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| 1 | 黄河三角洲湿地补水生态效益评价显示文摘借助景观模型强大的空间模拟功能和情景分析功能,运用生态经济学核算方法,以水和生态之间的关系为基础,对不同补水预案下的黄河三角洲湿地生态价值进行了评价。结果表明:实施生态补水后,湿地生态功能得到了有效恢复,湿地价值明显提高,湿地补水生态效益显著,若每年向湿地实施人工生态补水2.78亿-4.17亿m^3,则黄河三角洲湿地每年能提供生态价值140亿-160亿元,湿地功能和价值基本恢复到1992年自然保护区建立时的水平;补水量与湿地价值并不具有良好的线性关系,当水量增加到一定程度时,补水生态效益增幅减小,表明黄河三角洲湿地需水存在一个适宜范围,并非水量越大越好。 | 王瑞玲 连煜 黄锦辉 王新功 宋世霞 张绍峰 Marcel Marchand 叶亚平 | 2011 | 人民黄河2011，33，2： | 8 |
| 2 | Neural mechanisms of mindfulness and meditation: Evidence from neuroimaging studies显示文摘Mindfulness is the dispassionate,moment-by-moment awareness of sensations,emotions and thoughts.Mindfulness-based interventions are being increasingly used for stress,psychological well being,coping with chronic illness as well as adjunctive treatments for psychiatric disorders.However,the neural mechanisms associated with mindfulness have not been well characterized.Recent functional and structural neuroimaging studies are beginning to provide insights into neural processes associated with the practice of mindfulness.A review of this literature revealed compelling evidence that mindfulness impacts the function of the medial cortex and associated default mode network as well as insula and amygdala.Additionally,mindfulness practice appears to effect lateral frontal regions and basal ganglia,at least in some cases.Structural imaging studies are consistent with these findings and also indicate changes in the hippocampus.While many questions remain unanswered,the current literature provides evidence of brain regions and networks relevant for understanding neural processes associated with mindfulness. | William R Marchand | 2014 | World Journal of Radiology2014，6，7： | 5 |
| 3 | High-Resolution Crystal Structure and Redox Properties of Chloroplastic Triosephosphate Isomerase from Chlamydomonas reinhardtii显示文摘Triosephosphate isomerase (TPI ) 催化 glyceraldehyde-3-phosphate 的互变现象到 dihydroxyacetone 磷酸盐。光合的有机体通常包含位于细胞质和叶绿体的 TPI 的二 isoforms。当细胞质的 TPI 涉及 glycolysis 时, chloroplastic isoform 参予 CalvinBenson 周期,为碳固定负责的一个关键光合的过程。与它的细胞质的对应物相比, chloroplastic TPI 的功能的特征糟糕被调查了,它的三维的结构没被解决。最近,几研究包括 dithiol/disulfide 交换, glutathionylation,和 nitrosylation 作为不同氧化还原作用修正的一个潜在的目标建议了 TPI。然而,在蛋白质活动的既不效果也不位于这些氧化还原作用修正下面的分子的机制被调查了。这里,我们 recombinantly 生产了并且从单细胞的绿水藻 Chlamydomonas reinhardtii (Cr ) 净化了 TPI。酶的生物化学的性质被描出,它的结晶的结构在 1.1 的一个决定是坚定的 ? 。CrTPI 是有包含典型(/)8 桶褶层的子单元的 homodimer。尽管为 TRX 规定的证据都没被获得, CrTPI 被发现由 nitrosoglutathione 由氧化谷胱甘肽和 trans-nitrosylation 经历 glutathionylation,证实它到多重氧化还原作用修正的敏感。 | Mirko Zaffagnini Laure Michelet Chiara Sciabolini Nastasia Di Giacinto Samuel Morisse Christophe H. Marchand Paolo Trost Simona Fermani Stephane D Lemaire | 2014 | Molecular Plant2014，7，1： | 4 |
| 4 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 5 | B-vitamin intake, metabolic genes, and colorectal cancer risk (United States)显示文摘 | Marchand LL Donlon Hankin JH | 2002 | Cancer causes control2002，13，： | 2 |
| 6 | Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1显示文摘 | MARCHAND M Van Baren N Weynants P | | 0，，： | 2 |
| 7 | 阶层、健康和正义显示文摘 | Daniel Wikler Sarah Marchand Bruce Landesman | 2001 | 医学与哲学2001，22，4： | 2 |
| 8 | Aerosol Removal by Emergency Spray in PWR Containment显示文摘 | E. Porcheron P. Lemaitre D. Marchand | 2011 | Journal of Energy and Power Engineering2011，5，7： | 2 |
| 9 | Bovine pericardium for dural grafts: clinical results in 35 patients显示文摘 | Anson JA Marchand EP | 1996 | Neurosurgery1996，39，3： | 2 |
| 10 | Fiscal competition and the pattern of public spending显示文摘 | Michael Keen Maurice Marchand | 1997 | Journal of Public Economics1997，，1： | 2 |
| 11 | Idiopathic Chronic Eosinophilic Pneumonia显示文摘 | Eric Marchand Jean-Fran?ois Cordier | 2006 | Semin Respir Crit Care Med2006，，02： | 2 |
| 12 | Evidence for an involvement of supra-spinal δ- and spinal μ-opioid receptors in the antihyperalgesic effect of chronically administred clomipramine in mononeuropathic rats显示文摘 | MARCHAND F ARDID D CHAPUY E | 2003 | J Pharmacol Exp Ther2003，307，1： | 1 |
| 13 | Torque Ripple Minimization in Permanent Magnet Synchronous Servo Drive 显示文摘 | Colamartino F Marchand C Razek A | 1999 | IEEE Transactions on Energy Conversion1999，14，3： | 1 |
| 14 | Real-time markerless tracking for augmented reality: the virtuai visual servoing framework 显示文摘 | Muriel Pressigout Andrew I Comport Eric Marchand | 2006 | IEEE Transactions on Visualization and Computer Graphics Archive2006，12，4： | 1 |
| 15 | TiO2(B)/activated carbon non-aqueous hybrid system for energy storage 显示文摘 | BROUSSE T MARCHAND R TABERNA P L | 2006 | J Power Sources2006，158，1： | 1 |
| 16 | K ras mutation identifiction by hybridization to a polypyrrole DNA chip显示文摘 | Lopez Crapez E Livache T Marchand J | 2001 | Clin Chem2001，47，220： | 1 |
| 17 | Inducible differentiation and morphogenesis of bipotential liver cell lines from wild type mouse embryos显示文摘 | Marchand HS Weiss MC | 2002 | Hepatology2002，36，41： | 1 |
| 18 | Evaluation of Binding Selectivities of Caged Crown Ligands Toward Heavy Metals by Electrospray Ionization/Quadrupole Ion Trap Mass Spectrometry显示文摘 | Blair SM Brodbelt JS Marchand AP | 2000 | Anal Chem2000，72，11： | 1 |
| 19 | Immune and glial cell factors as pain mediators and modulators显示文摘 | McMahon S B Cafferty W B Marchand F | 2005 | Exp Neurol2005，192，2： | 1 |
| 20 | Association of the cyclin D1 ,A870G polymorphism with advanced colorectal cancer显示文摘 | Le Marchand L Seifried A Lure -Jones A | 2003 | JAMA2003，290，21： | 1 |
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