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| 1 | Nano-Graphene Oxide for Cellular Imaging and Drug Delivery显示文摘Two-dimensional graphene offers interesting electronic,thermal,and mechanical properties that are currently being explored for advanced electronics,membranes,and composites.Here we synthesize and explore the biological applications of nano-graphene oxide(NGO),i.e.,single-layer graphene oxide sheets down to a few nanometers in lateral width.We develop functionalization chemistry in order to impart solubility and compatibility of NGO in biological environments.We obtain size separated pegylated NGO sheets that are soluble in buffers and serum without agglomeration.The NGO sheets are found to be photoluminescent in the visible and infrared regions.The intrinsic photoluminescence(PL)of NGO is used for live cell imaging in the near-infrared(NIR)with little background.We found that simple physisorption viaπ-stacking can be used for loading doxorubicin,a widely used cancer drug onto NGO functionalized with antibody for selective killing of cancer cells in vitro.Owing to its small size,intrinsic optical properties,large specifi c surface area,low cost,and useful non-covalent interactions with aromatic drug molecules,NGO is a promising new material for biological and medical applications. | Xiaoming Sun Zhuang Liu Kevin Welsher Joshua Tucker Robinson Andrew Goodwin Sasa Zaric Hongjie Dai | 2008 | Nano Research2008，1，3： | 118 |
| 2 | 社会硅谷:社会创新的发生与发展显示文摘社会创新是为满足社会需求而进行的创造性行动和服务。近年来,随着人口老龄化、环境污染、酗酒等社会问题的日益严重,社会创新已迫在眉睫。尽管社会创新时有发生,但较之于商业和科技创新,人们对这方面的研究却较少。本文紧紧围绕社会创新的概念、发展简史、动力和过程等展开讨论,并把组合各种资源和能量以推动社会创新的机构喻为“社会硅谷”。 | 杰夫.摩根 Nick Wilkie Simon Tucker Rushanara Ali Francis Davis 张晓扬 | 2006 | 经济社会体制比较2006，，5： | 24 |
| 3 | No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk显示文摘AIM:To investigate the association of variations in the cyclooxygenase-2(COX2) and uridine diphosphate glucuronosyltransferase 1A6(UGT1A6) genes and non-steroidal anti-inflammatory drugs(NSAIDs) use with risk of colon cancer.METHODS:NSAIDs,which are known to reduce the risk of colon cancer,act directly on COX2 and reduce its activity.Epidemiological studies have associated variations in the COX2 gene with colon cancer risk,but others were unable to replicate this finding.Similarly,enzymes in the UGT1A6 gene have been demonstrated to modify the therapeutic effect of NSAIDs on colon adenomas.Polymorphisms in the UGT1A6 gene have been statistically shown to interact with NSAID intake to influence risk of developing colon adenomas,but not colon cancer.Here we examined the association of tagging single nucleotide polymorphisms(SNPs) in the COX2 and UGT1A6 genes,and their interaction with NSAID consumption,on risk of colon cancer in a population of 422 colon cancer cases and 481 population controls.RESULTS:No SNP in either gene was individually statistically significantly associated with colon cancer,nor did they statistically significantly change the protective effect of NSAID consumption in our sample.Like others,we were unable to replicate the association of variants in the COX2 gene with colon cancer risk(P > 0.05),and we did not observe that these variants modify the protective effect of NSAIDs(P > 0.05).We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk,although further studies will have to be conducted to confirm the association of these variants with colon adenomas.CONCLUSION:Our study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer. | Cheryl L Thompson Sarah J Plummer Alona Merkulova Iona Cheng Thomas C Tucker Graham Casey Li Li | 2009 | World Journal of Gastroenterology2009，15，18： | 11 |
| 4 | 两种快速检测西尼罗病毒方法的研究显示文摘目的建立可用于中国的蚊虫携带西尼罗病毒(WNV)监测的快速检测方法。方法选择两种快速检测方法VecTest试剂盒和Ramp系统,对其检测WNV的敏感性、精确性以及与流行性乙型脑炎(乙脑)病毒的交叉反应进行研究,同时对采自北京市野外的蚊虫进行WNV检测。结果Ramp试剂盒检测方法比VecTest试剂盒方法敏感性高,但后者检测时间短、操作简便,更适合现场筛查使用;经RT-PCR方法确认此2种快速检测方法无假阳性及假阴性结果;VecTest试剂盒和Ramp系统与乙脑病毒也无交叉反应。使用这2种检测方法对北京市6种野外蚊虫进行了WNV检测,结果均为阴性。结论VecTest试剂盒和Ramp系统均可用于WNV快速检测。 | 佟颖 曾晓芃 刘婷 肖萧 朱俊伟 Brad Tucker | 2006 | 中国媒介生物学及控制杂志2006，17，4： | 8 |
| 5 | 蒙椴树叶化学成分的研究显示文摘目的:对蒙椴树叶的化学成分进行研究。方法:通过使用乙醇溶液对蒙椴(T.mongolica Maxim.)树叶进行连续提取,利用柱层析、薄层层析、重结晶等分析提纯技术对提取物进行分离。结果:分离鉴定了3个化合物分别为β-香树脂醇乙酸酯(β-amyrin acetate)、β-香树脂醇(β-amyrin)和β-谷甾醇(β-sitosterol)。同时利用 GC-MS 对分离所得蜡状成分进行分析,确定该混合物所含烃的种类为十五到三十六碳的14种烷烃和贝壳杉-16-烯。结论:本实验方法可靠,可用于蒙椴树叶化学成分的研究。 | 王静媛 田福利 方利 David Tucker | 2005 | 药物分析杂志2005，25，9： | 8 |
| 6 | 比较临床应用第5天和第6天囊胚的玻璃化冷冻和传统的低温冷藏显示文摘Objective: To evaluate implantation of day 5 and day 6 vitrified and slow-frozen blastocysts. Design: Retrospective analysis comparing two cryopreservation techniques. Setting: Private IVF clinic. Patient(s): Five hundred eight cryopreserved embryo transfer candidates. Intervention(s): Supernumerary day 5 and day 6 blastocysts were vitrified or slow-frozen and transfered after warming or thawing. Main Outcome Measure(s): Comparison of two cryopreservation techniques with respect to survival rate, implantation, and pregnancy rates of day 5 and day 6 blastocysts. Result(s): In 254 vitrified transfer cycles, survival, embryonic implantation, and clinical pregnancy rates for day 5 blastocysts were 95.9% , 33.4% , 48.7% , respectively, and for day 6 blastocysts 97.5% , 25.9% , 42.8% . In 254 slow-frozen transfer cycles, survival, embryonic implantation, and clinical pregnancy rates for day 5 blastocysts were 91.4% , 29.6% , 42.8% , respectively, and for day 6 blastocysts 94.8% , 28.2% , 43.1% . Overall there was a slightly, but not significantly, higher outcome regarding implantation and clinical pregnancy with the use of day 5 blastocysts (31.3% and 45.4% , respectively) versus day 6 blastocysts (26.7, and 42.9% , respectively). Conclusion(s): Vitrification technique yields the same implantation and pregnancy rate as slow-frozen blastocyst transfers. Slow growing embryos can be cryopreserved on day 6, because they yield a satisfactory survival, implantation, and pregnancy rate. | Liebermann J. Tucker M.J. 张旸 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，11： | 8 |
| 7 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 8 | Assessing adequacy of emergency provider documentation among interhospital transferred patients with acute aortic dissection显示文摘BACKGROUND: Acute aortic dissection(AoD) is a hypertensive emergency often requiring the transfer of patients to higher care hospitals; thus, clinical care documentation and compliance with the Emergency Medical Treatment and Active Labor Act(EMTALA) is crucial. The study assessed emergency providers(EP) documentation of clinical care and EMTALA compliance among interhospital transferred AoD patients.METHODS: This retrospective study examined adult patients transferred directly from a referring emergency department(ED) to a quaternary academic center between January 1, 2011 and September 30, 2015. The primary outcome was the percentage of records with adequate documentation of clinical care(ADoCC). The secondary outcome was the percentage of records with adequate documentation of EMTALA compliance(ADoEMTALA). RESULTS: There were 563 electronically identified patients with 287 included in the final analysis. One hundred and five(36.6%) patients had ADoCC while 166(57.8%) patients had ADoEMTALA. Patients with inadequate documentation of EMTALA(IDoEMTALA) were associated with a higher likelihood of not meeting the American Heart Association(AHA) ED Departure SBP guideline(OR 1.8, 95% CI 1.03–3.2, P=0.04). Male gender, handwritten type of documentation, and transport by air were associated with an increased risk of inadequate documentation of clinical care(IDoCC), while receiving continuous infusion was associated with higher risk of IDoEMTALA.CONCLUSION: Documentation of clinical care and EMTALA compliance by Emergency Providers is poor. Inadequate EMTALA documentation was associated with a higher likelihood of patients not meeting the AHA ED Departure SBP guideline. Therefore, Emergency Providers should thoroughly document clinical care and EMTALA compliance among this critically ill group before transfer. | Mark Rose Carina Newton Benchaa Boualam Nancy Bogne Adam Ketchum Umang Shah Jordan Mitchell Safura Tanveer Tucker Lurie Walesia Robinson Rebecca Duncan Stephen Thom Quincy Khoi Tran | 2019 | World Journal of Emergency Medicine2019，10，2： | 5 |
| 9 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 10 | Milankovitch-driven cycles in the Precambrian of China:The Wumishan Formation显示文摘Carbonate strata of the Mesoproterozoic Wumishan Formation in the Jixian area near Tianjin are ~3300 m thick and were deposited over some 100 million years(from ~1310±20 Ma to ~1207±10 Ma).Metre-scale cycles(parasequences) dominate the succession.They are generally of the peritidal carbonate type,and mostly show an approximately symmetrical lithofacies succession with thick stromatolite biostromes and small thromboliteoncolite bioherms constituting the central part and tidal-flat dolomites forming the upper and lower parts.Lagoonal-supratidal dolomitic shales with palaeosol caps make up the topmost layers.The boundaries of the Wumishan cycles are typically exposure surfaces,and there is abundant evidence for fresh-water diagenesis.Widespread 1:4 stacking patterns indicate that the individual Wumishan cycles are sixthorder parasequences,with 4 parasequences constituting one fifth-order parasequence set.Locally,5-8 beds or couplets,can be discerned in some of the cycles.The regular vertical stacking pattern of beds within the sixth-order parasequences,forming the fifth-order parasequence sets,are interpreted as the result of environmental fluctuations controlled by Milankovitch rhythms,namely the superimposition of precession,and short and long-eccentricity.The widespread 1:4 stacking pattern in the cyclic succession,as well as the local 1:5-8 stacking patterns of the beds within the cycles,suggest that the Milankovitch rhythms had similar ratios in the Mesoproterozoic as in the Phanerozoic.Based on the cycle stacking patterns,26 thirdorder sequences can be distinguished and these group into 6 second-order,transgressiveregressive megasequences(or sequence sets),all reflecting a composite,hierarchical succession of relative sea-level changes. | Mei Mingxiang Maurice E. Tucker | 2013 | Journal of Palaeogeography2013，2，4： | 3 |
| 11 | Carbon dioxide insufflation during colonoscopy in deeply sedated patients显示文摘AIM:To compare the impact of carbon dioxide(CO2) and air insufflation on patient tolerance/safety in deeply sedated patients undergoing colonoscopy.METHODS:Patients referred for colonoscopy were randomized to receive either CO2 or air insufflation during the procedure.Both the colonoscopist and patient were blinded to the type of gas used.During the procedure,insertion and withdrawal times,caecal intubationrates,total sedation given and capnography readings were recorded.The level of sedation and magnitude of patient discomfort during the procedure was assessed by a nurse using a visual analogue scale(VAS)(0-3).Patients then graded their level of discomfort and abdominal bloating using a similar VAS.Complications during and after the procedure were recorded.RESULTS:A total of 142 patients were randomized with 72 in the air arm and 70 in the CO2 arm.Mean age between the two study groups were similar.Insertion time to the caecum was quicker in the CO2 group at 7.3 min vs 9.9 min with air(P = 0.0083).The average withdrawal times were not significantly different between the two groups.Caecal intubation rates were 94.4% and 100% in the air and CO2 groups respectively(P = 0.012).The level of discomfort assessed by the nurse was 0.69(air) and 0.39(CO2)(P = 0.0155) and by the patient 0.82(air) and 0.46(CO2)(P = 0.0228).The level of abdominal bloating was 0.97(air) and 0.36(CO2)(P = 0.001).Capnography readings trended to be higher in the CO2 group at the commencement,caecal intubation,and conclusion of the procedure,even though this was not significantly different when compared to readings obtained during air insufflation.There were no complications in both arms.CONCLUSION:CO2 insufflation during colonoscopy is more efficacious than air,allowing quicker and better cecal intubation rates.Abdominal discomfort and bloating were significantly less with CO2 insufflation. | Rajvinder Singh Eu Nice Neo Nazree Nordeen Ganesananthan Shanmuganathan Angelie Ashby Sharon Drummond Garry Nind Elizabeth Murphy Andrew Luck Graeme Tucker William Tam | 2012 | World Journal of Gastroenterology2012，18，25： | 3 |
| 12 | 学龄前儿童体力活动水平研究综述显示文摘本综述系统介绍了学龄前儿童(2-6岁)体力活动领域的相关研究。基于国民体育与体育教育协会(NAsPE)对学前儿童的体育运动指导原则进行测量,约半数儿童未达到身体锻炼建议的标准。仅有54%的参与者达到每日至少60分钟的身体活动水平。其中,男童比女童更多地参与体力活动。因此,一方面,需要在儿童中大力开展身体活动的有效干预;同时,鉴于标准化测量手段对于后续的比较研究与追踪研究十分重要,因而对于儿童体力活动的客观测量评估工具需进一步标化统一。 | Patricia Tucker 徐红 | 2014 | 青年学报2014，，3： | 3 |
| 13 | 云计算:充分发挥网络架构优势显示文摘当前,网络数据量、用户终端量的激增以及视频互动分享、设备协同、物联网等应用的蓬勃发展,使得市场和产业中需要全新的计算和服务模式。 | Lew Tucker | 2011 | 通信世界2011，，12： | 2 |
| 14 | Predictors of High-grade Esophagitis After Definitive Three-dimensional Conformal Therapy, Intensity-modulated Radiation Therapy, or Proton Beam Therapy for Non-small cell Lung Cancer显示文摘 | Daniel R. Gomez Susan L. Tucker Mary K. Martel Radhe Mohan Peter A. Balter Jose Luis Lopez Guerra Hongmei Liu Ritsuko Komaki James D. Cox Zhongxing Liao | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，： | 2 |
| 15 | No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer显示文摘AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based casecontrol study of incident colon cancer individuals (n= 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene. | Lynette S Phillips Cheryl L Thompson Alona Merkulova Sarah J Plummer Thomas C Tucker Graham Case Li Li | 2009 | World Journal of Gastroenterology2009，15，30： | 2 |
| 16 | Analysis of Sahelian vegetation dynamics using NOAA-AVHRR NDVI data from 1981–2003显示文摘 | A. Anyamba C.J. Tucker | 2005 | Journal of Arid Environments2005，，3： | 2 |
| 17 | The Effects of Salinity on Nitrogen Losses from an Oligohaline Estuarine Sediment显示文摘 | Anne E. Giblin Nathaniel B. Weston Gary T. Banta Jane Tucker Charles S. Hopkinson | 2010 | Estuaries and Coasts2010，，5： | 2 |
| 18 | Oxidative stress induces protein and DNA radical formation in follicular dendritic cells of the germinal center and modulates its cell death patterns in late sepsis显示文摘 | Saurabh Chatterjee Olivier Lardinois Suchandra Bhattacharjee Jeff Tucker Jean Corbett Leesa Deterding Marilyn Ehrenshaft Marcelo G. Bonini Ronald P. Mason | 2011 | Free Radical Biology and Medicine2011，，8： | 2 |
| 19 | Benthic metabolism and nutrient cycling in Boston Harbor, Massachusetts显示文摘 | Anne E. Giblin Charles S. Hopkinson Jane Tucker | 1997 | Estuaries1997，，2： | 2 |
| 20 | Involvement of cell motility in tumor progreasion显示文摘 | Boyer B Valles AM Tucker GC | 1993 | Symp Soc Exp Biol1993，47，： | 2 |
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