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| 1 | 近自然森林经营的理论体系及在幼龄林抚育改造中的实践显示文摘介绍了近自然森林经营理论及其在北京密云县不同植被区域的人工林近自然化经营试点研究成果.研究内容包括近自然的森林经营计划调查、群落生境制图及经营计划、目标树单株木林分施业体系等技术应用.结果表明,在保持森林生态系统结构和功能稳定的基础上,近自然森林经营具有投入成本低、抗灾害能力强的特点,能使森林同时发挥其生态、经济和社会效益. | 陆元昌 Knut Sturm 甘敬 雷相东 国红 | 2004 | 中国造纸学报2004，19，z1： | 32 |
| 2 | Current treatment of ulcerative colitis显示文摘Ulcerative colitis (UC) is a chronic disease featuring re- current inflammation of the colonic mucosa. The goal of medical treatment is to rapidly induce a steroid-free remission while at the same time preventing complica- tions of the disease itself and its treatment. The choice of treatment depends on severity, localization and the course of the disease. For proctitis, topical therapy with 5-aminosalicylic acid (5-ASA) compounds is used. More extensive or severe disease should be treated with oral and local 5-ASA compounds and corticosteroids to induce remission. Patients who do not respond to this treatment require hospitalization. Intravenous steroids or, when refractory, calcineurin inhibitors (cyclosporine, tacrolimus), tumor necrosis factor-α antibodies (infliximab) or immunomodulators (azathioprine, 6-mercaptopurine) are then called for. Indications for emergency surgery include refractory toxic megacolon, perforation, and continuous severe colorectal bleeding. Close collaboration between gastroenterologist and surgeon is mandatory in order not to delay surgical therapy when needed. This article is intended to give a general, practice-orientated overview of the key issues in ulcerative colitis treatment. Recommendations are based on published consensus guidelines derived from national and international guidelines on the treatment of ulcerative colitis. | Johannes Meier Andreas Sturm | 2011 | World Journal of Gastroenterology2011，17，27： | 28 |
| 3 | Epithelial restitution and wound healing in inflammatory bowel disease显示文摘Inflammatory bowel disease is characterized by a chronic inflammation of the intestinal mucosa. The mucosal epithelium of the alimentary tract constitutes a key element of the mucosal barrier to a broad spectrum of deleterious substances present within the intestinal lumen including bacterial microorganisms, various dietary factors, gastrointestinal secretory products and drugs. In addition, this mucosal barrier can be disturbed in the course of various intestinal disorders including inflammatory bowel diseases. Fortunately, the integrity of the gastrointestinal surface epithelium is rapidly reestablished even after extensive destruction. Rapid resealing of the epithelial barrier following injuries is accomplished by a process termed epithelial restitution, followed by more delayed mechanisms of epithelial wound healing including increased epithelial cell proliferation and epithelial cell differentiation. Restitution of the intestinal surface epithelium is modulated by a range of highly divergent factors among them a broad spectrum of structurally distinct regulatory peptides, variously described as growth factors or cytokines. Several regulatory peptide factors act from the basolateral site of the epithelial surface and enhance epithelial cell restitution through TGF-β-dependent pathways. In contrast, members of the trefoil factor family (TFF peptides) appear to stimulate epithelial restitution in conjunction with mucin glycoproteins through a TGF-β-independent mechanism from the apical site of the intestinal epithelium. In addition, a number of other peptide molecules like extracellular matrix factors and blood clotting factors and also non- peptide molecules including phospholipids, short-chain fatty acids (SCFA), adenine nucleotides, trace elements and pharmacological agents modulate intestinal epithelial repair mechanisms. Repeated damage and injury of the intestinal surface are key features of various intestinaldisorders including inflammatory bowel diseases and require constant repair of the epithelium. Enhancement of intestinal repair mechanisms by regulatory peptides or other modulatory factors may provide future approaches for the treatment of diseases that are characterized by injuries of the epithelial surface. | Andreas Sturm Axel U Dignass | 2008 | World Journal of Gastroenterology2008，14，3： | 24 |
| 4 | CNS-PNETS分子分类中出现新的脑肿瘤实体类型显示文摘中枢神经系统原始神经外胚层肿瘤(CNS—PNET)是具有高度侵袭性分化差的胚胎性肿瘤,主要好发于幼儿,也可见于青少年和成人。 | Sturm D Orr B A Toprak U H 李晓玲 王行富 | 2016 | 临床与实验病理学杂志2016，32，7： | 16 |
| 5 | 北京林区森林经营近自然度评价方法的研究与应用显示文摘通过对北京地区森林的近自然评价,构建了适合北京森林环境条件和自然规律的森林经营策略。首先根据现地植被情况和立地条件,对植被群落分级,然后再依据近自然度评价结果,绘制群落生境图,在此基础上设计了林分作业体系,该体系的应用可节约至少30%的造林经费,提高林分生长量25%以上。 | 刘刚 陆元昌 Knut Sturm 宁金魁 雷相东 | 2009 | 东北林业大学学报2009，37，5： | 15 |
| 6 | Particle size dependent sinterability and magnetic properties of recycled HDDR Nd-Fe-B powders consolidated with spark plasma sintering显示文摘The dependence of the magnetic properties on the particle size of recycled HDDR Nd-Fe-B powders was investigated,with the aim to assess the reprocessing potential of the end-of-life scrap magnets via spark plasma sintering(SPS).The as received recycled HDDR powder has coercivity(Hci)=830 kA/m and particles in the range from 30 to 700 μm(average 220 μm).After burr milling,the average particle size is reduced to 120 μm and subsequently the Hci of fine(milled) powder was 595 kA/m.Spark plasma sintering was exploited to consolidate the nanograined HDDR powders and limit the abnormal grain coarsening.The optimal SPS-ing of coarse HDDR powder at 750℃for 1 min produces fully dense magnets with Hci=950±100 kA/m which further increases to 1200 kA/m via thermal treatment at 750℃for 15 min.The burr milled fine HDDR powder under similar SPS conditions and after thermal treatment results in Hci=940 kA/m.The fine powder is further sieved down from 630 to less than 50 μm mesh size,to evaluate the possible reduction in Hci in relation to the particle size.The gain in oxygen content doubles for <50 μm sized particles as compared with coarser fractions(>200 μm).The XRD analysis for fractionated powder indicates an increase in Nd2O3 phase peaks in the finer(<100 μm)fractions.Similarly,the Hci reduces from 820 kA/m in the coarse particles(>200 μm) to 460 kA/m in the fine sized particles(<100μm).SPS was done on each HDDR powder fraction under the optimal conditions to measure the variation in Hci and density.The Hci of SPS-ed coarse fraction(>200 μm) is higher than 930 kA/m and it falls abruptly to just 70 kA/m for the fine sized particles(<100 μm).The thermal treatment further improves the Hci to>1000 kA/m only up to 100 μm sized fractions with>90% sintered density.The full densification(>99%) is observed only in the coarse fractions.The loss of coercivity and lack of sinterability in the fine sized particles(<100 μm) are attributed to a very high oxygen content.This implies that during recycling,if good magnetic properties are to be maintained or even increase the HDDR powder particles can be sized down only up to≥100 μm. | Awais Ikram Farhan Mehmood Richard Stuart Sheridan Muhammad Awais Allan Walton Anas Eldosouky Saso Sturm Spomenka Kobe Kristina Zuzek Rozman | 2020 | Journal of Rare Earths2020，38，1： | 5 |
| 7 | 结直肠癌术后吻合口瘘与表皮生长因子、转化生长因子-β1、血管内皮生长因子基因多态性的关系显示文摘目的观察表皮生长因子(EGF)61*G/A、转化生长因子-β1(TGF-β1)-509*TIC、血管内皮生长因子(VEGF)936*T/C基因功能多态性对术后结肠吻合口瘘的影响。方法采用聚合酶链反应-限制性片段长度多态性(PCR—RFLP)方法检测伴有和不伴有术后结肠吻合口瘘结直肠癌患者的EGF 61*G/A,TGF-β1—509*T/C,VEGF 936*T/C基因型。结果伴有术后结肠吻合口瘘的结直肠癌患者TGF-β1-509*T/T基因型比例(0.0%)低于无术后吻合口瘘的患者(15.2%),两者差异有统计学意义(P〈0.05)。伴有术后结肠吻合口瘘的VEGF 936*C/C基因型和C等位基因比例(65.9%和80.6%)低于无术后吻合口瘘的患者(82.6%和90.5%),两者差异有统计学意义(基因型x^2=5.755,P〈0.05;等位基因x^2=5.275,P〈0.05)。伴有术后结肠吻合口瘘的结直肠癌患者EGF 61*G/G基因型比例(25.0%)低于无术后吻合口瘘的患者(55.5%),但两者差异无统计学意义(x^2=1.591,P〉0.05)。结论TGF-β1-509*T/T基因型,VEGF 936*C/C基因型或936*C等位基因有助于减少术后结肠吻合口瘘的发生。 | 吴国洋 王效民 Michael Keese Till Hasenberg Jǒrg W. Sturm | 2008 | 中华实验外科杂志2008，25，3： | 5 |
| 8 | 血管内皮生长因子936T/C基因多态性与结直肠癌及术后吻合口瘘的关系显示文摘目的通过研究血管内皮生长因子(VEGF)936T/C基因多态性了解该因子对结直肠癌生成及术后结肠吻合口瘘的影响。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测结直肠癌及正常对照的VEGF936T/C基因型。结果结直肠癌患者VEGF936T/C基因型或等位基因与对照组相比无差异。伴有术后结肠吻合口瘘的结直肠癌患者其VEGF936C/C基因型及C等位基因比例低于无术后结肠吻合口瘘的患者,两者差异有统计学意义(P<0·05)。结论VEGF936C/C基因型或936C等位基因与结直肠癌的发生无关,但提示术后结肠吻合口瘘的发生率降低。 | 吴国洋 王效民 Michael Keese Till Hasenberg Jrg W. Sturm | 2006 | 中华外科杂志2006，44，21： | 4 |
| 9 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 2: Current management显示文摘 | Axel Dignass James O. Lindsay Andreas Sturm Alastair Windsor Jean-Frederic Colombel Mathieu Allez Gert D’Haens André D’Hoore Gerassimos Mantzaris Gottfried Novacek Tom ?resland Walter Reinisch Miquel Sans Eduard Stange Severine Vermeire Simon Travis Gert | 2012 | Journal of Crohn’s and Colitis2012，，10： | 4 |
| 10 | The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Special situations显示文摘 | Gert Van Assche Axel Dignass Walter Reinisch C. Janneke van der Woude Andreas Sturm Martine De Vos Mario Guslandi Bas Oldenburg Iris Dotan Philippe Marteau Alessandro Ardizzone Daniel C. Baumgart Geert D’Haens Paolo Gionchetti Francisco Portela Boris Vuce | 2009 | Journal of Crohn’s and Colitis2009，，1： | 3 |
| 11 | MECHANICS OF RELAXING SiGe ISLANDS ON A VISCOUS GLASS显示文摘A process has been developed recently to fabricate a structure com-prising,from top to bottom,a SiGe thin film,a glass layer,and a Si wafer.TheSiGe film is a perfect crystal,and is under biaxial compression.The SiGe film ispatterned into islands.On annealing,the glass flows and the islands relax.Theresulting strain-free islands are used as substrates,to grow epitaxial optoelectronicdevices.This article describes a series of studies on the annealing process,combiningexperiment and theory.A small island relaxes by expansion,starting at the edgesand diffusing to the center.A large island wrinkles before the expansion reaches thecenter.After some time,the wrinkles either disappear,or cause the island to fracture.We model the island as an elastic plate,and the glass layer as a viscous liquid.Thestrains in the islands are measured by X-ray diffraction and Raman spectroscopy,andthe wrinkle amplitudes by atomic force microscope.The data are compared with thetheoretical predictions.We determine the conditions under which the islands relax byexpansion without significant wrinkling,and demonstrate that a cap layer suppresseswrinkles,relaxing a large island crack-free. | R. Huang H. Yin J. Liang J. C. Sturm K. D. Hobart Z. Suo | 2002 | Acta Mechanica Sinica2002，18，5： | 2 |
| 12 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 13 | Long-term Results of Partial Pancreaticoduodenectomy for Ductal Adenocarcinoma of the Pancreatic Head: 25-Year Experience显示文摘 | Axel Richter M.D. Marco Niedergethmann M.D. J?rg W. Sturm M.D. Dietmar Lorenz M.D. Stefan Post M.D. Michael Trede M.D | 2003 | World Journal of Surgery2003，，3： | 2 |
| 14 | TGF-β1-509 T/T基因型与结直肠癌患者术后结肠吻合口瘘的关系显示文摘目的通过研究转化生长因子-β1(TGF-β1)基因功能的多态性,了解TGF-β1因子对结直肠癌术后结肠吻合口瘘的影响。方法采用PCR-RFLP方法检测结直肠癌组内157例伴有或不伴有术后结肠吻合口瘘患者及对照组117例的TGF-β1-509 T/C基因型。结果伴有术后结肠吻合口瘘的患者TGF-β1-509 T/T。基因型比例(0)低于无吻合口瘘的患者(13.2%),两者差异有统计学意义(P=0.012)。结直肠癌组TGF-β1-509基因型或等位基因与对照组差异无统计学意义(基因型χ^2=0.981,P〉0.05;等位基因χ^2=0.000,P〉0.05)。结论具TGF-β1-509 T/T基因型者术后结肠吻合口瘘的发生率较低。而TGF-β1-509 T/C基因多态性与结直肠癌的发生及发展无关。 | 吴国洋 王效民 Michael Keese Till Hasenberg Jorg W. Sturm | 2007 | 中华普通外科杂志2007，22，5： | 2 |
| 15 | Antisense repression of sucrose synthase in carrot (Daucus carota L.) affects growth rather than sucrose partitioning显示文摘 | Guo-Qing Tang Arnd Sturm | 1999 | Plant Molecular Biology1999，，4： | 2 |
| 16 | The wide spectrum of multidrug resistance 3 deficiency: From neonatal cholestasis to cirrhosis of adulthood显示文摘 | Emmanuel Jacquemin J. Marleen L. De Vree Danièle Cresteil Etienne M. Sokal Ekkehard Sturm Micheline Dumont George L. Scheffer Marianne Paul Martin Burdelski Piter J. Bosma Olivier Bernard Michelle Hadchouel Ronald P.J. Oude Elferink | 2001 | Gastroenterology2001，，6： | 2 |
| 17 | Long-term Results of Partial Pancreaticoduodenectomy for Ductal Adenocarcinoma of the Pancreatic Head: 25-Year Experience显示文摘 | Axel Richter Marco Niedergethmann J?rg W. Sturm Dietmar Lorenz Stefan Post Michael Trede | 2003 | World Journal of Surgery2003，，3： | 2 |
| 18 | Autonomic seizures versus syncope in 18q-deletion syndrome:a case report显示文摘 | Sturm K Knake S Schomburg U | 2000 | Epilepsia2000，41，8： | 1 |
| 19 | Stroke units, tissue plasminogen activator, aspirin and neuroprotection: which stroke intervention could provide the greatest community benefit显示文摘 | Gilligan AK Thrift AG Sturm JW | 2005 | Cerebrovasc Dis2005，20，4： | 1 |
| 20 | Loss of the tissue- specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma 显示文摘 | Sturm I Stephan C Gillissen B | 2006 | Cell Death Differ2006，13，4： | 1 |
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