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| 1 | Heteromeric and Homomeric Geranyl Diphosphate Synthases from Catharanthus roseus and Their Role in Monoterpene Indole Alkaloid Biosynthesis显示文摘Catharanthus roseus 是二很重要的 monoterpene 吲哚碱(MIA ) 的唯一的来源反癌症代理人:vinblastine 和长春新碱。MIA 拥有萜烯和分别地从 terpenoid 和 shikimate 小径导出的吲哚一半。Geranyl diphosphate (GPP ) ,入口点到萜烯一半的形成,由 GPP synthase (GPPS ) 是 isopentenyl diphosphate (IPP ) 和 dimethylallyl diphosphate (DMAPP ) 的冷凝作用的一个产品。这里,我们报导与顺序类似编码蛋白质到大子单元(CrGPPS.LSU ) 和 heteromeric GPPS,和 homomeric 的小子单元(CrGPPS.SSU ) 的三基因 GPPS。CrGPPS.LSU 是生产 GPP 和 geranyl geranyl diphosphate (GGPP ) 的 bifunctional 酶, CrGPPS.SSU 是不活跃的,而 CrGPPS 是形成 GPP 的 homomeric 酶。在 Escherichia coli 的两个子单元的合作表示与生产仅仅 GPP 的提高的活动导致了 heteromeric 酶。当 CrGPPS.LSU 和 CrGPPS 在更旧、更年轻的叶子显示出更高的表示时,分别地, CrGPPS.SSU 显示出一个增加的趋势并且逐渐地减少了。叶子的甲基 jasmonate (MeJA ) 处理显著地导致了仅仅 CrGPPS.SSU 的表示。而 CrGPPS 是 mitochondrial, GFP 本地化显示 CrGPPS.SSU 是 plastidial。在 C 的 AmGPPS.SSU 的短暂 overexpression。roseus 叶子导致了增加的 vindoline, vinblastine 和长春新碱的立即的 monomeric 先锋。尽管 C。roseus 有 heteromeric 和 homomeric GPPS 酶,我们的结果含有有为 MIA 生合成调整 GPP 流动的 CrGPPS.SSU 的仅仅 heteromeric GPPS 的参与。 | Avanish Rai Shachi S. Smita Anup Kumar Singh Karuna Shanker Dinesh A. Nagegowda | 2013 | Molecular Plant2013，6，5： | 20 |
| 2 | Autochthonous halotolerant plant growth-promoting rhizobacteria promote bacoside A yield of Bacopa monnieri(L.)Nash and phytoextraction of salt-affected soil显示文摘Phytoremediation is a promising approach for reclamation of salt-affected soil.Phytoextraction is the most commonly used process,which exploits plants to absorb,immobilize,and accumulate salt in their shoots.In this study,halotolerant plant growth-promoting rhizobacteria(PGPR)were isolated from the rhizosphere of wild grasses growing naturally in salt-affected areas of Lucknow,Uttar Pradesh(India)and were tested for their efficacies of salt-tolerance and plant growth-promoting(PGP)abilities.Based on 16S rRNA sequences,the most efficient halotolerant isolates possessing PGP traits were identified as Pseudomonas plecoglossicida(KM 233646),Acinetobacter calcoaceticus(KM 233647),Bacillus flexus(KM 233648),and Bacillus safensis(KM 233652).Application of these isolates as bio-inoculants significantly(P<0.05)increased the growth and bacoside A yield of a medicinal plant,Bacopa monnieri(L.)Nash,grown on natural salt-affected soil.The phytoremediation of salt-affected soil was evident by the substantial increase in shoot Na^+:K^+ratio of bio-inoculant-treated plants.When compared to un-inoculated control plants,the soil physico-chemical properties of bio-inoculant-treated plants were improved.The shoot and root biomass(fresh and dry weights),soil enzymes,and soil nutrient parameters showed significant positive correlations with the shoot Na+:K+ratio.Consequently,the halotolerant PGPR screened in this study could be useful for the reclamation of saline soils concomitant with improved plant growth and bacoside A yield. | Umesh PANKAJ Durgesh Narain SINGH Pooja MISHRA Pooja GAUR C.S.Vivek BABU Karuna SHANKER Rajesh Kumar VERMA | 2020 | Pedosphere2020，30，5： | 9 |
| 3 | Spinal manipulation therapy: Is it all about the brain? A current review of the neurophysiological effects of manipulation显示文摘Spinal manipulation has been an effective intervention for the management of various musculoskeletal disorders. However,the mechanisms underlying the pain modulatory effects of spinal manipulation remain elusive. Although both biomechanical and neurophysiological phenomena have been thought to play a role in the observed clinical effects of spinal manipulation, a growing number of recent studies have indicated peripheral, spinal and supraspinal mechanisms of manipulation and suggested that the improved clinical outcomes are largely of neurophysiological origin. In this article, we reviewed the relevance of various neurophysiological theories with respect to the findings of mechanistic studies that demonstrated neural responses following spinal manipulation. This article also discussed whether these neural responses are associated with the possible neurophysiological mechanisms of spinal manipulation. The body of literature reviewed herein suggested some clear neurophysiological changes following spinal manipulation, which include neural plastic changes, alteration in motor neuron excitability,increase in cortical drive and many more. However, the clinical relevance of these changes in relation to the mechanisms that underlie the effectiveness of spinal manipulation is still unclear. In addition,there were some major methodological flaws in many of the reviewed studies. Future mechanistic studies should have an appropriate study design and methodology and should plan for a long-term follow-up in order to determine the clinical significance of the neural responses evoked following spinal manipulation. | Giles Gyer Jimmy Michael James Inklebarger Jaya Shanker Tedla | 2019 | Journal of Integrative Medicine2019，17，5： | 3 |
| 4 | Studies on the decay characteristics of strontium aluminate phosphor on thermal treatment显示文摘 | Haranath D Virendra Shanker Harish Chander | 2002 | Material Chemistry and Phisics2002，，78： | 2 |
| 5 | Progress in the research and development of nerve conduits显示文摘The reconstruction after peripheral nerve damage, especially for long‐segment nerve defects, remains a clinical challenge. Autologous nerve graft transplantation is an efficient method for the repair of peripheral nerve defects, but the involved com‐plications and shortcomings have greatly limited the clinical efficacy of treatments offered to patients with nerve defects. Thus, there is an urgent need to develop new therapeutic strategies and explore alternatives to autologous nerve transplantation in clinical practice, based on the knowledge of the peripheral nerve regeneration mechanism and biological histocompatibility principles. With significant advances in the research and application of nerve conduits, they have been used to repair peripheral nerve injury for several decades. In this paper, the study background of nerve conduits, their applications in clinic, status of conduit material research and construction of tissue‐engineered artificial nerves were reviewed. | Xiyuan Wang Lin Chen Qiang Ao Aruna Sharma Hari Shanker Sharma | 2015 | Translational Neuroscience and Clinics2015，1，2： | 2 |
| 6 | Selenium – an antioxidative protectant in soybean during senescence显示文摘 | M. Djanaguiraman D. Durga Devi Arun K. Shanker J. Annie Sheeba U. Bangarusamy | 2005 | Plant and Soil2005，，1： | 2 |
| 7 | 激光表面熔化对SiC和MoS2颗粒增强Al-4.5Cu复合材料表面完整性的影响(英文)显示文摘以Al-4.5Cu合金为基体,用搅拌铸造法制备两种复合材料。一种是用10%SiC(质量分数)和2%MoS2(质量分数)进行增强,另一种是用10%SiC(质量分数)和4%MoS2(质量分数)进行增强。为了研究激光表面熔化(LSM)对材料表面性能的影响,采用CO2激光束对材料表面进行重熔。研究激光熔化表面的形貌、显微硬度、耐蚀性和耐磨性。将LSM后的整体表面完整性与铸态表面进行比较。结果表明,LSM能提高每种情况下表面的显微硬度和耐磨性。激光熔化表面孔隙率低,耐蚀性高。因此,LSM可以方便地应用于提高铝基复合材料的表面完整性。然而,在本研究中存在一个最佳的激光比能以获得最佳的表面完整性,约为38 J/m^2。 | Praveen Kumar BANNARAVURI Anil Kumar BIRRU Uday Shanker DIXIT | 2020 | Transactions of Nonferrous Metals Society of China2020，30，2： | 2 |
| 8 | Lowered expression levels of a tumor suppressor gene — Caveolin-1 within dysregulated gene networks of Fanconi anemia显示文摘 | Pavithra Shyamsunder Prasanna Vidyasekar Akshay Ranjan Shukla Sheila Mohan Rama Shanker Verma | 2013 | Gene2013，，： | 2 |
| 9 | Randomized Clinical Trial of Cutting Balloon Angioplasty versus High-Pressure Balloon Angioplasty in Hemodialysis Arteriovenous Fistula Stenoses Resistant to Conventional Balloon Angioplasty显示文摘 | Syed Arafat Aftab Kiang Hiong Tay Farah G. Irani Richard Hoau Gong Lo Apoorva Gogna Benjamin Haaland Seck Guan Tan Siew Png Chng Shanker Pasupathy Hui Lin Choong Bien Soo Tan | 2013 | Journal of Vascular and Interventional Radiology2013，，： | 2 |
| 10 | Involvement of iron and free radicals in benzene toxicity显示文摘 | Khan W A Gupta A Shanker U | 1984 | Biochem Pharmacol1984，33，13： | 1 |
| 11 | TNF-related apoptosis-inducing ligand as a therapeutic agent in au-toimmunity and cancer 显示文摘 | Cretney E Shanker A Yagita H | 2006 | Immunol Cell Biol2006，84，1： | 1 |
| 12 | An in vitro technique for measuring contact angles on the corneal surface and its application to evaluate corneal wetting propertlies of water sohble polymers 显示文摘 | Shanker RM Ahmed I Bottrassa PA | 1995 | IntJPharm1995，119，2： | 1 |
| 13 | Methylmercury-induced reactive oxygen species formation in neonatal cerebral astrocytic cultures is attenuated by antioxidants显示文摘 | Aschner M | 2003 | Brain Res Mol Brain Res2003，110，1： | 1 |
| 14 | A case report on XO/XX/XXX mixoploidy in goat 显示文摘 | Bhatia S Shanker V | 1990 | The Veterinary Record1990，126，： | 1 |
| 15 | Biofilm vaccine of Aeromonas hydrophila-standardization of dose and duration for oral vaccination of carps 显示文摘 | Azad I S Shanker K M Mohan C V | 1999 | Fish & Shellfish Immunology1999，9，： | 1 |
| 16 | Flood risk mapping for Pad River incorporating sediment transport显示文摘 | Shanker K S Aminuddin A G Sanusi S A | 2003 | Environmental Modelling and Software2003，18，2： | 1 |
| 17 | Glucosamine infusion in rats mimics the β-cell dysfunction of non-insulin-dependent diabetes mellitus显示文摘 | Shanker RR Zhu JS Baron AD | | 0，，： | 1 |
| 18 | Bioinformatically mined simple sequence repeats in UniGene of Citrus sinensis显示文摘 | Shanker A Bhargava A Bajpai R | 2007 | Scientia Horticulturae2007，113，： | 1 |
| 19 | Persistence of acetamipfid in tea and its transfer from made tea to infusion 显示文摘 | GUPTA M SHANKER A | 2008 | Food Chem2008，111，4： | 1 |
| 20 | Study of mercury-selenium (Hg-Se) interactions and their impact on Hg uptake by the radish (Raphanus sativus) plant显示文摘 | Shanker K Mishra S Srivastava S | | 0，，09： | 1 |
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