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| 1 | NG2 Cell Response in the CNP-EGFP Mouse After Contusive Spinal Cord Injury显示文摘成年动物中枢神经系统中的NG2细胞具有异质性。脊髓损伤(SCI)后,具有少突胶质前体细胞(OPCs)功能的NG2细胞亚型如何产生反应性变化及对其正常的发育过程有何影响目前还不清楚。本文采用少突胶质细胞系细胞表达EGFP的CNP-EGFP小鼠,研究正常和SCI后的NG2细胞的特征。在正常小鼠的白质中,对EGFP+NG2+双极细胞和EGFPnegNG2+多极细胞进行鉴别。SCI后,白质损伤边缘区中的EGFP+NG2+细胞3 d增殖达高峰,损伤中心区的EGFPnegNG2+细胞增殖在损伤后7 d达高峰。损伤后EGFP+NG2+细胞的Olig2、Sox10、Sox17等转录因子、基本的膜电生理参数以及钾电流表型均与发育过程增殖的OPCs一致。EGFPnegNG2+细胞不表达少突胶质发生中的转录因子。EGFP+CC1+少突胶质细胞6周时包含在EGFP+NG2+细胞增殖峰时表达BrdU的细胞。EGFPnegCC1+少突胶质细胞未被观察到。神经胶质生长因子2和成纤维细胞生长因子2处理促进少突胶质发生,提高EGFPnegNG2+细胞数量。因此,通过EGFP和转录因子表达,时空增殖类型及对生长因子的反应,两种类型的NG2+细胞对SCI刺激发生反应。SCI后EGFP+NG2+细胞经受细胞和生理变化特征,与在早期出生后的少突胶质发生过程中NG2+细胞中的变化类似。 | JUDITH M LYTLE RAMESH CHITTAJALLU JEAN R WRATHALL VITTORIO GALLO | 2009 | 神经损伤与功能重建2009，4，1： | 7 |
| 2 | 多支冠状动脉疾病且曾行冠状动脉搭桥术的患者中血运重建方法的预测因素和经皮冠状动脉介入术或再次冠状动脉搭桥术的长期预后显示文摘Aims: The optimal revascularization strategy in patients with symptomatic multivessel coronary artery disease(CAD) and previous coronary artery bypass grafting(CABG) remains unknown. Methods and results: We evaluated all patients with previous CABG undergoing isolated, non- emergency multivessel revascularization between 1 January 1995 and 31 December 2000. The analysis concentrated on the independent predictors of the revascularization method, as well as on long- term mortality and its predictors, after calculating a propensity score for the method of revascularization. There were 2191 patients(1487 with reoperation and 704 with percutaneous coronary intervention, PCI) in the study. The most important factors in choosing reoperation were presence of more diseased or occluded grafts, previous infarction, lower ejection fraction(EF), longer interval from first CABG, and more total occlusions of native arteries, as well as absence of a patent mammary graft. The distribution of the propensity score was skewed towards the two extremes. At 5 years, the unadjusted cumulative survival was 79.5% for CABG and 75.3% for PCI, P=0.008. After adjustment for the propensity score for PCI vs. CABG, PCI was associated with a hazard ratio of 1.47(0.94- 2.28), P=0.09. The most powerful predictors of mortality were higher age and lower EF. Conclusion: The choice of the revascularization method in patients with previous CABG is dictated mostly by anatomical considerations and less by clinical characteristics. In contrast, clinical characteristics predominantly affect long- term outcome, whereas the method of revascularization has a limited effect. A randomized clinical trial addressing this important segment of the population with ischaemic heart disease is warranted. | Brener S.J. Lytle B.W. Casserly I.P. 王亭忠 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，6： | 3 |
| 3 | 信息资源管理的进展:1979—1986显示文摘 | Lytle,RH | 1992 | 国外图书情报工作1992，，3： | 2 |
| 4 | Adaptation to natural flow regimes显示文摘 | David A. Lytle N.LeRoy Poff | 2003 | Trends in Ecology & Evolution2003，，2： | 2 |
| 5 | The Impact of a Statewide Pre-Hospital STEMI Strategy to Bypass Hospitals Without Percutaneous Coronary Intervention Capability on Treatment Times显示文摘 | Emil L. Fosbol Christopher B. Granger James G. Jollis Lisa Monk Li Lin Barbara L. Lytle Ying Xian J. Lee Garvey Greg Mears Claire C. Corbett Eric D. Peterson Seth W. Glickman | 2013 | Circulation2013，，5： | 2 |
| 6 | Apalladiumsulfide catalyst for electrolylic plating显示文摘 | Bladon J J LamolaA Lytle F W | 1996 | Electrochem Soc1996，143，： | 1 |
| 7 | Intrathecal baelofen withdrawal: A case report and review of the literature 显示文摘 | Alden TD Lytle RA Park TS Noetzel MJ Ojemann Jr2 2002 | 2002 | Childs Nerv Syst2002，18，： | 1 |
| 8 | Predicators of re-operation after myocardial revascularization显示文摘 | Cosgrove D M Loop F D Lytle B W | 1986 | J Thorac Cardiovasc Surg1986，92，： | 1 |
| 9 | Construction and Characterization of a 1,3-Propanediol Operon显示文摘 | Skraly F A Lytle B L Cameron D C | 1998 | Appl Environ Microbiol1998，64，： | 1 |
| 10 | Overexpression of ATP sulfurylase in Indian mustard leads to increased selenate uptake,reduction,and tolerance显示文摘 | PILON-MITS E A H HWANG S LYTLE C M | 1999 | Plant Physiol1999，119，10： | 1 |
| 11 | Comparison of saphenous vein and internal thoracic artery graft patency by coronary system 显示文摘 | Sabik JF Lytle BW Blaekstone EH | 2005 | Ann Thorae Surg2005，79，2： | 1 |
| 12 | Iron corrosionscales : model for scale growth,iron release,and coloredwater formation 显示文摘 | Sarin P Snoeyink V L Lytle D A ei al | 2004 | J Environ Eng-ASCE2004，130，4： | 1 |
| 13 | Selenium assimil-ation and volatilization from dimethylselenoniopmpionate by Indianmustard显示文摘 | DE SOUZA M P LYTLE C M MULHOLLANI)M M | 2000 | Plant Physiol2000，122，4： | 1 |
| 14 | Target mRNAs are repressed as ef-ficiently by microRNA-binding sites in the 5 ’ UTR as in the3’UTR 显示文摘 | Lytle JR Yario TA Steitz JA | 2007 | Proc Natl Acad Sci USA2007，104，23： | 1 |
| 15 | TargetmRNAs are repressed as efficiently by microRNA-binding sites in the 5'UTR as in the 3-UTR显示文摘 | LYTLE J R YARIO T A STEITZ J A | 2007 | ProcNat Acad Sci2007，104，： | 1 |
| 16 | 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease显示文摘 | Loren F. Hiratzka George L. Bakris Joshua A. Beckman Robert M. Bersin Vincent F. Carr Donald E. Casey Kim A. Eagle Luke K. Hermann Eric M. Isselbacher Ella A. Kazerooni Nicholas T. Kouchoukos Bruce W. Lytle Dianna M. Milewicz David L. Reich Souvik Sen Jul | 2010 | Journal of the American College of Cardiology2010，，14： | 1 |
| 17 | The body image and re- lationship scale:development and validation of a measure of body image in female breast cancer suivivors显示文摘 | Hormes JA Lytle LA Gross CR | 2008 | J Clin Oncol2008，26，8： | 1 |
| 18 | Comparison of saphenous vein and internal thoracic artery graft patency by coronary system 显示文摘 | Sabik JF Lytle BW Blackstone EH | 2005 | Ann Thorac Surg2005，79，2： | 1 |
| 19 | Two internal thoracic artery grafts are better than one显示文摘 | Lytle BW Blackstone EH Loop FD | 1999 | J Thorac Cardiovase Surg1999，117，5： | 1 |
| 20 | On-pump and off-pump coronary bypass sur- gery显示文摘 | Lytle BW | 2007 | Circ J2007，116，5： | 1 |
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