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| 1 | Laparoscopic colorectal surgery:current status andimplementation of the latest technological innovations显示文摘The introduction of laparoscopy is an example of surgical innovation with a rapid implementation in many areas of surgery. A large number of controlled studiesand meta-analyses have shown that laparoscopic colorectal surgery is associated with the same benefits than other minimally invasive procedures, including lesser pain, earlier recovery of bowel transit and shorter hospital stay. On the other hand, despite initial concerns about oncological safety, well-designed prospective randomized multicentre trials have demonstrated that oncological outcomes of laparoscopy and open surgery are similar. Although the use of laparoscopy in colorectal surgery has increased in recent years, the percentages of patients treated with surgery using minimally invasive techniques are still reduced and there are also substantial differences among centres. It has been argued that the limiting factor for the use of laparoscopic procedures is the number of surgeons with adequate skills to perform a laparoscopic colectomy rather than the tumour of patients' characteristics. In this regard, future efforts to increase the use of laparoscopic techniques in colorectal surgery will necessarily require more efforts in teaching surgeons. We here present a review of recent controversies of the use of laparoscopy in colorectal surgery, such as in rectal cancer operations, the possibility of reproducing complete mesocolon excision, and the benefits of intracorporeal anastomosis after right hemicolectomy. We also describe the results of latest innovations such as single incision laparoscopic surgery, robotic surgery and natural orifice transluminal endoscopic surgery for colon and rectal diseases. | Marta Pascual Silvia Salvans Miguel Pera | 2016 | World Journal of Gastroenterology2016，22，2： | 32 |
| 2 | Glutamate transporters in brain ischemia: to modulate or not?显示文摘在这评论,我们简短描述 glutamate (Glu ) 在中央神经系统(CNS ) 的新陈代谢和它的特定的运输和受体。此后,我们集中于有刺激性的氨基酸 transporters, cystine/glutamate antiporters (系统 x c -) 和小囊的 glutamate transporters,明确地在 CNS 和位于 Glu transporters 的规定下面的分子的机制探讨他们的地点和角色。我们响应组织缺氧或局部缺血在 Glu transporter 表示有关改变从在 vitro 或在 vivo 研究提供证据,包括支持在击病人的 Glu transporters 的角色的有限人的数据。而且,通过表示的调整或 Glu transporters 的活动导致大脑忍耐到局部缺血的潜力也被讨论。最后我们包含 ischemic preconditioning 和药理学代理人的申请的现在的策略,例如 β酮抗菌素, amitriptyline, riluzole 和 N-acetylcysteine,它对局部缺血导致紧张的纸巾的重要保护。 | Weronika KRZYZANOWSKA Bartosz POMIERNY Magorzata FILIP Joanna PERA | 2014 | Acta Pharmacologica Sinica2014，，4： | 17 |
| 3 | Stem cell therapy for Parkinson’s disease: safety and modeling显示文摘For decades,clinicians have developed medications and therapies to alleviate the symptoms of Parkinson’s disease,but no treatment currently can slow or even stop the progression of this localized neurodegeneration.Fortunately,sparked by the genetic revolution,stem cell reprogramming research and the advancing capabilities of personalization in medicine enable forward-thinking to unprecedented patient-specific modeling and cell therapies for Parkinson’s disease using induced pluripotent stem cells(iPSCs).In addition to modeling Parkinson’s disease more accurately than chemically-induced animal models,patient-specific stem cell lines can be created,elucidating the effects of genetic susceptibility and sub-populations’differing responses to in vitro treatments.Sourcing cell therapy with iPSC lines provides ethical advantages because these stem cell lines do not require the sacrifice of human zygotes and genetically-specific drug trails can be tested in vitro without lasting damage to patients.In hopes of finally slowing the progression of Parkinson’s disease or re-establishing function,iPSC lines can ultimately be corrected with gene therapy and used as cell sources for neural transplantation for Parkinson’s disease.With relatively localized neural degeneration,similar to spinal column injury,Parkinson’s disease presents a better candidacy for cell therapy when compared to other diffuse degeneration found in Alzheimer’s or Huntington’s Disease.Neurosurgical implantation of pluripotent cells poses the risk of an innate immune response and tumorigenesis.Precautions,therefore,must be taken to ensure cell line quality before transplantation.While cell quality can be quantified using a number of assays,a yielding a high percentage of therapeutically relevant dopaminergic neurons,minimal de novo genetic mutations,and standard chromosomal structure is of the utmost importance.Current techniques focus on iPSCs because they can be matched with donors using human leukocyte antigens,thereby reducing the severity and risk of immune rejection.In August of 2018,researchers in Kyoto,Japan embarked on the first human clinical trial using iPSC cell therapy transplantation for patients with moderate Parkinson’s disease.Transplantation of many cell sources has already proven to reduce Parkinson’s disease symptoms in mouse and primate models.Here we discuss the history and implications for cell therapy for Parkinson’s disease,as well as the necessary safety standards needed for using iPSC transplantation to slow or halt the progression of Parkinson’s disease. | Theo Stoddard-Bennett Renee Reijo Pera | 2020 | Neural Regeneration Research2020，15，1： | 5 |
| 4 | 心脏X综合征患者的异常皮质疼痛过程 | Valeriani M. Sestito A. Le Pera D. G. A. Lanza 滕增辉 | 2005 | 世界核心医学期刊文摘(心脏病学分册)2005，0，10： | 4 |
| 5 | Petrography of Middle Jurassic to Early Cretaceous sandstones in the Kutch Basin,western India:Implications on provenance and basin evolution显示文摘This paper investigates the provenance of Middle Jurassic to Early Cretaceous sediments in the Kutch Basin, western India, on the basis of mineralogical investigations of sandstones composition(Quartz-Feldspar-Lithic(QFL)fragment), Zircon-Tourmaline-Rutile(ZTR) index, and mineral chemistry of heavy detrital minerals of the framework.The study also examines the compositional variation of the sandstone in relation to the evolution of the Kutch Basin, which originated as a rift basin during the Late Triassic and evolved into a passive margin basin by the end Cretaceous. This study analyzes sandstone samples of Jhumara, Jhuran and Bhuj Formations of Middle Jurassic,Upper Jurassic and Lower Cretaceous, respectively, in the Kutch Mainland. Sandstones record a compositional evolution from arkosic to subarkosic as the feldspar content decreases from 68% in the Jhumara Formation to 27%in the Bhuj Formation with intermediate values in the Jhuran Formation. The QFL modal composition indicates basement uplifted and transitional continental settings at source. Heavy mineral content of these sandstones reveals the occurrence of zircon, tourmaline, rutile, garnet, apatite, monazite and opaque minerals. Sub-rounded to well-rounded zircon grains indicate a polycyclic origin. ZTR indices for samples in Jhumara, Jhuran and Bhuj Formations are 25%, 30% and 50% respectively. Chemistry of opaque minerals reveals the occurrence of detrital varieties such as ilmenite, rutile, hematite/magnetite and pyrite, in a decreasing order of abundances. Chemistry of ilmenites in the Jhumara Formation reveals its derivation from dual felsic igneous and metabasic source, while those in Jhuran and Bhuj Formations indicate a metabasic derivation. Chemistry of garnet reveals predominantly Fe-rich(almandine) variety of metabasic origin. X-ray microscopic study provides the percentage of heavy minerals ranging from 3% to 5.26%. QFL detrital modes reflect the evolution of the basin from an active rift to a passive margin basin during the Mesozoic. Integration of results from QFL modal composition of the sandstones, heavy mineral analysis and mineral chemistry, suggests sediment supply from both northern and eastern highlands during the Middle Jurassic. The uplift along the Kutch Mainland Fault in the Early Cretaceous results in curtailment of sediment input from north. | Angana Chaudhuri Santanu Banerjee Emilia Le Pera | 2018 | Journal of Palaeogeography2018，7，3： | 4 |
| 6 | 外科减肥手术后高血压缓解和复发的预测因素显示文摘目前,只有很少量研究涉及外科减肥手术后高血压得到缓解和复发的影响因素,没有可用于预测高血压复发相关因素的信息。该研究的目的是评估在外科减肥手术后第1年和第3年里高血压的缓解情况和复发率,并寻找可能的预测因素。 | Benaiges D Sagué M Flores-Le Roux JA Pedro-Botet J Ramón JM Villatoro M Chillarón JJ Pera M Más A Grande L Goday A 陈云 | 2016 | 中华高血压杂志2016，24，9： | 2 |
| 7 | Chemical and minero-petrographical changes on granulite rocks affected by weathering processes显示文摘The purpose of this work is to study the weathering processes of the granulite rocks of the Serre Massif (southern Calabria,Italy) using a multidisciplinary approach based on field studies,geochemical modeling,and minero?petrographical analyses.The granulite rocks are plagioclase-rich with minor amphibole,clinopyroxene,orthopyroxene,biotite,and garnet and their texture are coarse-grained.The reaction path modeling was performed to simulate the evolution of groundwaters upon interaction with local granulite by means of the software package EQ3/6,version 8.0a.Simulations were performed in kinetic (time) mode under a closed system at a constant temperature of 11.5℃,(which reproduces the average temperature of local area) and fixing the fugacity of CO2 at 10-2.34 bar (mean value).During the most advanced stage of weathering the main mineralogical changes are: partial destruction and transformation of biotite and plagioclase associated with neoformation of ferruginous products and secondary clay minerals producing a change in the origin rock fabric.The secondary solid phases observed during the geochemical modeling (kaolinite,vermiculite and ferrihydrite) are similar to those found in this natural system.Thus,the soil-like material mainly characterized by mostly sand to gravel grain-size fractions is the final result of the weathering processes. | Carmine APOLLARO Francesco PERRI Emilia LE PERA Ilaria FUOCO Teresa CRITELLI | 2019 | Frontiers of Earth Science2019，13，2： | 2 |
| 8 | Evaluation of Compost Maturity by Means of Chemical and Microbial Analyses显示文摘 | Riffaldi R Leviminzi R Pera A | 1986 | Waste Manage Res1986，，4： | 1 |
| 9 | lnfluence of posts and cores on light transmission through different all-ceramic crowns Spectrophoto metric and clinical evaluation显示文摘 | Carossa S Lombarardo S Pera P | 2001 | Int J Prosthodont2001，36，14： | 1 |
| 10 | Embryonic stem cell lines from human blastocysts:somatic differentiation in vitro显示文摘 | Pera MF Fong CY | 2000 | Nat Biotech2000，18，： | 1 |
| 11 | Evaluating toxicity of immature compost显示文摘 | Zucconit F Pera A Forte M | 1981 | Biocycle1981，22，： | 1 |
| 12 | Energymanagement strategy for embedded fuel-cell systems using fuzzy logic显示文摘 | Tekin M Hissel D Pera M C | 2007 | IEEE Transactions on lndustrialElectronics2007，54，1： | 1 |
| 13 | Influence of Chemical and Ischemic Preconditioning on Cytokine Expression after Focal Brain Ischemia显示文摘 | Pera J Zawadzka M Kaminska B | 2004 | Neurosci Res2004，，1： | 1 |
| 14 | 显示文摘 | Pera M Grande L Gelabert M | 1998 | Ann Thorac Surg1998，65，： | 1 |
| 15 | Adenocarcinoma of the esophagogastric junction and Barrett's esophagus 显示文摘 | Cameron A J Lomboy CT Pera M | 1995 | Gastroenterology1995，109，5： | 1 |
| 16 | Phase II trial of preoperative chemoradiotherapy with oxaliplatin, cisplatin, and 5-FU in locally advanced esophageal and gastric cancer 显示文摘 | Pera M Gallego R Montagut C | 2012 | Ann Oncol2012，23，3： | 1 |
| 17 | Embryonic stem cell lines from human blastocysts:somatic differentiation in vitro显示文摘 | Pera MF Fong CY | 2000 | Nat Biotechnol2000，18，4： | 1 |
| 18 | Increasing incidence of adenocarcinoma of the esophagus and esophagogastric junction显示文摘 | Pera M Cameron AJ Trastek VF | 1993 | Gastroenterology1993，104，2： | 1 |
| 19 | A mutational analysis of the SLC26A4 gene in Spanish hearing- impaired families provides new insights into the genetic causes of Pendred syn- drome and DFNIM hearing loss显示文摘 | Pera A Villamar M Vinuela A | 2008 | Eur J Hum Genet2008，16，： | 1 |
| 20 | The biology of Composting: a Re-view显示文摘 | Bertoldi M de Vallini G Pera A | 1983 | Waste Management &Reseach1983，，1： | 1 |
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