|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 微生物色氨酸代谢诱导芳基烃受体活化同时改善酒精所致的肝损伤显示文摘【据Gut 2020年10月报道】题:微生物色氨酸代谢诱导芳基烃受体活化同时改善酒精所致的肝损伤(作者Wrzosek L等)慢性饮酒是肝脏相关死亡的一个重要原因。在小鼠和人类中,特定的肠道微生物群与酒精性肝病的易感性或耐药性有关。研究目的是确定肠道微生物群可以改善酒精引起的肝脏病变的机制。 | WRZOSEK L CIOCAN D HUGOT C 马博 金清龙 | 2020 | 临床肝胆病杂志2020，36，11： | 4 |
| 2 | NOD2/CARD15 gene mutations in North Algerian patients with inflammatory bowel disease显示文摘AIM: To analyse allelic frequency of NOD2 gene variantsand to assess their correlation with inflammatory bowel disease(IBD) in Algeria.METHODS: We studied 132 unrelated patients diagnosed with IBD, 86 with Crohn's disease(CD) and 46 with ulcerative colitis(UC). Data was prospectively collected between January 2011 and December 2013. The demographic and clinical characteristics were recorded for all the patients. A group of 114 healthy unrelated individuals were selected as controls. All groups studied originated from different regions of North Algeria and confirmed the Algerian origin of their parents and grandparents. Informed and written consent was obtained from each of the participants. All individuals were genotyped for the three CDassociated NOD2 variants(p.Arg702 Trp, p.Gly908 Arg and p.Leu1007 fsins C mutations) using the polymerase chain reaction-restriction fragment length polymorphism method. Allele and genotype frequencies in patients and control subjects were compared by χ2 test and Fisher's exact test where appropriate. Odds ratios(OR) and 95% confidence intervals(95%CI) were also estimated. Association analyses were performed to study the influence of these variants on IBD and on clinical phenotypes.RESULTS: The p.Arg702 Trp mutation showed the highest frequency in CD patients(8%) compared to UC patients(2%)(P = 0.09, OR = 3.67, 95%CI: 0.48-4.87) and controls(5%)(P = 0.4, OR = 1.47, 95%CI: 0.65-3.31). In CD patients allelic frequencies of p.Gly908 Arg and p.Leu1007 fsins C variants compared to HC were 3% vs 2%(P = 0.5, OR = 1.67, 95%CI: 0.44-6.34); 2% vs 1%(P = 0.4 OR = 2.69 95%CI: 0.48-14.87 respectively). In UC patients, allelic frequencies of p.Gly908 Arg and p.Leu1007 fsins C variants compared to HC were 1% vs 2%(P = 1, OR = 1.62, 95%CI: 0.17-4.74) and 2% vs 1%(P = 0.32, OR = 0.39, 95%CI: 0.05-2.87). The total frequency of the mutated NOD2 chromosomes was higher in CD(13%), than in HC(8%) and UC(5%). In addition, NOD2 variants were linked to a particular clinical sub-phenotype in CD in this Algerian cohort. As expected, the three NOD2 variants showed a significant association with CD but did not reach statistical significance, despite the fact that the allele frequency of NOD2 variants was in the range found in most of the European populations. This might be due to the non-exposure of the NOD2 carriers to environmental factors, required for the expression of the disease.CONCLUSION: Further analyses are necessary to study genetic and environmental factors in IBD in the Algerian population, using larger patient groups. | Aziza Boukercha Hamida Mesbah-Amroun Amira Bouzidi Houria Saoula Mhamed Nakkemouche Maryline Roy Jean-Pierre Hugot Chafia Touil-Boukoffa | 2015 | World Journal of Gastroenterology2015，21，25： | 3 |
| 3 | Increased Risk for Nonmelanoma Skin Cancers in Patients Who Receive Thiopurines for Inflammatory Bowel Disease显示文摘 | Laurent Peyrin–Biroulet Kiarash Khosrotehrani Fabrice Carrat Anne–Marie Bouvier Jean–Baptiste Chevaux Tabassome Simon Frank Carbonnel Jean–Frédéric Colombel Jean–Louis Dupas Philippe Godeberge Jean–Pierre Hugot Marc Lémann Stéphane Nahon Jean–Marc Sabaté | 2011 | Gastroenterology2011，，5： | 3 |
| 4 | Intestinal barrier dysfunction triggered by invasive bacteria显示文摘 | F Barreau JP Hugot | 2013 | Current Opinion in Microbiology2013，，： | 2 |
| 5 | Growlh in Paediatric Crohn's Disease显示文摘 | Cezard JP Touati G Alberti C Hugot JP Brinon C Czemichow P | 2002 | Horni Res2002，58，1： | 1 |
| 6 | Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease显示文摘 | Hugot J P Chamaillard M Zouali H | 2001 | Nature2001，411，6837： | 1 |
| 7 | Polyanllne Fili ts for ProtectionAgainst Corrosion显示文摘 | M C Bernard A Hugot - Le Goff S Joiret P V Phong | 2001 | Synthetic Metals2001，119，13： | 1 |
| 8 | Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae显示文摘 | Chassaing Benoit Rolhion Nathalie de Vallée Amélie Salim Sa’ad Y Prorok-Hamon Maelle Neut Christel Campbell Batty J S?derholm Johan D Hugot Jean-Pierre Colombel Jean-Frédéric Darfeuille-Michaud Arlette | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 9 | Thiol WR-1065 and disulfide WR-33278, two metabolites of the drug Ethol(WR-2721), protect DNA against fast neutron induced strand breakage 显示文摘 | Savoye C Swenberg C Hugot S | 1997 | Int J Radiat Biol1997，71，： | 1 |
| 10 | Association of NOD2 Ieucine-rich recepeat variants with susceptibility to Crohn's disease显示文摘 | Hugot JP Chamaillard M Zouali H | 2001 | Nature2001，411，： | 1 |
| 11 | Structure of very thin TiO2 films studied by Raman spectroscopy with interference enhancement 显示文摘 | Hugot Le Goff A | 1986 | Thin Solid Films1986，142，2： | 1 |
| 12 | Early diagnosis of renal function recovery by cystain C in renal allograft recipients显示文摘 | Thervet E LeBricon T Hugot M | 2000 | Transplant Proc2000，32，： | 1 |
| 13 | Mapping of a susceptibility locus for Crohn's disease on chromosome 16显示文摘 | HUGOT J P LAURENT-PUGI P GOWER-ROUSSEAU C | 1996 | Nature1996，379，6568： | 1 |
| 14 | Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease显示文摘 | Hugot JP Chamalliard M Zouali H | 2001 | Nature2001，411，6837： | 1 |
| 15 | Primates and their pinworm parasites:the Cameron hypothe-sis revisited显示文摘 | HUGOT J P | 1999 | Systematic Biology1999，48，： | 1 |
| 16 | Crohn’s disease: the cold chain hypothesis显示文摘 | Jean-Pierre Hugot Corinne Alberti Dominique Berrebi Edouard Bingen Jean-Pierre Cézard | 2003 | The Lancet . 2003 (9400)2003，，： | 1 |
| 17 | Sur le genre Auchenacantha (Oxyuridae: Nematoda) parasites de Dermoptères. Etude de la morphologie et de la distribution des formes显示文摘 | J. P. Hugot | 1986 | Systematic Parasitology1986，，4： | 1 |
| 18 | Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease显示文摘 | Hugot JP Chamaillard M Zouali H | 2001 | Nature2001，411，6837： | 1 |
| 19 | Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease显示文摘 | HUGOT J P CHAMAILLARD M ZOUALI H | 2001 | Nature2001，411，6837： | 1 |
| 20 | Crohn's disease: the cold chain hypothesis显示文摘 | Hugot J P Alberti C Berrebi D | 2003 | Lancet2003，362，9400： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员