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| 1 | p53 mutations in colorectal cancer-molecular pathogenesis and pharmacological reactivation显示文摘Colorectal cancer(CRC) is one of the most common malignancies with high prevalence and low 5-year survival.CRC is a heterogeneous disease with a complex,genetic and biochemical background.It is now generally accepted that a few important intracellular signaling pathways,including Wnt/β-catenin signaling,Ras signaling,and p53 signaling are frequently dysregulated in CRC.Patients with mutant p53 gene are often resistant to current therapies,conferring poor prognosis.Tumor suppressor p53 protein is a transcription factor inducing cell cycle arrest,senescence,and apoptosis under cellular stress.Emerging evidence from laboratories and clinical trials shows that some small molecule inhibitors exert anti-cancer effect via reactivation and restoration of p53 function.In this review,we summarize the p53 function and characterize its mutations in CRC.The involvement of p53 mutations in pathogenesis of CRC and their clinical impacts will be highlighted.Moreover,we also describe the current achievements of using p53 modulators to reactivate this pathway in CRC,which may have great potential as novel anti-cancer therapy. | Xiao-Lan Li Jianbiao Zhou Zhi-Rong Chen Wee-Joo Chng | 2015 | World Journal of Gastroenterology2015，21，1： | 30 |
| 2 | 基于DTW的语音关键词检出显示文摘针对少资源语言的语音关键词检出技术受到了广泛关注。该文在基于动态时间规整(dynamic time warping,DTW)的关键词检出框架下,提出了基于音素边界的局部匹配策略,用以解决基于样例的语音关键词检出任务中的近似查询问题。在QUESST 2014评测数据上采用多种特征进行了实验验证。实验结果显示:基于音素边界的局部匹配策略不仅在近似查询T2和T3任务上的检出效果明显提升,在精确查询T1任务上也获得了有效提升。随后的系统融合实验表明,该策略能够大幅提升融合系统的性能。 | 侯靖勇 谢磊 杨鹏 肖雄 梁祥智 徐海华 王磊 吕航 马斌 CHNG EngSiong 李海洲 | 2017 | 清华大学学报(自然科学版)2017，57，1： | 11 |
| 3 | Hypoxia increases adipogenesis and affects adipocytokine production in orbital fibroblasts-a possible explanation of the link between smoking and Graves' ophthalmopathy显示文摘AIM:To assess the effects of hypoxia on human orbital fibroblasts(OF)on adipogenesis and adipocytokine production.METHODS:Human OF were derived from tissues obtained from patients with Graves'ophthalmopathy(GO)and from patients without known thyroid diseases undergoing blepharoplasty.The OF were cultured separately under normoxic and hypoxic conditions.Comparisons of adipocytokine concentrations using multiplex ELISA and lipid accumulation in the cells using Oil Red O staining were subsequently performed.RESULTS:There was increased adipogenesis in OF from GO subject when exposed to hypoxic culture conditions.This was not observed in OF from normal controls.Hypoxia led to an increase in leptin and a decrease in MCP-1 secretion in OF cultures.CONCLUSION:Hypoxia induces adipogenesis in OF and may represent a mechanism by which smoking contributes to deterioration of GO.We also found novel changes to leptin and MCP-1 production in OF cultures exposed to hypoxia suggesting important roles of these cytokines in the disease process. | Chiaw Ling Chng Oi Fah Lai Charmaine Sze-Min Chew Yu Pei Peh Stephanie Man-Chung Fook-Chong Lay Leng Seah Daphne Hsu-Chin Khoo | 2014 | International Journal of Ophthalmology(English edition)2014，7，3： | 10 |
| 4 | Identification and targeting leukemia stem cells: The path to the cure for acute myeloid leukemia显示文摘Accumulating evidence support the notion that acute myeloid leukemia(AML) is organized in a hierarchical system, originating from a special proportion of leukemia stem cells(LSC). Similar to their normal counterpart, hematopoietic stem cells(HSC), LSC possess selfrenewal capacity and are responsible for the continued growth and proliferation of the bulk of leukemia cells in the blood and bone marrow. It is believed that LSC are also the root cause for the treatment failure and relapse of AML because LSC are often resistant to chemotherapy. In the past decade, we have made significant advancement in identification and understanding the molecular biology of LSC, but it remains a daunting task to specifically targeting LSC, while sparing normalHSC. In this review, we will first provide a historical overview of the discovery of LSC, followed by a summary of identification and separation of LSC by either cell surface markers or functional assays. Next, the review will focus on the current, various strategies for eradicating LSC. Finally, we will highlight future directions and challenges ahead of our ultimate goal for the cure of AML by targeting LSC. | Jianbiao Zhou Wee-Joo Chng | 2014 | World Journal of Stem Cells2014，6，4： | 9 |
| 5 | miRNA deregulation in multiple myeloma显示文摘多重骨髓瘤(公里) 是医不好的血浆房间恶意并且是第二很普通的 hematological 癌症。它被建筑群描绘,周期性基因并且 epigenetic 畸形。最近的出版物连接了 miRNAs,到包括公里的癌症的基因管理者的一个新奇的班。miRNAs 是大约 20 核苷酸,单个海滨,镇压的非编码的 RNA 由 mRNA 的基因表示降级或翻译压抑。异常 miRNA 表示侧面在公里被描述了,并且他们在公里致病的功能的角色逐渐地正在被认出。这评论在公里管理在未来研究和 miRNAs 的利用上在公里和提议观点在 miRNAs 的角色上总结当前的文学。 | BI Chong Lei CHNG Wee Joo | 2011 | Chinese Medical Journal2011，，19： | 5 |
| 6 | Novel mechanism of drug resistance to proteasome inhibitors in multiple myeloma显示文摘Multiple myeloma(MM) is a cancer caused by uncontrolled proliferation of antibody-secreting plasma cells in bone marrow, which represents the second most common hematological malignancy. MM is a highly heterogeneous disease and can be classified into a spectrum of subgroups based on their molecular and cytogenetic abnormalities. In the past decade, novel therapies, especially, the first-in-class proteasome inhibitor bortezomib, have been revolutionary for the treatment of MM patients. Despite these remarkable achievements, myeloma remains incurable with a high frequency of patients suffering from a relapse, due to drug resistance. Mutation in the proteasome β5-subunit(PSMB5) was found in a bortezomib-resistant cell line generated via long-term coculture with increasing concentrations of bortezomib in 2008, but their actual implication in drug resistance in the clinic has not been reported until recently. A recent study discovered four resistance-inducing PSMB5 mutations from a relapsed MM patient receiving prolonged bortezomib treatment. Analysis of the dynamic clonal evolution revealed that two subclones existed at the onset of disease, while the other two subclones were induced. Protein structural modeling and functional assays demonstrated that all four mutations impaired the binding of bortezomib to the 20 S proteasome, conferring different degrees of resistance. The authors further demonstrated two potential approaches to overcome drug resistance by using combination therapy for targeting proteolysis machinery independent of the 20 S proteasome. | Jianbiao Zhou Wee-Joo Chng | 2019 | World Journal of Clinical Oncology2019，10，9： | 3 |
| 7 | MMSET: Role and Therapeutic Opportunities in Multiple Myeloma显示文摘 | Zhigang Xie Wee Joo Chng Dong Soon Lee | 2014 | BioMed Research International2014，，： | 2 |
| 8 | Hepatitis B virus reactivation in B-cell lymphoma patients treated with rituximab: Analysis from the Asia Lymphoma Study Group显示文摘 | Seok Jin Kim Chiun Hsu Yu-Qin Song Kevin Tay Xiao-Nan Hong Junning Cao Jin Seok Kim Hyeon Seok Eom Joon Hyeok Lee Jun Zhu Kian-Meng Chang Arry Harryanto Reksodiputro Daryl Tan Yeow Tee Goh Jejung Lee Tanin Intragumtornchai Wee-Joo Chng Ann-Lii Cheng Soon | 2013 | European Journal of Cancer2013，，： | 2 |
| 9 | Randomized Clinical Trial of Cutting Balloon Angioplasty versus High-Pressure Balloon Angioplasty in Hemodialysis Arteriovenous Fistula Stenoses Resistant to Conventional Balloon Angioplasty显示文摘 | Syed Arafat Aftab Kiang Hiong Tay Farah G. Irani Richard Hoau Gong Lo Apoorva Gogna Benjamin Haaland Seck Guan Tan Siew Png Chng Shanker Pasupathy Hui Lin Choong Bien Soo Tan | 2013 | Journal of Vascular and Interventional Radiology2013，，： | 2 |
| 10 | MicroRNA: Important Player in the Pathobiology of Multiple Myeloma显示文摘 | Chonglei Bi Wee Joo Chng Kazuyuki Shimizu | 2014 | BioMed Research International2014，，： | 2 |
| 11 | Effect of hydrogen peroxide on intertubular dentine显示文摘 | Chng HK Ramli HN Yap AU | 2005 | J Dent2005，33，5： | 1 |
| 12 | LIN28/LIN28B : an emer- ging oncogenic driver in cancer stem cells 显示文摘 | ZHOU J NG S B CHNG W J | 2013 | Int J Bio- chem Cell Biol2013，45，： | 1 |
| 13 | Hydrogen-bonding interactions between water and the one- and two-electron-reduced forms of vitamin K1: Applying quinone electrochemistry to determine the moisture content of non-aqueous solvents显示文摘 | Hui Y Chng ELK Chng C Y L | 2009 | Journal of the American Chemical Society2009，31，4： | 1 |
| 14 | The management of vein of Galen aneurysmal malformations显示文摘 | Lasjaunias PL Chng SM Sachet M | 2006 | Neurosurgery2006，59，53： | 1 |
| 15 | The complete sequence of a Singapore isolate of odontoglossum ringspot virus and comparison with other ,et al(es显示文摘 | Chng C G Wong S M Mahtani P H | 1996 | Gene1996，171，2： | 1 |
| 16 | On vortex shedding from bluff bodies with base cavities显示文摘 | Cai J S Chng T L | 2009 | Physics of Fluids2009，21，03： | 1 |
| 17 | Immunogenicity of a truncated enterovirus 71 VP1 protein fused to a Newcastle disease virus nucleocapsid protein fragment in mice 显示文摘 | Chng W C Saw W T Yusoff K | 2011 | Acta Virol2011，55，3： | 1 |
| 18 | Nanoindenta- tion study of human premolars subjected to bleaching agent 显示文摘 | Hairul Nizam B R Lim C T Chng H K etal | 2005 | J Biomech2005，38，11： | 1 |
| 19 | Prognostic value of chromosome 1 q21 gain by fluorescent in situ hybridization and in- crease CKS1B expression in myeloma 显示文摘 | Fonseea R Van Wier SA Chng WJ | 2006 | Leukemia2006，20，11： | 1 |
| 20 | Gradient radial basis function networks for nonlinear and nonstationary time series prediction显示文摘 | Chng E S Chen S Mulgrew B | 1996 | IEEE Transactions on Neural Networks1996，7，1： | 1 |
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