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| 1 | 胆固醇结石病人肝脏胆小管侧膜ATP基因表达差异的研究显示文摘目的:本研究旨在测定比较胆石病人与对照组肝脏胆小管侧膜转运蛋白表达差异,以探讨胆石病发生的分子生物学机制。方法:研究包括20例胆囊胆固醇结石病人和11例无胆石症的对照。测定血清胆固醇和甘油三酯、胆汁胆固醇、胆汁酸和磷脂含量,采用Carey表计算胆汁胆固醇饱和指数。实时定量PCR法测定肝脏胆小管侧膜转运蛋白(ABCG5、ABCG8、ABCBll和ABCB4)mRNA的表达量。结果:胆石组血清胆固醇低于对照组(P<0.05)。胆石组胆汁胆固醇摩尔百分比和胆固醇饱和指数较对照组显著升高(P<0.01)。胆石组肝脏胆小管侧膜胆固醇转运蛋白ABCG5和ABCG8表达高于对照组,且后者差异具有统计学显著性(ABCG5:31.44±3.17Vs25.72±3.27,ABCG8:27.53±3.06vs17.81±2.23)。ABCBll和ABCB4表达在两组间差异无显著性。结论:本研究显示,胆石病主要病理生理异常为胆汁胆固醇过饱和,与肝脏胆小管侧膜胆固醇转运蛋白ABCG5和ABCG8的mRNA表达增加有关。 | 蒋兆彦 韩天权 所广军 袁作彪 姜志宏 商俊 蔡杏兴 Gsta Eggertsen Curt Einarsson 张圣道 | 2005 | 外科理论与实践2005，10，1： | 24 |
| 2 | Differential expression of interleukin-1/Toll-like receptor signaling regulators in microscopic and ulcerative colitis显示文摘AIM:To investigate Toll-like receptor(TLR)signaling regulators in microscopic and ulcerative colitis patients.METHODS:Total RNA and microRNA were isolated from fresh frozen colonic biopsies of non-inflamed controls and patients with active or in-remission collagenous colitis(CC),lymphocytic colitis(LC),or ulcerative colitis(UC).We compared expressions of interleukin-1receptor-associated kinase(IRAK)-2,IRAK-M,interleukin(IL)-37,microRNA(miR)-146a,miR-155,and miR-21 using quantitative real time reverse transcription polymerase chain reaction.RESULTS:IRAK-M expression was increased in LC patients with active disease in histopathological remission(LC-HR;P=0.02)and UC patients(P=0.01),but no differences in IRAK-2 expression were detected compared to controls.miR-146a,-155 and-21 expressions were increased in LC-HR(P=0.04,0.07,and 0.004)and UC(P=0.02,0.04 and 0.03)patients.miR-146a and miR-21 expressions were significantly enhanced in UC patients compared to UC remission(UC-R;P=0.01and 0.04).Likewise,active CC patients showed significantly increased expression of miR-155(P=0.003)and miR-21(P=0.006).IL-37 expression was decreased in both CC(P=0.03)and LC(P=0.04)patients with a similar trend in UC patients but not statistically significant,whilst it was increased in UC-R patients compared to controls(P=0.02)and active UC(P=0.001).CONCLUSION:The identification of differentially expressed miRNAs,IL-37,and IRAK-M suggests different pathophysiologic mechanisms in various disease stages in LC,CC,and UC. | Sezin Gunaltay Nils Nyhlin Ashok Kumar Kumawat Curt Tysk Johan Bohr Olof Hultgren Elisabeth Hultgren Hornquist | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 3 | A rapid method for extraction of cotton ( Gossypium spp.) genomic DNA suitable for RFLP or PCR analysis显示文摘 | Andrew H. Paterson Curt L. Brubaker Jonathan F. Wendel | 1993 | Plant Molecular Biology Reporter1993，，2： | 9 |
| 4 | High level of deoxycholic acid in human bile does not promote cholesterol gallstone formation显示文摘AIM: To study whether patients with excess deoxycholic acid (DCA) differ from those with normal percentage of DCA with respect to biliary lipid composition and cholesterol saturation of gallbladder bile.METHODS: Bile was collected during operation through puncturing into the gallbladder from 122 cholesterol gallstone patients and 46 gallstone-free subjects undergoing cholecystectomy. Clinical data, biliary lipids, bile acid composition,presence of crystals and nucleation time were analyzed.RESULTS: A subgroup of gallstone patients displayeda higher proportion of DCA in bile than gallstone free subjects.By choosing a cut-off level of the 90th percentile, a group of 13 gallstone patients with high DCA levels (mean 50percent of total bile acids) and a large group of 109 patients with normal DCA levels (mean 21 percent of total bile acids)were obtained. The mean age of the patients with high DCA levels was higher than that of the group with normal levels (mean age: 62 years vs45 years) and so was the mean BMI (28.3 vs. 24.7). Plasma levels of cholesterol and triglycerides were slightly higher in the DCA excess groups compared with those in the normal DCA group. There was no difference in biliary lipid composition, cholesterol saturation, nucleation time or occurrence of cholesterol crystals in bile between patients with high and normal levels of DCA.CONCLUSION: Gallstone patients with excess DCA were of older age and had higher BMI than patients with normal DCA. The two groups of patients did not differ with respect to biliary lipid composition, cholesterol saturation, nucleation time or occurrence of cholesterol crystals. It is concluded that DCA in bile does not seem to contribute to gallstone formation in cholesterol gallstone patients. | Ulf Gustafsson Staffan Sahlin Curt Einarsson | 2003 | World Journal of Gastroenterology2003，9，7： | 5 |
| 5 | 胆固醇结石病人肝脏脂质代谢异常的分子生物学研究显示文摘目的:研究导致胆石病人胆汁胆固醇过饱和的肝脏胆固醇和胆汁酸代谢途径中的分子生物学改变。方法:收集22例胆石病人和13例无胆石病的对照病人肝脏活检组织、胆囊胆汁和血浆。采用实时定量PCR检测肝脏基因表达,采用Western印迹法测定蛋白含量。结果:胆石病人较对照组ABCG5/ABCG8和LXRα基因的mRNA表达水平分别增加51%、59%和102%。肝脏SRBI的mRNA和蛋白含量均增加。结论:胆石病人ABCG5/ABCG8基因表达上调,可能与LXRα表达增加促进相关,这些异常是导致胆汁胆固醇过饱和的原因。此外,胆汁中过多的胆固醇可能来源于经肝脏高密度脂蛋白受体SRBI的摄取,而不是由于肝脏合成和酯化的异常。 | 蒋兆彦 姜翀弋 胡海 所广军 Paolo Parini Gsta Eggertsen Matthew A Davis Lawrence L Rudel Curt Einarsson 韩天权 张圣道 | 2007 | 外科理论与实践2007，12，5： | 4 |
| 6 | Challenges and opportunities for nanomaterials in spectral splitting for high-performance hybrid solar photovoltaic-thermal applications:A review显示文摘Hybrid photovoltaic-thermal(PV-T)collectors,which are capable of cogenerating useful thermal energy and electricity from the same aperture area,have a significantly higher overall efficiency and ability to displace emissions compared to independent,separate photovoltaic panels,solar thermal collectors or combinations thereof.Spectral splitting has emerged as a promising route towards next-generation high-performance PV-T collectors,and nanotechnology plays an important role in meeting the optical and thermal requirements of advanced spectral splitting PV-T collector designs.This paper presents a comprehensive review of spectral splitting technologies based on nanomaterials for PV-T applications.Emerging nanomaterials(nanofluids,nanofilms and nanowires)suitable for achieving spectral splitting based on reflection,diffraction,refraction and/or absorption approaches in PV-T collectors are presented,along with the associated challenges and opportunities of these design approaches.The requirements from such materials in terms of optical properties,thermal properties,stability and cost are discussed with the aim of guiding future research and innovation,and developing this technology towards practical application.Nanofluids and nanofilms are currently the most common nanomaterials used for spectral splitting,with significant progress made in recent years in the development of these materials.Nevertheless,there still remains a considerable gap between the optical properties of currently-available filters and the desired properties of ideal filters.Aiming to instruct and guide the future development of filter materials,a simple generalized method is further proposed in this paper to identify optimal filters and efficiency limits of spectral splitting PV-T systems for different scenarios.It is found that the optimal filter of a spectral splitting PV-T system is highly sensitive to the value of thermal energy relative to that of electricity,which therefore depends strongly on the application and location.The efficiency limit of spectral splitting PV-T collectors is significantly higher than that of standalone PV panels.The stability of nanomaterial filters remains a critical challenge for their long-term employment and also for high-temperature operation in practical applications. | Gan Huang Sara Riera Curt Kai Wang Christos N.Markides | 2020 | Nano Materials Science2020，2，3： | 3 |
| 7 | ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use: A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents显示文摘 | Deepak L. Bhatt James Scheiman Neena S. Abraham Elliott M. Antman Francis K.L. Chan Curt D. Furberg David A. Johnson Kenneth W. Mahaffey Eamonn M. Quigley Robert A. Harrington Eric R. Bates Charles R. Bridges Mark J. Eisenberg Victor A. Ferrari Mark A. Hl | 2008 | Circulation2008，，18： | 3 |
| 8 | Gallbladder bile composition in patients with Crohn's disease显示文摘瞄准:进一步阐明高度的致病和机制在 Crohn 的疾病胆石冒形成的风险。方法:胆囊胆汁与 Crohn 的疾病从病人被获得为选任的外科被招收(17 与 ileal/ileocolonic 疾病并且 7 与 Crohn 的大肠炎) 。十四个胆石病人用作控制。十二指肠的胆汁与 ursodeoxycholic 酸在治疗前后从十个健康题目被获得。胆汁为胆汁的类脂化合物,胆汁酸,胆红素,晶体,和水晶察觉时间(CDT ) 被分析。胆固醇浸透索引是计算的。结果:胆红素的胆汁的集中比在有胆固醇胆石的病人在有 Crohn 的疾病的病人更高是大约 50% 。有 Crohn 包含回肠的疾病的十个病人和三那些与 Crohn 的大肠炎把胆固醇浸透胆汁。与 i 一起的四个病人忠实疾病并且那些之一在他们的胆汁与结肠的疾病显示了胆固醇晶体。大约有 Crohn 的疾病的病人的 1/3 有短 CDT。有 ursodeoxycholic 酸的健康题目的治疗没在十二指肠的胆汁增加胆红素的集中。有 Crohn 的疾病的几个病人,与或没有 i 忠实切除术 / 疾病把胆囊胆汁与胆固醇和短 CDT 使过饱和并且包含了胆固醇晶体。胆红素的胆汁的集中也不由于胆汁酸吸收不良可能与 Crohn 的大肠炎在病人被增加。结论:几个因素可能具有为与 Crohn 的疾病在病人开发胆固醇和颜料类型的胆石的高风险的重要性。 | Annika Lapidus Jan-Erikkerlund Curt Einarsson | 2006 | World Journal of Gastroenterology2006，12，1： | 3 |
| 9 | 新型大功率电传动内燃机车显示文摘三相交流传动技术在重载货运中已得到了成功的证实。一种六轴4000牵引马力、采用三相交流传动的内燃机车在1993年投入批量生产,现已制造了70多台并投入运用。已有资料表明,轮轨间的粘着达到了45%这一前所未有的水平。3台这种机车在担当重载运煤列车牵引任务时正在取代5台3000牵引马力的直流机车。三相交流传动技术的可靠性已经达到了最初的目标,而且机车的性能不断地超过预期依。已经设计出一种适合5000和6000牵引马力的新型电传动内燃机车总构架。装用5000牵引马力柴油机的机车将在1995年投入批量生产,而装用全新的6000牵引马力柴油机的机车将在1997年投入批量生产。一台这种机车将取代今天的两台3000牵引马力的机车。作为这种新型大功卒电传动内燃机车的结果,铁路用户将在资产利用及运营成本方面获得巨大的改善。 | Curt A.Swenson Dr.Rudolf Wagner 吴雅丽 | 1995 | 国外内燃机车1995，，6： | 2 |
| 10 | 机车径向转向架对轮轨磨耗的影响显示文摘自从美国GM公司的电气动力部(EMD)为重载货运机车设计的3轴径向转向架在1993年投产以来,已运行了1.12多亿km。到1996年底,将有超过800台应用这种新转向架技术的交流和直流传动机车投入使用。相对容易得到的车轮磨耗数据表明,尽管粘着显著增加(起动重载列车时达45%,运行时达35%或更高),但轮缘磨耗实际上已消失,踏面磨耗也没增加。车轮磨耗数据还表明,车轮寿命将可能延长一倍,即使由于磨耗到限踏面进行恢复外形加工之后的车轮也如此。这是由于很低的轮缘磨耗减少了在修整车轮过程中的去料量。车轮磨耗结果也提出了改变铁路传统旋轮制度的新课题。径向转向架对减少钢轨磨耗的影响很难估算,本文只探讨几种钢轨磨耗的情况。最近的实验可使人们对轮-轨冲角对轮轨磨耗的影响有更深刻的认识。提出将现场和实验数据与费用模型结合起来以预计出由于改善钢轨和车轮磨耗而带来的寿命期成本节省量的方法。 | Curt A.Swenson R.Thomas Scott 刘爱东 曾令岩 | 1999 | 国外内燃机车1999，，6： | 2 |
| 11 | Homeomorphic extension of strongly spirallike mappings in C^n显示文摘In this paper we consider a proper subclass nA of the full class of spirallike mappings on the Euclidean unit ball Bn in Cn with respect to a given linear operator A. We use the method of subordination chains to obtain an upper growth result for nA , and we obtain various examples of mappings in the same class of normalized biholomorphic mappings on the unit ball Bn in Cn . We also prove that the class nA is compact, while the full class of spirallike mappings with respect to a linear operator need not be compact in dimension n≥2, even when the operator is diagonal. This is one of the motivations for considering the class nA . Finally we prove that if f is a quasiregular strongly spirallike mapping on Bn such that ||[Df(z)]-1 Af(z)|| is uniformly bounded on Bn , then f extends to a homeomorphism of R2n onto itself. In addition, if A + A* = 2aI n for some a >0, this extension is also quasiconformal on R2n . | CURT Paula KOHR Gabriela KOHR Mirela | 2010 | Science China Mathematics2010，53，1： | 2 |
| 12 | Inflammation-related gene expression profiles of salivary extracellular vesicles in patients with head trauma显示文摘At present,there is no reliable biomarker for the diagnosis of traumatic brain injury(TBI).Studies have shown that extracellular vesicles released by damaged cells into biological fluids can be used as potential biomarkers for diagnosis of TBI and evaluation of TBI severity.We hypothesize that the genetic profile of salivary extracellular vesicles in patients with head trauma differs from that in uninjured subjects.Findings from this hypothesis would help investigate the severity of TBI.This study included 19 subjects,consisting of seven healthy controls who denied history of head trauma,six patients diagnosed with concussion injury from an outpatient concussion clinic,and six patients with TBI who received treatment in the emergency department within 24 hours after injury.Real-time PCR analysis of salivary extracellular vesicles in participants was performed using TaqMan Human Inflammation array.Gene expression analysis revealed nine upregulated genes in emergency department patients(LOX5,ANXA3,CASP1,IL2RG,ITGAM,ITGB2,LTA4H,MAPK14,and TNFRSF1A)and 13 upregulated genes in concussion clinic patients compared with healthy participants(ADRB1,ADRB2,BDKRB1,HRH1,HRH2,LTB4R2,LTB4R,PTAFR,CYSLTR1,CES1,KLK1,MC2R,and PTGER3).Each patient group had a unique profile.Comparison between groups showed that 15 inflammation-related genes had significant expression change.Our results indicate that inflammation biomarkers can be used for diagnosis of TBI and evaluation of disease severity.This study was approved by the Institutional Review Board on December 18,2015(approval No.0078-12)and on June 9,2016(approval No.4093-16). | Yan Cheng Mandy Pereira Neha P.Raukar John L.Reagan Mathew Quesenberry Laura Goldberg Theodor Borgovan W Curt LaFrance Jr Mark Dooner Maria Deregibus Giovanni Camussi Bharat Ramratnam Peter Quesenberry | 2020 | Neural Regeneration Research2020，15，4： | 2 |
| 13 | ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use显示文摘 | Deepak L. Bhatt James Scheiman Neena S. Abraham Elliott M. Antman Francis K.L. Chan Curt D. Furberg David A. Johnson Kenneth W. Mahaffey Eamonn M. Quigley Robert A. Harrington Eric R. Bates Charles R. Bridges Mark J. Eisenberg Victor A. Ferrari Mark A. Hl | 2008 | Journal of the American College of Cardiology2008，，18： | 2 |
| 14 | Void fill and support techniques to stabilize drift excavated through a transition zone mined by a TBM at the Stillwater mine显示文摘Stillwater Mining Company is the only U.S. producer of platinum group metals(PGMs) and the largest producer outside of South Africa and Russia. The company controls a considerable portion of the J-M reef and is currently developing the ‘‘Blitz Project,' which will provide a main haulage level, ore pass systems,backfill plants, and flow-through ventilation to increase production and ensure sustainable extraction of this critical strategic mineral. While driving two sub-parallel footwall laterals 8125 m in length, one of the development drifts experienced a massive fall in a geologically disturbed area created by a mafic dike intrusion. Combinations of a void fill material(Tekseal), polyurethane injection, fore poling coupled with steel arches, and supplemental bolting allow safe and efficient advance through this geologically disturbed zone. This paper presents the details of this project. | Johnson Josh Jacobs Curt Ferster Mark Tadolini Stephen | 2017 | International Journal of Mining Science and Technology2017，27，1： | 2 |
| 15 | Is depressive disorder linked to anxiety disorder among anorexics and bulimics? 显示文摘 | GODART N T CURT F PERDEREAU F | 2005 | Encephale2005，31，： | 1 |
| 16 | Impact of cancer related fatigue on the lives of patients New findings from the Fatigue coalition显示文摘 | Curt G Bteitbart W Cella D | 2000 | The on cologist2000，5，5： | 1 |
| 17 | Ethanol stimulates bile acid formation in primary human hepatocytes显示文摘 | Lisa-Mari Nilsson Jan Sj?vall Stephen Strom Karl Bodin Greg Nowak Curt Einarsson Ewa Ellis | 2007 | Biochemical and Biophysical Research Communications2007，，4： | 1 |
| 18 | Tracking changes following spinal cord injury:insights from neuroimaging显示文摘 | Freund P Curt A Friston K Thompson A | 2013 | Neuroscientist2013，19，2： | 1 |
| 19 | Evaluation of technique to overcome small dataset problems during neural-network based contamination classification of packaged beef using integrated olfactory sensor system显示文摘 | Lav R. Khot Suranjan Panigrahi Curt Doetkott Young Chang Jacob Glower Jayendra Amamcharla Catherine Logue Julie Sherwood | 2011 | LWT - Food Science and Technology2011，，2： | 1 |
| 20 | STAT proteins and transcriptional response to extracellular signals显示文摘 | Curt M H | 2000 | TISs2000，25，： | 1 |
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