|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk显示文摘AIM:To investigate the association of variations in the cyclooxygenase-2(COX2) and uridine diphosphate glucuronosyltransferase 1A6(UGT1A6) genes and non-steroidal anti-inflammatory drugs(NSAIDs) use with risk of colon cancer.METHODS:NSAIDs,which are known to reduce the risk of colon cancer,act directly on COX2 and reduce its activity.Epidemiological studies have associated variations in the COX2 gene with colon cancer risk,but others were unable to replicate this finding.Similarly,enzymes in the UGT1A6 gene have been demonstrated to modify the therapeutic effect of NSAIDs on colon adenomas.Polymorphisms in the UGT1A6 gene have been statistically shown to interact with NSAID intake to influence risk of developing colon adenomas,but not colon cancer.Here we examined the association of tagging single nucleotide polymorphisms(SNPs) in the COX2 and UGT1A6 genes,and their interaction with NSAID consumption,on risk of colon cancer in a population of 422 colon cancer cases and 481 population controls.RESULTS:No SNP in either gene was individually statistically significantly associated with colon cancer,nor did they statistically significantly change the protective effect of NSAID consumption in our sample.Like others,we were unable to replicate the association of variants in the COX2 gene with colon cancer risk(P > 0.05),and we did not observe that these variants modify the protective effect of NSAIDs(P > 0.05).We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk,although further studies will have to be conducted to confirm the association of these variants with colon adenomas.CONCLUSION:Our study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer. | Cheryl L Thompson Sarah J Plummer Alona Merkulova Iona Cheng Thomas C Tucker Graham Casey Li Li | 2009 | World Journal of Gastroenterology2009，15，18： | 11 |
| 2 | Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-Analysis显示文摘 | Ulrike Peters Shuo Jiao Fredrick R. Schumacher Carolyn M. Hutter Aaron K. Aragaki John A. Baron Sonja I. Berndt Stéphane Bézieau Hermann Brenner Katja Butterbach Bette J. Caan Peter T. Campbell Christopher S. Carlson Graham Casey Andrew T. Chan Jenny Chan | 2012 | Gastroenterology2012，，： | 4 |
| 3 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 4 | Divergent Oncogenic Changes Influence Survival Differences between Colon and Rectal Adenocarcinomas显示文摘 | Matthew F. Kalady Julian A. Sanchez Elena Manilich Jeff Hammel Graham Casey James M. Church | 2009 | Diseases of the Colon & Rectum2009，，： | 1 |
| 5 | Non-Traditionally Certified School Leaders' Self-Perceptions of Background Knowledge and Needs 显示文摘 | CASEY GRAHAM BROWN | 2011 | International Journal of Business and Social Science2011，12，2： | 1 |
| 6 | Epidemiology of Hypertrophic Cardiomyopathy–Related Death: Revisited in a Large Non–Referral-Based Patient Population显示文摘 | Barry J. Maron Iacopo Olivotto Paolo Spirito Susan A. Casey Pietro Bellone Thomas E. Gohman Kevin J. Graham David A. Burton Franco Cecchi | 2000 | Circulation: Journal of the American Heart Association2000，，8： | 1 |
| 7 | Cancer Risks for MLH 1 and MSH 2 Mutation Carriers显示文摘 | James G. Dowty Aung K. Win Daniel D. Buchanan Noralane M. Lindor Finlay A. Macrae Mark Clendenning Yoland C. Antill Stephen N. Thibodeau Graham Casey Steve Gallinger Loic Le Marchand Polly A. Newcomb Robert W. Haile Graeme P. Young Paul A. James Graham G. | 2013 | Human Mutation2013，，3： | 1 |
| 8 | BRMS1 contributes to the negative regulation of uPA gene expression through recruitment of HDAC1 to the NF-κB binding site of the uPA promoter显示文摘 | Muzaffer Cicek Ryuichi Fukuyama Mine S. Cicek Steven Sizemore Danny R. Welch Nywana Sizemore Graham Casey | 2009 | Clinical & Experimental Metastasis2009，，3： | 1 |
| 9 | Non Traditionally Certified School Leaders Self--Perceptions of Background Knowledge and Needs显示文摘 | Casey Graham Brown | 2011 | International Journal of Business and Social Sci- ence2011，，2： | 1 |
| 10 | Quality Assessment and Correlation of Microsatellite Instability and Immunohistochemical Markers among Population- and Clinic-Based Colorectal Tumors显示文摘 | Mine S. Cicek Noralane M. Lindor Steven Gallinger Bharati Bapat John L. Hopper Mark A. Jenkins Joanne Young Daniel Buchanan Michael D. Walsh Loic Le Marchand Terrilea Burnett Polly A. Newcomb William M. Grady Robert W. Haile Graham Casey Sarah J. Plummer | 2011 | The Journal of Molecular Diagnostics2011，，3： | 1 |
| 11 | Fluorescence in situ hybridization of cytologic specimens from Barrett’s esophagus: a pilot feasibility study显示文摘 | Gary W. Falk Marek Skacel Terry L. Gramlich Graham Casey John R. Goldblum Ray R. Tubbs | 2004 | Gastrointestinal Endoscopy2004，，2： | 1 |
| 12 | Genomic structure of TBX2 indicates conservation with distantly related T-box genes显示文摘 | Christine E. Campbell Graham Casey Kristine Goodrich | 1998 | Mammalian Genome1998，，1： | 1 |
| 13 | Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells显示文摘 | Muzaffer Cicek Rajeev S. Samant Michael Kinter Danny R. Welch Graham Casey | 2004 | Clinical and Experimental Metastasis2004，，2： | 1 |
| 14 | 结直肠癌患者MLH1和MSH2基因突变的转变分析显示文摘背景:准确发现、解释结直肠癌患者错配修复基因的种系突变对临床治疗至关重要。近来的资料表明,错配修复突变具有高度的异质性,仅凭常规DNA测序无法检测到许多突变。 | Graham Casey Noralane M. Lindor Nickolas Papadopoulos 许峰(译) 祝学光(校) | 2006 | 美国医学会杂志(中文版)2006，25，2： | 0 |
| 15 | 台北艺术中心显示文摘正近年来,世界各地的演艺中心数目渐增,但不知何故,这些演艺中心似乎达成一种共识,呈现出雷同的空间组合:一座约2000席的大型演艺厅和一个1500席的中型剧院,再加上一个黑盒子剧场。标志性的外形,饰以典型19世纪做法的保守内部剧场布局,以及见证社会阶级观念的包厢。纵然剧院最基本的构造元素如舞台、镜框式剧场和观众席等已有三千多年的历史,但我们仍不应以此为借口,让现代剧场建筑的创新发展停滞不前。 | Yannis Chan Hin-Yeung Cheung Jim Dodson Inge Goudsmit Alasdair Graham Vincent Kersten Chiaju Lin Vivien Liu Kai Sun Luk Kevin Mak Slobodan Radoman Roberto Requejo Saul Smeding Elaine Tsui Viviano Villarreal Casey Wang Leonie Wenz Frans Parthesius Iwan Baan | 2012 | 建筑技艺2012，，4： | 0 |
| 16 | 台北艺术中心显示文摘为什么过去百年间最令人兴奋的剧场盛事总是发生在正规场所之外?建筑如何才能超越自身卑微的命运,摆脱那种限制各种可能的宿命?
近年来,世界各地的演艺中心数目渐增,但不知何故,这些演艺中心似乎达成一种共识,呈现出雷同的空间组合:一座约2 000席的大型演艺厅和一个1 500席的中型剧院,再加上一个黑盒子剧场。 | Yannis Chan Hin-Yeung Cheung Inge Goudsmit Vincent Kersten Chiaju Lin Kevin Mak Jim Dodson Alasdair Graham Vivien Liu Kai Sun Luk Slobodan Radoman Roberto Requejo Saul Smeding Elaine Tsui Viviano Villarreal Casey Wang Leonie Wenz | 2014 | 城市环境设计2014，，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员