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| 1 | Optimal timing and route of nutritional support after esophagectomy: A review of the literature显示文摘Some controversy surrounds the postoperative feeding regimen utilized in patients who undergo esophagectomy.Variation in practices during the perioperative period exists including the type of nutrition started,the delivery route,and its timing.Adequate nutrition is essential for this patient population as these patients often present with weight loss and have altered eating patterns after surgery,which can affect their ability to regain or maintain weight.Methods of feeding after an esophagectomy include total parenteral nutrition,nasoduodenal/nasojejunal tube feeding,jejunostomy tube feeding,and oral feeding.Recent evidence suggests that early oral feeding is associated with shorter LOS,faster return of bowel function,and improved quality of life.Enhanced recovery pathways after surgery pathways after esophagectomy with a component of early oral feeding also seem to be safe,feasible,and cost-effective,albeit with limited data.However,data on anastomotic leaks is mixed,and some studies suggest that the incidence of leaks may be higher with early oral feeding.This risk of anastomotic leak with early feeding may be heavily modulated by surgical approach.No definitive data is currently available to definitively answer this question,and further studies should look at how these early feeding regimens vary by surgical technique.This review aims to discuss the existing literature on the optimal route and timing of feeding after esophagectomy. | Richard Zheng Courtney L Devin Michael J Pucci Adam C Berger Ernest L Rosato Francesco Palazzo | 2019 | World Journal of Gastroenterology2019，25，31： | 11 |
| 2 | Palliative chemotherapy for gastroesophageal cancer in old and very old patients: A retrospective cohort study at the National Center for Tumor Diseases, Heidelberg显示文摘AIM:To investigate the outcome of palliative chemotherapy in old patients with gastroesophageal cancer at the National Center for Tumor Diseases,Heidelberg.METHODS:Using a prospectively generated database,we retrospectively analyzed 55 patients≥70years under palliative chemotherapy for advanced gastroesophageal cancer at the outpatient clinic of the National Center for Tumor Diseases Heidelberg,Germany between January 2006 and December2013.Further requirements for inclusion were(1)histologically proven diagnosis of gastroesophageal cancer;(2)advanced(metastatic or inoperable)disease;and(3)no history of radiation or radiochemotherapy.The clinical information included Eastern Cooperative Oncology Group performance status(ECOG PS),presence and site of metastases at diagnosis,date of previous surgery and perioperative chemotherapy,start and stop date of first-line treatment,toxicities and consecutive dosage reductions of first-line treatment,response to first-line therapy,date of progression,usage of second-line therapies and date and cause of death.Survival times[progression-free survival(PFS),overall survival(OS)and residual survival(RS)]were calculated.Toxicity and safety were examined.Prognostic factors including ECOG PS,age and previousperioperative treatment were analyzed.RESULTS:Median age of our cohort was 76 years.86%of patients received a combination of two cytotoxic drugs.76 percent of patients had an oxaliplatin-based first-line therapy with the oxaliplatin and 5-fluorouracil regimen being the predominantely chosen regimen(69%).Drug modifications due to toxicity were necessary in 56%of patients,and 11%of patients stopped treatment due to toxicities.Survival times of our cohort are in good accordance with the major phaseⅢtrials that included mostly younger patients:PFS and OS were 5.8 and 9.5 mo,respectively.Survival differed significantly between patient groups with low(≤1)and high(≥2)ECOG PS(12.7 mo vs 3.8 mo,P<0.001).Very old patients(≥75 years)did not show a worse outcome in terms of survival.Patients receiving secondline treatment(51%)had a significantly longer RS than patients with best supportive care(6.8 vs 1.4 mo,P=0.001).Initial ECOG PS was a strong prognostic factor for PFS,OS and RS.CONCLUSION:Old patients with non-curable gastroesophageal cancer should be offered chemotherapy,and ECOG PS is a tool for balancing benefit and harm upfront.Second-line treatment is reasonable. | Anne Katrin Berger Stefanie Zschaebitz Christine Komander Dirk Jger Georg Martin Haag | 2015 | World Journal of Gastroenterology2015，21，16： | 6 |
| 3 | Interactive labelling of a multivariate dataset for supervised machine learning using linked visualisations,clustering,and active learning显示文摘Supervised machine learning techniques require labelled multivariate training datasets.Many approaches address the issue of unlabelled datasets by tightly coupling machine learning algorithms with interactive visualisations.Using appropriate techniques,analysts can play an active role in a highly interactive and iterative machine learning process to label the dataset and create meaningful partitions.While this principle has been implemented either for unsupervised,semi-supervised,or supervised machine learning tasks,the combination of all three methodologies remains challenging.In this paper,a visual analytics approach is presented,combining a variety of machine learning capabilities with four linked visualisation views,all integrated within the mVis(multivariate Visualiser)system.The available palette of techniques allows an analyst to perform exploratory data analysis on a multivariate dataset and divide it into meaningful labelled partitions,from which a classifier can be built.In the workflow,the analyst can label interesting patterns or outliers in a semi-supervised process supported by active learning.Once a dataset has been interactively labelled,the analyst can continue the workflow with supervised machine learning to assess to what degree the subsequent classifier has effectively learned the concepts expressed in the labelled training dataset.Using a novel technique called automatic dimension selection,interactions the analyst had with dimensions of the multivariate dataset are used to steer the machine learning algorithms.A real-world football dataset is used to show the utility of mVis for a series of analysis and labelling tasks,from initial labelling through iterations of data exploration,clustering,classification,and active learning to refine the named partitions,to finally producing a high-quality labelled training dataset suitable for training a classifier.The tool empowers the analyst with interactive visualisations including scatterplots,parallel coordinates,similarity maps for records,and a new similarity map for partitions. | Mohammad Chegini Jürgen Bernard Philip Berger Alexei Sourin Keith Andrews Tobias Schreck | 2019 | Visual Informatics2019，3，1： | 3 |
| 4 | Multitarget stool DNA for colorectal cancer screening:A review and commentary on the United States Preventive Services Draft Guidelines显示文摘Multitarget stool DNA(mt-sDNA) testing was approved for average risk colorectal cancer(CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program(2014).The United States Preventive Services Task Force(USPSTF) October 2015 draft recommendation for CRC screening included mt-s DNA as an 'alternative' screening test that 'may be useful in select clinical circumstances',despite its very high sensitivity for early stage CRC.The evidence supporting mt-s DNA for routine screening use is robust.The clinical efficacy of mt-s DNA as measured by sensitivity,specificity,life-years gained(LYG),and CRC deaths averted is similar to or exceeds that of the other more specifically recommended screening options included in the draft document,especially those requiring annual testing adherence.In a population with primarily irregular screening participation,tests with the highest point sensitivity and reasonable specificity are more likely to favorably impact CRC related morbidity and mortality than those depending on annual adherence.This paper reviews the evidence supporting mt-s DNA for routine screening and demonstrates,using USPSTF's modeling data,that mt-s DNA at three-year intervals provides significant clinical net benefits and fewer complications per LYG than annual fecal immunochemical testing,high sensitivity guaiac based fecal occult blood testing and 10-year colonoscopy screening. | Barry M Berger Bernard Levin Robert J Hilsden | 2016 | World Journal of Gastrointestinal Oncology2016，8，5： | 3 |
| 5 | Fiber-bundle coupled diode end-pumped Nd:YAG laser显示文摘 | Berger J Welch D F Streifer W | 1988 | Opt Lett1988，13，4： | 2 |
| 6 | PICU患儿死亡后组织家长随访会议的实施方案研(摘要)显示文摘目的许多儿童的死亡地点在PICU。丧子的父母经常希望能与救治过患儿的医生们开一个随访会议。我们试图制定一套实施方案,对PICU医生提供组织相关会议的指导。 | Eggly S Meert KL Berger J 杨明(译) 钱素云(校) | 2011 | 中国小儿急救医学2011，18，2： | 2 |
| 7 | Symposium-Minimally invasive total hip arthroplasty 显示文摘 | Berry Daniel J Berger Richard A Callaghan John J | 2003 | J Bone Joint Surg (Am)2003，85，11： | 2 |
| 8 | No-reflow during coronary intervention :observations and implications 显示文摘 | Leopold JA Berger C J Cupples LA | 2000 | Circulation2000，102，： | 2 |
| 9 | Malrotation causing patellofemoral complications after total knee arthroplasty 显示文摘 | Berger RA Crosset LS Jacobs J J | 1998 | ClinOrthop1998，356，2： | 1 |
| 10 | Simple syntheses of pyrimidine-2'- deoxyribonucleosides 显示文摘 | Berger J | 1959 | JAm Chem Soc1959，81，： | 1 |
| 11 | Supercritical fluids crystallization of budesonide and flunisolide 显示文摘 | Velaga S E Berger R Carlfors J | 2002 | Pharm Res2002，19，10： | 1 |
| 12 | Relationship between delay in performing direct coronary angioplasty and early clinical outcome in patients with acute myocardial infarction: results from the global use of strategies to open occluded arteries in Acute Coronary Syndromes (GUSTO-Ⅱb) trial显示文摘 | Berger PB Ellis SG Holmes DR J | 1999 | Circulation1999，，1： | 1 |
| 13 | The coexistence of multiple distribution systems for financial services: The case of property-liability insurance显示文摘 | Berger Allen N Cummins J David Weiss Mary A | 1997 | Journal of Business1997，10，： | 1 |
| 14 | A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion显示文摘 | Hansen C L Skordalakes E Berger J M | 2002 | Proc Natl Acad Sci USA2002，99，16： | 1 |
| 15 | Finite element modeling of engagement of rough and wet clutches显示文摘 | F Sadeghi C M Krousgrill | 1996 | Trans of ASME Journal of Tribology1996，118，： | 1 |
| 16 | Geology and structural evolution of the Muruntau gold deposit, Kyzylkum Desert, Uzbekistan 显示文摘 | Berger B R Kurbanov N K | 1996 | Ore Geology Reviews1996，11，： | 1 |
| 17 | Lithium ion induced surface reativity change on MgO nanoparticles显示文摘 | BERGER R SCHUH J STERRER M DIWALD O KNOZINGER E | 2007 | J Catalysis2007，247，： | 1 |
| 18 | A novel,automated method of temperature cycling to produce cryoprecipitate显示文摘 | Rock G Berger R Lange J eta1 | 2001 | Transfusion2001，41，2： | 1 |
| 19 | The mechanisms of action of PPARS显示文摘 | Berger J Moller DE | 2002 | Annu Rev Med2002，53，： | 1 |
| 20 | Early and sustained udal oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial显示文摘 | Steinhubl SR Berger PB Tift Mann J | 2002 | JAMA2002，288，19： | 1 |
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