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| 1 | Cirrhotic patients and older people显示文摘The global population is aging,and so the number of older cirrhotic patients is increasing.Older patients are characterised by a risk of frailty and comorbidities,and age is a risk factor for mortality in cirrhotic patients.The incidence of nonalcoholic fatty liver disease as an aetiology of cirrhosis is increasing,while that of chronic viral hepatitis is decreasing.Also,cirrhosis is frequently idiopathic.The management of portal hypertension in older cirrhotic patients is similar to that in younger patients,despite the greater risk of treatment-related adverse events of the former.The prevalence of hepatocellular carcinoma increases with age,but its treatment is unaffected.Liver transplantation is generally recommended for patients<70 years of age.Despite the increasing prevalence of cirrhosis in older people,little data are available and few recommendations have been proposed.This review suggests that comorbidities have a considerable impact on older cirrhotic patients. | Paul Carrier Marilyne Debette-Gratien Jérémie Jacques Véronique Loustaud-Ratti | 2019 | World Journal of Hepatology2019，11，9： | 6 |
| 2 | Infectious etiopathogenesis of Crohn's disease显示文摘Important advances during the last decade have been made in understanding the complex etiopathogenesis of Crohn’s disease(CD).While many gaps in our knowledge still exist,it has been suggested that the etiology of CD is multifactorial including genetic,environmental and infectious factors.The most widely accepted theory states that CD is caused by an aggressive immune response to infectious agents in genetically predisposed individuals.The rise of genome-wide association studies allowed the identification of loci and genetic variants in several components of host innate and adaptive immune responses to microorganisms in the gut,highlighting an implication of intestinal microbiota in CD etiology.Moreover,numerous independent studies reported a dysbiosis,i.e.,a modification of intestinal microbiota composition,with an imbalance between the abundance of beneficial and harmful bacteria.Although microorganisms including viruses,yeasts,fungi and bacteria have been postulated as potential CD pathogens,based on epidemiological,clinicopathological,genetic and experimental evidence,their precise role in this disease is not clearly defined.This review summarizes the current knowledge of the infectious agents associated with an increased risk of developing CD.Therapeutic approaches to modulate the intestinal dysbiosis and to target the putative CD-associated pathogens,as well as their potential mechanisms of action are also discussed. | Jessica Carriere Arlette Darfeuille-Michaud Hang Thi Thu Nguyen | 2014 | World Journal of Gastroenterology2014，20，34： | 4 |
| 3 | 艺术博物馆的诗学显示文摘博物馆和艺术史之间一直存在着相互关联、并行不悖的关系。博物馆通常沿用艺术史的叙述模式,按照年代顺序陈列展品。而实际上,通过直观的欣赏,博物馆可以向观众传达策展人的意图和对作品的'诠释',只是目前看来,布展的'诗学'尚未得到足够的重视。本文通过介绍分析华盛顿国家画廊伊斯兰艺术展、纽约现代艺术博物馆中马蒂斯《舞Ⅰ》的陈列方式、葡萄牙殖民开拓艺术展、安纳托利亚小地毯展,以及提埃波罗绘画细节摄影展,说明作为一个整体的博物馆,其作用远大于所有藏品简单相加的总和,它本身就是一种叙述方式、一件'艺术作品',值得学习研究。 | David Carrier 沈蕾 | 2010 | 文化艺术研究2010，3，3： | 4 |
| 4 | Detection of ginkgolides-A in Ginkgo biloba cell cultures显示文摘 | Carrier D J Chauret N Mancini M | 1991 | Plant Cell Reports1991，10，5： | 3 |
| 5 | Ribavirin:Past,present and future显示文摘Before the advent of direct acting antiviral agents(DAAs) ribavirin, associated to pegylated-interferon played a crucial role in the treatment of chronic hepatitis C, preventing relapses and breakthroughs. In the present era of new potent DAAs, a place is still devoted to the drug. Ribavirin associated with sofosbuvir alone is efficient in the treatment of most cases of G2 infected patients. All options currently available for the last difficult-to-treat cirrhotic G3 patients contain ribavirin. Reducing treatment duration to 12 wk in G1 or G4 cirrhotic compensated patients is feasible thanks to ribavirin. Retreating patients with acquired anti NS5 A resistance-associated variants using ribavirin-based strategies could be useful. The addition of ribavirin with DAAs combinations however, leads to more frequent but mild adverse events especially in cirrhotic patients. Preliminary data with interferon-free second generation DAAs combinations without ribavirin suggest that future of the drug is jeopardized even in difficult-totreat patients: The optimization of ribavirin dosage according to an early monitoring of blood levels has been suggested to be relevant in double therapy with peginterferon or sofosbuvir but not with very potent combinations of more than two DAAs. | Véronique Loustaud-Ratti Marilyne Debette-Gratien Jérémie Jacques Sophie Alain Pierre Marquet DenisSautereau Annick Rousseau Paul Carrier | 2016 | World Journal of Hepatology2016，8，2： | 3 |
| 6 | Association of types of diabetes and insulin dependency on birth outcomes显示文摘BACKGROUND Diabetes rates among pregnant women in the United States have been increasing and are associated with adverse pregnancy outcomes.AIM To investigate differences in birth outcomes(preterm birth,macrosomia,and neonatal death)by diabetes status.METHODS Cross-sectional design,using linked Missouri birth and death certificates(singleton births only),2010 to 2012(n=204057).Exposure was diabetes non-diabetic,pre-pregnancy diabetes-insulin dependent(PD-I),pre-pregnancy diabetes-non-insulin dependent(PD-NI),gestational diabetes-insulin dependent(GD-I),and gestational diabetes-non-insulin dependent(GD-NI).Outcomes included preterm birth,macrosomia,and infant mortality.Confounders included demographic characteristics,adequacy of prenatal care,body mass index,smoking,hypertension,and previous preterm birth.Bivariate and multivariate logistic regression assessed differences in outcomes by diabetes status.RESULTS Women with PD-I,PD-NI,and GD-I remained at a significantly increased odds for preterm birth(aOR 2.87,aOR 1.77,and aOR 1.73,respectively)and having a very large baby[macrosomia](aOR 3.01,aOR 2.12,and aOR 1.96,respectively);in reference to non-diabetic women.Women with GDNI were at a significantly increased risk for macrosomia(aOR1.53),decreased risk for their baby to die before their first birthday(aOR 0.41)and no difference in risk for preterm birth in reference to non-diabetic women.CONCLUSION Diabetes is associated with the poor birth outcomes.Clinical management of diabetes during pregnancy and healthy lifestyle behaviors before pregnancy can reduce the risk for diabetes and poor birth outcomes. | Pamela K Xaverius Steven W Howard Deborah Kiel Jerry E Thurman Ethan Wankum Catherine Carter Clairy Fang Romi Carriere | 2022 | World Journal of Clinical Cases2022，10，7： | 2 |
| 7 | HCV ‐associated B ‐cell non‐ H odgkin lymphomas and new direct antiviral agents显示文摘 | Paul Carrier Arnaud Jaccard Jérémie Jacques Tessa Tabouret Marilyne Debette‐Gratien Julie Abraham Laura Mesturoux Pierre Marquet Sophie Alain Denis Sautereau Marie Essig Véronique Loustaud‐Ratti | 2015 | Liver Int2015，，10： | 2 |
| 8 | 回忆德国纳粹时期的大屠杀显示文摘'大屠杀'中,600万犹太人以及成千上万的政治反对派、残疾人、吉普赛人(罗姆人)、同性恋者和'反社会的'人被屠杀。纳粹政权垮台后,历届德国政府一直在努力修补与受害者的代表和亲属之间的关系。本文追溯了东、西德政府以及1989年统一后的德国政府所采取的和解措施,也描绘了语言性的、象征性的和仪式性的表达对德国大屠杀社会记忆演变的影响。这些表达通常是对那些由政治家及其学术顾问预设的记忆模式的回避或颠覆。有鉴于对大屠杀的集体记忆是动态、多元的,甚或经常是自相矛盾的,本文作者告诫人们:对待这一至今仍以不同寻常的方式发挥着深刻影响的、震撼人心的事件,切莫自以为是。 | Peter Carrier 伍迅 | 2011 | 史林2011，，2： | 2 |
| 9 | European Association for the Study of the Liver and French hepatitis C recent guidelines: The paradigm shift显示文摘The latest Association Fran?aise pour l'Etude du Foie-French Association for Study of the Liver(AFEF) and European Association for the Study of the Liver(EASL) recommendations announce a change of paradigm, for the management of patients infected with hepatitis C virus(HCV). The AFEF recommendations focus on the elimination of HCV infection on a national level by preventing reinfection, in less than ten years. This goal involves the facilitation of patients' management in a simplified pathway by increasing screening procedures and access to pangenotypic treatments mainly in the 'reservoir' population of people who inject drugs and migrants. Even in the complex pathway of patients with previous comorbidities, AFEF takes the option of a therapeutic simplification. The EASL guidelines position themselves on the state of the art with a precise description of all therapeutic options available, without separating simplified and complex pathways even if they take into account the epidemiological evolution of difficult-to-treat populations. | Véronique Loustaud-Ratti Marilyne Debette-Gratien Paul Carrier | 2018 | World Journal of Hepatology2018，10，10： | 2 |
| 10 | Consensus Statements on the Risk, Prevention, and Treatment of Venous Thromboembolism in Inflammatory Bowel Disease: Canadian Association of Gastroenterology显示文摘 | Geoffrey C. Nguyen Charles N. Bernstein Alain Bitton Anthony K. Chan Anne M. Griffiths Grigorios I. Leontiadis William Geerts Brian Bressler J. Decker Butzner Marc Carrier Nilesh Chande John K. Marshall Chadwick Williams Clive Kearon | 2014 | Gastroenterology2014，，3： | 2 |
| 11 | Transmembrane ICa contributes to rate-dependent changes of action potentials in human ventricular myocytes显示文摘 | Li GR Yang B Feng J Bosch RF Carrier M Nattel S | 1999 | Am J Physiol1999，276，12： | 2 |
| 12 | Outcomes among 562 recipients of placental-blood transplants from unrelated donors显示文摘 | Carrier C Scaradavou A | 1998 | N Engl J Med1998，339，： | 1 |
| 13 | 显示文摘 | Lambert J F Che M | 1997 | J Am Chem Soc1997，19，10： | 1 |
| 14 | IL-17 and Th17 cells显示文摘 | Korn T Carrier Y Gao W | 2009 | Annu Rev Immunol2009，27，： | 1 |
| 15 | Effect on hepatitis B virus DNA levds in children infected with different genotypes显示文摘 | Sangfelt P Norder H Magnius LO Interferon - alpha 2b treament in hepatitis B carriers | 1997 | Acta Paediatr1997，86，2： | 1 |
| 16 | Continuous monitoring of cholesterol oleate hydrolysis by hormone-sensitive lipase and other cholesterol csterases显示文摘 | Ali Y B Carriere F Verger R | 2005 | J Lipid Res2005，46，5： | 1 |
| 17 | Interaction of the regulatory domains of murine Cyplal gene with two DNAbinding proteins in addition to the Ah receptor and the Ah receptor nuclear translocator (ARNT) 显示文摘 | Carrier F Chang CY Duh JL | 1994 | Biochem Pharmacol1994，48，9： | 1 |
| 18 | Mortality and morbidity associat- ed with osteoporosis drug treatment following hip fracture显示文摘 | Cree MW Juby AG Carriere KC | 2003 | Os- teoooros Int2003，14，9： | 1 |
| 19 | Goodbye,Hazen; Hello,Kozeny-Car-man 显示文摘 | Carrier W D | 2003 | Journal of Geotechnical andGeoenvironmental Engineering2003，129，11： | 1 |
| 20 | Reciprocal develop?mental pathways for the generation of pathogenic effector Th17 and regulatory T cell显示文摘 | Bettelli E Carrier Y Gao W | 2006 | Nature2006，441，23： | 1 |
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