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| 1 | Total neoadjuvant therapy vs standard therapy of locally advanced rectal cancer with high-risk factors for failure显示文摘BACKGROUND For locally advanced rectal cancer(LARC),standard therapy[consisting of neoadjuvant chemoradiotherapy(CRT),surgery,and adjuvant chemotherapy(ChT)]achieves excellent local control.Unfortunately,survival is still poor due to distant metastases,which remains the leading cause of death among these patients.In recent years,the concept of total neoadjuvant treatment(TNT)has been developed,whereby all systemic ChT-mainly affecting micrometastases-is applied prior to surgery.AIM To compare standard therapy and total neoadjuvant therapy for LARC patients with high-risk factors for failure.METHODS In a retrospective study,we compared LARC patients with high-risk factors for failure who were treated with standard therapy or with TNT.High-risk for failure was defined according to the presence of at least one of the following factors:T4 stage;N2 stage;positive mesorectal fascia;extramural vascular invasion;positive lateral lymph node.TNT consisted of 12 wk of induction ChT with capecitabine and oxaliplatin or folinic acid,fluorouracil and oxaliplatin,CRT with capecitabine,and 6-8 wk of consolidation ChT with capecitabine and oxaliplatin or folinic acid,fluorouracil and oxaliplatin prior to surgery.The primary endpoint was pathological complete response(pCR).In total,72 patients treated with standard therapy and 89 patients treated with TNT were included in the analysis.RESULTS Compared to standard therapy,TNT showed a higher proportion of pCR(23%vs 7%;P=0.01),a lower neoadjuvant rectal score(median:8.43 vs 14.98;P<0.05),higher T-and N-downstaging(70%and 94%vs 51%and 86%),equivalent R0 resection(95%vs 93%),shorter time to stoma closure(mean:20 vs 33 wk;P<0.05),higher compliance during systemic ChT(completed all cycles 87%vs 76%;P<0.05),lower proportion of acute toxicity grade≥3 during ChT(3%vs 14%,P<0.05),and equivalent acute toxicity and compliance during CRT and in the postoperative period.The pCR rate in patients treated with TNT was significantly higher in patients irradiated with intensity-modulated radiotherapy/volumetricmodulated arc radiotherapy than with 3D conformal radiotherapy(32%vs 9%;P<0.05).CONCLUSION Compared to standard therapy,TNT provides better outcome for LARC patients with high-risk factors for failure,in terms of pCR and neoadjuvant rectal score. | Mojca Tuta Nina Boc Erik Brecelj Monika Peternel Vaneja Velenik | 2021 | World Journal of Gastrointestinal Oncology2021，13，2： | 3 |
| 2 | Neutrophil and monocyte CD64 indexes, lipopolysaccharide-binding protein, procalcitonin and C-reactive protein in sepsis of critically ill neonates and children显示文摘 | Mojca Groselj-Grenc Alojz Ihan Maja Pavcnik-Arnol Andreja Natasa Kopitar Tanja Gmeiner-Stopar Metka Derganc | 2009 | Intensive Care Medicine2009，，11： | 2 |
| 3 | The role of gender and sex hormones in ischemic-reperfusion injury in isolated rat hearts显示文摘 | PrimoZ Kular Mojca Lunder | 2007 | Europe-an Journal of Pharmacology2007，561，13： | 1 |
| 4 | High Prognostic Impact of Flow Cytometric Minimal Residual Disease Detection in Acute Myeloid Leukemia: Data From the HOVON/SAKK AML 42A Study显示文摘 | Monique Terwijn Wim L.J. van Putten Angèle Kelder Vincent H.J. van der Velden Rik A. Brooimans Thomas Pabst Johan Maertens Nancy Boeckx Georgine E. de Greef Peter J.M. Valk Frank W.M.B. Preijers Peter C. Huijgens Angelika M. Dr?ger Urs Schanz Mojca Jongen | 2013 | Journal of Clinical Oncology2013，，31： | 1 |
| 5 | Simulation-a new educational paradigm?显示文摘Simulation is a modern educational tool that has recently gained in the field of medical education. The use of simulation continues to expand, and studies evaluating the effectiveness of simulation-based medical education are ongoing. The history of medical education and adult educational theory are reviewed, and the details of effective simulation techniques are described. Finally, outcomes of simulation-based medical education are summarized. | Mojca Konia Aubrey Yao | 2013 | The Journal of Biomedical Research2013，27，2： | 1 |
| 6 | Solubility and diffusivity of CO2 in carboxylated polyesters 显示文摘 | Mojca Skerget Z M Z E | 2010 | Journal of Supercritical Fluids2010，，51： | 1 |
| 7 | Polymorphisms in the promoter region of the basic fibroblast growth factor gene and proliferative diabetic retinopathy in Caucasians with type 2 diabetes显示文摘 | Mojca Globo?nikPetrovi? MihaKrkovi? Jo?koOsredkar MarkoHawlina DanielPetrovi? | 2008 | Clinical & Experimental Ophthalmology2008，，2： | 1 |
| 8 | The dynamics of melittin-induced membrane permeability显示文摘 | Ga?per Kokot Mojca Mally Sa?a Svetina | 2012 | European Biophysics Journal2012，，5： | 1 |
| 9 | High-performance liquid chromatographic analysis of mevinolin as mevinolinic acid in fermentation broth显示文摘 | Jozica Friedrich Mateja Zuzek Mojca Bencina | 1995 | J Chromatogr A1995，704，： | 1 |
| 10 | Adhesion of two Lactobacillus gasseri probiotic strains on Caco-2 cells 显示文摘 | Bojana B M Mojca N Metoda Z | 2003 | Food Technol Biotechnol2003，41，1： | 1 |
| 11 | Antioxidant and antimicrobial activity of guarana seed extracts 显示文摘 | Lucija M Mojca S Keljko K | 2007 | Food Chem2007，104，： | 1 |
| 12 | Clinical and laboratory methods in diag nosis of acute appendicitis in children显示文摘 | Mojca Groselj Grenc | 2007 | Croat Med J2007，48，3： | 1 |
| 13 | Antioxidant and antimicrobial activity of guarana seed extracts显示文摘 | Lucija Majheni? Mojca ?kerget ?eljko Knez | 2007 | Food Chemistry2007，，3： | 1 |
| 14 | Ecological alternatives to the re duction and oxidation processes in dyeing with vat and sul phur dyes显示文摘 | Mojca Bozica Vanja Kokol | | 0，，02： | 1 |
| 15 | Clinical and laboratory methods in diagnosis of acute appendicitis in children显示文摘 | Mojca G Stane R Dubravka V | 2007 | Croat Med J2007，48，3： | 1 |
| 16 | Thecholesterol content of eggs produced by the Slovenianautochthonous Styrian hen显示文摘 | Mojca Simcic Vekoslava Stibilj Antonija Holcman | 2009 | Food Chemistry2009，114，： | 1 |
| 17 | Estimation of solid solubilities in supercritical carbon dioxide:Peng-Robinson adjustable binary parameters in the near critical region显示文摘 | MOJCA SKERGET ZORKA ZELJKO K | 2002 | Fluid Phase Equilibria2002，203，： | 1 |
| 18 | Extraction of phenolic compounds from elder berry and different grape marc varieties using organic solvents and/or supercritical carbon dioxide显示文摘 | T(U)NDE VATAI MOJCA (S)KERGET ZELJKO KNEZ | 2009 | Journal of Food Engineering2009，90，： | 1 |
| 19 | Evaluation of the phenolic content, antioxidant activity and colour of Slovenian honey显示文摘 | Jasna Bertoncelj Ur?ka Dober?ek Mojca Jamnik Terezija Golob | 2007 | Food Chemistry2007，，2： | 1 |
| 20 | Techniques for fingerprint recovery on vegetable and fruit surfaces used in Slovenia-A preliminary study显示文摘 | Matej Trapecar Mojca Kern Vinkovic | 2008 | Science and Justice2008，48，： | 1 |
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