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| 1 | Review of risk factors for human echinococcosis prevalence on the Qinghai-Tibet Plateau, China: a prospective for control options显示文摘Objective: Echinococcosis is a major parasitic zoonosis of public health importance in western China. In 2004, the Chinese Ministry of Health estimated that 380,000 people had the disease in the region. The Qinghai-Tibet Plateau is highly co-endemic with both alveolar echinococcosis (AE) and cystic echinococcosis (CE). In the past years, the Chinese government has been increasing the financial support to control the diseases in this region. Therefore, it is very important to identify the significant risk factors of the diseases by reviewing studies done in the region in the past decade to help policymakers design appropriate control strategies. Review: Selection criteria for which literature to review were firstly defined. Medline, CNKI (China National Knowledge Infrastructure), and Google Scholar were systematically searched for literature published between January 2000 and July 2011. Significant risk factors found by single factor and/or multiple factors analysis were listed, counted, and summarized. Literature was examined to check the comparability of the data;age and sex specific prevalence with same data structures were merged and used for further analysis. A variety of assumed social, economical, behavioral, and ecological risk factors were studied on the Plateau. Those most at risk were Tibetan herdsmen, the old and female in particular. By analyzing merged comparable data, it was found that females had a significant higher prevalence, and a positive linearity relationship existed between echinococcosis prevalence and increasing age. In terms of behavioral risk factors, playing with dogs was mostly correlated with CE and/or AE prevalence. In terms of hygiene, employing ground water as the drinking water source was significantly correlated with CE and AE prevalence. For definitive hosts, dog related factors were most frequently identified with prevalence of CE or/and AE;fox was a potential risk factor for AE prevalence only. Overgrazing and deforestation were significant for AE prevalence only. Conclusion: Tibetan herdsmen communities were at the highest risk of echinococcosis prevalence and should be the focus of echinococcosis control. Deworming both owned and stray dogs should be a major measure for controlling echinococcosis;treatment of wild definitive hosts should also be considered for AE endemic areas. Health education activities should be in concert with the local people's education backgrounds and languages in order to be able to improve behaviors. Further researches are needed to clarify the importance of wild hosts for AE/CE prevalence, the extent and range of the impacts of ecologic changes (overgrazing and deforestation) on the AE prevalence, and risk factors in Tibet. | Qian Wang Yan Huang Liang Huang Wenjie Yu Wei He Bo Zhong Wei Li Xiangman Zeng Dominique A Vuitton Patrick Giraudoux Philip S Craig Weiping Wu | 2014 | Infectious Diseases of Poverty2014，3，1： | 35 |
| 2 | 泡状棘球蚴病宿主淋巴细胞的变化及意义显示文摘目的 为探讨泡状棘球蚴病宿主体内淋巴细胞在免疫调节和发病中的作用。方法 对泡球蚴感染BALB/c小鼠观察至 2 5周 ,在不同时间取脾制备细胞悬液 ,检测CD+ 4 ,CD+ 8细胞数量。对 2 5例泡球蚴病患者和 18例健康人群 ,用FCM分析了CD+ 3 ,CD+ 4 ,CD+ 8,CD+ 19,CD+ 3 8,CD+ 56和HLA -DR+ 细胞的变化。结果 泡球蚴感染BALB/c小鼠后 ,1~ 8周以CD+ 4 细胞为主 ,随后CD+ 4 细胞减少 ,CD+ 8细胞增加 ,2 0周后改变显著 (P <0 0 5 ) ,CD+ 4 /CD+ 8比值迅速倒置。泡状棘球蚴病患者CD+ 3细胞未发生改变 ,CD+ 4 细胞较正常对照组下降 (P <0 0 5 ) ,CD+ 8细胞上升 (P <0 0 5 ) ,使CD+ 4 /CD+ 8比值降低 (P <0 0 5 )。CD+ 56细胞较正常对照组显著性降低 (P <0 0 1) ,CD+ 19,CD+ 3 8和HLA -DR+ 细胞未发生改变 (P >0 0 5 )。结论 泡球蚴感染小鼠前 8周 ,以CD+ 4 细胞反应为主 ,具有保护性免疫。感染后期逐渐以CD+ 8细胞为主 ,使机体呈免疫抑制状态 ,有利于泡球蚴生存。泡状棘球蚴病患者机体呈免疫抑制状态 。 | 李富荣 石佑恩 史大中 DA Vuitton PS Craig | 2003 | 中国人兽共患病杂志2003，19，3： | 21 |
| 3 | Impact of overgrazing on the transmission of Echinococcus multilocularis in Tibetan pastoral communities of Sichuan Province,China显示文摘背景过度放牧被假定增加是包虫 multilocularis 的中间的主人的小哺乳动物的人口密度,在 Qinghai 西藏高原的牙槽的包虫病的病原体。这研究测试了过度放牧可能支持的假设通过增加小哺乳动物的人口的包虫 multilocularis 传播,在擦伤惯例的西藏的牧剧 communities.Methods 的中间的主人,小哺乳动物索引和狗包虫 rnultilocularis 感染数据被收集分析在用的 nonpararnetric 测试和多重逐步的逻辑 regression.Results 过度放牧和包虫 rnultilocularis 传播之间的关系调查一公社的牧场存在,可得到的牧草为放牧是缺乏的。开(普通) 牧场被过度放牧并且与附近的 fenced 相比有小哺乳动物的更高的洞穴密度(私人) 牧场;由附近的 fenced 区域测量的开的牧场上的这个高过度放牧压力在开的牧场导致了小哺乳动物的更高的洞穴密度。在开的牧场的小哺乳动物的中部的洞穴密度独立地与附近犬的包虫 multilocularis 感染被联系(P=0.003, OR=1.048 ) 过度放牧的 .Conclusion 可以通过增加小哺乳动物的人口密度支持包虫 multilocularis 的传播。 | WANG Qian XIAO Yong-fu Dominique A Vuitton Peter M Schantz Francis Raoul Christine Budke Maiza Campos-Ponce Philip S Craig Patrick Giraudoux | 2007 | Chinese Medical Journal2007，，3： | 20 |
| 4 | 泡球蚴感染过程中宿主CD_4^+细胞凋亡和凋亡相关基因转录水平的研究显示文摘目的 为了探讨泡球蚴感染宿主CD+ 4 淋巴细胞缺失的机制 ,以及泡球蚴感染与宿主CD+ 4 淋巴细胞凋亡及凋亡相关基因转录水平的相关性。方法 利用尼龙柱和补体法从泡球蚴感染 12周 ,2 5周和正常对照组BALB/c小鼠脾脏分离出纯CD+ 4 ,CD+ 8细胞 ,在体外分别经EmAg ,anti-CD3 ,IL - 2 ,TNFα ,PWM刺激培养 16h ;Tunel和PI双染后 ,FCM分析凋亡细胞数 ;并用C -myc ,TGF - β ,bcl- 2cDNA探针检测感染 2 5周EmAg诱导CD+ 4 细胞的凋亡相关基因转录水平。结果 FCM分析 ,感染 12周组CD+ 4 ,CD+ 8细胞凋亡数同正常对照组无明显差别 (P >0 0 5 ) ,感染 2 5周组CD+ 4 细胞凋亡数较正常对照组显著增高 (P <0 0 1) ,也显著性高于同组CD+ 8细胞 (P <0 0 1)。CD+ 4 细胞内C -myc,TGF - βmRNA水平较正常对照组显著升高 (P <0 0 5 ) ,而bcl- 2mRNA水平则减弱 (P <0 0 5 )。结论 泡球蚴寄生宿主后期 ,可诱导宿主成熟T细胞中CD+ 4 细胞发生凋亡 ,使宿主处于免疫抑制状态。凋亡的形成与凋亡信号增加 ,抑制信号减弱所引起。 | 李富荣 石佑恩 史大中 DA Vuitton PS Craig | 2003 | 中国人兽共患病杂志2003，19，4： | 19 |
| 5 | 犬体内细粒棘球绦虫和多房棘球绦虫的混合感染显示文摘目的 证实家犬体内是否存在细粒棘球绦虫和多房棘球绦虫混合感染。方法 从新疆和静县巴音布鲁克草原现场收购的30条牧羊犬,经麻醉后处死解剖,在1只雌性牧羊犬小肠内发现棘球绦虫成虫1万条以上,经显微镜观察,疑为细粒棘球绦虫和多房棘球绦虫混合感染。用Eglf/r和EM-15/17EM引物分别对两种棘球绦虫的线粒体DNA特异目的片段进行序列分析鉴定。结果 形态学观察:细粒棘球绦虫孕节长大,生殖孔偏后,位于节片一侧中部。子宫有不规则的分支和侧突(侧囊),内含虫卵200~800个。多房棘球绦虫较短小,4~5体节。孕节中子宫呈简单的囊状,无侧囊。生殖孔开口于侧缘的前半部。线粒体12S RNA序列鉴定,扩增样本DNA经同源序列比较发现,与细粒棘球绦虫G1型具有相同的序列;扩增样本与多房棘球绦虫具有相同的序列。分别确定为细粒棘球绦虫和多房棘球绦虫两种虫种。结论 首次证实家犬体内存在细粒棘球绦虫和多房棘球绦虫的混合感染。 | 温浩 张亚楼 Jean-Mathieu BART Giraudoux P Vuitton DA 马旭东 邹林樾 苗玉清 Craig PS | 2006 | 中国寄生虫学与寄生虫病杂志2006，24，1： | 18 |
| 6 | Components of the mitogen-activated protein kinase cascade are activated in hepatic cells by Echinococcus multilocularis metacestode显示文摘AIM: To explore the effect of Echinococcus multilocularis (E. multilocularis) on the activation of mitogen-activated protein kinase (MAPK) signaling pathways and on liver cell proliferation. METHODS: Changes in the phosphorylation of MAPKs and proliferating cell nuclear antigen (PCNA) expression were measured in the liver of patients with alveolar echinococcosis (AE). MAPKs, MEK1/2 [MAPK/ extracellular signal-regulated protein kinase (ERK) kinase] and ribosomal S6 kinase (RSK) phosphorylation were detected in primary cultures of rat hepatocytes in contact in vitro with (1) E. multilocularis vesicle fluid (EmF), (2) E. multilocularis-conditioned medium (EmCM). RESULTS: In the liver of AE patients, ERK 1/2 and p38 MAPK were activated and PCNA expression was increased, especially in the vicinity of the metacestode. Upon exposure to EmF, p38, c-Jun N-terminal kinase (JNK) and ERK1/2 were also activated in hepatocytes in vitro, as well as MEK1/2 and RSK, in the absence of any toxic effect. Upon exposure to EmCM, only JNK was up-regulated. CONCLUSION: Previous studies have demonstrated an influence of the host on the MAPK cascade in E. multilocularis. Our data suggest that the reverse, i.e. parasite-derived signals efficiently acting on MAPK signaling pathways in host liver cells, is actually operating. | Ren-Yong Lin Jun-Hua Wang Xiao-Mei Lu Xiao-Tao Zhou Georges Mantion Hao Wen Dominique A Vuitton Lysiane Richert | 2009 | World Journal of Gastroenterology2009，15，17： | 15 |
| 7 | 阿苯达唑治疗泡球蚴病患者血清中Th1/Th2型细胞因子的变化及临床意义显示文摘目的 为探讨泡球蚴病患者经阿苯达唑治疗后 ,机体免疫应答的状态和对病程转归影响。方法 35例泡球蚴病患者经阿苯达唑治疗 1 2月前后 ,血清中sIL - 2R ,IFN -γ ,IL - 4IL - 5 ,IL - 6 ,TNFα,及特异性IgG ,IgE抗体进行检测。 结果 在治疗 1 2月后 ,Th1型细胞因子sIL - 2R ,IFN -γ无改变 (P >0 0 5) ,Th2型细胞因子IL - 4显著性下降 (P <0 0 1 ) ,IL - 5在患者中检出率明显降低 (P <0 0 1 ) ,TNFα和IgE水平较治疗前显著性下降 (P <0 0 1 )。 结论 泡球蚴病患者治疗后 ,Th2型细胞因子反应减弱 。 | 李富荣 石佑恩 史大中 DA Vuitton PS Craig | 2003 | 中国人兽共患病杂志2003，19，2： | 14 |
| 8 | Grass height and transmission ecology of Echinococcus multilocularis in Tibetan communities, China显示文摘背景牙槽的包虫病是在西方的中国的公共健康意义的主要动物病。过度放牧最近为牙槽的包虫病的传播作为一个潜在的风险因素被假定。研究被设计进一步由调查过度放牧怎么影响了中间的主人的洞穴密度测试过度放牧的假设小哺乳动物并且小哺乳动物的洞穴密度怎么与狗包虫 multilocularis infection.Methods 被联系学习地点被发现了牙槽的包虫病是流行的区域的以前的研究选择。数据包括草高度,挖中间的主人的密度烘便的样品以及全球放系统(GPS ) 放的小哺乳动物,狗和狐狸,在 Shiqu 县从领域调查被收集,四川省,中国。烘便的样品用 copro-PCR 被分析。在烘便的样品的蠕虫,牙齿,骨头和头发视觉上被检验。包括 chi 平方和概括线性模型的单个因素和 multifactor 分析工具被把草高度用作在同质的牧场擦伤压力的一个代理用于这些 data.Results ,在导致的牧场发现那棵更高的草的这研究降低小哺乳动物的洞穴密度 X^2=A.67O , P=0.031 , coefficient=-1.570 )。在狗的包虫 multilocularis 蠕虫负担是显著地统计上与中介的最大的密度有关招待 Ochotona spp。(X^2=5.250, P=0.022, coefficient=0.028 ) 。在拥有的狗的流行断然被相关到在 200 米半径以内看见的迷路的狗的数字(Wald X^2=8.375, P=0.004,机会 ratio=1.198 ) 。结论我们的调查结果支持过度放牧支持的假设牙槽的包虫病的传播并且在牙槽的包虫病的传播证实迷路的狗的角色。 | WANG Qian Francis Raoul Christine Budke Philip S. Craig XIAO Yong-fu, Dominique A. Vuitton,Maiza Campos-Ponce, QIU Dong-chuan, David Pleydell and Patrick Giraudoux XIAO Yong-fu Dominique A. Vuitton Maiza Campos-Ponce QIU Dong-chuan David Pleydell Patrick Giraudoux | 2010 | Chinese Medical Journal2010，，1： | 12 |
| 9 | 人白细胞抗原-DRB1等位基因与中国西部泡状棘球蚴病易感性的研究显示文摘目的 了解人白细胞抗原 (HLA) DRB1等位基因与泡球蚴病相关性 ,阐明泡球蚴病的免疫学发病机制 ,探寻泡球蚴病的易感基因或抗病基因提供线索。方法 应用PCR/SSP技术 ,对中国西部甘肃省漳县、岷县泡球蚴病高流行区 4个乡的 35例患者和 10 4例正常人群进行了HLA DRB1基因型分析。结果 患者组HLA DRB1 0 40x基因频率为 2 6 % (18/70 ) ,正常对照组为 10 % (2 0 /2 0 8)(RR =4.45 ,χ2 =13.6 7,P <0 .0 1,EF =0 .2 0 )。HLA DRB1 0 70 1基因频率 ,患者组为 3% (2 /70 ) ,正常组为 14% (2 9/2 0 8) ,(RR =0 .16 ,χ2 =6 .2 6 ,P <0 .0 5 ,PF =0 .30 )。其他等位基因频率在患者组与正常组间差异无显著意义 (χ2 =0 .0 3~ 1.87,P >0 .0 5 )。结论 HLA DRB1 0 40x基因与泡状棘球蚴病具有相关性 ,所调查地区泡球蚴病的高流行与遗传因素有关。HLA DRB1 0 70 | 李富荣 石佑恩 史大中 DA Vuitton PS Craig | 2000 | 中华医学杂志2000，80，6： | 9 |
| 10 | 阿苯达唑治疗前后泡状棘球蚴病患者淋巴细胞亚群变化及临床意义显示文摘目的 探讨泡球蚴病患者经阿苯达唑治疗后 ,机体免疫应答的状态和对病程转归的影响。 方法 7例未治疗泡球蚴病患者 ,6例经阿苯达唑治疗 12个月泡球蚴病患者 ,6例经阿苯达唑治疗 2 4个月泡球蚴病患者和 18例非流行区健康人群 ,用 FCM分析了 CD3+ 、CD4 + 、CD8+ 、CD1 9+ 、CD38+ 、CD1 6 + 56 + 和 HL A- DR+ 细胞的数量。 结果 治疗 12个月后 ,患者 CD8+细胞数继续上升 (P<0 .0 1) ,CD4 + / CD8+比值进一步倒置 ;治疗 2 4个月后 ,CD4 +细胞数开始升高 (P<0 .0 5 ) ,CD8+ 细胞数下降 ,CD4 + / CD8+ 比值升高 (P<0 .0 5 ) ;CD1 9+ 细胞在治疗 2 4个月后显著性升高 (P<0 .0 5 ) ;CD38+ 和 HL A-DR+ 细胞在治疗 2 4个月后呈显著性下降 (P<0 .0 1)。 结论 泡球蚴病患者治疗后 ,CD8+ 细胞引起的免疫抑制状态有所减轻 ,机体的保护性免疫应答有所恢复。 | 李富荣 石佑恩 史大中 DA Vuitton PS Craig | 2003 | 中国寄生虫病防治杂志2003，16，3： | 8 |
| 11 | 多房棘球蚴感染宿主CD4^+T淋巴细胞缺失机制的探讨显示文摘目的 探讨多房棘球蚴感染宿主CD4^+T淋巴细胞缺失的机制,多房棘球蚴感染与宿主T淋巴细胞亚群凋亡相互关系。方法 利用尼龙柱和补体法从多房棘球蚴感染12wk,25wk和正常对照组BALB/c 小鼠脾脏分离出纯CD4^+、CDS8^+T细胞,在体外分别经多房棘球蚴抗原(EmAg)、抗CD3抗原(anti-CD3)、白细胞介素-2(IL-2)、肿瘤坏死因子α(TNFα)及商陆丝裂原(PWM)刺激培养16h,用DNA凝胶电泳分析;透射电镜观察形态学变化;原位末端标记法(Tunel)和碘化丙锭(PI)双染后,流式细胞仪(FCM)分析凋亡细胞数和凋亡发生的细胞周期。结果 感染25wk小鼠,CD4^+T细胞DNA电泳图均出现典型“梯形”条带,透射电镜见染色质浓染、胞质出泡、凋亡小体形成;CD8^+T细胞DNA电泳国无梯形带,透射电镜见染色质浓染,电子密度增强。FCM分析,感染12wk小鼠,CD4^+、CD8^+T细胞凋亡数与正常对照组差异无显著性意义(P>0.05);感染25wk小鼠,CD4^+T细胞凋亡数较正常对照组显著增高(P<0.01),也显著高于同组CD8^+T细胞(P<0.01)。凋亡主要发生在细胞周期S期。结论 多房棘球蚴寄生宿主后期,可诱导宿主成熟CD4^+T细胞发生活化诱导性死亡(AICD),使宿主处于免疫抑制状态。 | 李富荣 石佑恩 史大中 DA Vuitton PS Craig | 2003 | 中国寄生虫学与寄生虫病杂志2003，21，4： | 6 |
| 12 | A historical view of alveolar echinococcosis, 160 years after the discovery of the first case in humans: part 1. What have we learnt on the distribution of the disease and on its parasitic agent?显示文摘自从著名科学家鲁道夫·弗乔在 1855 在疾病的起源在南部的德国和一个寄生虫的正确鉴定观察的开始的 2 个盒子,牙槽的包虫病(AE ) 的地方性的区域的边阶从来没停下来过膨胀。寄生虫连续地在瑞士被认出,然后为疾病在长的俄国,奥地利和法国考虑了同样唯一的地方性的区域。盒子在 1939 在土耳其被揭示;然后,许多注意对阿拉斯加并且到北海道被给予,在日本。状况完全由科学家的国际社区在中国地方性的区域的识别以后在 1991 变化了。世界地图被 AE 的鉴定,并且由盒子的识别在中亚在大多数中央 / 东方的欧洲和波罗的语州的国家在第 21 世纪的开始完成。直到现在,疾病从来然而没在南方半球并且在英国被报导过。在 mid-1950s ,由在阿拉斯加的 Rausch 和德国诗人,并且由在德国的 Vogel 的示范,在 2 寄生虫种类之间的区别负责分别地为膀胱的包虫病(“胞虫疾病”)和 AE 结束在“二元论者”之间的长持续的争论,谁相信了那最后证明了真的理论,和“ unicists ”,相信了为两疾病负责的单个种。在第 20 世纪的结束,分子的生物学充分证实了“二元论者”理论当把几新种加到开始描述的 E 时。granulosus;在过去的十年以内,它也证实很少变化在西藏的高原上在一些中间的动物宿主在包虫(E.) multilocularis 种类,和那 AE-Iooking 感染以内存在确实由于新种,从 E 不同。multilocularis,命名 E。shiquicus。自从 1970 年代,在风景之间的唯一的生态的相互作用,主人,和 E。multilocu/aris 日益增多地被描出。为寄生虫周期的维护的啮齿类动物 / 兔类动物水库尺寸的重要角色在第 20 世纪的最后 2 十年以内被认出了。并且在在由农业 / 林地的陆地使用的小哺乳动物和个性的高密度之间的一种靠近的关系的发现在污染压力上强调了政治 / 经济的决定的责任。在欧洲和日本和在中国的狗的主要角色的狐狸的都市化关于权威的主人和预防措施在 21 st 世纪的开始代表新买卖。 | Dominique Angele Vuitton WANG Qian ZHOU Hong-xia Francis Raoul Jenny Knapp Solange Bresson-Hadni WEN Hao Patrick Giraudoux | 2011 | Chinese Medical Journal2011，，18： | 5 |
| 13 | HLA-DRB1 allele in 35 patients with alveolar echinococcosis in Gansu Province of China显示文摘Objective To investigate the association between histocompatibility leukocyte antigen (HLA)-DRB1 alleles and alveolar echinococcosis (AE).Methods Thirty-five patients with AE in high prevalence areas in Gansu Province of China were tested for the HLA-DRB1 gene using the polymerase chain reaction with sequence-specific primer (PCR-SSP) technique. The results were compared with those of 104 healthy individuals.Results The frequency of the HLA-DRB1*040x gene was 26% in the patient group,which was significantly higher than that in the control group (9.62%) with a relative risk (RR) of 4.45 (χ 2 =13.67, P <0.01),and an etiological fraction (EF) of 0.20. The frequency of the HLA-DRB1 *0701 allele was significantly lower in the patient group (2.86%) as compared to the control group (13.94%; χ 2=6.67,P <0.05) with a preventable fraction (PF) of 0.30. The frequencies of other DRB1 alleles were not significantly different.Conclusion Susceptibility to AE is significantly associated with the HLA-DRB1*040x. HLA-DRB1 *0701 gene might confer protection against AE in humans. | 李富荣 石佑恩 史大中 Dominique Angele Vuitton Philip Simon Craig | 2003 | Chinese Medical Journal2003，，10： | 4 |
| 14 | Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans显示文摘 | Enrico Brunetti Peter Kern Dominique Angèle Vuitton | 2009 | Acta Tropica2009，，1： | 4 |
| 15 | 肝泡型包虫病临床分期与sIL-2R、TNF-α和IFN-γ含量的关系显示文摘为探讨肝泡型包虫病 (Alveolar echinococcosis AE)临床分期与 s IL- 2 R,TNF- α和 IFN- γ含量的关系和意义 ,将经B超和血清学方法证实的 2 3例 AE病人和对照组 1 2人采血后 ,用 ELISA双抗体夹心法 ,做 s IL- 2 R,TNF-α和 IFN-γ含量的测定。按 B超肝脏扫描的声像损害情况 ,将 AE分期 (组 ) ,对照相应细胞因子的含量 ,经方差分析和 Q检验 ,讨论细胞因子在 AE发育增殖中的可能作用和临床意义。结果 P2 组、P3 组、P4组和对照组 s IL- 2 R每 m L含量均值分别为 96.57u、2 2 6.44u、1 93.81 u、1 1 0 .89u;TNF- α含量均值分别为 P2 组 1 .1 2 μg/ L,P3 组 3.67μg/ L,P4组 1 .30 μg/ L,对照组则为 0 .40μg/ L;IFN-γ含量均值分别为 P2 组 360 ng/ L,P3 组 486 ng/ L,P4组 2 59ng/ L,对照组则为 1 5.63 ng/ L;各组经方差分析和 Q检验 ,证实 AE病人病理的三个不同时期 ,其 s IL- 2 R,TNF- α和 IFN- γ的含量均有显著性差异 (P<0 .0 1 )。 s IL- 2 R含量均值除 P2 与对照组无差异外 (P>0 .0 5) ,其余各组与 P2 组和对照组均有显著性差异 (P<0 .0 5) ;TNF- α含量在 P3 组最高 (P<0 .0 1 ) ;AE各组病人的 IFN- γ含量明显高于对照组 (P<0 .0 1 ) ,而 AE病人组间却并无差异 (P>0 .0 5)。低水平的 s IL- | 史大中 李富荣 B Bartholomot DA Vuitton PS Craig | 2001 | 地方病通报2001，16，4： | 4 |
| 16 | Railway wheel profile fine-tuning system for profile recommendation显示文摘This paper develops a wheel profile fine-tuning system(WPFTS)that comprehensively considers the influence of wheel profile on wheel damage,vehicle stability,vehicle safety,and passenger comfort.WPFTS can recommend one or more optimized wheel profiles according to train operators’needs,e.g.,reducing wheel wear,mitigating the development of wheel out-of-roundness(OOR),improving the shape stability of the wheel profile.Specifically,WPFTS includes four modules:(I)a wheel profile generation module based on the rotary-scaling finetuning(RSFT)method;(II)a multi-objective generation module consisting of a rigid multi-body dynamics simulation(MBS)model,an analytical model,and a rigid–flexible MBS model,for generating 11 objectives related to wheel damage,vehicle stability,vehicle safety,and passenger comfort;(III)a weight assignment module consisting of an adaptive weight assignment strategy and a manual weight assignment strategy;and(IV)an optimization module based on radial basis function(RBF)and particle swarm optimization(PSO).Finally,three cases are introduced to show how WPTFS recommends a wheel profile according to train operators’needs.Among them,a wheel profile with high shape stability,a wheel profile for mitigating the development of wheel OOR,and a wheel profile considering hunting stability and derailment safety are developed,respectively. | Yunguang Ye Jonas Vuitton Yu Sun Markus Hecht | 2021 | Railway Engineering Science2021，29，1： | 3 |
| 17 | Serum sIL-2R,TNF-α and IFN-γ in alveolar echinococcosis显示文摘AIM: To approach the relationship between alveolar echinococcosis (AE) pathology and level of sIL-2R,TNF-α and IFN-γ in sera and the significance of cytokines in development of AE.METHODS: After 23 patients with AE were confirmed by ELISA and ultrasound, their sera were collected and the concentrations of sIL-2R,TNF-α and IFN-γ were detected by double antibody sandwich. Twelve healthy adults served as controls. According to the status of livers of AE patients by ultrasound scanning, they were divided into 4 groups: P2,P3, P4 groups and C group (control). Average of concentrations of sIL-2R, TNF-α and IFN-yin homologous group was statistically analyzed by both ANOV and Newman-Keuls, respectively.RESULTS: The mean of sIL-2R in P2 group was 97±29, P3:226±80, P4:194±23 and control group (111±30)×10^3 u/L(P<0.01). The mean of TNF-α in P2 group was 1.12±0.20, P3:3.67±1.96, P4:1.30±0.25 and control group 0.40±0.19 μg/L(P<0.01). The mean of IFN-γ in P2 group was 360±20, P3:486±15, P4:259±19 and control group: 16±2 ng/L (P<0.01).Judged by ANOV and Newman-Keuls, the mean concentrations of sIL-2R, TNF-α and IFN-γ had a significant difference among groups. Except for P2group, the mean sIL-2R between other groups of AE patients had a significant difference (P<0.05). The mean of TNF-α concentration in P3 group was the highest (P<0.01). The mean of IFN-γ concentration in all patients was higher than that in control group (P<0.01),but there was no difference between AE groups (P>0.05).CONCLUSION: Low sIL-2R level indicates an early stage of AE or stable status, per contra, a progression stage. Higher level of TNF-α might be related to the lesion of liver. The role of single IFN-γ is limited in immunological defense against AE and it can not fully block pathological progression. | Da-Zhong Shi Fu-Rong Li B Bartholomot DA Vuitton PS Craig | 2004 | World Journal of Gastroenterology2004，10，24： | 3 |
| 18 | Auto-versus allo-transplantation of the liver for end-stage alveolar echinococcosis?显示文摘'We dreamt of it; they did it!' Reading the paper by WEN et al in this issue of the Chinese Medical Journal,1 we can not help but remember when our colleague Prof.Jean-Philippe Miguet, a hepatologist who was the first at the beginning of the 1970s to review the clinical cases of alveolar echinococcosis (AE)observed in our region of Eastern France and to renew our interest in that disease, used to tell Prof.Michel Gillet,his colleague hepatic surgeon who was the first in 1986 to succeed in transplanting a liver in a patient with AE:2 'You should rather resect the parasitic lesions from the diseased liver of the patient after removing it from the patient's body and re-transplant it!' We were at the beginning of the 1980s; it sounded like a joke, and for the first time, 30 years later, it has become true.In addition to a technical performance, this success in doing ex vivo resection of AE lesions and auto-transplanting the remaining liver is likely to become a demonstration of the best indication of that technique. | Georges A Mantion | 2011 | Chinese Medical Journal2011，，18： | 3 |
| 19 | Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans显示文摘 | Enrico Brunetti Peter Kern Dominique Angèle Vuitton | 2009 | Acta Tropica2009，，1： | 2 |
| 20 | WHO classification of alveolar echinococcosis: Principles and application显示文摘 | Peter Kern Hao Wen Naoki Sato Dominique A. Vuitton Beate Gruener Yinmei Shao Eric Delabrousse Wolfgang Kratzer Solange Bresson-Hadni | 2005 | Parasitology International2005，，： | 2 |
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