添加50 mg/kg桑叶黄酮可增加输卵管重量,而添加10、50 mg/kg桑叶黄酮均可增加血液中孕酮和雌二醇含量。由此可见,日粮中添加10~100 mg/kg桑叶黄酮能提高海兰褐蛋鸡产蛋率、降低腹脂率;而添加10、50 mg/kg桑叶黄酮均可显著增加十二指肠长度,提高孕酮和雌二醇含量。综合分析,桑叶黄酮在49~56周龄蛋鸡日粮中的适宜添加量为10~100 mg/kg。 | 丰源 王明珠 李涛 侯启瑞 吴萍 Boris Ramos Serrano 沈曼曼 赵卫国 | 2023 | 中国畜牧杂志2023，59，4： | 4 |
| 17 | Biliary cystadenoma显示文摘The diagnosis of cystadenoma is rare, even more so when located in the extrahepatic bile duct.Unspeciflc clinical signs may lead this pathology to be misdiagnosed.The need for pathological anatomy in order to distinguish cystadenomas from simple biliary cysts is crucial.The most usual treatment nowadays is resection of the bile duct, together with cholecystectomy and Roux-en-Y reconstruction. | Miguel A Hernandez Bartolome Sagrario Fuerte Ruiz Israel Manzanedo Romero Beatriz Ramos Lojo Ignacio Rodriguez Prieto Luis Gimenez Alvira Rosario Granados Carreo Manuel Limones Esteban | 2009 | World Journal of Gastroenterology2009，15，28： | 4 |
| 18 | Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer显示文摘Objective:Long-term survivors(LS)of non-small cell lung cancer(NSCLC)without driver alterations,displaying an overall survival(OS)of more than 3 years,comprise around 10%of cases in several series treated with chemotherapy.There are classical prognosis factors for these cases[stage,Eastern Cooperative Oncology Group(ECOG),etc.],but more data are required in the literature.In this multi-center study,we focused on LS of advanced NSCLC with OS above 36 months to perform a clinical-pathological and molecular characterization.Methods:In the first step,we conducted a clinical-pathological characterization of the patients.Afterwards,we carried out a genetic analysis by comparing LS to a sample of short-term survivors(SS)(with an OS less than 9 months).We initially used whole-genome RNA-seq to identify differentiating profiles of LS and SS,and later confirmed these with reverse transcription-polymerase chain reaction(RT-PCR)for the rest of the samples.Results:A total of 94 patients were included,who were mainly men,former smokers,having adenocarcinoma(AC)-type NSCLC with an ECOG of 0-1.We obtained an initial differential transcriptome expression,displaying 5 over-and 33 under-expressed genes involved in different pathways:namely,the secretin receptor,surfactant protein,trefoil factor 1(T FF1),serpin,Ca-channels,and Tolllike receptor(TLRs)families.Finally,RT-PCR analysis of 40(20 LS/20 SS)samples confirmed that four genes(surfactant proteins and SFTP)were significantly down-regulated in SS compared to LS by using an analysis of covariance(ANCOVA)model:SFTPA1(P=0.023),SFTPA2(P=0.027),SFTPB{P=0.02),and SFT PC(P=0.047).Conclusions:We present a sequential genetic analysis of a sample of NSCLCLS with no driver alterations,obtaining a differential RNA-seq/RT-PCR profile showing an abnormal expression of SF genes. | Juan Moreno-Rubio Santiago Ponce Rosa Alvarez Maria Eugenia Olmedo Sandra Falagan Xabier Mielgo Fatima Navarro Patricia Cruz Luis Cabezon-Gutierrez Carlos Aguado Gonzalo Colmenarejo Marta Munoz-Fernandez de Leglaria Ana Belen Enguita Maria Cebollero Amparo Benito Isabel Alemany Carolina del Castillo Ricardo Ramos Ana Ramirez de Molina Enrique Casado Maria Sereno | 2020 | Cancer Biology & Medicine2020，17，2： | 4 |
| 19 | Electrohydromechanical analysis based on conductivity gradient in microchannel显示文摘Fluid manipulation is very important in any lab-on-a-chip system. This paper analyses phenomena which use the alternating current (AC) electric field to deflect and manipulate coflowing streams of two different electrolytes (with conductivity gradient) within a microfluidic channel. The basic theory of the electrohydrodynamics and simulation of the analytical model are used to explain the phenomena. The velocity induced for different voltages and conductivity gradient are computed. The results show that when the AC electrical signal is applied on the electrodes, the fluid with higher conductivity occupies a larger region of the channel and the interface of the two fluids is deflected. It will provide some basic reference for people who want to do more study in the control of different fluids with conductivity gradient in a microfluidic channel. | 姜洪源 任玉坤 敖宏瑞 Antonio Ramos | 2008 | Chinese Physics B2008，17，12： | 4 |
| 20 | Tribological performance of tributylmethylammonium bis(trifluoromethylsulfonyl)amide as neat lubricant and as an additive in a polar oil显示文摘The ionic liquid(IL) tributylmethylammonium bis(trifluoromethylsulfonyl)amide([N4441][NTf2]) was used as neat lubricant and as an additive(1.5 wt%) in a polar oil to study its friction and wear reducing properties.Tribological tests were completed for 90 minutes at room temperature and 100 °C in a reciprocating configuration at loads of 30 and 70 N,10 Hz-frequency,and 4 mm stroke length.Wear volume was measured by confocal microscopy and the surface-IL interaction determined by XPS.The main findings were that neat IL showed the best tribological behavior;the IL-containing mixture behaved similar to the base oil regarding friction,however outperformed the antiwear behavior of the base oil under higher temperature;surface-IL chemical interaction was found mainly at 100 °C. | Rubén GONZáLEZ Diego RAMOS David BLANCO Alfonso FERNáNDEZ-GONZáLEZ Jose L.VIESCA Mark HADFIELD Antolin HERNáNDEZ BATTEZ | 2019 | Friction2019，7，3： | 3 |
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