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| 1 | The Formation of Anthocyanic Vacuolar Inclusions in Arabidopsis thaliana and Implications for the Sequestration of Anthocyanin Pigments显示文摘Anthocyanins 是在大多数植物的大中央液泡积累的 flavonoid 颜料。在液泡内, anthocyanins 能被发现一致地分布式或作为 sub-vacuolar 颜料身体的部分, Anthocyanic Vacuolar 包括(AVI ) 。用作为一个模型在 anthocyanin 引入的条件下面变得理解 AVI 怎么被形成的 Arabidopsis 幼苗,我们这里证明 AVI 的累积强烈与 cyanidin 3 配糖物(C3G ) 和衍生物的形成相关。在 5-O 位置(5gt 异种) 失败到 glycosylate anthocyanidins 的 Arabidopsis 异种积累 AVI 在几乎子叶的每个表皮的房间作为与野类型的幼苗相比,在的地方仅仅房间表演 AVI 的小部分。当幼苗与 vanadate 被对待时,类似的现象被观察。在 AVI 的形成为 autophagy 加亮一个角色,我们证明防碍 autophagic 过程(atg 异种) 的各种各样的异种显示 AVI 的更低的数字,除了 anthocyanins 的减少的累积。有趣地, vanadate 在 atg 异种增加 AVI 的数字,建议几条小径可能参予 AVI 形成。一起拿,我们的结果为能够积累 anthocyanin 颜料的 sub-vacuolar 分隔空间的形成建议新奇机制。 | Lucille Pourcel Niloufer G. Irani Yuhua LU Ken Riedl Steve Schwartz Erich Grotewold | 2010 | Molecular Plant2010，3，1： | 14 |
| 2 | Synthesis of linear low-density polyethylene-g-poly(acrylic acid)-co-starch/organo-montmorillonite hydrogel composite as an adsorbent for removal of Pb(Ⅱ) from aqueous solutions显示文摘The purpose of this work is to remove Pb(II) from the aqueous solution using a type of hydrogel composite. A hydrogel composite consisting of waste linear low density polyethylene, acrylic acid, starch, and organo-montmorillonite was prepared through emulsion polymerization method. Fourier transform infrared spectroscopy(FTIR), Solid carbon nuclear magnetic resonance spectroscopy(CNMR)), silicon-29 nuclear magnetic resonance spectroscopy(Si NMR)), and X-ray diffraction spectroscope((XRD) were applied to characterize the hydrogel composite. The hydrogel composite was then employed as an adsorbent for the removal of Pb(II) from the aqueous solution. The Pb(II)-loaded hydrogel composite was characterized using Fourier transform infrared spectroscopy(FTIR)),scanning electron microscopy(SEM)), and X-ray photoelectron spectroscopy((XPS)). From XPS results, it was found that the carboxyl and hydroxyl groups of the hydrogel composite participated in the removal of Pb(II). Kinetic studies indicated that the adsorption of Pb(II)followed the pseudo-second-order equation. It was also found that the Langmuir model described the adsorption isotherm better than the Freundlich isotherm. The maximum removal capacity of the hydrogel composite for Pb(II) ions was 430 mg/g. Thus, the waste linear low-density polyethylene-g-poly(acrylic acid)-co-starch/organo-montmorillonite hydrogel composite could be a promising Pb(II) adsorbent. | Maryam Irani Hanafi Ismail Zulkifli Ahmad Maohong Fan | 2015 | Journal of Environmental Sciences2015，27，1： | 11 |
| 3 | Rac1 regulates the release of Weibel-Palade Bodies in human aortic endothelial cells显示文摘Background The release of Weibel-Palade Bodies (WPB) is a form of endothelial cell activation But the signal transduction pathway leading to WPB release is not yet defined We hypothesized that small G-protein rac1 and reactive oxygen species (ROS) mediate the ligand induced release of Weibel-Palade Bodies Methods We tested this hypothesis by using wild-type and mutant adenoviral rac1 expression vectors, and by manipulating the production and destruction of superoxide and hydrogen peroxide in human aortic endothelial cells (HAEC) KH*2/5DResults Thrombin (1 0 Unit, 30 min) induced the increase of WPB release by 3 7-fold in HAEC, and that H 2O 2 (0 1 mmol/L, 30 min) induced by 4 5-fold These results correlated with thrombin-stimulated activation of rac-GTP binding activity by 3 5-fold, and increase of ROS production by 3 4-fold The dominant negative adenoviral rac-N17 gene transfer dramatically inhibited the release of WPB by 64 2% (control) and 77 3% (thrombin-stimulation), and decreased ROS production by 65 5% (control) and 83 6% (thrombin-stimulation) compared with non-infected cells, respectively Anti-oxidants, catalase and N-acetyl-cysteine significantly decreased the release of WPB by 34% and 79% in control cells, and further decreased by 63 6% and 46 7% in rac-N17 transferred cells compared with non-infected cells We also confirmed that rac1 was located upstream of ROS in the WPB release pathway KH*2/5DConclusions Small G-protein rac1 medicates ligand-induced release of Weibel-Palade Bodies in human aortic endothelial cells, and the signal pathway of WPB release is a rac1-dependent ROS regulating | 杨水祥 闫娟 Shailesh S.Deshpande Kaikobad Irani Charles J.Lowenstein | 2004 | Chinese Medical Journal2004，，8： | 6 |
| 4 | What are the current and potential future roles for endoscopic ultrasound in the treatment of pancreatic cancer?显示文摘Pancreatic adenocarcinoma is the fourth leading cause of cancer-related death in the United States. Due to the aggressive tumor biology and late manifestations of the disease, long-term survival is extremely uncommon and the current 5-year survival rate is 7%. Over the last two decades, endoscopic ultrasound(EUS) has evolved from a diagnostic modality to a minimally invasive therapeutic alternative to radiologic procedures and surgery for pancreatic diseases. EUSguided celiac plexus intervention is a useful adjunct to conventional analgesia for patients with pancreatic cancer. EUS-guided biliary drainage has emerged as a viable option in patients who have failed endoscopic retrograde cholangiopancreatography. Recently, the use of lumen-apposing metal stent to create gastrojejunal anastomosis under EUS and fluoroscopic guidance in patients with malignant gastric outlet obstruction has been reported. On the other hand, anti-tumor therapies delivered by EUS, such as the injection of anti-tumor agents, brachytherapy and ablations are still in the experimental stage without clear survival benefit. In this article, we provide updates on well-established EUS-guided interventions as well as novel techniques relevant to pancreatic cancer. | Stephen Y Oh Shayan Irani Richard A Kozarek | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，7： | 5 |
| 5 | Bifurcation in a 3-DOF Airfoil with Cubic Structural Nonlinearity显示文摘Limit cycle oscillations (LCOs) as well as nonlinear aeroelastic analysis of a 3-DOF aeroelastic airfoil motion with cubic restoring moments in the pitch degree of freedom are investigated.Aeroelastic equations of an airfoil with control surface in an incompressible potential flow are presented in the time domain.The harmonic balance (HB) method is utilized to calculate the LCO frequency and amplitude for the airfoil.Also the semi-analytical method has revealed the presence of stable and unstable limit cycles,along with stability reversal in the neighborhood of a Hopf bifurcation.The system response is determined by numerically integrating the governing equations using a standard Runge-Kutta algorithm and the obtained results are compared with the HB method.Also the results by the third order HB (HB3) method for control surface are consistent with the other numerical solution.Finally,by combining the numerical and the HB methods,types of bifurcation,be it supercritical,subcritical,or divergent flutter area are identified. | Saied IRANI Hamid SARRAFZADEH Mohammad Reza AMOOZGAR | 2011 | Chinese Journal of Aeronautics2011，24，3： | 4 |
| 6 | Deactivation studies of bifunctional Fe-HZSM5 catalyst in Fischer-Tropsch process显示文摘A physical mixture of alkali-promoted iron catalyst with binder based on Fischer-Tropsch synthesis and an acidic co-catalyst (HZSM5) for syngas conversion to hydrocarbons was studied in a fixed bed micro reactor. Deactivation data were obtained during the synthesis over a 1400 h period. The deactivation studies on iron catalyst showed that this trend followed the phase transformation Fe2.2C ( ε′) → Fe5C2 (χ) → Fe3C (θ), and the final predominant phase of the catalyst was Fe3C (θ). Deactivation of zeolite component in bifunctional catalyst may be caused by coking over the zeolitic component, dealumination of zeolite crystals, and migration of alkali promoters from iron catalyst under synthesis conditions. The deactivation rate of iron catalyst was also obtained. | Ali Nakhaei Pour Seyed Mehdi Kamali Shahri Yahya Zamani Mohammad Irani Shohreh Tehrani | 2008 | Journal of Natural Gas Chemistry2008，17，3： | 3 |
| 7 | Burden of onchocerciasis-associated epilepsy:first estimates and research priorities显示文摘Background:Since the 1990s,evidence has accumulated of an increased prevalence of epilepsy in onchocerciasisendemic areas in Africa as compared to onchocerciasis-free areas.Although the causal relationship between onchocerciasis and epilepsy has yet to be proven,there is likely an association.Here we discuss the need for disease burden estimates of onchocerciasis-associated epilepsy(OAE),provide them,detail how such estimates should be refined,and discuss the socioeconomic impact of OAE,including a cost-estimate for anti-epileptic drugs.Main body:Providing OAE burden estimates may aid prevention of epilepsy in onchocerciasis-endemic areas by inciting and informing collaboration between onchocerciasis control programmes and mental health services.Epilepsy not only massively impacts the health of those affected,but it also carries a high socioeconomic burden for the households and communities involved.We used previously published geospatial estimates of onchocerciasis in Africa and a separately published logistic regression model quantifying the association between onchocerciasis and epilepsy to estimate the number of OAE cases.We then applied disability weights for epilepsy to quantify the burden in terms of years of life lived with disability(YLD)and estimate the cost of treatment.We estimate that in 2015 roughly 117000 people were affected by OAE across onchocerciasis-endemic areas previously under the African Programme for Onchocerciases control(APOC)mandate where OAE has ever been reported or suspected,and another 264000 persons in onchocerciasis-endemic areas where OAE has never been investigated before.The total number of YLDs due to OAE was 39300 and 88700 in these areas respectively,based on a weighted mean disability weight of 0.336.The burden of OAE is approximately 13%of the total YLDs attributable to onchocerciasis and 10%of total YLDs attributable to epilepsy.We estimated that by 2015 the total costs of treatment with antiepileptic drug for OAE cases would have been a minimum of 12.4 million US$.Conclusions:These estimates suggest a considerable health,social and economic burden of OAE in Africa.The treatment and care for people with epilepsy,especially in hyperendemic onchocerciasis areas with high epilepsy prevalence thus requires more financial and human resources. | Natalie V.S.Vinkeles Melchers Sarah Mollenkopf Robert Colebunders Michael Edlinger Luc E.Coffeng Julia Irani Tresor Zola Joseph N.Siewe Sake Jde Vlas Andrea S.Winkler Wilma A.Stolk | 2018 | Infectious Diseases of Poverty2018，7，1： | 3 |
| 8 | A simple method for inducing nonalcoholic steatohepatitis with fibrosis显示文摘Background: Nonalcoholic fatty liver disease(NAFLD) is increasingly occurring in sedentary people, and may progress to NASH and hepatocellular carcinoma. It is essential to design affordable animal models for the study of various diseases, including fatty liver, which was the aim of the study. In this study, a high-fat diet was devised that triggers NASH’s animal model quickly and easily. High-fat diet(HFD) was used both with intra-mouth oral gavage and in combination with animal pellets.Methods: Twenty-four male C57 BL/6 J mice were divided into HFD and ND groups, which received a high-fat diet and a normal diet, respectively. At the end of the experiment(fourth week of treatment), body and liver weights, biochemical parameters, PPAR-α gene expression and histopathologic characteristics of the liver were evaluated.Results: During 4 weeks, body weight of mice did not show a significant increase in the HFD group compared to the ND group, while weight gain of the liver was significant. Histological assessment of the HFD group’s liver confirmed NASH symptoms. In the HFD group, HDL-c, SOD, catalase, FRAP, adiponectin, and PPAR-α decreased significantly, and lipid profiles, hepatic enzymes, MDA, leptin, and TNF-α showed a significant increase compared to the ND group.Conclusion: Our high-fat diet has successfully induced all aspects of NASH with fibrosis in 4 weeks, and with low cost. | Leyla Yahaghi Azadeh Ebrahim-Habibi Nasim Hayati-Roodbari Shiva Irani Parichehreh Yaghmaei | 2019 | Animal Models and Experimental Medicine2019，2，4： | 2 |
| 9 | Multi - frame estimate of planar motion 显示文摘 | ZELINIK - MANOR IRANI M | 2000 | IEEE Transaction on PAMI2000，22，10： | 2 |
| 10 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 11 | Randomized Clinical Trial of Cutting Balloon Angioplasty versus High-Pressure Balloon Angioplasty in Hemodialysis Arteriovenous Fistula Stenoses Resistant to Conventional Balloon Angioplasty显示文摘 | Syed Arafat Aftab Kiang Hiong Tay Farah G. Irani Richard Hoau Gong Lo Apoorva Gogna Benjamin Haaland Seck Guan Tan Siew Png Chng Shanker Pasupathy Hui Lin Choong Bien Soo Tan | 2013 | Journal of Vascular and Interventional Radiology2013，，： | 2 |
| 12 | Use of an over-the-scope clipping device: multicenter retrospective results of the first U.S. experience (with videos)显示文摘 | Todd H. Baron Louis M. Wong Kee Song Andrew Ross Jeffrey L. Tokar Shayan Irani Richard A. Kozarek | 2012 | Gastrointestinal Endoscopy2012，，1： | 2 |
| 13 | Altered Hypothalamic Leptin, Imulin, and Melanocorfin Binding Associated with Moderate- Fat Dietand Predisposition to Obesity 显示文摘 | Irani BG Dunn- Meynell AA Levin BE | 2007 | Endocrinology2007，148，： | 1 |
| 14 | Properties of cryopreserved fetal liver stem/progenitor cells that exhibit long-term repopulation of the normal rat liver显示文摘 | Malhi H Irani AN Gagandeep S | 2002 | Cell Sci2002，115，13： | 1 |
| 15 | Improving resolution by image matching显示文摘 | Irani M Peleg S | 1991 | CVGIP : Graphical Models and Image Proc1991，53，3： | 1 |
| 16 | An analytical model for optimization of NC tool cutting path显示文摘 | LAKKARAJU R K RAMAN S IRANI S A | 1992 | Int J Prod Res1992，30，1： | 1 |
| 17 | Expression of estrogen related proteins in hormone refractory pros tate cancer: association with tumor progression显示文摘 | Celhay O Yacoub M Irani J | 2010 | J Urol2010，184，5： | 1 |
| 18 | Management of Knowledge in project environments显示文摘 | Love D E Peter Edum-Fotwe Francis Irani Zahir | 2003 | International Journal of Project Management2003，21，： | 1 |
| 19 | Online Strategies for Dynamic Power Management in Systems with Multiple Power-Saving States显示文摘 | Sandy Irani Sandeep Shukla Rajesh Gupta | 2003 | ACM Transactions on Embedded Computing Systems2003，2，3： | 1 |
| 20 | N-methyl-d-aspartate anti- body encephalitisl Temporal progression of clinical and para- clinical observations in a predominantly non-paraneoplastic dis order of both sexes显示文摘 | Irani SR Bern K~ Waters Pp | 2010 | Brain2010，133，： | 1 |
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