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| 1 | Nuclear magnetic resonance based metabolomics and liverdiseases:Recent advances and future clinical applications显示文摘Metabolomics is defined as the quantitative measurement of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modification.It is an'omics'technique that is situated downstream of genomics,transcriptomics and proteomics.Metabolomics is recognized as a promising technique in the field of systems biology for the evaluation of global metabolic changes.During the last decade,metabolomics approaches have become widely used in the study of liver diseases for the detection of early biomarkers and altered metabolic pathways.It is a powerful technique to improve our pathophysiological knowledge of various liver diseases.It can be a useful tool to help clinicians in the diagnostic process especially to distinguish malignant and non-malignant liver disease as well as to determine the etiology or severity of the liver disease.It can also assess therapeutic response or predict drug induced liver injury.Nevertheless,the usefulness of metabolomics is often not understood by clinicians,especially the concept of metabolomics profiling or fingerprinting.In the present work,after a concise description of the different techniques and processes used in metabolomics,we will review the main research on this subject by focusing specifically on in vitro proton nuclear magnetic resonance spectroscopy based metabolomics approaches in human studies.We will first consider the clinical point of view enlighten physicians on this new approach and emphasis its future use in clinical'routine'. | Roland Amathieu Mohamed Nawfal Triba Corentine Goossens Nadia Bouchemal Pierre Nahon Philippe Savarin Laurence Le Moyec | 2016 | World Journal of Gastroenterology2016，22，1： | 6 |
| 2 | Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma显示文摘AIM: To assess the predictive value of the insulinlike growth factor 2 (Igf2) methylation profile for the occurrence of Hepatocellular Carcinoma (HCC) in hepatitis C (HCV) cirrhosis. METHODS: Patients with: (1) biopsy-proven compensated HCV cirrhosis; (2) available baseline frozen liver sample; (3) absence of detectable HCC; (4) regular screening for HCC; (5) informed consent for genetic analysis were studied. After DNA extraction from liver samples and bisulfite treatment, unbiased PCR and DHPLC analysis were performed for methylation analysis at the Igf2 locus. The predictive value of the Igf2 methylation profile for HCC wasassessed by Kaplan-Meier and Cox methods. RESULTS: Among 94 included patients, 20 developed an HCC during follow-up (6.9 ± 3.2 years). The methylation profile was hypomethylated, intermediate and hypermethylated in 13, 64 and 17 cases, respectively. In univariate analysis, two baseline parameters were associated with the occurrence of HCC: age (P = 0.01) and prothrombin (P = 0.04). The test of linear tendency between the three ordered levels of Igf2 methylation and probability of HCC occurrence was significant (Log Rank, P = 0.043; Breslow, P = 0.037; Tarone-Ware, P = 0.039). CONCLUSION: These results suggest that hypomethylation at the Igf2 locus in the liver could be predictive for HCC occurrence in HCV cirrhosis. | Philippe Couvert Alain Carrié Jacques Pariès Jenny Vaysse Audrey Miroglio Antoine Kerjean Pierre Nahon Jamel Chelly Jean-Claude Trinchet Michel Beaugrand Nathalie Ganne-Carrié | 2008 | World Journal of Gastroenterology2008，14，35： | 6 |
| 3 | Increased Risk for Nonmelanoma Skin Cancers in Patients Who Receive Thiopurines for Inflammatory Bowel Disease显示文摘 | Laurent Peyrin–Biroulet Kiarash Khosrotehrani Fabrice Carrat Anne–Marie Bouvier Jean–Baptiste Chevaux Tabassome Simon Frank Carbonnel Jean–Frédéric Colombel Jean–Louis Dupas Philippe Godeberge Jean–Pierre Hugot Marc Lémann Stéphane Nahon Jean–Marc Sabaté | 2011 | Gastroenterology2011，，5： | 3 |
| 4 | PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis显示文摘 | Erwan Guyot Angela Sutton Pierre Rufat Christelle Laguillier Abdellah Mansouri Richard Moreau Nathalie Ganne-Carrié Michel Beaugrand Nathalie Charnaux Jean-Claude Trinchet Pierre Nahon | 2012 | Journal of Hepatology2012，，： | 2 |
| 5 | Peptic ulcer disease: one in five is related to neither H elicobacter pylori nor aspirin/NSAID intake显示文摘 | C. Charpignon B. Lesgourgues A. Pariente S. Nahon A. Pelaquier G. Gatineau‐Sailliant A.‐M. Roucayrol A. Courillon‐Mallet | 2013 | Aliment Pharmacol Ther2013，，8： | 2 |
| 6 | Early Administration of Azathioprine vs Conventional Management of Crohn’s Disease: a Randomized Controlled Trial显示文摘 | Jacques Cosnes Anne Bourrier David Laharie Stéphane Nahon Yoram Bouhnik Franck Carbonnel Matthieu Allez Jean-Louis Dupas Jean-Marie Reimund Guillaume Savoye Pauline Jouet Jacques Moreau Jean-Yves Mary Jean-Frédéric Colombel | 2013 | Gastroenterology2013，，： | 2 |
| 7 | Albumin and alpha - feto- protein gene expression in various nonhepatic rat tissues 显示文摘 | Nahon JL Tratner I Pollard A | 1988 | J Biol Chem1988，263，11： | 1 |
| 8 | Assessment of liver fibrosis using transient elastography in patients with alcoholic liver disease显示文摘 | Pierre Nahon Adrien Kettaneh Iulia Tengher-Barna Marianne Ziol Victor de Lédinghen Catherine Douvin Patrick Marcellin Nathalie Ganne-Carrié Jean-Claude Trinchet Michel Beaugrand | 2008 | Journal of Hepatology2008，，6： | 1 |
| 9 | A comparison of ship - mounted and cage - mounted passive heave compensation systems 显示文摘 | F R Driscoll M Nahon R G Lueck | 2000 | Journal of Offshore Mechanics and Arctic Engineering2000，122，3： | 1 |
| 10 | A refocusing modified velocity map imaging electron/ion spectrometer adapted to synchrotron radiation studies显示文摘 | Garcia G A Nahon L Harding C J | 2005 | Review of Scientific Instruments2005，76，05： | 1 |
| 11 | Hepatic iron over- load and risk of hepatocellular carcinoma in cirrhosis显示文摘 | Nahon P Ganne-Carri N Trinchet JC | 2010 | Gastro- enterol Clin Biol2010，34，1： | 1 |
| 12 | ' Socioeconomic and psychological factors associated with nonadherence to treatment in inflammatory bowel disease patients: results of the ISSEO survey,' 显示文摘 | Nahon S Lahmek P Saas C | 2011 | Inflammatory Bowel Diseases2011，17，6： | 1 |
| 13 | Workspace analysis and optimization of a novel 3-dof parallel manipulator 显示文摘 | Carretero J A Nahon M A Podhorodeski R P | 2000 | Int Journal of Robotics and Automation2000，15，4： | 1 |
| 14 | The motion of a deep-sea remotely operated vehicle system Part Ⅰ: Motion observations显示文摘 | DRISCOLL F R LUECK R G NAHON M | 2000 | Ocean Engineering2000，27，： | 1 |
| 15 | Workspace analysis and optimization of a novel 3-dof parallel mechanism 显示文摘 | Carretero J A Nahon M Podhorodeski R P | 2000 | International Journal of Robotics and Automation2000，15，4： | 1 |
| 16 | Favourable prognosis of upper gastrointestinal bleeding in 1041 older patients: results of prospective mulficenln~ study显示文摘 | Nahon S Nouel O Hagege H | 2008 | Clin Gastroenterol Hepatol2008，6，1： | 1 |
| 17 | Geochemistry of laterites, stability of Algoethite, Al-hematite, and Fe^3+-kaolinite in bauxites and ferricretes: An approach to the mechanism of concretion formation显示文摘 | Tardy Y Nahon D | 1985 | American Journal of Science1985，285，： | 1 |
| 18 | Association between the PNPLA3 (rs738409 C > G) variant and hepatocellular carcinoma: evi- dence from a meta-analysis of individual participant data 显示文摘 | Tr6po E Nahon P Bontempi G | 2014 | Hepatol- ogy2014，59，6： | 1 |
| 19 | The melan ortins and melanin-concentrating hor- mone in the central regulation of feeding behavior and energy homeostasis显示文摘 | NAHON JL | 2006 | Comptes Rendus Biologies2006，329，8： | 1 |
| 20 | Is idiopathic chronic pancreatitis an autoimmune disease? 显示文摘 | Nahon Uzan K Levy P O'Toole D | 2005 | Clin Gastroenterol Hepatol2005，3，9： | 1 |
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