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| 1 | Effect of transjugular intrahepatic portosystemic shunt on pulmonary gas exchange in patients with portal hypertension and hepatopulmonary syndrome显示文摘AIM: To assess the impact of transjugular intrahepatic portosystemic shunt (TIPS) on pulmonary gas exchange and to evaluate the use of TIPS for the treatment of hepatopulmonary syndrome (HPS).METHODS: Seven patients, three of them with advanced HPS, in whom detailed pulmonary function tests were performed before and after TIPS placementat the University of Alabama Hospital and at the Hospital Clinic, Barcelona, were considered.RESULTS: TIPS patency was confirmed by hemodynamic evaluation. No changes in arterial blood gases were observed in the overall subset of patients. Transient arterial oxygenation improvement was observed in only one HPS patient, early after TIPS, but this was not sustained 4 mo later.CONCLUSION: TIPS neither improved nor worsened pulmonary gas exchange in patients with portal hypertension. This data does not support the use of TIPS as a specific treatment for HPS. However, it does reinforce the view that TIPS can be safely performed for the treatment of other complications of portal hypertension in patients with HPS. | Graciela Martínez-Pallí Britt B Drake Joan-Carles García-Pagán Joan-Albert Barberà Miguel R Arguedas Robert Rodriguez-Roisin Jaume Bosch Michael B Fallon | 2005 | World Journal of Gastroenterology2005，11，43： | 11 |
| 2 | Simultaneous biodegradation of nitrogen-containing aromatic compounds in a sequencing batch bioreactor显示文摘许多包含氮的芳香的混合物( NAC ),如此的 asnitrobenzene ( NB ), 4-nitrophenol ( 4-NP ),苯胺(一),并且2,4二硝基酚( 2,4-DNP ),从污染的水是 environmentallyhazardous ,和他们的移动主要挑战之一正在面对 wastewatertreatment plants.In 这研究,合成废水包含 NB ,从 50~180 mg/L 的 4-NP,2,4-DNP ,和 atconcentrations 被喂进定序批反应堆( SBR ) .Analyses ofthe SBR 系统显示它同时移开超过99% | LIU Xing-yu WANG Bao-jun JIANG Cheng-ying ZHAO Ke-xin Harold L. Drake LIU Shuang-Jiang | 2007 | Journal of Environmental Sciences2007，19，5： | 10 |
| 3 | The expression and functions of microRNAs in pancreatic adenocarcinoma and hepatocellular carcinoma显示文摘Pancreatic adenocarcinoma and hepatocellular carcinoma are devastating human malignancies that are characterized by poor prognosis,late onset,and a lack of known biomarkers.New diagnostic and therapeutic molecular targets are desperately needed to develop novel and effective treatment strategies.MicroRNAs (miRNAs) are an emerging class of molecules with roles in various cellular processes,including growth,survival,and apoptosis.Most importantly,aberrant expression of miRNAs has been implicated in cancer pathogenesis.miRNA expression profiles of pancreatic adenocarcinoma and hepatocellular carcinoma indicate selective overexpression of oncogenic miRNAs and down-regulation of tumor suppressive miRNAs in these cancers.This review summarizes results from key studies conducted to characterize the miRNA expression profiles of pancreatic adenocarcinoma and hepatocellular carcinoma and describes the potential mechanisms by which some oncogenic or tumor suppressive miRNAs act.Furthermore,this review outlines novel therapeutic strategies for targeting miRNAs. | Wei Li Drake G. LeBrun Min Li | 2011 | Chinese Journal of Cancer2011，30，8： | 6 |
| 4 | 纳米减摩润滑剂在发动机中的应用效果研究显示文摘利用合成和复配技术制备了纳米减摩润滑剂,采用LPW4型柴油发动机考察了该润滑剂的实际应用效果,分析了纳米润滑剂对油品理化指标和减摩润滑性能的影响,研究了纳米润滑剂改善发动机油压、油耗和尾气排放等外特性的效果。结果表明:经过620 h的可靠性发动机试验,纳米润滑剂中金属元素Fe含量较专用机油降低了47.8%,机油压力提高了15.8%,说明纳米润滑剂具有优良的减摩润滑性能;与专用机油相比,纳米润滑剂的燃油消耗降低了3.6%,发动机的尾气颗粒含量降低了26.7%,排放烟度降低了51.3%,说明纳米润滑剂具有良好的节能效果和环保特性。这是由于纳米润滑剂充分利用了纳米特性和多种功能添加剂的复合协同功效,提升了传统润滑油的减摩润滑性能和整体性能。 | 史佩京 许一 徐滨士 Louise Drake Bryan Draper | 2006 | 润滑与密封2006，31，7： | 5 |
| 5 | Engineering porous organic polymers for carbon dioxide capture显示文摘As atmospheric CO_2 levels rise, the development of physical or chemical adsorbents for CO_2 capture and separation is of great importance on the way towards a sustainable low-carbon future. Porous organic polymers are promising candidates for CO_2 capture materials owing to their structural flexibility, high surface area, and high stability. In this review, we highlight high-performance porous organic polymers for CO_2 capture and summarize the strategies to enhance CO_2 uptake and selectivity, such as increasing surface area, increasing interaction between porous organic polymers and CO_2, and pore surface functionalization. | Ning Huang Gregory Day Xinyu Yang Hannah Drake Hong-Cai Zhou | 2017 | Science China Chemistry2017，60，8： | 4 |
| 6 | High school sports programs differentially impact participation by sex显示文摘背景:研究表明,参加体育活动可降低儿童和青少年肥胖的风险。学校是促进儿童和青少年参加体育活动的理想环境,但目前尚不清楚体育活动的'获得'和'选择'如何影响学生的参与度,也不清楚学校体育课的特点对学生参与体育的影响是否存在性别差异。本研究旨在评价高中体育运动项目的特点,并确定这些体育课程对男女生参与运动队的影响程度。方法:用电话采访的方式纵向调查了1,244名新罕布什尔州和佛蒙特州的学生。学生自述他们小学至高中阶段参与运动队的情况。通过调查高中职员了解体育机会。在本研究中,'体育机会'是指每100名学生所对应的学校提供的体育项目种类《选择)和学校提供的体育种类中不限制参加人数的体育项目的比例(获得)。结果:约70%的儿童参加了至少一个体育运动队,男生为73%,女生为66%。研究发现在性别和两个体育机会变量之间存在显著交互影响。控制小学生参与体育活动和其他协变量后,发现如果学校不限制最受欢迎的体育项目的参与人数,男生会参加更多的体育运动队(RR=1.12,p<0.01)。相反,如果学校提供广泛的体育项目,女生会参加更多的体育运动队(RR=1 47,p<0.001)。结论:前人研究表明,参加体育活动能带来许多健康效益。对公共卫生工作包括预防肥胖而言,学校体育课可能是一个重要而有效但未被充分利用的对象。要使青少年参加更多的体育活动,就应综合考虑学校体育项目的获得和选择。学校可运用不同策略,促使男生和女生更多地参加体育活动。 | Keith M. Drake Meghan R. Longacre Todd MacKenzie Linda J. Titus Michael L. Beach Andrew G. Rundle Madeline A. Dalton | 2015 | Journal of Sport and Health Science2015，4，3： | 3 |
| 7 | Isolation, screening and identifi cation of Bacillus spp. as direct-fed microbial candidates for aflatoxin B_1 biodegradation显示文摘Objective: To evaluate the ability of Bacillus spp. as direct-fed microbials(DFM) to biodegrade al atoxin B1(AFB1) by using an in vitro digestive model simulating in vivo conditions.Methods: Sixty-nine Bacillus isolates were obtained from intestines, and soil samples were screened by using a selective media method against 0.25 and 1.00 μg/m L of AFB1 in modii ed Czapek-Dox medium. Plates were incubated at 37 °C and observed every two days for two weeks. Physiological properties of the three Bacillus spp. candidates were characterized biochemically and by 16 S r RNA sequence analyzes for identii cation. Tolerance to acidic p H, osmotic concentrations of Na Cl, bile salts were tested, and antimicrobial sensitivity proi les were also determined. Bacillus candidates were individually sporulated by using a solid fermentation method and combined. Spores were incorporated into 1 of 3 experimental feed groups: 1) Negative control group, with unmedicated starter broiler feed without AFB1; 2) Positive control group, with negative control feed contaminated with 0.01% AFB1; 3) DFM treated group, with positive control feed supplemented with 109 spores/g. After digestion time(3:15 h), supernatants and digesta were collected for high-performance liquid chromatography l uorescence detection analysis by triplicate.Results: Three out of those sixty-nine DFM candidates showed ability to biodegrade AFB1 in vitro based on growth as well as reduction of l uorescence and area of clearance around each colony in modii ed Czapek-Dox medium which was clearly visible under day light after 48 h of evaluation. Analysis of 16S-DNA identii ed the strains as Bacillus amyloliquefaciens, Bacillus megaterium and Bacillus subtilis. The three Bacillus strains were tolerant to acidic conditions(p H 2.0), tolerant to a high osmotic pressure(Na Cl at 6.5%), and were able to tolerate 0.037% bile salts after 24 h of incubation. No signii cant dif erences(P > 0.05) were observed in the concentrations of AFB1 in neither the supernatants nor digesta samples evaluated by highperformance liquid chromatography with l uorescence detection between positive control or DFM treated groups. Conclusions: In vitro digestion time was not enough to confirm biodegradation of AFB1. Further studies to evaluate the possible biodegradation ef ects of the BacillusDFM when continuously administered in experimentally contaminated feed with AFB1, are in progress. | Rosario Galarza-Seeber Juan David Latorre Xochitl Hernandez-Velasco Amanda Drake Wolfenden Lisa Renee Bielke Anita Menconi Billy Marshall Hargis Guillermo Tellez | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，9： | 3 |
| 8 | Synthetic Vaginal Tapes for Stress Incontinence: Proposals for Improved Regulation of New Devices in Europe显示文摘 | Paul Abrams Christopher R. Chapple Marcus Drake Suzy El-Neil Susanne Ludgate Anthony R.B. Smith | 2011 | European Urology2011，，： | 3 |
| 9 | Strawberry sweetness and consumer preference are enhanced by specific volatile compounds显示文摘Breeding crops for improved flavor is challenging due to the high cost of sensory evaluation and the difficulty of connecting sensory experience to chemical composition.The main goal of this study was to identify the chemical drivers of sweetness and consumer liking for fresh strawberries(Fragaria×ananassa).Fruit of 148 strawberry samples from cultivars and breeding selections were grown and harvested over seven years and were subjected to both sensory and chemical analyses.Each panel consisted of at least 100 consumers,resulting in more than 15,000 sensory data points per descriptor.Three sugars,two acids and 113 volatile compounds were quantified.Consumer liking was highly associated with sweetness intensity,texture liking,and flavor intensity,but not sourness intensity.Partial least square analyses revealed 20 volatile compounds that increased sweetness perception independently of sugars;18 volatiles that increased liking independently of sugars;and 15 volatile compounds that had positive effects on both.Machine learning-based predictive models including sugars,acids,and volatiles explained at least 25%more variation in sweetness and liking than models accounting for sugars and acids only.Volatile compounds such asγ-dodecalactone;5-hepten-2-one,6-methyl;and multiple medium-chain fatty acid esters may serve as targets for breeding or quality control attributes for strawberry products.A genetic association study identified two loci controlling ester production,both on linkage group 6 A.Co-segregating makers in these regions can be used for increasing multiple esters simultaneously.This study demonstrates a paradigm for improvement of fruit sweetness and flavor in which consumers drive the identification of the most important chemical targets,which in turn drives the discovery of genetic targets for marker-assisted breeding. | Zhen Fan Tomas Hasing Timothy S.Johnson Drake M.Garner Michael L.Schwieterman Christopher R.Barbey Thomas A.Colquhoun Charles A.Sims Marcio F.R.Resende Vance M.Whitaker | 2021 | Horticulture Research2021，8，1： | 2 |
| 10 | Engineering humanized mice for improved hematopoietic reconstitution显示文摘人性化的老鼠是与在整个老鼠的生活产生人的血房间的各种各样的系的人的造血的干细胞嫁接的 immunodeficient 动物。这篇文章在人性化的老鼠的产生考察最近的进展,集中于实际考虑。我们讨论不同 immunodeficient 接受者老鼠紧张,人的造血的干细胞的来源,在扩大的进展和调制接受者老鼠的 cytokine 环境的造血的干细胞,和技术的基因修正的特征,以便提高特定的人的血系房间的宪法。我们加亮新技术创造的机会并且讨论怎么为特定的研究应用程序做基本模型的拓宽的数组的最好的使用上的实际考虑。 | Adam C Drake Qingfeng Chen lianzhu Chen | 2012 | Cellular & Molecular Immunology2012，9，3： | 2 |
| 11 | Nitrogen Fertilizer Influences Fruit Quality, Soil Nutrients and Cover Crops, Leaf Color and Nitrogen Content, Biennial Bearing and Cold Hardiness of ’Golden Delicious’显示文摘 | John Thomas Raese Stephen R. Drake Eric A. Curry | 2007 | Journal of Plant Nutrition2007，，10： | 2 |
| 12 | Of mice and men: what rodent models don't tell us显示文摘 | Adam C Drake | 2013 | Cellular & Molecular Immunology2013，10，4： | 2 |
| 13 | Stratified-charge combustion: modeling and imaging of a spray-guided direct-injection spark-ignition engine显示文摘 | Michael C. Drake Todd D. Fansler Andreas M. Lippert | 2004 | Symposium (International) on Combustion2004，，2： | 2 |
| 14 | Evidence of oxidative damage in Alzheimer’s disease brain: central role for amyloid β-peptide显示文摘 | D.Allan Butterfield Jennifer Drake Chava Pocernich Alessandra Castegna | 2001 | Trends in Molecular Medicine2001，，12： | 2 |
| 15 | Silicon carbide makes superior mirrors显示文摘 | BLOCH J R DRAKE R J | 1989 | Laser Focus World1989，28，3： | 2 |
| 16 | ‘This place gives me space’: place and creativity in the creative industries显示文摘 | Graham Drake | 2003 | Geoforum2003，，4： | 2 |
| 17 | A theoretical study of the accuracy of tomographic retrieval of cloud liquid with an airborne radiometer显示文摘 | Drake J F Warner J | 1988 | J Atmos Oceanic Tech1988，5，： | 2 |
| 18 | Field tests of an airborne remote sensing technique for measuring the distribution of liquid water in convective cloud显示文摘 | Warner J J F Drake | 1988 | J Atmos Oceanic Tech1988，5，： | 2 |
| 19 | Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity显示文摘 | Suzanne L Topalian Charles G Drake Drew M Pardoll | 2011 | Current Opinion in Immunology2011，，2： | 2 |
| 20 | 癫痫患者P50听觉诱发电位的研究显示文摘目的 探讨 P5 0在癫痫患者检测中的临床价值。方法 对 2 5例癫痫患者 (其中 7例额叶癫痫 ;18例颞叶癫痫 )进行 P5 0测试 ,分析 P5 0波的潜伏期和波幅 (峰峰值 )以及在不同刺激频率时 P5 0波幅 (峰峰值 )的比率。选择年龄、性别与患者组相匹配的 2 5名健康受试者对照组。结果 癫痫患者组 P5 0波的潜伏期较长 ,波幅则显著减低 ,其中以 18例颞叶癫痫患者表现显著 ,7例额叶癫痫患者不明显。刺激频率稍加快时 ,患者组 P5 0的波幅比率明显减小。结论 P5 0波的潜伏期和波幅反应异常与颞叶功能障碍密切相关 ,可帮助临床鉴别额、颞叶癫痫灶 ;其波幅衰减现象似与癫痫发作间期行为和认知改变相关 ,但也可能受药物的影响。 | 童晓欣 Miles E. Drake Jr | 2000 | 华中医学杂志2000，24，4： | 2 |
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