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| 1 | Free radical scavenging potential of Lagenaria siceraria(Molina) Standl fruits extract显示文摘Objective:To elucidate free radical scavenging activity of ethanolic extract Lagenaria siceraria (L.siceraria)(Molina) fruit.Methods:The free radical scavenging activity of the L siceraria (Molina) fruit extract was assayed by usingα,α-diphenyl-β-picrylhydrazyl(DPPH). 2,20-azinobis 3-ethyl henzothiazoline-6-sulfonate(ABTS),FRAP,reducing power,chelating ability andβ-carotene bleaching assay.Results:The IC50values of DPPH and ABTS radicalscavenging activity was found to be 1.95 mg/mL and 19 mg/mL,respectively.In ferrous chelation assay,the percentage of inhibition was found to be 89.21%.The reducing power of ethanolic extract of L siceraria(Molina) fruit was 0.068 at 1 mg/mL and increased to 0.192 at 5 mg/mL Theβ-carotene linoleate bleaching assay was 46.7%at 5 mg/mL and antioxidant activity using FRAP at 0.305 for 1 mg/mL to 0.969 for 5 mg/mL Conclusions:The results indicate that L siceraria (Molina) fruit could be an important sources of natural radical scavengers. | Vijayakumar Mayakrishnan Selvi Veluswamy Krishnakumari Shanmuga Sundaram Priya Kannappan Noorlidah Abdullah | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，1： | 3 |
| 2 | Comparison of contrast sensitivity and visual acuity between deep anterior lamellar keratoplasty and penetrating keratoplasty in patients with keratoconus显示文摘AIM: To evaluate postoperative visual acuity and contrast sensitivity results following deep anterior lamellar keratoplasty (DALK) and penetrating keratoplasty (PK) in patients with keratoconus (KC). METHODS: All the patients' records with KC who had PK or DALK surgery between May 2010 and May 2011 were retrospectively reviewed. Sixty patients who underwent successful corneal transplantation for KC: 30 eyes underwent DALK and 30 eyes underwent PK were included in this study. Preoperative and postoperative mean logarithm of the minimum angle of resolution (logMAR) uncorrected visual acuity (UCVA), logMAR best spectacle-corrected visual acuity (BSCVA) and intraocular pressure (IOP) were evaluated. Contrast sensitivity tests (CS) were done preoperative and 2 months after all sutures had removed. All surgeries were performed under regional anesthesia (retrobulbar anesthesia) by 1 surgeon (B.K.) who was experienced in penetrating and lamellar keratoplasty techniques. RESULTS: The mean age of the DALK group was 29.67±4.95 (range 18-40) years and the PK group was 28.7±3.53 (range 18-39) years. Preoperatively there was no significant difference in the logMAR UCVA, logMAR BSCVA and IOP between the DALK (1.281±0.56; 0.97±0.85; 12.07±2.12mmHg) and PK (1.34±0.21; 0.98±0.21; 13±2.12mmHg) groups. One-year after surgery there was no significant difference in the mean logMAR UCVA and IOP between the DALK (0.46±0.37; 11.73±2.1mmHg) and PK (0.38±0.21; 12±2.12mmHg) groups. The mean contrast sensitivity was evaluated by CC-100 Topcon LCD at 1.5, 2.52, 4.23, 7.10 and 11.91 cycles per degree (cs/deg) spatial frequencies before and 2 months after the all sutures had removed. CONCLUSION: All patients with keratoconus in both DALK and PK groups performed good visual function postoperatively. The mean contrast sensitivity increased considerably at all spatial frequencies compared with preoperative levels in the DALK and PK groups. The mean post-operative evaluation of contrast sensitivity measurements was not significantly different between the two groups. | Mehmet Orcun Akdemir Baran Kandemir Isil Bahar Sayman Cem Selvi OmerKamil Dogan | 2012 | International Journal of Ophthalmology(English edition)2012，5，6： | 3 |
| 3 | Role of omega-3 polyunsaturated fatty acids,citrus pectin,and milk-derived exosomes on intestinal barrier integrity and immunity in animals显示文摘The gastrointestinal tract of livestock and poultry is prone to challenge by feedborne antigens,pathogens,and other stress factors in the farm environment.Excessive physiological inflammation and oxidative stress that arises firstly disrupts the intestinal epithelial barrier followed by other components of the gastrointestinal tract.In the present review,the interrelationship between intestinal barrier inflammation and oxidative stress that contributes to the pathogenesis of inflammatory bowel disease was described.Further,the role of naturally existing immunomodulatory nutrients such as the omega-3 polyunsaturated fatty acids,citrus pectin,and milk-derived exosomes in preventing intestinal barrier inflammation was discussed.Based on the existing evidence,the possible molecular mechanism of these bioactive nutrients in the intestinal barrier was outlined for application in animal diets. | Tamil Selvi Sundaram Carlotta Giromini Raffaella Rebucci Juraj Pistl Mangesh Bhide Antonella Baldi | 2022 | Journal of Animal Science and Biotechnology2022，13，5： | 3 |
| 4 | Notch signaling in hepatocellular carcinoma:molecular targetingin an advanced disease显示文摘The use of alternative therapeutic approaches in advanced carcinogenesis is a growing investigative base.One such cancer,primary liver cancer,is one of the most commonly occurring cancers worldwide and often presents in late stage disease consequently preventing traditional curative modalities.As a result,hepatocellular carcinoma(HCC),representing the majority of primary liver cancer,is the third most common cause of cancer-related deaths globally.Survival rates are linked to stage of presentation as well as concomitant cirrhosis limiting the 5-year survival in these patients to<20%.Alternative strategies are in dire need as patients in this cohort have limited palliative options.Currently,sorafenib is the only approved systemic therapy;however,it has a limited survival advantage and low effi cacy prompting the empirical need for further evaluation.Understanding of cancer therapy has led to an enhanced focus on the Notch pathway as a potential target for advanced HCC.Notch signaling is a critical component of development and cell fate and has been linked to various modalities including liver regeneration and as a key driver in carcinogenesis.In this review,we will provide a review of the current status of the Notch signaling in liver cancer and of Notch as an alternative potential strategy for advanced HCC. | Kevin M.Sokolowski Mariappan Balamurugan Selvi Kunnimalaiyaan T.Clark Gamblin Muthusamy Kunnimalaiyaan | 2015 | Hepatoma Research2015，1，1： | 3 |
| 5 | Influence of preoperative coronary collateral circulation on in-hospital mortality in patients undergoing coronary artery bypass graft surgery with intra-aortic balloon pump support显示文摘 | Hasan Gungor Cemil Zencir Abraham Samuel Babu Cagdas Akgullu Ufuk Eryilmaz All Zorlu Mithat Selvi Sevil Onay Tunay Kurtoglu | 2014 | Chinese Medical Journal2014，，17： | 3 |
| 6 | End-to-end computational approach to the design of RNA biosensors for detecting miRNA biomarkers of cervical cancer显示文摘Cervical cancer is a global public health subject as it affects women in the reproductive ages,and accounts for the second largest burden among cancer patients worldwide with an unforgiving 50%mortality rate.Relatively scant awareness and limited access to effective diagnosis have led to this enormous disease burden,calling for point-of-care,minimally invasive diagnosis methods.Here,an end-to-end quantitative unified pipeline for diagnosis has been developed,beginning with identification of optimal biomarkers,concurrent design of toehold switch sensors,and finally simulation of the designed diagnostic circuits to assess performance.Using miRNA expression data in the public domain,we identified miR-21-5p and miR-20a-5p as blood-based miRNA biomarkers specific to early-stage cervical cancer employing a multi-tier algorithmic screening.Synthetic riboregulators called toehold switches specific to the biomarker panel were then designed.To predict the dynamic range of toehold switches for use in genetic circuits as biosensors,we used a generic grammar of these switches,and built a neural network model of dynamic range using thermodynamic features derived from mRNA secondary structure and interaction.Second-generation toehold switches were used to overcome the design challenges associated with miRNA biomarkers.The resultant model yielded an adj.R^(2)~0.71,outperforming earlier models of toehold-switch dynamic range.Reaction kinetics modelling was performed to predict the sensitivity of the second-generation toehold switches to the miRNA biomarkers.Simulations showed a linear response between 10 nM and 100 nM before saturation.Our study demonstrates an end-to-end computational workflow for the efficient design of genetic circuits geared towards the effective detection of unique genomic/nucleic-acid signatures.The approach has the potential to replace iterative experimental trial and error,and focus time,money,and efforts.All software including the toehold grammar parser,neural network model and reaction kinetics simulation are available as open-source software(http://gffzz188fe103f8f1460asponq0wxx959x6v6q.ffgz.tsg.suse.edu.cn/SASTRA-iGEM2019)under GNU GPLv3 licence. | Priyannth Ramasami S.Baabu Shivaramakrishna Srinivasan Swetha Nagarajan Sangeetha Muthamilselvan Thamarai Selvi Raghavv R.Suresh Ashok Palaniappan | 2022 | Synthetic and Systems Biotechnology2022，7，2： | 2 |
| 7 | Comparison between Capsule Endoscopy and Magnetic Resonance Enterography for the Detection of Polyps of the Small Intestine in Patients with Familial Adenomatous Polyposis显示文摘 | E. Akin A. Demirezer Bolat S. Buyukasik O. Algin E. Selvi O. Ersoy Martin Keuchel | 2012 | Gastroenterology Research and Practice2012，，： | 2 |
| 8 | An eco-friendly water mediated synthesis of 1,2,3-triazolyl-2-aminopyrimidine hybrids as highly potent anti-bacterial agents显示文摘An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz. water. The hybrid molecules exhibit significant anti-bacterial activity when screened against three human pathogens viz. Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. In comparison to the commercially marketed drug tetracycline, some of them are equally potent and a few are more potent. | Sangaraiah Nagarajan Poovan Shanmugavelan Murugan Sathishkumar Ramasamy Selvi Alagusundaram Ponnuswamy Hariharan Harikrishnan Vellasamy Shanmugaiah | 2014 | Chinese Chemical Letters2014，25，3： | 2 |
| 9 | Corrosion resistance and microstructure of electrodeposited nickel cobalt alloy coatings 显示文摘 | MEENU S S SELVI V E WILLIAM GRIPS V K | 2006 | Surface & Coating Technology2006，201，： | 1 |
| 10 | Hyperhomo- cysteniemia, inflammation and autnimmunity 显示文摘 | LAZZERINI P E CAPECCHI P L SELVI E | 2007 | Autoimmun Rev2007，6，7： | 1 |
| 11 | Capsule Endoscopy Findings in Celiac Disease显示文摘 | Osman Ersoy Ebru Akin Serdar Ugras Semnur Buyukasik Eyup Selvi Güven Güney | 2009 | Digestive Diseases and Sciences2009，，4： | 1 |
| 12 | Factors that are asso- ciated with injury to the inferior alveolar nerve in high-risk patients after removal of third molars显示文摘 | Selvi F Dodson T B Nattestad A | 2013 | Br J Oral Maxillofac Surg2013，51，8： | 1 |
| 13 | A survey on re- source allocation and task scheduling algorithms in cloud environment显示文摘 | Gokilavani M SelviS Udhayakumar C | 2013 | International Journal of Engineering and Innovative Technology2013，3，4： | 1 |
| 14 | MicroRNAs,macro Control:Regulation of miRNA processing显示文摘 | Selvi D Bart JK Izabella SP | 2010 | RNA2010，16，6： | 1 |
| 15 | Factors that are associated with injury to the inferior alveolar nerve in high-risk patients after removal of third molars 显示文摘 | Selvi F Dodson TB Nattestad A | 2013 | Br J Oral Maxillofac Surg2013，51，8： | 1 |
| 16 | Radiation Exposure from Diagnostic Imaging Studies Among Patients with Inflammatory Bowel Disease in a Safety-Net Health-Care System显示文摘 | Jason K. Hou Hoda M. Malaty Selvi Thirumurthi | 2014 | Digestive Diseases and Sciences2014，，： | 1 |
| 17 | Real-time simulation and performance analysis of multimachine power systems using DSPACE simulator显示文摘 | Ramya R Selvi K Murali K | 2016 | Transactions of the Society for Modeling and Simulation International2016，92，1： | 1 |
| 18 | Keeping Quality of Salt Cured Shark carcharhinus sorrah显示文摘 | Tamil Selvi A | 1999 | Journal of Food Science and Technology1999，36，5： | 1 |
| 19 | Corrosion Inhibition of Mild Steel by Benzotriazole Derivatives in Acidic Medium 显示文摘 | Tamil Selvi S Raman V Rajendran N | 2003 | J ApplEleetrochem2003，33，12： | 1 |
| 20 | Role of p16,CK17,p63,and human papillomavirus in diagnosis of cervical intraepithelial neoplasia and distinction from its mimics显示文摘 | Selvi K Badhe BA Papa D | 2014 | Int J Surg Pathol2014，22，3： | 1 |
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