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| 1 | Recurrent Clostridium difficile infections:The importance of the intestinal microbiota显示文摘Clostridium difficile infections(CDI)are a leading cause of antibiotic-associated and nosocomial diarrhea.Despite effective antibiotic treatments,recurrent infections are common.With the recent emergence of hypervirulent isolates of C.difficile,CDI is a growing epidemic with higher rates of recurrence,increasing severity and mortality.Fecal microbiota transplantation(FMT)is an alternative treatment for recurrent CDI.A better understanding of intestinal microbiota and its role in CDI has opened the door to this promising therapeutic approach.FMT is thought to resolve dysbiosis by restoring gut microbiota diversity thereby breaking the cycle of recurrent CDI.Since the first reported use of FMT for recurrent CDI in 1958,systematic reviews of case series and case report have shown its effectiveness with high resolution rates compared to standard antibiotic treatment.This article focuses on current guidelines for CDI treatment,the role of intestinal microbiota in CDI recurrence and current evidence about FMT efficacy,adverse effects and acceptability. | Marie Céline Zanella Terrier Martine Louis Simonet Philippe Bichard Jean Louis Frossard | 2014 | World Journal of Gastroenterology2014，20，23： | 5 |
| 2 | Identification of biomarkers of human pancreatic adenocarcinomas by expression profiling and validation with gene expression analysis in endoscopic ultrasound-guided fine needle aspiration samples显示文摘瞄准:比较胰腺的腺癌织物标本的基因表示侧面,胰腺的人和腺癌和白血病房间线和正常的胰取样以便区分差别的冒号表示了基因并且在内视镜的指导超声的好针渴望( 指导EUS 的 FNA )由量的即时 RT-PCR ( RT-QPCR )验证基因的一个子集的微分表示标本。方法:包含 1176 基因的商业地奉献的癌症 cDNA 宏数组(地图集人癌症 1.2 ) 被使用。不同统计途径(层次聚类的、主要部件分析(PCA ) 和 SAM ) 被用来分析表示数据。RT-QPCR 和免疫组织化学的研究被用于结果的确认。结果:RT-QPCR 验证了 LCN2 的增加的表示(lipocalin 2 ) 并且第一次在恶意的胰的小块地(织物类型 plasminogen 使活跃之物或 tPA ) 同样与正常相比胰。Immunohistochemical 分析证实了在癌入侵的管的上皮细胞局部性的 LCN2 蛋白质的增加的表示。在与胰腺的腺癌从病人通过指导 EUS 的 FNA 获得的 12 件样品的小块地和 LCN2 抄本的分析与在正常纸巾发现的那些比较显示出显著地增加的表示层次,显示高质量的 RNA 的足够的数量能与这种技术被获得。结论:表示介绍是一个有用方法识别简历标记和潜在的目标基因。在胰腺的癌症的指导 EUS 的 FNA 样品的分子的分析为胰腺的腺癌的诊断作为珍贵策略出现。 | Henrik Laurell Michèle Bouisson Philippe Berthelémy Philippe Rochaix Sébastien Déjean Philippe Besse Christiana Susini Lucien Pradayrol Nicole Vaysse Louis Buscail | 2006 | World Journal of Gastroenterology2006，12，21： | 5 |
| 3 | Increased Risk for Nonmelanoma Skin Cancers in Patients Who Receive Thiopurines for Inflammatory Bowel Disease显示文摘 | Laurent Peyrin–Biroulet Kiarash Khosrotehrani Fabrice Carrat Anne–Marie Bouvier Jean–Baptiste Chevaux Tabassome Simon Frank Carbonnel Jean–Frédéric Colombel Jean–Louis Dupas Philippe Godeberge Jean–Pierre Hugot Marc Lémann Stéphane Nahon Jean–Marc Sabaté | 2011 | Gastroenterology2011，，5： | 3 |
| 4 | Saccharomyces boulardii Does Not Prevent Relapse of Crohn’s Disease显示文摘 | Arnaud Bourreille Guillaume Cadiot Gérard Le Dreau David Laharie Laurent Beaugerie Jean–Louis Dupas Philippe Marteau Patrick Rampal Dominique Moyse Ashraf Saleh Marie–Emmanuelle Le Guern Jean–Paul Galmiche | 2013 | Clinical Gastroenterology and Hepatology2013，，8： | 3 |
| 5 | Improved clinical outcome using polytetrafluoroethylene-coated stents for tips: Results of a randomized study显示文摘 | Christophe Bureau Juan carlos Garcia-Pagan Philippe Otal Gilles Pomier-Layrargues Valérie Chabbert Carlos Cortez Pierre Perreault Jean marie Péron Juan G. Abraldes Louis Bouchard José Ignacio Bilbao Jaume Bosch Hervé Rousseau Jean pierre Vinel | 2004 | Gastroenterology2004，，2： | 3 |
| 6 | Formation of the highest sand dunes on Earth显示文摘 | Xiaoping Yang Louis Scuderi Tao Liu Philippe Paillou Hongwei Li Jufeng Dong Bingqi Zhu Weiwei Jiang Andrew Jochems Gary Weissmann | 2011 | Geomorphology2011，，1： | 2 |
| 7 | Soluble CD40 ligand in prediction of acute severe pancreatitis显示文摘瞄准:在胰腺炎严厉估计可溶的 CD40L (sCD40L ) 的早可预测性。方法:在 2000 年 2 月和 2003 年 2 月之间,有尖锐胰腺炎的 279 个连续病人有希望地在我们的学习被注册。在这份报告, 40 个病人与温和并且有严重胰腺炎的 40 个病人随机被学习。sCD40L 集中被测量在承认以后的 48 个小时。结果:sCD40L 层次显著地更高在在严重胰腺炎的承认以后的 48 个小时比在温和胰腺炎。用 1000 的截止,检测疾病的一堂严重功课的 sCD40L 的 pg/L,敏感和特性为 CRP 与 72% 和 81% 相比分别地是 78% 和 62% 。发现那 CRP 的逻辑回归分析统计上是唯一的能检测疾病的一堂严重功课的重要标记。结论:这些调查结果显示 CRP 仍然是一个珍贵标记而 sCD40L 层次应该在进一步的研究被估计,决定尖锐胰腺炎的严厉和预后。 | Jean Louis Frossard Philippe Morel Brenda Kwak Catherine Pastor Thierry Berney Léo Buhler Alain Von Laufen Sandrine Demulder Francois Mach | 2006 | World Journal of Gastroenterology2006，12，10： | 2 |
| 8 | Role of endoscopic ultrasound in the screening and follow-up of high-risk individuals for familial pancreatic cancer显示文摘Managing familial pancreatic cancer(FPC)is challenging for gastroenterologists,surgeons and oncologists.High-risk individuals(HRI)for pancreatic cancer(PC)(FPC or with germline mutations)are a heterogeneous group of subjects with a theoretical lifetime cumulative risk of PC over 5%.Screening is mainly based on annual magnetic resonance imaging(MRI)and endoscopic ultrasound(EUS).The goal of screening is to identify early-stage operable cancers or high-risk precancerous lesions(pancreatic intraepithelial neoplasia or intraductal papillary mucinous neoplasms with high-grade dysplasia).In the literature,target lesions are identified in 2%-5%of HRI who undergo screening.EUS appears to provide better identification of small solid lesions(0%-46%of HRI)and chronicpancreatitis-like parenchymal changes(14%-77%of HRI),while MRI is probably the best modality to identify small cystic lesions(13%-49%of HRI).There are no specific studies in HRI on the use of contrast-enhanced harmonic EUS.EUS can also be used to obtain tissue samples.Nevertheless,there is still limited evidence on the accuracy of imaging procedures used for screening or agreement on which patients to treat.The cost-effectiveness of screening is also unclear.Certain new EUS-related techniques,such as searching for DNA abnormalities or protein markers in pancreatic fluid,appear to be promising. | Diane Lorenzo Vinciane Rebours Frédérique Maire Maxime Palazzo Jean-Michel Gonzalez Marie-Pierre Vullierme Alain Aubert Pascal Hammel Philippe Lévy Louis de Mestier | 2019 | World Journal of Gastroenterology2019，25，34： | 2 |
| 9 | Data mining for power system security assessment--a large scale study显示文摘 | Wehenkel Louis Mack Philippe | 2002 | IEEE Power Engineering Society Winter Meeting2002，1，1： | 2 |
| 10 | Optimising monitoring in the management of Crohn’s disease: A physician’s perspective显示文摘 | Pavol Papay Ana Ignjatovic Konstantinos Karmiris Heda Amarante Pal Milheller Brian Feagan Geert D’Haens Philippe Marteau Walter Reinisch Andreas Sturm Flavio Steinwurz Laurence Egan Julián Panés Edouard Louis Jean-Frédéric Colombel Remo Panaccione | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
| 11 | How Tokyo' S subway inspired the pads RER 显示文摘 | Louis Sato Philippe Essig | 2000 | Japan Railway @ Transport Review2000，，： | 1 |
| 12 | Inhibitory Effect of theCree Traditional Medicine Wiishichimanaanh ( Vaccinium vitis -idaea) on Advanced Glycation Endproduct Formation : Identification ofActive Principles显示文摘 | Louis - Philippe B Cory SH Ammar S | 2010 | Phytother Res2010，24，5： | 1 |
| 13 | Severe acute pancreatitis and reduced acinar cell apoptosis in the exocrine pancreas of mice deficient for the Cx32 gene显示文摘 | Jean–Louis Frossard Laura Rubbia–Brandt Matthew A. Wallig Messod Benathan Thomas Ott Philippe Morel Antoine Hadengue Susanne Suter Klaus Willecke Marc Chanson | 2003 | Gastroenterology2003，，2： | 1 |
| 14 | Identification and characterization of a spinal muscular atrophy-determining gene显示文摘 | Suzie Lefebvre Lydie Bürglen Sophie Reboullet Olivier Clermont Philippe Burlet Louis Viollet Bernard Benichou Corinne Cruaud Philippe Millasseau Massimo Zeviani Denis Le Paslier Jean Frézal Daniel Cohen Jean Weissenbach Arnold Munnich Judith Melki | 1995 | Cell1995，，1： | 1 |
| 15 | CML9, an Arabidopsis calmodulin‐like protein, contributes to plant innate immunity through a flagellin‐dependent signalling pathway显示文摘 | Louis‐Jér?me Leba Cécilia Cheval Inmaculada Ortiz‐Martín Benoit Ranty Carmen R. Beuzón Jean‐Philippe Galaud Didier Aldon | 2012 | The Plant Journal2012，，6： | 1 |
| 16 | Statin in Combination With β-Blocker Therapy Reduces Postoperative Stroke After Coronary Artery Bypass Graft Surgery显示文摘 | Denis Bouchard Michel Carrier Philippe Demers Raymond Cartier Michel Pellerin Louis P. Perrault Jean Lambert | 2011 | The Annals of Thoracic Surgery2011，，3： | 1 |
| 17 | Increased Adipose Tissue Expression of Hepcidin in Severe Obesity Is Independent From Diabetes and NASH显示文摘 | Soumeya Bekri Philippe Gual Rodolphe Anty Nathalie Luciani Monsef Dahman Bala Ramesh Antonio Iannelli Aline Staccini–Myx Dominique Casanova Imed Ben Amor Marie–Christine Saint–Paul Pierre–Michel Huet Jean–Louis Sadoul Jean Gugenheim Surjit Kaila S. Srai A | 2006 | Gastroenterology2006，，3： | 1 |
| 18 | Diploid/Polyploid Syntenic Shuttle Mapping and Haplotype-Specific Chromosome Walking Toward a Rust Resistance Gene (Bru1) in Highly Polyploid Sugarcane (2n ~ 12x ~ 115)显示文摘 | Le Cunff Lo?c Garsmeur Olivier Raboin Louis Marie Pauquet Jérome Telismart Hugues Selvi Athiappan Grivet Laurent Philippe Romain Begum Dilara Deu Monique Costet Laurent Wing Rod Glaszmann Jean Christophe D’Hont Angélique | 2008 | Genetics2008，，1： | 1 |
| 19 | Early prediction of acute pancreatitis: Prospective study comparing computed tomography scans, ranson, glasgow, acute physiology and chronic health evaluation II scores, and various serum markers显示文摘 | John H. Robert M.D. Jean Louis Frossard M.D. Bernadette Mermillod M.S. Claudio Soravia M.D. Nouri Mensi M.S. Marc Roth M.D. Adrien Rohner M.D. Antoine Hadengue M.D. Philippe Morel M.D | 2002 | World Journal of Surgery2002，，5： | 1 |
| 20 | Arterial Embolotherapy for Endoscopically Unmanageable Acute Gastroduodenal Hemorrhage: Predictors of Early Rebleeding显示文摘 | Romaric Loffroy Boris Guiu Philippe D'Athis Lise Mezzetta Alice Gagnaire Jean–Louis Jouve Pablo Ortega–Deballon Nicolas Cheynel Jean–Pierre Cercueil Denis Krausé | 2009 | Clinical Gastroenterology and Hepatology2009，，5： | 1 |
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