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| 1 | Alcoholic liver disease and the gut-liver axis显示文摘Alcoholic liver disease (ALD) is one of the leading causes of liver diseases and liver-related death worldwide. Of the many factors that contribute to the pathogenesis of ALD, gut-derived lipopolysaccharide (LPS) plays a central role in induction of steatosis, inflammation, and fi brosis in the liver. In this review, we discuss the mechanisms by which alcohol contributes to increased gut permeability, the activation of Kupffer cells, and the infl ammatory cascade by LPS. The role of the Toll-like receptor 4 (TLR4) complex in LPS recognition and the importance of the TLR4-induced signaling pathways are evaluated in ALD. | Gyongyi Szabo Shashi Bala | 2010 | World Journal of Gastroenterology2010，16，11： | 50 |
| 2 | Emerging role of microRNAs in liver diseases显示文摘MicroRNAs are a class of small non-coding RNAs that are found in plants, animals, and some viruses. They modulate the gene function at the post-transcriptional level and act as a fine tuner of various processes, such as development, proliferation, cell signaling, and apopto-sis. They are associated with different types and stages of cancer. Recent studies have shown the involvement of microRNAs in liver diseases caused by various factors, such as Hepatitis C, Hepatitis B, metabolic disorders, and by drug abuse. This review highlights the role of microRNAs in liver diseases and their potential use as therapeutic molecules. | Shashi Bala Miguel Marcos Gyongyi Szabo | 2009 | World Journal of Gastroenterology2009，15，45： | 25 |
| 3 | 基于B-L气动模型的旋转水平风机叶片经典颤振稳定性分析显示文摘研究旋转水平轴风力机叶片周期时变气弹系统的经典颤振稳定性特性。叶片结构采用具有挥舞和扭转耦合的典型界面振动模型,引入Beddoes-Leishman气动模型为旋转叶片提供低攻角处周期时变的非定常气动力;为了研究颤振边界,利用标量风速和挥舞/扭转固有频率比对所建立的旋转叶片气弹模型进行变型。在此基础上,通过时域响应曲线分析旋转叶片挥舞自由度和扭转自由度气弹稳定性特性,分析了标量速度,叶片刚度,挥舞/扭转固有频率比和结构阻尼的影响,揭示了旋转叶片经典颤振边界的变化规律且其准确性得到验证。 | 李迺璐 穆安乐 Balas M J | 2015 | 振动与冲击2015，34，23： | 9 |
| 4 | Removal of Ammonia from Wastewater Effluent by Chlorella Vulgaris显示文摘The capability of Chlorella vulgaris to remove nitrogen in the form of ammonia and/or ammonium ions from wastewater effluent in a local wastewater treatment plant (i.e., the Mill Creek Plant in Cincinnati, Ohio, U.S.A.) was studied. The wastewater effluent leaving the plant was found to include high concentra-tions of nitrogen (7.7±0.19 mg/L) (ammonia (NH3) and/or ammonium ion (NH4+)) and total inorganic carbon (58.6±0.28 mg/L) at pH 7, and to be suitable for growing Chlorella vulgaris. When Chlorella vulgaris was cul-tivated in a batch mode under a closed system, half of the nitrogen concentration was dramatically removed in 48 h after a 24-h lag-phase period. Total inorganic carbon concentration also concomitantly decreased during the rapid growth-phase. The total biomass weight gained during the entire cultivation period balanced out well with the total amount of inorganic carbon and nitrogen removed from the culture medium. These results indicate that wastewater can be synergistically used to polish residual nutrients in wastewater as well as to cultivate microalgae for biofuel production. | Jinsoo Kim Bala P.Lingaraju Rachael Rheaume Joo-Youp Lee Kaniz F.Siddiqui | 2010 | Tsinghua Science and Technology2010，15，4： | 9 |
| 5 | 钻井液智能堵漏材料研究进展显示文摘钻井液智能堵漏材料已成为近年来石油开采领域的全新研究方向。与传统堵漏材料直接桥堵的方式不同,智能堵漏材料的特别之处在于拥有应对环境变化的能力,同时还具有针对性强、封堵效果突出、对地层损害小等特点。目前国内外关于智能堵漏材料的研究主要分为智能凝胶和形状记忆材料两个方向。其中,智能凝胶流动性相对较好,能够不受地层孔隙大小的影响,自适应能力强,可依据不同地层温度进行不同胶态间的转化,也可通过控制注入地层后凝胶的固结时间来提高封堵效率。相比之下,形状记忆材料的研究较多,包括形状记忆聚合物及形状记忆合金两种。形状记忆合金的延展性及抗疲劳能力比较突出,虽然形变量较小,但是承压能力强,易于形成网状结构,可明显提升桥堵作用,因此其封堵能力突出;形状记忆聚合物堵漏材料不仅形变量大,而且原料成本低,可保护储集层不受污染,能够有效应对复杂结构地层漏失问题。本文综述了钻井液智能堵漏材料的最新研究进展,尤其是对智能凝胶堵漏材料及形状记忆堵漏材料的研制方法、性能特点、应用情况等进行分析和总结,并对新型智能堵漏材料进行了介绍。 | 潘一 徐明磊 郭奇 廖广志 杨双春 Kantoma Daniel Bala | 2021 | 材料导报2021，35，9： | 8 |
| 6 | 钻井液用流型调节剂的研究进展显示文摘流型调节剂是用来改善钻井液流变性的处理剂,通过增黏提切使钻井液具有较高的动塑比和较好的剪切稀释性。但随着大位移井、大斜度定向井及深水、超深水井等技术的发展,复杂地层中钻井液的流变性还是易出现黏度、切力不足,性能衰减过快,甚至失去悬浮与携带能力的问题,尤其是大位移井和复杂井经常出现井眼清洁能力不足的问题。该文主要按钻井液类型:典型钻井液用流型调节剂、恒流变钻井液用流型调节剂和其他钻井液用流型调节剂,综述了现有钻井液用流型调节剂的研究进展和应用情况。对不同钻井液用流型调节剂的增黏提切能力、耐温性、环保性和价格优势进行比较和评价,随后对流型调节剂未来的发展方向提出了建议,以期为相关研究提供参考。 | 杨双春 宋洪瑞 郭奇 廖广志 潘一 KANTOMA DANIEL BALA | 2020 | 精细化工2020，37，9： | 7 |
| 7 | Plasma microRNA profiles distinguish lethal injury in acetaminophen toxicity: A research study显示文摘AIM: To investigate plasma microRNA (miRNA) profiles indicative of hepatotoxicity in the setting of lethal acetaminophen (APAP) toxicity in mice. METHODS: Using plasma from APAP poisoned mice, either lethally (500 mg/kg) or sublethally (150 mg/kg) dosed, we screened commercially available murine microRNA libraries (SABiosciences, Qiagen Sciences, MD) to evaluate for unique miRNA profiles between these two dosing parameters. RESULTS: We distinguished numerous, unique plasma miRNAs both up- and downregulated in lethally compared to sublethally dosed mice. Of note, many of the greatest up- and downregulated miRNAs, namely 574-5p, 466g, 466f-3p, 375, 29c, and 148a, have been shown to be associated with asthma in prior studies. Interestingly, a relationship between APAP and asthma has been previously well described in the literature, with an as yet unknown mechanism of pathology. There was a statistically significant increase in alanine aminotransferase levels in the lethal compared to sublethal APAP dosing groups at the 12 h time point (P < 0.001). There was 90% mortality in the lethally compared to sublethally dosed mice at the 48 h time point (P = 0.011). CONCLUSION: We identified unique plasma miRNAs both up- and downregulated in APAP poisoning which are correlated to asthma development. | Jeanine Ward Shashi Bala Jan Petrasek Gyongyi Szabo | 2012 | World Journal of Gastroenterology2012，18，22： | 6 |
| 8 | 智能钻井液的化学体系及辅助系统研究进展显示文摘传统钻井液的指向性不足、自适应能力弱、监测困难且人工操作过于繁琐,智能钻井液具有更强的针对性,钻井液性能也更加突出,同时能够大幅缩减人工干预程度。该文对智能钻井液化学体系的研发、钻井液智能辅助系统的功能强化及开发应用进行了综述,指出了当前智能钻井液技术虽在化学体系、智能传送及监测装置、智能平台等方面都有所发展,但在智能化学体系方面尚不能实现对钻井液性能参数的精准控制,智能钻井液的研制及其平台建设智能方向过于单一,不能满足当前钻井现场需要,建议未来的钻井液智能化应向综合性多元化方向发展。 | 潘一 徐明磊 郭永成 KANTOMA Daniel Bala 廖广志 杨双春 | 2020 | 精细化工2020，37，11： | 6 |
| 9 | Radiation and concomitant chemotherapy for patients with glioblastoma multiforme显示文摘Postoperative external beam radiotherapy was considered the standard adjuvant treatment for patients with glioblastoma multiforme until the advent of using the drug temozolomide(TMZ) in addition to radiotherapy. High-dose volume should be focal, minimizing whole brain irradiation. Modern imaging, using several magnetic resonance sequences, has improved the planning target volume definition. The total dose delivered should be in the range of 60 Gy in fraction sizes of 1.8-2.0 Gy. Currently, TMZ concomitant and adjuvant to radiotherapy has become the standard of care for glioblastoma multiforme patients. Radiotherapy dose-intensification and radiosensitizer approaches have not improved the outcome. In spite of the lack of high quality evidence, stereotactic radiotherapy can be considered for a selected group of patients. For elderly patients, data suggest that the same survival benefit can be achieved with similar morbidity using a shorter course of radiotherapy(hypofractionation). Elderly patients with tumors that exhibit methylation of the O-6-methylguanine-DNA methyltransferase promoter can benefit from TMZ alone. | Salvador Villà Carme Balaà Sílvia Comas | 2014 | Chinese Journal of Cancer2014，33，1： | 6 |
| 10 | Long-term aspirin pretreatment in the prevention of cerulein-induced acute pancreatitis in rats显示文摘AIM:To investigate the effects of long term pretreatment with low-,medium-and high-dose aspirin(acetylsalicylic acid,ASA) on a model of acute pancreatitis(AP) induced in rats.METHODS:Forty male Wistar rats were used.Three experimental groups,each consisting of eight animals,received low-(5 mg/kg per day),medium-(150 mg/kg per day) and high-dose(350 mg/kg per day) ASA in supplemented pellet chow for 100 d.Eight animals,serving as the AP-control group,and another eight,serving as reference value(RV) group,were fed with standard pellet chow for the same period.After pretreatment,AP was induced in the experimental animals by intraperitoneal administration of cerulein(2 × 50 μg/kg),while the RV group received saline in the same way.Twelve hours after the second injection,the animals were sacrificed.Pancreatic tissue and plasma samples were collected.One part of the collected pancreatic tissues was used for histopathological evaluation,and the remaining portion was homogenized.Cytokine levels [tumor necrosis factor,interleukin(IL)1β,IL-6],hemogram parameters,biochemical parameters(amylase and lipase),nuclear factor-κB,aspirin triggered lipoxins and parameters related to the antioxidant system(malondialdehyde,nitric oxide,hemeoxygenase-1,catalase and superoxide dismutase) were measured.RESULTS:Cerulein administration induced mild pancreatitis,characterized by interstitial edema(total histopathological score of 5.88 ± 0.44vs 0.25 ± 0.16,P < 0.001).Subsequent pancreatic tissue damage resulted in an increase in amylase(2829.71 ± 772.48 vs 984.57 ± 49.22 U/L,P = 0.001) and lipase(110.14 ± 75.84 U/L vs 4.71 ± 0.78 U/L,P < 0.001) in plasma,and leucocytes(6.89 ± 0.48 vs 4.36 ± 0.23,P = 0.001) in peripheral blood.Cytokines,IL-1β(18.81 ± 2.55 pg/μg vs 6.65 ± 0.24 pg/μg,P = 0.002) and IL-6(14.62 ± 1.98 pg/μg vs 9.09 ± 1.36 pg/μg,P = 0.04) in pancreatic tissue also increased.Aspirin pretreatment reduced the increase in the aforementioned parameters to a certain degree and partially improved the histopathological alterations caused by cerulein.No evidence of side effects related to chronic ASA administration(e.g.,inflammation or bleeding) was observed in the gastrointestinal tract in macroscopic and histopathological examination.CONCLUSION:Long term ASA pretreatment could prevent and/or ameliorate certain hematological,serological and histological alterations caused by ceruleininduced AP. | Ibrahim Akyazi Evren Eraslan Ahmet Gülubuk Elif Ergül Ekiz Zeynep L rakli Damla Haktanir Deniz Aktaran Bala Mete zkurt Erdal Matur Mukaddes zcan | 2013 | World Journal of Gastroenterology2013，19，19： | 5 |
| 11 | Petrogenesis and Tectonic Implications of Peralkaline A-Type Granites and Syenites from the Suizhou-Zaoyang Region,Central China显示文摘In this study, we present systematic petrological, geochemical, LA-ICP-MS zircon U-Pb ages and Nd isotopic data for the A-type granites and syenites from Suizhou-Zaoyang region. The results show that the peralkaline A-type granites and syenites were episodically emplaced in Suizhou-Zaoyang region between 450±3 and 441±7 Ma which corresponds to Late Ordovician and Early Silurian periods, respectively. Petrologically, the syenite-peralkaline granite association comprises of nepheline normative-syenite and alkaline granite in Guanzishan and quartz normative syenite and alkaline granite in Huangyangshan. The syenite-granite associations are ferroan to alkali in composition. They depict characteristics of typical OIB(oceanic island basalts) derived A-type granites in multi-elements primitive normalized diagram and Yb/Ta vs. Y/Nb as well as Ce/Nb vs. Y/Nb binary plots. Significant depletion in Ba, Sr, P, Ti and Eu indicates fractionation of feldspars, biotite, amphiboles and Ti-rich augite. The values of ?Nd(t) in Guanzishan nepheline syenite and alkaline granite are +1.81 and +2.26, respectively and the calculated two-stage model age for these rocks are 1 040 and 1 003 Ma, respectively. On the other hand, the Huangyangshan alkaline granite has ?Nd(t) values ranging from +2.61 to +3.46 and a relatively younger two-stage Nd model age values ranging from 906 to 975 Ma, respectively. Based on these data, we inferred that the Guanzishan nepheline syenites and granites were formed from fractional crystallization of OIB-like basic magmas derived from upwelling of metasomatized lithospheric mantle. The Huangyangshan quartz syenite and granite on the other hand, were formed from similar magmas through fractional crystallization with low input from the ancient crustal rocks. Typically, the rocks exhibit A1-type granite affinity and classified as within plate granites associated with the Ordovician crustal extension and the Silurian rifting. | Hafizullah Abba Ahmed Changqian Ma Lianxun Wang Ladislav A.Palinkas Musa Bala Girei Yuxiang Zhu Mukhtar Habib | 2018 | Journal of Earth Science2018，29，5： | 5 |
| 12 | Anti-chikungunya activity of luteolin and apigenin rich fraction from Cynodon dactylon显示文摘Objective:To obtain Iuteolin and apigenin rich fraction from the ethanolic extract of Cynodon dactylon(L.)(C.dactylon) Pers and evaluate the fraction's cytotoxicity and anti-Chikungunya potential using Vero cells.Methods:The ethanolic extract of C.dactylon was subjected to silica gel column chromatography to obtain anti-chikungunya virus(CHIKV) fraction.Reverse phase-HPLC and GC-MS studies were carried out to identily the major phytochemicals in the fraction using phylochemical standards.Cytotoxicity and the potential of the fraction against CHIKV were evaluated in vitro using Vero cells.Reduction in viral replication was assessed by reverse transcriptase-polymerase chain reaction(RT-PCR) after treating the viral infected Vero cells with the fraction.Results:Reverse Phase-HPLC and GC-MS studies confirmed the presence of flavonoids,luteolin and apigenin as major phytochemicals in the anti-CHIKV ethanolic fraction of C.dactylon- The fraction was found to exhibit potent viral inhibitory activity(about 98%) at the concentration of 50 μg/mL as observed by reduction in cytopathic effect,and the cytotoxic concentration of the fraction was found to be 250 μg/mL.RT-PCR analyses indicated that the reduction in viral mRNA synthesis in fraction treated infected cells was much higher than the viral infected control cells.Conclusions:Luteolin and apigenin rich ethanolic fraction from C.dactylon can be utilized as a potential therapeutic agent against CHIKV infection as the fraction does not show cytotoxicity while inhibiting the virus. | Krishnan Saravana Murali Srinivasan Sivasubramanian Savariar Vincent Shanmugaraj Bala Murugan Bupesh Giridaran Sundaram Dinesh Palani Gunasekaran Kaveri Krishnasamy Ramalingam Sathishkumar | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，5： | 5 |
| 13 | Chikungunya infection:A potential re-emerging global threat显示文摘Infectious diseases are indeed a lifelong threat to everyone irrespective of age, sex, lifestyle and socio-economic status. The infectious diseases have persisted among the prominent causes of death globally. Recently, re-emergence of Chikungunya viral infection harmed many in Asian and African countries. Chikungunya was considered as a major threat in developing and underdeveloped countries; the recent epidemiological outbreak of Chikungunya in La Reunion urges the global researchers to develop effective vaccine against this viral disease. In this review, Chikungunya, pathogenesis and epidemiology were briefly described. | Shanmugaraj Bala Murugan Ramalingam Sathishkumar | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，10： | 5 |
| 14 | 马来西亚棕榈油在食品和饲料中的应用及油棕行业可持续发展的研究进展显示文摘目前棕榈油是全球第一大产量的植物油,其性状稳定,含有丰富的维生素E和类胡萝卜素等营养成分,且价格具有竞争力,因此被广泛应用于食品加工及饲料等行业。马来西亚作为世界棕榈油主要生产国和出口国之一,对全球棕榈油市场具有重要贡献。综述了马来西亚棕榈油生产、贸易及可持续发展状况,并对棕榈油在食品和饲料行业的应用进行总结,以期为棕榈油的消费和应用提供参考。 | 胡明明 季敏 马银辉 牛跃庭 陈诗晴 王丹丹 Jun Hao Yoong Nagendran Bala Sundram Ainie Hj Kuntom | 2021 | 中国油脂2021，46，8： | 5 |
| 15 | Magnesium based implants for functional bone tissue regeneration–A review显示文摘Magnesium(Mg)has emerged as one of the third-generation biomaterials for regeneration and support of functional bone tissue.Mg is a better choice over permanent implants such as titanium,stainless steel,cobalt-chrome as magnesium is biodegradable and does not require a second surgery for its removal after bone tissue recovery.It also reduces the risk of stress shielding as its elastic modulus is closer to human bone in comparison to permanent implants and other biodegradable metallic implants based on Iron and Zinc.Most importantly,Mg is osteoconductive thus stimulates new bone formation and possess anti-bacterial properties hence reducing the risk of failure due to infection.Despite its advantages,a major concern with pure Mg is its rapid bio-corrosion in presence of body fluids due to which the mechanical integrity of the implant deteriorates before healing of the tissue is complete.Mechanical properties of Mg-based implants can be enhanced by mechanical processing,alloying,and topology optimization.To reduce the corrosion/degradation rate,Mg has been alloyed with metals,reinforced with ceramics,and surface coatings have been applied so that the degradation rate of Mg-based implant matches with that of healing rate of bone tissue.The present review discusses the effect of alloying elements and reinforcing ceramics on microstructure,mechanical,and corrosion properties of Mg-based orthopedic implants.In addition,the biocompatibility of Mg-based alloys,composites,and coatings applied on Mg implants has been highlighted.Further,different methods of fabricating porous implants have been highlighted as making the implant porous facilitates the growth of new bone tissue through the pores. | Gavish Uppal Amit Thakur Amit Chauhan Saroj Bala | 2022 | Journal of Magnesium and Alloys2022，10，2： | 4 |
| 16 | IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice显示文摘 | Petrasek Jan Bala Shashi Csak Timea Lippai Dora Kodys Karen Menashy Victoria Barrieau Matthew Min So-Yun Kurt-Jones Evelyn A Szabo Gyongyi | 2012 | EN2012，，10： | 4 |
| 17 | 基于Floquet理论的旋转风机叶片动力失速气弹稳定性研究显示文摘研究旋转风力机叶片动力失速气弹稳定性问题。叶片结构采用标量化的挥舞和扭转自由度耦合的振动运动模型,旋转风机叶片的气动力由Beddoes-Leishman失速模型来模拟,通过攻角在深度失速区域内的变化来计算出周期时变的非线性气动失速负载。在系统静平衡点附近对非线性气弹系统进行线性化,采用Floquet理论分析旋转叶片动力失速气弹稳定性,其结果得到系统时域响的验证。通过数值分析,揭示了挥舞扭转固有频率比和结构阻尼对颤振边界的影响。 | 李迺璐 穆安乐 Balas M J | 2015 | 振动与冲击2015，34，24： | 4 |
| 18 | 五配位单核钴配合物的单晶结构和磁性能(英文)显示文摘制备了五配位单核钴配合物[Co(TMC)Cl]ClO_4(1,TMC=1,4,7,10-tetramethyl-1,4,7,10-tetraazacyclododecane)。配合物1结晶于单斜晶系:P21,晶胞参数为a=0.805 95(7) nm,b=1.486 58(12) nm,c=0.813 64(7) nm,β=110.190(2)°,V=0.914 93(13) nm^3,Z=2,T=120(2) K。钴与来自TMC配体的4个氮原子和1个氯离子配位,形成了扭曲的四方锥配位构型。磁性测试揭示了高自旋的钴离子具有场诱导的慢弛豫行为。 | 张翠娟 Sukhen Bala 倪兆平 童明良 | 2019 | 无机化学学报2019，35，5： | 4 |
| 19 | Risk Assessment for Tuzla Naval Base Breakwater显示文摘In the applications of reliability-based risk assessment methodology in Turkey, only wave characteristics, tidal range, storm surge, wave set-up, and structural system parameters were included in the past. Tsunami risk was not considered as a major design parameter and thus, was not included in the computation. After a strong earthquake (M w= 7.4) occurred near the town of Golcuk, Izmit Bay, Western Turkey at 00:01 GMT on August 17, 1999, chaotic water movements were observed on the coast of the Marmara Sea. Rubble mound breakwaters demonstrated very little damage, as predicted by the reliability-based risk assessment model developed in this study for the Tuzla Naval Base. For determination of the probability of occurrence under design conditions, which is a function of storm waves, tidal range, storm surge, and tsunami height, the Monte Carlo simulation was interrelated with the β Ⅱ method. For the Tuzla Naval Base main breakwater, tsunami was not the key design parameter when compared to storm waves, however, in places with great seismic activity, tsunami risk can be significant depending on the probability of occurrence and the magnitude of the tsunami. | Can Elmar BALAS | 2003 | 海洋工程:英文版2003，17，3： | 4 |
| 20 | Fabrication of Noble metal-semiconductor hybrid nanostructures using phase transfer显示文摘 | Tanushree Bala Ajay Singh Ambarish Sanyal Catriona O'Sullivan Fathima Laffir Claudia Coughlan Kevin M. Ryan | 2013 | Nano Research2013，6，2： | 3 |
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