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| 1 | Quality indicators for colonoscopy: Current insights and caveats显示文摘Colonoscopy is the diagnostic modality of choice for investigation of symptoms suspected to be related to the colon and for the detection of polyps and colorectal cancer(CRC). Colonoscopy with removal of detected polyps has been shown to reduce the incidence and mortality of subsequent CRC. In many countries, population screening programs for CRC have been initiated, either by selection of patients for colonoscopy with fecal occult blood testing or by offering colonoscopy directly to average-risk individuals. Several endoscopy societies have formulated quality indicators for colonoscopy. These quality indicators are almost always incorporated as process indicators, rather than outcome measures. This review focuses on the quality indicators bowel preparation, cecal intubation rate, withdrawal time, adenoma detection rate, patient comfort, sedation and complication rate, and discusses the scientific evidence supporting them,as well as their potential shortcomings and issues that need to be addressed. For instance, there is still no clear and generally accepted definition of adequatebowel preparation, no robust scientific evidence is available supporting a cecal intubation rate ≥ 90% and the association between withdrawal time and occurrence of interval cancers has not been clarified. Adenoma detection rate is currently the only quality indicator that has been shown to be associated with interval colorectal cancer, but as an indicator it does not differentiate between subjects with one or more adenoma detected. | Hendrikus JM Pullens Peter D Siersema | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，12： | 7 |
| 2 | Alpha-adrenoceptor antagonism by Crassostrea gigas oyster extract inhibits noradrenalineinduced vascular contraction in Wistar rats显示文摘OBJECTIVE: Crassostrea gigas oyster extract has been reported to have antioxidant, antihypertensive and lipid-lowering properties that may be useful for treating cardiovascular diseases. This study aimed to evaluate the effect of C. gigas oyster extract on cardiovascular function in tissues from healthy rats. METHODS: Single-cell microelectrode and isolated thoracic aortic organ bath studies were performed on tissues from 8-week-old healthy Wistar rats, using varying concentrations of C. gigas oyster extract. To elucidate a mechanism of action for the oyster's vasoactive properties, concentration response curves were carried out in the presence of a calcium channel inhibitior(verapamil), a nitric oxide synthase inhibitor(N G-nitro-L-arginine methyl ester), a potassium channel inhibitor(4-aminopyridine), in addition to the α-adrenoceptor inhibitor prazosin. RESULTS: Oyster solution at 7 500 mg/m L inhibited noradrenaline-induced contraction in isolated aortic rings. Cardiac electrophysiology results showed that neither concentration of oyster solution was able to significantly reduce action potential duration at all phases of repolarisation in left ventricular papillary muscles from healthy animals. CONCLUSION: When administered to healthy vascular tissue, C. gigas oyster extract inhibits contraction induced by noradrenaline. This effect is likely to be mediated through α-adrenoceptor inhibition, and to a lesser extent, calcium modulating activity. | Kylie Connolly Douglas Jackson Candice Pullen Andrew Fenning | 2015 | Journal of Integrative Medicine2015，13，3： | 3 |
| 3 | Risk - and response -based classification of childhood B - precursor acute lymphoblastic leukemia: A combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children's Cancer Group (CCG) 显示文摘 | Schultz KR Pullen DJ Sather HN | 2007 | Blood2007，109，3： | 1 |
| 4 | Surface oxide cracking associated with oxidation-induced grain boundary sliding in the underlying alloy显示文摘 | NYCHKAJ A PULLEN C HE MY | 2004 | Acta Mater2004，52，： | 1 |
| 5 | A random network model of message transmission显示文摘 | Pullen K W | 1986 | Networks1986，16，4： | 1 |
| 6 | The Flame Retardants Tetrabromobisphenol A-Bisallylether Suppress the Induction of Interleukin-2 Receptor a Chain (CD25) in Murine Splenocytes显示文摘 | Sabine Pullen Ronald Boecker Gisa Tiegs | 2003 | Toxicology2003，184，： | 1 |
| 7 | Effects of oncogenic ErbB2on G1 cell cycle regulators in breast tumor cells显示文摘 | Sutterluty H Pullen N | 2000 | Oncogene2000，19，13： | 1 |
| 8 | Hydra mutants of arabidopsis are defective in dterol profiles and auxin and ethylene signaling显示文摘 | SOUTER M TOPPINGJ PULLEN M | 2002 | The Plant Cell2002，14，： | 1 |
| 9 | The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70 S6k显示文摘 | von Manteuffel SR Dennis PB Pullen N | 1997 | Mol Cell Biol1997，17，9： | 1 |
| 10 | Motion capture assisted animation 显示文摘 | Pullen Katherine Bregler Christoph | 2001 | Texturing and Synthesis Computer Graphics2001，3，7： | 1 |
| 11 | On the plastic contact of rough surfaces 显示文摘 | PULLEN J WILLIAMSON J B P | 1972 | Proc R Soc London Ser A1972，327，： | 1 |
| 12 | Dynamic programming app-lied to ship fleet management显示文摘 | Nicholson T A J Pullen R D | 1971 | Operational Research Quarterly1971，22，3： | 1 |
| 13 | Phosphorylation and activation of p70s6k by PDK1显示文摘 | Pullen N Dennis P B Andjelkovic M | 1998 | Science1998，279，5351： | 1 |
| 14 | Localisation of NMU1R and NMU2R in human and rat central nervous system and effects of neuromedin-U following central administration in rats 显示文摘 | Gartlon J Szekeres P Pullen M | 2004 | Psychopharmacology2004，177，12： | 1 |
| 15 | Risk- and response- based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children' s Cancer Group (CCG) 显示文摘 | Schultz KR Pullen D J Sather HN | 2007 | Blood2007，109，3： | 1 |
| 16 | Urban canopy modeling of the New York City metropolitan area: A comparison and validation of single-and multilayer parameterizations显示文摘 | HOLT T PULLEN J | 2007 | Mon Wea Rev2007，135，5： | 1 |
| 17 | On the plastic contact of rough surfaces显示文摘 | PULLEN J WILLIAMSON J B P | 1972 | Proceedings of the Royal Society of London1972，327，： | 1 |
| 18 | The flame retardants tetrabromobisphenol A and tetrabromobisphenol A- bisallylether suppress the induction of interleukin-2 receptor alpha chain (CD25) in murine splenocytes 显示文摘 | Pullen S Boecker R Tiegs G | 2003 | Toxicology2003，184，1： | 1 |
| 19 | Stimulation of hyaluronan synthetase by platelet-derived growth factor bb in human prostate smooth muscle cells显示文摘 | Pullen M Thomas K Wu H | 2001 | Pharmacology2001，62，2： | 1 |
| 20 | Platinum anticancer agents and antidepressants:desipramine enhances platinum-based cytotoxicity in human colon cancer cells显示文摘 | Kabolizadeh P Engelmann B Pullen N | | 0，，： | 1 |
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