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| 1 | 内脏脂肪组织通过产生骨桥蛋白调控成纤维细胞衰老促进心脏衰老显示文摘老化通过增加包括骨桥蛋白(osteopontin,OPN)在内的细胞外基质(extracellular matrix,ECM)蛋白的沉积引起心脏结构和功能改变进而导致进行性间质纤维化。虽然已知OPN参与各种病理状况,但其在心肌衰老中的作用仍不清楚。 | Sawaki D Czibik G Pini M Ternacle J Suffee N Mercedes R Marcelin G Surenaud M Marcos E Gual P Clément K Hue S Adnot S Hatem SN Tsuchimochi I Yoshimitsu T Hénégar C Derumeaux G 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，3： | 14 |
| 2 | Diabetes mellitus, revascularization and outcomes in elderly patients with myocardial infarction-related cardiogenic shock显示文摘Background The prognostic role of diabetes mellitus(DM)in elderly patients with myocardial infarction-related cardiogenic shock(MI-CS)remains controversial.Little information exists about the impact of intensive cardiac care unit(ICCU)and revascularization on outcomes of elderly patients with MI-CS.We aimed to assess the prognostic impact of DM according to age in patients with MI-CS,and to analyze the impact ICCU management and revascularization on in-hospital mortality in MI-CS patients at older ages.Methods Discharge episodes with diagnosis of CS associated with MI were selected from the Spanish National Health System’s Basic Data Set.Centers were classified according to their availability of ICCU.Main outcome measured was in-hospital mortality.Results A total of 23,590 episodes of MI-CS were identified,of whom 12,447(52.8%)were in patients aged≥75 years.The impact of DM on in-hospital mortality was different among age subgroups.While in younger patients,DM was associated to a higher mortality risk(0.52 vs.0.47,OR=1.12,95%CI:1.06–1.18,χ^2<0.001),this association became non-significant in older patients(0.76 vs.0.81,χ^2=0.09).Adjusted mortality rate of MI-CS aged≥75 years was lower in patients admitted to hospitals with ICCU(adjusted mortality rate:74.2%vs.77.7%,P<0.001)and in patients undergoing revascularization(74.9%vs.77.3%,P<0.001).Conclusions Prognostic impact of DM in patients with MI-CS was different according to age,with a significantly lower impact at older ages.The availability of ICCU and revascularization were associated with better outcomes in these complex patients. | Miquel Gual Albert Ariza-Solé María García Márquez Cristina Fernández JoséL Bernal Francesc Formiga María-Isabel Barrionuevo JoséC Sánchez-Salado Victòria Lorente Júlia Pascual Isaac Llaó Oriol Alegre Angel Cequier Javier Elola | 2020 | Journal of Geriatric Cardiology2020，17，10： | 2 |
| 3 | Anemia in patients with high-risk acute coronary syndromes admitted to Intensive Cardiac Care Units显示文摘Background Little information exists about the role of anemia in patients with acute coronary syndromes(ACS)admitted to Intensive Cardiac Care Units(ICCU).The aim of this study was to assess the prevalence of anemia and its impact on management and outcomes in this clinical setting.Methods All consecutive patients admitted to eight different ICCUs with diagnosis of non-ST segment elevation ACS(NSTEACS)were prospectively included.Anemia was defined as hemoglobin<130 g/L in men and<120 g/L in women.The association between anemia and mortality or readmission at six months was assessed by the Cox regression method.Results A total of 629 patients were included.Mean age was 66.6 years.A total of 197 patients(31.3%)had anemia.Coronary angiography was performed in most patients(96.2%).Patients with anemia were significantly older,with a higher prevalence of comorbidities,poorer left ventricle ejection fraction and higher GRACE score values.Patients with anemia underwent less often coronary angiography,but underwent more often intraaortic counterpulsation,non-invasive mechanical ventilation and renal replacement therapies.Both ICCU and hospital stay were significantly longer in patients with anemia.Both the incidence of mortality(HR=3.36,95%CI:1.43–7.85,P=0.001)and the incidence of mortality/readmission were significantly higher in patients with anemia(HR=2.80,95%CI:2.03–3.86,P=0.001).After adjusting for confounders,the association between anemia and mortality/readmission remained significant(P=0.031).Conclusions Almost one of three NSTEACS patients admitted to ICCU had anemia.Most patients underwent coronary angiography.Anemia was independently associated to poorer outcomes at 6 months. | Victoria Lorente Jaime Aboal Cosme Garcia Jordi Sans-Rosello Antonia Sambola Rut Andrea Carlos Tomas Gil Bonet David Vinas Nabil el Ouaddi Santiago Montero Javier Cantalapiedra Margarida Pujol Isabel Hernandez Maria Perez-Rodriguez Isaac Llao Jose C Sanchez-Salado Miquel Gual Albert Ariza-Sole 无 | 2020 | Journal of Geriatric Cardiology2020，17，1： | 2 |
| 4 | MAP kinases and mTOR mediate insulin-induced phosphorylafion of insulin receptor substrate-1 on serlne residues 307,612 and 632 显示文摘 | Gual P Gremeanx T Gonzalez T | 2003 | Diabetologia2003，46，11： | 1 |
| 5 | Alteration in insulin action:Role of IRS-1 serine phosphorylation in the retroregulation of insulin signalling显示文摘 | Gual P Gremeaux T | 2004 | Am Endocrinol (Paris)2004，65，1： | 1 |
| 6 | Positive and negative regulation of insulin signaling through IRS-1 phosphorylation 显示文摘 | Gual P Le Marchand-Brustel Y Tanti JF | 2005 | Biochimie2005，87，： | 1 |
| 7 | Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes显示文摘 | Bouzakri K Roques M Gual P | | 0，，： | 1 |
| 8 | Determination of the impact force on a plate by piezoelectric film sensors显示文摘 | Gual L Hurlebaus S | 1999 | Archive of Applied Mechanics1999，69，910： | 1 |
| 9 | Positive and negative regulation of insulin signaling through IR S-1 phosphorylation显示文摘 | Gual P Le Marchand-Brustel Y Tanti JF | 2005 | Biochmine2005，87，1： | 1 |
| 10 | Self-esteem, personality, and eating disorders: Baseline assessment of a prospective population-based cohort 显示文摘 | GUAL P PEREZ-GASPAR M MARTINEZ-GONZALEZ MA | 2002 | Int J Eat Disord2002，31，3： | 1 |
| 11 | Differential re- quirement of the last C-terminal tail of Met receptor for cell transformation and invasiveness 显示文摘 | Gual P Giordano S Anguissola S | 2001 | Oncogene2001，20，39： | 1 |
| 12 | Positive and negative regulation of insulin signaling through IRS -1 phosphorylation显示文摘 | Gual P Marchand-Brustel YL Tanti JF | 2005 | Biochimie2005，87，： | 1 |
| 13 | Sustained recruit- ment of phospholipase C - gamma to Gabl is required for HGF - in- duced branching tubulogenesis 显示文摘 | GUAL P GIORDANO S WILLIAMS T A | 2000 | Oncogene2000，19，12： | 1 |
| 14 | Determination of residual chlorine in greywater using o-tolidine显示文摘 | MARCH J G GUAL M SIMONET B M | 2002 | Talanta2002，58，： | 1 |
| 15 | Acquisition of learning outcomes by students from the Medical School of the University of Barcelona (Catalonia, Spain): A student survey显示文摘 | Pales J Gual A Gomar C | 2008 | Medical Teacher2008，30，7： | 1 |
| 16 | The Migrasta- tin family:Discovery of potent cell migration inhibitors by chemical synthesis 显示文摘 | Njardarson J T Gual C Shan D | 2004 | J Am Chem Soc2004，126，11： | 1 |
| 17 | M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease显示文摘 | Jinghong Wan Merieme Benkdane Fatima Teixeira‐Clerc Stéphanie Bonnafous Alexandre Louvet Fouad Lafdil Fran?oise Pecker Albert Tran Philippe Gual Ariane Mallat Sophie Lotersztajn Catherine Pavoine | 2014 | Hepatology2014，，1： | 1 |
| 18 | Positive and negative regulation of insulin signaling through IRS-1 phosphorylation显示文摘 | Gual P Le Marchand-Brustel Y Tanti J F | 2005 | Bioehimie2005，87，1： | 1 |
| 19 | Alteration in insulin action:role of IRS-1 serine phosphorylation in the retroregulation of insulin signaling显示文摘 | Tanti JF Gual P Gremeaux T | 2004 | Ann Endocrinol2004，65，1： | 1 |
| 20 | Effects of sleeve gastrectomy in high fat diet-induced obese mice: respective role of reduced caloric intake, white adipose tissue inflammation and changes in adipose tissue and ectopic fat depots显示文摘 | Anne-Sophie Schneck Antonio Iannelli Stéphanie Patouraux Déborah Rousseau Stéphanie Bonnafous Beatrice Bailly-Maitre Ophélia Thuc Carole Rovere Patricia Panaia-Ferrari Rodolphe Anty Albert Tran Philippe Gual Jean Gugenheim | 2014 | Surgical Endoscopy2014，，2： | 1 |
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