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| 1 | Factors affecting healing after arthroscopic rotator cuff repair显示文摘Rotator cuff repair has been shown to have good longterm results. Unfortunately, a significant proportion of repairs still fail to heal. Many factors, both patient and surgeon related, can influence healing after repair. Older age, larger tear size, worse muscle quality, greater muscle-tendon unit retraction, smoking, osteoporosis, diabetes and hypercholesterolemia have all shown to negatively influence tendon healing. Surgeon related factors that can influence healing include repair construct-single vs double row, rehabilitation, and biologics including platelet rich plasma and mesenchymalstem cells. Double-row repairs are biomechanically stronger and have better healing rates compared with single-row repairs although clinical outcomes are equivalent between both constructs. Slower, less aggressive rehabilitation programs have demonstrated improved healing with no negative effect on final range of motion and are therefore recommended after repair of most full thickness tears. Additionally no definitive evidence supports the use of platelet rich plasma or mesenchymal stem cells regarding improvement of healing rates and clinical outcomes. Further research is needed to identify effective biologically directed augmentations that will improve healing rates and clinical outcomes after rotator cuff repair. | Amir M Abtahi Erin K Granger Robert Z Tashjian | 2015 | World Journal of Orthopedics2015，6，2： | 16 |
| 2 | Role of the endothelium in inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBD) are a complex group of diseases involving alterations in mucosal immunity and gastrointestinal physiology during both initiation and progressive phases of the disease.At the core of these alterations are endothelial cells,whose continual adjustments in structure and function coordinate vascular supply,immune cell emigration,and regulation of the tissue environment.Expansion of the endothelium in IBD(angiogenesis),mediated by inflammatory growth factors,cytokines and chemokines,is a hallmark of active gut disease and is closely related to disease severity.The endothelium in newly formed or inflamed vessels differs from that in normal vessels in the production of and response to inflammatory cytokines,growth factors,and adhesion molecules,altering coagulant capacity,barrier function and blood cell recruitment in injury.This review examines the roles of the endothelium in the initiation and propagation of IBD pathology and distinctive features of the intestinal endothelium contributing to these conditions. | Walter E Cromer J Michael Mathis Daniel N Granger Ganta V Chaitanya J Steven Alexander | 2011 | World Journal of Gastroenterology2011，17，5： | 10 |
| 3 | 宇宙成因核素^(10)Be揭示的北祁连山侵蚀速率特征显示文摘山脉侵蚀速率的大小和时空分布信息是研究山脉构造—气候相互作用和地貌演化的关键切入点,其大小是受气候还是构造控制争论已久。宇宙成因核素10Be方法为从千年至万年尺度上定量研究流域平均侵蚀速率提供了一种先进和快捷的技术手段,为揭示侵蚀速率与现代气候和构造地貌因子的关系并进行相关分析提供了基础。利用该方法对北祁连山近现代侵蚀速率进行了研究。所采集的9个流域现代河沙样品,结合前人数据进行共同分析,结果显示该区侵蚀速率的变化范围为18.7~833 mm/ka,北祁连山中段的侵蚀速率约为323 mm/ka,该区侵蚀速率与降雨量没有明显的对应关系,但与流域平均坡度呈现很好的非线性关系,揭示坡度是该区侵蚀速率的最主要控制因素。通过对比北祁连山地表平均侵蚀速率和该区域的断层垂直滑动速率发现整体上该区域地表侵蚀速率要低于祁连山北缘断层的垂直滑动速率,反映了北祁连山正处于地形抬升和生长的过程之中。 | 胡凯 方小敏 赵志军 Darryl Granger | 2015 | 地球科学进展2015，30，2： | 8 |
| 4 | 1999~2006年急性冠脉综合征患者死亡及心力衰竭发生率降低显示文摘背景:有关药物和介入治疗对ST段抬高型和非ST段抬高型急性冠脉综合征(non—ST-segment elevation acute coronary syndrome,NSTE ACS)患者的作用,随机试验已经提供了足够的证据,但是是否已经转化为相应的临床变化还不清楚。
目的:确定ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)和NSTE ACS患者的院内治疗改变是否伴随临床结果的改善。
设计、地点及患者:全球急性冠脉事件注册研究(Global Registry of Acute Coronary Events,GRACE)是一项多国家队列研究。自1999年7月1日至2006年12月31日,该研究共入选并随访了来自14个国家、113家医院的44372例ACS患者。
主要观测指标:当前循证药物和介入治疗应用的趋势及患者预后(死亡、充血性心力衰竭、肺水肿、心源性休克、卒中和心肌梗死)。
结果:随着研究时间的进展,相关药物的应用增加(β-受体阻滞剂、他汀类药物、血管紧张素转换酶抑制剂、行或未行经皮冠状动脉介入治疗[percutaneous coronary intervention,PCI]患者应用噻氯毗啶、糖蛋白Ⅱb/Ⅲa抑制剂和低分子肝素;P〈0.001)。STEMI患者药物再灌注治疗下降了22个百分点(95%可信区间[confidence interval,CI],-27~-17),而直接PCI增加了37个百分点(95%CI,33—41)。在NSTEMI患者中,PCI的比例显著升高了18个百分点(95%CI,15~20)。充血性心力衰竭和肺水肿在STEMI患者中降低了9个百分点(95%CI,-12~-6),在NSTEACS患者中降低了6.9个百分点(95%CI,-8.4~-4.7)。STEMI患者的院内死亡率降低了18个百分点(95%CI,-5.3~-1.9),心源性休克降低了24个百分点(95%CI,-4.3~-0.5)。校正了危险评分后,NSTEACS患者的院内死亡率降低了0.7个百分点(95%CI,-1.7~0.3);STEMI患者6个月随访时卒中发生率降低了0.8个百分点(95%CI,-1.7~0.1),心肌梗死发生率降低了2.8个百分点(95%CI,-6.4~0.9)。NSTEACS患者6个月死亡率降低了1.6个百分点(95%CI,-3.0~-0.1),卒中发生率降低了0.7个百分点(95%CI,-1.4~0.1)。
结论:在本项多国家观察性研究中,ACS患者治疗的改善与6个月新发心力衰竭、死亡率、卒中和心肌梗死发生率显著降低相关。 | Keith A. A. Fox Philippe Gabriel Steg Kim A. Eagle Shaun G. Goodman Frederick A. Anderson Christopher B. Granger Marcus D. Flather Andrzej Budaj Ann Quill Joel M. Gore 康俊萍(译) 马长生(校) | 2007 | 美国医学会杂志(中文版)2007，26，6： | 6 |
| 5 | Association between painful physical symptoms and clinical outcomes in Chinese patients with major depressive disorder:a three-month observational study显示文摘背景痛苦的物理症状( PPS )可以作为专业的一个部件介绍在中国病人的 .Their 效果一直不是的压抑的混乱( MDD ) investigated.This 分析在疾病严厉报导变化,治疗模式,在一个中国队的生活和结果的质量根据存在(PPS+)或痛苦的物理 symptoms.Methods 的缺席(PPS-),从来自中国的亚洲国家和区域的病人的大观察3月的研究的中国病人的亚群是 classi 49.56 (26.49 ) 为 PPS- 的 vs.16.60 (20.99 ) , P 0.01 ) ,更多被压抑(HAMD17,平均数(SD ) :25.32 (5.47 ) 为 PPS- 的 vs.23.33 (5.24 ) , P=0.002 ) 并且生活的有的更差的质量(EQ-5D 健康状态,平均数(SD ) :38.48 (22.38 ) 为 PPS- 的 vs.49.57 (18.54 ) , P 0.001 ).PPS+ 病人在压抑的症状严厉显示出更少的全面改进(HAMD17,从基线(95% CI ) 的变化:-17.38(-18.65,-16.12) vs.-19.20 (为 PPS- 的 -20.05,-18.35) , P=-0.032;CGI-S,从基线(95% CI ) 变化:-2.85(-3.11,-2.58) vs.-3.20 (为 PPS- 的 -3.38,-3.02) , P=0.044 ).Conclusions PPS 比与当抗抑郁剂被给时,比 PPS- 与更大的 MDD 严厉和更少的改进联系的亚洲 populations.PPS+were 的以前的研究相比期望是不太经常的。 | LI Hui-chun ZHANG Ming-yuan WANG Gang ZHANG Hong-geng ZHANG Hong-yan LIU Ying LI Ming ZHANG Cong-pei TANG Ji-sheng WU Wen-yuan Pritibha Singh Renee Elizabeth Granger Joel Raskin ANG Qiu-qing | 2010 | Chinese Medical Journal2010，，15： | 5 |
| 6 | 妊娠期高血压免疫因子、肿瘤坏死因子α、血管紧张素Ⅱ1型受体自身抗体对妊娠可溶性fms样酪氨酸1和可溶性Endoglin产物的影响显示文摘最近研究发现先兆子痫中血管新生因子、可溶性fms样酪氨酸激酶(sFlt-1)和可溶性Endoglin(sEn-doglin)不平衡;然而尚不清楚它们过度分泌的启动机制。方法:长期给予怀孕大鼠肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)或抗血管紧张素Ⅱ受体的自身抗体(AT1-AA),测定其循环和胎盘的sFlt-1和(或)sEndoglin以确定这些因素的免疫调节作用。 | Parrish MR Murphy SR Rutland S Wallace K Wenzel K Wallukat G Keiser S Ray LF Dechend R Martin JN Granger JP La Marca B 黄晓斌 | 2010 | 中华高血压杂志2010，18，12： | 5 |
| 7 | Intestinal stasisassociated bowel in flam mation显示文摘 | Shunichiro Komatsu 1, Yuji Nimura 1 and D.Neil Granger 2 | 1999 | World Journal of Gastroenterology1999，5，6： | 5 |
| 8 | Red Cell Distribution Width as a Novel Prognostic Marker in Heart Failure显示文摘 | G. Michael Felker Larry A. Allen Stuart J. Pocock Linda K. Shaw John J.V. McMurray Marc A. Pfeffer Karl Swedberg Duolao Wang Salim Yusuf Eric L. Michelson Christopher B. Granger | 2007 | Journal of the American College of Cardiology2007，，1： | 5 |
| 9 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 10 | A generalized supervised classification scheme to produce provincial wetland inventory maps:an application of Google Earth Engine for big geo data processing显示文摘Wetlands are important natural resources due to their numerous ecological services.Consequently,identifying their locations and extents is imperative.The stability,repeatability,cost-effectiveness,multi-scale coverage,and proper spatial resolution imagery of satellites provide a valuable opportunity for their use in various large-scale applications,such as provincial wetland mapping.To do so,it is required to(1)process and classify big geo data(i.e.a large amount of satellite datasets)in a time-and computationally-efficient approach and(2)collect a large amount of field samples.In this study,Google Earth Engine(GEE)and machine learning algorithms were utilized to process thousands of remote sensing images and produce provincial wetland inventory maps of the three Canadian provinces of Manitoba,Quebec,and Newfoundland and Labrador(NL).Additionally,using GEE,a generalized supervised classification method is proposed to produce a regional wetland map from a large area(e.g.,a province)when lacking field samples.In fact,using the field data from only Manitoba and assuming that all wetlands in Canada have similar characteristics,the wetland maps were generated for the other two provinces.The overall classification accuracies for Manitoba,Quebec,and NL were 84%,78%,and 82%,respectively,indicating the high potential of the proposed method for aiding provincial wetland inventory systems. | Meisam Amani Brian Brisco Majid Afshar S.Mohammad Mirmazloumi Sahel Mahdavi Sayyed Mohammad Javad Mirzadeh Weimin Huang Jean Granger | 2019 | Big Earth Data2019，3，4： | 4 |
| 11 | 《未来的光防护:挑战与机遇》共识解读:国际防晒化妆品发展趋势及对中国的启示显示文摘目前对防晒化妆品的认识还存在一些误区,如防晒系数越高越好,防晒剂可以引起使用者缺钙等。防晒化妆品也存在诸如防晒系数测定和标识方法不统一、防护波长范围不足、对人体及环境的安全性不明等许多问题和挑战。本文阐述国际上防晒化妆品面临的问题、发展趋势及对中国防晒化妆品研发的启示等,供临床医师参考。 | 赖维 郑跃 Granger Corinne Trullas Carles Krutmann Jean 刘玮 | 2020 | 中华皮肤科杂志2020，53，12： | 3 |
| 12 | The grammatical and lexical patterning of MAKE in native and non-native student writing显示文摘 | B Altenberg S Granger | 2001 | Applied Linguistics2001，，： | 3 |
| 13 | Inflammatory and Injury Responses to Ischemic Stroke in Obese Mice显示文摘 | Satoshi Terao Gokhan Yilmaz Karen Y. Stokes Mami Ishikawa Takeshi Kawase D Neil Granger | 2008 | Stroke2008，，3： | 2 |
| 14 | Apixaban versus warfarin in patients with atrial fibrillation显示文摘 | Granger CB Alexander JH McMurray JJ | | New England Journal of Medicine0，，： | 2 |
| 15 | Molecular determinants of shear rate-dependent leukocyte adhesion in postcapillary venules显示文摘 | BIENVENU K GRANGER D N | 1993 | Am J Physiol1993，264，2： | 2 |
| 16 | Functional outcomes assessment in shoulder surgery显示文摘The effective evaluation and management of orthopaedic conditions including shoulder disorders relies upon understanding the level of disability created by the disease process. Validated outcome measures are critical to the evaluation process. Traditionally, outcome measures have been physician derived objective evaluations including range of motion and radiologic evaluations. However, these measures can marginalize a patient's perception of their disability or outcome. As a result of these limitations, patient self-reported outcomes measures have become popular over the last quarter century and are currently primary tools to evaluate outcomes of treatment. Patient reported outcomes measures can be general health related quality of life measures, health utility measures, region specific health related quality of life measures or condition specific measures. Several patients self-reported outcomes measures have been developed and validated for evaluating patients with shoulder disorders. Computer adaptive testing will likely play an important role in the arsenal of measures used to evaluate shoulder patients in the future. The purpose of this article is to review the general health related quality-of-life measures as well as the jointspecific and condition specific measures utilized in evaluating patients with shoulder conditions. Advancesin computer adaptive testing as it relates to assessing dysfunction in shoulder conditions will also be reviewed. | James D Wylie James T Beckmann Erin Granger Robert Z Tashjian | 2014 | World Journal of Orthopedics2014，5，5： | 2 |
| 17 | Modulation ofleukocyte-endothelial interactions by reactive metabolites of oxygen and nitrogen relevance to ischemic heart disease显示文摘 | Grisham MS Granger DN Lefer BJ | 1998 | Free Rad Bill Med1998，25，： | 2 |
| 18 | Combination of forecasts显示文摘 | BATES J M GRANGER C W J | 1969 | Operations Research Quaterly1969，20，4： | 2 |
| 19 | The Impact of a Statewide Pre-Hospital STEMI Strategy to Bypass Hospitals Without Percutaneous Coronary Intervention Capability on Treatment Times显示文摘 | Emil L. Fosbol Christopher B. Granger James G. Jollis Lisa Monk Li Lin Barbara L. Lytle Ying Xian J. Lee Garvey Greg Mears Claire C. Corbett Eric D. Peterson Seth W. Glickman | 2013 | Circulation2013，，5： | 2 |
| 20 | On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease显示文摘 | Fumito Saijo Alexandra B. Milsom Nathan S. Bryan Selena M. Bauer Thorsten Vowinkel Marina Ivanovic Chris Andry D. Neil Granger Juan Rodriguez Martin Feelisch | 2009 | Nitric Oxide2009，，2： | 2 |
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