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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | Management of Helicobacter pylori infection in Latin America: A Delphi technique-based consensus显示文摘AIM: To optimize diagnosis and treatment guidelines for this geographic region, a panel of gastroenterologists, epidemiologists, and basic scientists carried out a structured evaluation of available literature.METHODS: Relevant questions were distributed among the experts, who generated draft statements for consideration by the entire panel. A modified three-round Delphi technique method was used to reach consensus. Critical input was also obtained from representatives of the concerned medical community. The quality of the evidence and level of recommendation supporting each statement was graded according to United States Preventive Services Task Force criteria.RESULTS: A group of ten experts was established. The survey included 15 open-ended questions that were distributed among the experts, who assessed the articles associated with each question. The levels of agreement achieved by the panel were 50% in the first round, 73.3% in the second round and 100% in the third round. Main consensus recommendations included:(1) when available, urea breath and stool antigen test(HpSA) should be used for non-invasive diagnosis;(2) detect and eradicate Helicobacter pylori(H. pylori) in all gastroscopy patients to decrease risk of peptic ulcer disease, prevent o retard progression in patients with preneoplastic lesions, and to prevent recurrence in patients treated for gastric cancer;(3) further investigate implementation issues and health outcomes of H. pylorieradication for primary prevention of gastric cancer in high-risk populations;(4) prescribe standard 14-d triple therapy or sequential therapy for first-line treatment;(5) routinely assess eradication success post-treatment in clinical settings; and(6) select second- and third-line therapies according to antibiotic susceptibility testing.CONCLUSION: These achievable steps toward better region-specific management can be expected to improve clinical health outcomes. | Antonio Rollan Juan Pablo Arab M Constanza Camargo Roberto Candia Paul Harris Catterina Ferreccio Charles S Rabkin Juan Cristóbal Gana Pablo Cortés Rolando Herrero Luisa Durán Apolinaria García Claudio Toledo Alberto Espino Nicole Lustig Alberto Sarfatis Catalina Figueroa Javier Torres Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，31： | 2 |
| 3 | The EBV action in tonsils and adenoids显示文摘 | ENDO L H SAKANO E CAMARGO L A | 2003 | Int Congress Series2003，1257，： | 1 |
| 4 | The role of angiotensin AT1 receptors in the diuretic, natriuretie, kaliuretic and blood pressure responses induced by angiotensin II activation of the median preoptic nucleus in conscious rats 显示文摘 | Ferreira-do-Vale C Renzi A Camargo G P | 1995 | Braz J Med Biol Res1995，28，10： | 1 |
| 5 | Effects of taurine supplementation upon food intake and central insulin signaling in malnourished mice fed on a high-fat diet显示文摘 | Camargo R L Batista T M Ribeiro R A | 2013 | Advances in Experi- mental Medicine and Biology2013，4776，： | 1 |
| 6 | Acid rain and nitrogen deposition in a sub-tropical watershed (Piracicaba): ecosystem consequences显示文摘 | Krusche A V de Camargo P B Cerri C E | 2003 | Environmental Pollution2003，121，3： | 1 |
| 7 | QSAR study for the soybean 15-1ipoxygenase inhibitory activity of organosulfur compounds derived from the essential oil of garlic显示文摘 | Camargo A B Marchevsky E Luco J M | | 0，，08： | 1 |
| 8 | Revisiting the influence of the Quasi-Biennial Oscillation on tropical cyclone activity 显示文摘 | CAMARGO S J SOBEL A H | 2010 | J Clim2010，23，21： | 1 |
| 9 | Influence of Western North Pacific tropical cyclones on their environment显示文摘 | SOBEL A H CAMARGO S J | 2005 | J Atmos SCI2005，62，： | 1 |
| 10 | The N terminal pro-BNP investiation of dyspnea in the emerency department (PRIDE) study显示文摘 | JANUZZI J L J R CAMARGO C A ANWARUDDIN S | 2005 | Am J Cardiol2005，95，8： | 1 |
| 11 | Cluster analysis of typhoon tracks Part I: General properties显示文摘 | CAMARGO S J ROBERTSON A W GAFFNEY S J | 2007 | J Climate2007，20，14： | 1 |
| 12 | Clonal relation ships determined by multilocus sequence typing among entero pathogenic Escherichia coil isolated in Brazil显示文摘 | Pitondo-Silva A Minarini LA Camargo IL | 2009 | Can J Microbi ol2009，55，6： | 1 |
| 13 | Medial septal area ANGⅡreceptor subtypes in the regulation of urine and sodium ex-cretion induced by vasopressin显示文摘 | PAVAN DE ARRUDA CAMARGO G M DE ARRUDA CA-MARGO L A ABRAOB SAAD W | 2011 | JRAAS2011，12，1： | 1 |
| 14 | Intraoperative autolo- gous blood recovery in prostate cancer surgery: in vivo validation using a tumour marker显示文摘 | Poli M Camargo A Villa L | 2008 | Vox Sang2008，95，4： | 1 |
| 15 | Association between leptin and asthma in adults显示文摘 | Sood A Ford ES Camargo CA Jr | 2006 | Thorax2006，61，4： | 1 |
| 16 | An image-processing based algorithm to automatically identify plant disease visual symptoms显示文摘 | A Camargo J S Smith | | 0，，01： | 1 |
| 17 | An AFLP marker linked to the Pm-I gene that confers resistance to Podosphaera xanthii race 1 in Cucumis melo显示文摘 | Teixeira A P M Baeerto F A S Camargo L E A | 2008 | Genetics and Molecular Biology2008，31，2： | 1 |
| 18 | Comparative bioremediation of soils contaminated with diesel oil by natural attenuation,biostimulation and bioaugmentation显示文摘 | Bento F M Camargo F A Okeke B C | 2005 | Bioresource technology2005，96，： | 1 |
| 19 | Astringency removal of ' Giombo' persimmon fruits submitted to different temperatures 显示文摘 | Antoniolli L R De Camargo e Castro P R Kluge R A | 2002 | Pesquisa Agropecuaria Brasileira2002，37，5： | 1 |
| 20 | The Problem of Helicobacter pylori Resistance to Antibiotics:A Systematic Review in Latin America显示文摘 | CAMARGO M C GARCA A RIQUELME A | 2014 | Am J Gastroenterol2014，109，： | 1 |
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