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| 1 | STUDY ON THE HOT DEFORMATION BEHAVIORS OF Al-Zn-Mg-Cu-Cr ALUMINUM ALLOY显示文摘Al-Zn-Mg-Cu-Cr 铝合金的热变丑行为和 mierostructures 用热模拟测试,光显微镜学和传播电子显微镜学被学习了。作为结果,在各种各样的变丑条件下面的真压力对真紧张曲线和微观结构被获得。微观结构逐渐地倾向与升起的变丑温度和与变丑温度的减少或与提起紧张率精制的再结晶谷物动态再结晶。在在随后的热处理的 Zener-HoUomon 参数(Z) 和平均再结晶谷物尺寸之间的量的关系被建立。 | G. Y. Lin Z.F. Zhang H. Zhang D.S. Peng J. Zhou | 2008 | Acta Metallurgica Sinica(English Letters)2008，21，2： | 19 |
| 2 | Id2 regulates the proliferation of squamous cell carcinoma in vitro via the NF-κB/Cyclin D1 pathway显示文摘Squamous cell carcinoma (SCC) is a significant cause of cancer morbidity and mortality worldwide, with an incidence of up to 166 cases per 100 000 population. It arises in the skin, upper aerodigestive tract, lung, and cervix and affects more than 200 000 Americans each year. We report here that a microarray experiment comparing 41 SCC and 13 normal tissue specimens showed that Id2, a gene that controls the cell cycle, was significantly up-regulated in SCC. Enforced expression of Id2 in vitro stimulated the proliferation of SCC cells and up-regulated the transcription of nuclear factor kappa B (NF-κB) and cyclin D1. Enhancement of the NF-κB activity with p65 significantly increased the cell proliferation and the transcription of cyclin D1, whereas inhibition of the NF-κB activity with I kappa B alpha mutant (IκBα M) and pyrroline dithiocarbamate (PDTC) abrogated cell proliferation and transcription of cyclin D1. Furthermore, a mutated NF-κB binding site in the cyclin D1 promoter fully abrogated the Id2-induced transcription of cyclin D1. Taken together, these data indicate that Id2 induces SCC tumor growth and proliferation through the NF-κB/cyclin D1 pathway. | Chuan Wang Qiang Chen Yuki Hamajima Wei Sun Yi-Qing Zheng Xiao-Hua Hu Frank G. Ondrey Ji-Zhen Lin | 2012 | Chinese Journal of Cancer2012，31，9： | 8 |
| 3 | Genotoxic and tumorigenic pyrrolizidine alkaloids in Chinese herbal plants显示文摘Pyrrolizidine alkaloids are a class of hepatotoxic and tumorigenic compounds detected in Chinese herbal plants, contaminated foods, and dietary supplements. In this review, the sources, toxicity, genotoxicity, tumorigenicity, and the metabolic pathways, particular the activation pathways leading to hepatotoxicity and tumorigenicity, of pyrrolizidine alkaloids are briefly discussed, with a focus on the most recent important findings concerning the genotoxic mechanism by which riddelliine liver tumors. This mechanism involves the formation of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts and may be general to most carcinogenic pyrrolizidine alkaloids. | P.P. Fu Q. Xia M.W. Chou G. Lin | 2005 | Journal of Nanjing Medical University2005，19，1： | 6 |
| 4 | A Sustained Virologic Response Is Durable in Patients With Chronic Hepatitis C Treated With Peginterferon Alfa-2a and Ribavirin显示文摘 | Mark G. Swain Ming–Yang Lai Mitchell L. Shiffman W. Graham E. Cooksley Stefan Zeuzem Douglas T. Dieterich Armand Abergel Mário G. Pess?a Amy Lin Andreas Tietz Edward V. Connell Moisés Diago | 2010 | Gastroenterology2010，，5： | 3 |
| 5 | ncRNA- and Pc2 Methylation-Dependent Gene Relocation between Nuclear Structures Mediates Gene Activation Programs显示文摘 | Liuqing Yang Chunru Lin Wen Liu Jie Zhang Kenneth A. Ohgi Jonathan D. Grinstein Pieter C. Dorrestein Michael G. Rosenfeld | 2011 | Cell2011，，4： | 2 |
| 6 | A note on the numerical simulations of flow past a wavy square-section cylinder显示文摘经过有几何骚乱的方形节的柱体的流动被数字模拟调查。额外的条款,由于印射转变模仿的介绍,进转变 Navier 的骚乱的效果司烧方程,是正确地发源,并且在以前的文学的不正确的被指出并且分析。而且,在涡度之间的关系特别在柱体表面上,并且骚乱理论上被导出并且解释。计算与另一个目的在 0.006, 0.025 和 0.167 的起浪的 100 和 180 和三个振幅的二个雷纳兹数字被执行在身体上在 wake 和力量在旋涡动力学上探索不同雷纳兹数字和骚乱的效果。数字结果证明了在 0.025 的温和起浪,流的 K á r m á n 旋涡为 Re = 完全被压制 100,当强迫的旋涡脱臼被显得在时近在 180 的雷纳兹数字醒来。drag 减小在 Re = 直到 21.6% 100 和 25.7% 在 Re = 180 为 0.167 的高起浪与非起浪的柱体相比。电梯和与不同雷纳兹数字和波浪险峻改变的 Strouhal 数字也被获得。 | G. C. Ling L. M. Lin | 2008 | Acta Mechanica Sinica2008，24，1： | 2 |
| 7 | Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function显示文摘 | Lin Chen Simon N. Willis Andrew Wei Brian J. Smith Jamie I. Fletcher Mark G. Hinds Peter M. Colman Catherine L. Day Jerry M. Adams David C.S. Huang | 2005 | Molecular Cell2005，，3： | 2 |
| 8 | The Impact of a Statewide Pre-Hospital STEMI Strategy to Bypass Hospitals Without Percutaneous Coronary Intervention Capability on Treatment Times显示文摘 | Emil L. Fosbol Christopher B. Granger James G. Jollis Lisa Monk Li Lin Barbara L. Lytle Ying Xian J. Lee Garvey Greg Mears Claire C. Corbett Eric D. Peterson Seth W. Glickman | 2013 | Circulation2013，，5： | 2 |
| 9 | Randomized Clinical Trial of Cutting Balloon Angioplasty versus High-Pressure Balloon Angioplasty in Hemodialysis Arteriovenous Fistula Stenoses Resistant to Conventional Balloon Angioplasty显示文摘 | Syed Arafat Aftab Kiang Hiong Tay Farah G. Irani Richard Hoau Gong Lo Apoorva Gogna Benjamin Haaland Seck Guan Tan Siew Png Chng Shanker Pasupathy Hui Lin Choong Bien Soo Tan | 2013 | Journal of Vascular and Interventional Radiology2013，，： | 2 |
| 10 | 首次证实结核分枝杆菌发生了对异烟肼的复敏显示文摘背景:结核分枝杆菌耐药株在全世界范围内呈现播散的趋势,对全球的公共卫生造成了严重威胁。然而,关于耐药突变在菌群中是否永久存在,或者说在没有药物压力下耐药突变是否会发生逆转,目前还没有定论。目的:为证实在1位耐多药结核(TB)病人身上发生了异烟肼(INH)复敏的情况,并研究与之相关的细菌生存能力的降低。设计:应用基因型分析和表型分析研究来自1位肺结核病人的耐异烟肼分离株发生异烟肼复敏的情况。应用全敏感株重新构建了与复敏发生前katG突变一致的细菌模型(H_(37) Rv katG::katGW300G),并测试了此菌株对INH的敏感性和对氧化压力的反应。结果:基因分型和药物敏感性试验显示在不应用INH治疗的情况下,同一基因型的结核分枝杆菌菌株发生了从INH耐药向INH敏感的转变。对这种现象的基因型基础也进行了分析,发现katG的第300位密码子发生了改变,从GGG(甘氨酸,G)回复到野生型密码子TGG(色氨酸,W)。菌株H_(37)Rv katG::katG W300G对INH耐药,但是也同时显示出对氧化压力的反应性差。结论:此次研究证实,在没有INH药物压力的情况下,一些INH耐药突变株会转变成药物敏感的表型。此次发现对于研究异烟肼耐药的菌株和临床使用INH的时限可能有广泛的意义。 | E. T. Richardson S-Y. G. Lin B. A. Pinsky E. Desmond N.Banaei 黄海荣(译) 刘宇红(审校) | 2009 | 国际结核病与肺部疾病杂志2009，4，4： | 1 |
| 11 | p38 MAP Kinase Interacts with and Stabilizes Pancreatic and Duodenal Homeobox-1显示文摘 | G. Zhou H. Wang S.-H. Liu K. M. Shahi X. Lin J. Wu X.-H. Feng J. Qin T.-H. Tan F. C. Brunicardi | 2013 | Current Molecular Medicine2013，，3： | 1 |
| 12 | Rocky desertification and its causes in karst areas: a case study in Yongshun County, Hunan Province, China显示文摘 | Y. J. Xiong G. Y. Qiu D. K. Mo H. Lin H. Sun Q. X. Wang S. H. Zhao J. Yin | 2009 | Environmental Geology2009，，7： | 1 |
| 13 | Revolutionary Advances in the Management of Traumatic Wounds in the Emergency Department During the Last 40 Years: Part II显示文摘 | Richard F. Edlich George T. Rodeheaver John G. Thacker Kant Y. Lin David B. Drake Shelley S. Mason Courtney A. Wack Margot E. Chase Curt Tribble William B. Long Robert J. Vissers | 2010 | Journal of Emergency Medicine2010，，2： | 1 |
| 14 | Effect of water stress on photosystem 2 in two wheat cultivars显示文摘 | W. -J. Liu S. Yuan N. -H. Zhang T. Lei H. -G. Duan H. -G. Liang H. -H. Lin | 2006 | Biologia Plantarum2006，，4： | 1 |
| 15 | Hierarchically Designed SiOx/SiOy Bilayer Nanomembranes as Stable Anodes for Lithium Ion Batteries显示文摘 | Lin Zhang Junwen Deng Lifeng Liu Wenping Si Steffen Oswald Lixia Xi Manab Kundu Guozhi Ma Thomas Gemming Stefan Baunack Fei Ding Chenglin Yan Oliver G. Schmidt | 2014 | Adv Mater2014，，26： | 1 |
| 16 | Gangdese retroarc thrust belt and foreland basin deposits in the Damxung area, southern Tibet显示文摘 | Alex Pullen Paul Kapp George E. Gehrels Peter G. DeCelles Edwin H. Brown J. Matthew Fabijanic Lin Ding | 2008 | Journal of Asian Earth Sciences2008，，5： | 1 |
| 17 | Tannin Dynamics of Propagules and Leaves of Kandelia candel and Bruguiera gymnorrhiza in the Jiulong River Estuary, Fujian, China显示文摘 | Y. M. Lin J. W. Liu P. Xiang P. Lin G. F. Ye L. S. L. Sternberg | 2006 | Biogeochemistry2006，，3： | 1 |
| 18 | A Meta-analysis of Prospective Trials Comparing Percutaneous and Surgical Tracheostomy in Critically Ill Patients显示文摘 | Bradley D. Freeman Karen Isabella Natatia Lin Timothy G. Buchman | 2000 | Chest2000，，5： | 1 |
| 19 | Predictors of Postoperative Complications After Trimodality Therapy for Esophageal Cancer显示文摘 | Jingya Wang Caimiao Wei Susan L. Tucker Bevan Myles Matthew Palmer Wayne L. Hofstetter Stephen G. Swisher Jaffer A. Ajani James D. Cox Ritsuko Komaki Zhongxing Liao Steven H. Lin | 2013 | International Journal of Radiation Oncology Biology Physics2013，，5： | 1 |
| 20 | Who will fail laparoscopic Nissen fundoplication? Preoperative prediction of long-term outcomes显示文摘 | Craig B. Morgenthal Edward Lin Matthew D. Shane John G. Hunter C. Daniel Smith | 2007 | Surgical Endoscopy2007，，11： | 1 |
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