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| 1 | LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition显示文摘Despite the structural conservation of PTEN with dual-specificity phosphatases,there have been no reports regarding the regulatory mechanisms that underlie this potential dual-phosphatase activity.Here,we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase activity.Mechanistically,high glucose,TGF-β,CTGF,SHH,and IL-6 induce the expression of a long non-coding RNA,GAEA(Glucose Aroused for EMT Activation),which associates with an RNA-binding E3 ligase,MEX3C,and enhances its enzymatic activity,leading to the K27-linked polyubiquitination of PTEN.The MEX3C-catalyzed PTEN^K27-polyUb activates its protein serine/threonine phosphatase activity and inhibits its phosphatidylinositol/protein tyrosine phosphatase activity.With this altered enzymatic activity,PTEN^K27-polyUb dephosphorylates the phosphoserine/threonine residues of TWIST1,SNAI1,and YAP1,leading to accumulation of these master regulators of EMT.Animals with genetic inhibition of PTEN^K27-polyUb,by a single nucleotide mutation generated using CRISPR/Cas9(Pten^K80R/K80R),exhibit inhibition of EMT markers during mammary gland morphogenesis in pregnancy/lactation and during cutaneous wound healing processes.Our findings illustrate an unexpected paradigm in which the lncRNA-dependent switch in PTEN protein serine/threonine phosphatase activity is important for physiological homeostasis and disease development. | Qingsong Hu Chunlai Li Shouyu Wang Yajuan Li Bo Wen Yanyan Zhang Ke Liang Jun Yao Youqiong Ye Heidi Hsiao Tina K.Nguyen Peter K.Park Sergey D.Egranov David H.Hawke Jeffrey R.Marks Leng Han Mien-Chie Hung Bing Zhang Chunru Lin Liuqing Yang | 2019 | Cell Research2019，29，4： | 8 |
| 2 | Determination of indices and critical values of gas parameters of the first gas outburst in a coal seam of the Xieqiao Mine显示文摘Based on the important role in mine safety played by parameters of the first gas outburst, we propose a method of combining historic data, theoretical analysis and experimental research for the purpose of critical values of gas parameters of the first gas outburst in a coal seam of the Xieqiao Mine. According to a characteristic analysis and a summary of the rules of coal and gas outbursts in the No.8 coal seam of a Huainan mine, we have investigated their effect on coal and gas outbursts in terms such as ground stress, gas, and coal structure. We have selected gas parameters and determined the critical values of each of the following indices: gas content as 7.7 m 3 /t, tectonic coal as 0.8 m thick, the absolute gas emission as 2 m 3 /min, the rate of change as 0.7 m 3 /min, the gas desorption index of a drilling chip K 1 as 0.26 mL/(g min 1/2 ) and the values of desorption indexes 4h 2 as 200 Pa. From a verification of the production, the results indicate that application of each index and their critical values significantly improve the level of safety in the production process, relieve the burden upon the mine, save much labor and bring clear economic benefits. | Ou Jianchun Liu Mingju Zhang Chunru Liu Yanwei Wei Jianping | 2012 | International Journal of Mining Science and Technology2012，22，1： | 4 |
| 3 | A lincRNA switch for embryonic stem cell fate显示文摘 | Liuqing Yang Chunru Lin Michael G Rosenfeld | 2011 | Cell Research2011，21，12： | 4 |
| 4 | Robust state-space realizations of digital filters against finite word length errors显示文摘This article deals with two important issues in digital filter implementation:roundoff noise and limit cycles. A novel class of robust state-space realizations, called normal realizations, is derived and characterized. It is seen that these realizations are free of limit cycles. Another interesting property of the normal realizations is that they yield a minimal error propagation gain. The optimal realization problem, defined as to find those normal realizations that minimize roundoff noise gain, is formulated and solved analytically. A design example is presented to demonstrate the behavior of the optimal normal realizations and to compare them with several well-known digital filter realizations in terms of minimizing the roundoff noise and the error propagation. | He Xiongxiong Li Gang Zhu Guangxin Wan Chunru | 2008 | Journal of Systems Engineering and Electronics2008，19，5： | 3 |
| 5 | ncRNA- and Pc2 Methylation-Dependent Gene Relocation between Nuclear Structures Mediates Gene Activation Programs显示文摘 | Liuqing Yang Chunru Lin Wen Liu Jie Zhang Kenneth A. Ohgi Jonathan D. Grinstein Pieter C. Dorrestein Michael G. Rosenfeld | 2011 | Cell2011，，4： | 2 |
| 6 | Synthesis and Antitumor Activity Evaluation of γ-Monofluorinated and γγy-Difluorinated Goniothalamin Analogues显示文摘一系列小说, -difluorinated Goniothalamin 类似物 4a4i 和 6a6i 被综合。关键步通过脂肪分解酵素 AK 包括了邻近 gem-difluoromethylene 组的 C-5 stereocenter 的构造催化运动分辨率,经由联合的 Stille 的芳基组的介绍,和由 1,5-oxidative 的 lactonization 环合。这些, -difluorinated Goniothalamin 类似物 4a4i 和他们的 enantiomers 6a6i,和几相应 -monofluorinated Goniothalamin,类似物生物学上与四根不同癌症房间线被作比较。复合 7h 在 micromolar 范围作为父母(R)-Goniothalamin 显示出将近相等的力量。在在 antitumor 活动的 fluoromethylene 和 gem-difluoromethylene 之间的不同氟的符号效果通过生物鉴定数据的分析被讨论。 | Yi Yang Zhenjun Yang Chunru Cheng Fengling Qing | 2013 | Chinese Journal of Chemistry2013，31，6： | 2 |
| 7 | Luminescent single-molecule magnet of metallofullerene DyErScN@Ih-C80显示文摘Magneto-luminescent molecules have significant applications in data storage and quantum computing.However,design of these bi-functional molecules coupled with magnetic behavior and photoluminescence is still challenging.In this work,we report a metallofullerene DyErScN @In-C80 exhibiting single-molecule magnet (SMM) behavior and near-infrared emission.For DyErScN @Ih-C80,two functional lanthanide metal ions of Dy^3+(SMM function) and Er^3+(luminescent function) are integrated inside a fullerene cage using a trimetallic nitride template,and its structure has been unambiguously characterized by single-crystal X-ray diffraction.Magnetic measurements revealed that DyErScN @Ih-C80 behaves as a SMM with a blocking temperature up to 9 K resulting from the intramolecular magnetic interaction between Dy^3+ and Er^3+ ions.Moreover,DyErScN @In-C80 exhibits temperature-dependent near-infrared emission around 1.5 pm with multiple splitting peaks from Er^3+,which arises from the influence of Dy^3+ ion.This study provides a new strategy to synthesize new magneto-luminescent molecule materials. | Mingzhe Nie Jin Xiong Chong Zhao Haibing Meng Kun Zhang Yibo Han Jie Li Bingwu Wang Lai Feng Chunru Wang Taishan Wang | 2019 | Nano Research2019，12，7： | 2 |
| 8 | Antidepressant effect of bioactive compounds from Paecilomyces tenuipes in mice and rats显示文摘A bioactive compound from Paecilomyces tenuipes (BCPT) has an inhibitory effect on monoamine oxidase A (MAO-A) in vitro. Researchers have thought that BCPT may be a potential antidepressant. The MAO-A suppressor moclobemide served as a control, and this study investigated the mechanisms of BCPT as an antidepressant. Results demonstrated that BCPT induced significantly increased sucrose intake in chronic unpredictable stressed rats, shortened immobility time in forced swimming mice, improved the scores of blepharoptosis and akinesia in reserpine-treated mice, increased the number of 5-hydroxy tryptophan-induced head-twitches, remarkably enhanced the expression of hippocampus mineralcorticoid receptor and glucocorticoid receptor mRNA, decreased the ratio of mineralcorticoid receptor to glucocorticoid receptor and raised the levels of dopamine, norepinephrine and 5-hydroxytryptamine, while decreasing hydroxyindole acetic acid levels or dihydroxy-phenyl acetic acid in chronic unpredictable stressed rats. Behavioral test results suggested that BCPT potentially had antidepressant-like activity. Meanwhile, BCPT increased the levels of neurotransmitters, and mineralcorticoid receptor and glucocorticoid receptor mRNA in the hippocampus, which may be an important mechanism of its antidepressant effect. | Hongwei Kan Liang Ming Chunru Li Hongxing Kan Bei Sun Yan Liang | 2010 | Neural Regeneration Research2010，5，20： | 2 |
| 9 | Block orthogonal greedy algorithm for stable recovery of block-sparse signal representa- tions显示文摘 | Lv Xianlei Wan Chunru Bi Guoan | 2010 | Signal Processing2010，90，12： | 1 |
| 10 | Multiway Dynamic Trust Chain Model on Virtual Machine for Cloud Computing显示文摘This paper sums up four security factors after analyzing co-residency threats caused by the special multitenant environment in the cloud.To secure the factors,a multiway dynamic trust chain transfer model was proposed on the basis of a measurement interactive virtual machine and current behavior to protect the integrity of the system.A trust chain construction module is designed in a virtual machine monitor.Through dynamic monitoring,it achieves the purpose of transferring integrity between virtual machine.A cloud system with a trust authentication function is implemented on the basis of the model,and its practicability is shown. | Jie Zhu Guoyuan Lin Fucheng You Huaqun Liu Chunru Zhou | 2016 | China Communications2016，13，7： | 1 |
| 11 | Sustainable agricultural development inChina显示文摘 | Cheng Xu Han Chunru Donald C Taylor | | World Development0，220，8： | 1 |
| 12 | Modulating morphology via side-chain engineering of fused ring electron acceptors for high performance organic solar cells显示文摘In this work, four fused ring electron acceptors(FREAs), 2F-C5, 2F-C6, 2F-C8 and 2F-C10, are developed to investigate the effect of side-chain size on the molecular properties and photovoltaic performance of FREA systematically. The elongation of side-chains in the FREAs not only improves their solubility in the processing solvent, but also enhances their miscibility with the donor PBDB-T. It helps the FREA diffuse into the donor PBDB-T during film-formation, thus leading to the decrease in domain size and domain purity from PBDB-T:2F-C5 to PBDB-T:2F-C10 blend films in sequence. The smaller domain size affords more D/A interfaces to benefit exciton dissociation and inhibit monomolecular recombination. However, severe bimolecular recombination occurs when the domain purity decreases to a critical point. Due to the dual function of the increment of side-chain length, both short-circuit current density(J_(SC)) and fill factor(FF) of devices exhibit an evolution of first increasing then decreasing from 2F-C5, 2F-C6, 2F-C8 to 2F-C10 based OSCs. The PBDB-T:2F-C8 based OSCs get a fine balance in morphology with moderate domain size as well as high domain purity simultaneously for the least charge carrier recombination, thus achieving the highest power conversion efficiency of 12.28% with the best J_(SC)(21.27 mA cm^(-2)) and FF(71.96%). | Fuwen Zhao Dan He Jingming Xin Shuixing Dai Han Xue Li Jiang Zhixiang Wei Wei Ma Xiaowei Zhan Yongfang Li Chunru Wang | 2019 | Science China Chemistry2019，62，6： | 1 |
| 13 | lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs显示文摘 | Liuqing Y Chunru L Chunyn J | 2013 | Nature2013，500，7464： | 1 |
| 14 | ESR dating of Pleistocene archaeological localities of the Nihewan Basin, Nirth China-Preliminary results显示文摘 | LIU Chunru YIN Gongming GAO Lu | 2010 | Quaternary Geochronology2010，5，： | 1 |
| 15 | Tone interference suppression in DS-SS systems with modified discrete Fourier transform 显示文摘 | WEI Yongmei BI Guoan WAN Chunru | 2008 | Signal Process2008，88，11： | 1 |
| 16 | Oral nano-antioxidants improve sleep by restoring intestinal barrier integrity and preventing systemic inflammation显示文摘Sleep deprivation(SD)is a severe public health threat that can cause systemic inflammation and nerve damage.Few effective and side-effect-free drugs are available to address SD.However,the bidirectional communications between the brain and gut provide new strategies for anti-SD therapeutics.Here we explored oral delivery of fullerene nano-antioxidants(FNAO)in the SD model to improve sleep by regulating abnormal intestinal barrier and systemic inflammation via the brain-gut axis.SD caused excessive reactive oxygen species(ROS)production and hyperactive inflammatory responses in the intestines of zebrafish and mouse models,leading to disturbed sleep patterns and reduced brain nerve activity.Of note,based on the property of the conjugatedπbond of the C_(60)structure to absorb unpaired electrons,oral FNAO efficiently reduced the excessive ROS in the intestines,maintained redox homeostasis and intestinal barrier integrity,and ameliorated intestinal and systemic inflammation,resulting in superior sleep improvement.Our findings suggest that maintaining intestinal homeostasis may be a promising avenue for SD-related nerve injury therapy. | Zhanfeng Wu Lei Liu Lei Li Xinran Cao Wang Jia Xiaodan Liao Zhongpu Zhao Hedong Qi Guoqiang Fan Huiqiang Lu Chunying Shu Mingming Zhen Chunru Wang Chunli Bai | 2023 | National Science Review2023，10，12： | 1 |
| 17 | Fully conjugated tri(perylene bisimides):an approach to the construction of ntype graphene nanoribbons显示文摘 | Qian Hualei Negri F Wang Chunru | 2008 | J Am Chem Soc2008，130，17： | 1 |
| 18 | Covalently bonded two spin centers of paramagnetic metallofullerene dimer显示文摘Paramagnetic endohedral metallofullerenes with well protected unpaired spin have potential applications in molecular-scale qubit processing and magnetoreception system. In this study, a paramagnetic metallofullerene Sc_(3)C_(2)@C_(80) dimer with covalently bonded two spin centers was synthesized. Electron paramagnetic resonance (EPR) results further revealed the varied spin-nuclei couplings and paramagnetic property for Sc_(3)C_(2)@C_(80) dimer. Briefly, the Sc_(3)C_(2)@C_(80) dimer in toluene solution shows EPR hyperfine splittings originating from the spin-Sc couplings. However, the Sc_(3)C_(2)@C_(80) dimer in solid state shows the disappearance of hyperfine structure and a single EPR signal caused by its two-spin-center structure. The transformation of EPR signals can be further finely modulated by controlling the dynamic motion of Sc_(3)C_(2)@C80 dimer in chloronaphthalene. The Sc_(3)C_(2)@C_(80) dimer with two spin centers possesses varied paramagnetic properties, demonstrating its potential as new magnetic material. | Haibing Meng Yongqiang Chai Chong Zhao Mingzhe Nie Chunru Wang Taishan Wang | 2021 | Nano Research2021，14，12： | 1 |
| 19 | Influencing factors of colostrum exposure to low-level lead and their relationship with early neural development of infants显示文摘BACKGROUND: Exposure to low-level lead has a toxic effect on the development of neonates, which has attracted wide attention. Colostrum lead level can be used as the indication of lead exposure. OBJECTIVE: To observe the relationship of colostrum lead level and the neurobehavioral development of infants. DESIGN: A prospective control observation. SETTING: Center for Maternal and Child Health, Shanxi Provincial Children's Hospital. PARTICIPANTS: Totally 128 neonates of full-term normal delivery, 76 male and 52 female, from Shanxi Provincial Maternal and Child Health Center and Jiexiu Maternal and Child Health Center were involved in this study. All the involved neonates had no peripartal ischemic/hypoxic history or fetus intrauterine developmental lag. Pregnant women had no various acute and chronic diseases in pregnancy, family history of neurological disease or occupational lead exposure. 128 portions of colostrum sample of full-term normal delivery were collected. Informed consents of detected items were obtained from the puerperants and their relatives. METHODS: ① Experimental grouping: Lead level in the colostrum was determined by atomic absorption spectrometry. According to lead level in the colostrum, the neonates were classified into two exposure groups of greater than or equal to 0.24 μmol/L in a high-level lead group and less than 0.24 μ mol/L in a low-level lead group. ② Experimental evaluation: Mental developmental index (MDI) and psychological developmental index (PDI) of 3-month-old infants were evaluated with Bayley Scales of Infant Development (BSID). The relationships of MDI, PDI and colostrum lead level were performed correlation regression analysis; The relationship of colostrum lead level and development was performed multi-factor analysis with family environment and health questionnaires. MAIN OUTCOME MEASURES: ① Evaluation results of MDI and PDI. ② Multi-factor analysis results. RESULTS: Totally 128 neonates were involved in the study. Ten and eleven neonates were lost due to emigration in the high-level lead group and low-level lead group respectively, and the other 107 neonates participated in the final analysis. ① MDI and PDI in the high-level lead group were significantly lower than those in the low-level lead group, respectively (P < 0.01); Regression analysis results showed that two developmental indexes were statistically negatively correlated with colostrum lead level (regression equation y = 1.9+0.01x1,-0.04x2,+0.04x3,+0.03x4). ② Four variables of the factors included by family environment and health questionnaires were taken into equation. Large maternal age, irrational dietary pattern in pregnancy and pollution degree of habitation environment in pregnancy were the risk factors of colostrum lead level (partial regression coefficien t =0.598 4,0.426 8,0.306 7,P < 0.05-0.01), and calcium supplementation in pregnancy was a protective factor (partial regression coefficien t =-0.455 8, P < 0.01). CONCLUSION: High colostrum lead level will have adverse effects on the early development of neonates; Large maternal age, irrational dietary pattern in pregnancy and pollution degree of habitation environment in pregnancy are the risk factors of colostrum lead level, and calcium supplementation in pregnancy was a protective factor. | Shiguang Li Guoping Wang Kui Fu Chunru Qi Xianguo Wu Qinghao Kong Yingyi Liang | 2007 | Neural Regeneration Research2007，2，9： | 1 |
| 20 | Adaptive design of FIR filter with applications in broadband beamforming显示文摘 | Yang Yixin Wan Chunru Sun Chao | 2004 | IEEE Region2004，10，： | 1 |
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