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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | 地下列车移动荷载作用下隧道及自由场的动力响应解显示文摘针对地下列车运行引起的隧道和自由场上的振动响应问题,利用隧道-自由场动态相互作用系统在隧道轴线方向上的一致性或周期性,采用Fourier变换和Floquet变换等方法,在频率-波数域内推导了在移动荷载作用下隧道及自由场的动力响应解,此解把地下列车运行引起的动力响应问题归结到计算频率-波数域内的传递函数和频域内的移动外荷载的问题上,传递函数采用三维周期性有限元-边界元耦合的数值模型来计算,移动外荷载主要考虑为频域内轨道不平顺情况下的轮轨接触力。利用此动力响应解对北京地铁1号线东单站至建国门站区间的动力响应进行了计算,计算结果表明此方法具有良好的适用性。 | 刘卫丰 刘维宁 Gupta S Degrande G | 2008 | 振动与冲击2008，27，5： | 19 |
| 3 | 地铁振动预测的周期性有限元-边界元耦合模型显示文摘针对地铁列车运行引起的隧道结构和自由场中的振动响应问题,提出了一个在频率-波数域内的三维周期性有限元-边界元耦合的数值模型,此模型中隧道结构采用有限元法计算,自由场采用边界元法模拟。此模型采用Floquet变换,利用隧道和自由场在隧道轴线方向上的周期性,把无限长的隧道及自由场的网格划分限制在一个基本元内,这样使动力学数值计算的效率大大提高。利用此模型计算了在隧道底板上施加固定单位谐振荷载情况下隧道-自由场相互作用系统的动力响应,结果表明此模型可应用于地铁列车运行引起的隧道和自由场中的动力响应预测。 | 刘卫丰 刘维宁 Gupta S Degrande G | 2009 | 振动工程学报2009，22，5： | 13 |
| 4 | 肥胖患者的冠状动脉微血管功能障碍和心血管病风险显示文摘全世界有〉5亿的肥胖人群,其心血管病风险增加的病理生理机制是复杂的,并且可能涉及脂肪细胞相关因子的过量分泌,导致血管氧化应激增加,神经激素活性上调,以及低度全身炎症,可能导致交感神经系统激活增加,血管张力改变,冠状动脉微血管功能障碍(coronary microvascular dysfunction, CMD) 。 | Bajaj NS Osborne MT Gupta A Tavakkoli A Bravo PE Vita T Bibbo CF Hainer J Dorbala S Blankstein R Bhatt DL Di Carli MF Taqueti VR 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 11 |
| 5 | 地铁列车运行引起的隧道和自由场的动力响应预测显示文摘针对地铁列车运行引起的隧道和自由场动力响应的预测,提出一种计算方法。根据移动荷载作用下隧道及自由场的动力响应解,可以把地铁列车运行引起的振动问题归结到计算频率-波数域内的传递函数和频域内移动轴荷载的问题上,传递函数采用三维周期性有限元-边界元耦合的数值模型来计算,移动轴荷载主要考虑为频域内轨道不平顺激励下的轮轨接触力。利用此方法对北京地铁4号线北京大学东门站北侧区间地铁列车运行引起的隧道和自由场的振动响应进行了预测,并比较了普通无碴轨道和钢弹簧浮置板轨道的动力响应。结果表明:此方法具有很好的适用性;浮置板轨道具有很好的减振作用,但对低频段振动没有效果。 | 刘卫丰 刘维宁 GUPTA S DEGRANDE G | 2010 | 工程力学2010，27，1： | 7 |
| 6 | Non-alcoholic fatty liver disease may not be a severe disease at presentation among Asian Indians显示文摘瞄准:与非含酒精的脂肝疾病(NAFLD ) 评估病人的临床、生物化学的侧面并且在表示估计他们的组织学的严厉。方法:介绍给所有印度的肝诊所的连续病人与提起的 transaminases 医学科学(AIIMS ) 开创到乘正常的上面的限制的至少 1.5,并且组织学地证实的非酒精的脂肝疾病被包括。或谁有重要白酒吸入或另外的肝疾病的积极标记的病人正在服知道生产脂肝的药被排除。这个组的临床、生物化学、组织学的侧面被学习。结果:有 NAFLD 的 51 个病人形成了学习人口。他们的中部的年龄和 BMI 是 34 (17-58 ) 年并且 26.7 (21.3-32.5 ) kg/m (2 ) 分别地并且(90.1%) 46 是男性。病人的多数有温和发炎,也分级 1 [32 (63%)] 或等级 2 [16 (31%)] 并且仅仅 3 (6%) 病人们有严重(等级 3 ) 发炎。23 (45%) , 19 (37%) , 8 (16%) 并且 1 (2%) 病人有 0, 1, 2 和 3 纤维变性分别地在索引活体检视和没有上有的舞台肝硬化。在 univariate 分析上,甘油三酸酯铺平超过 150 mg %( 或 = 7.1;95% CI:1.6-31.5, P = 0.002 ) 并且著名计算机生产厂商 / 中高音 ratio>1 (或 = 14.3;95% CI:1.4-678.5, P = 0.008 ) 与发炎的高等级被联系,任何一个都没与先进纤维变性被联系。在上多变量逻辑回归分析, hypertriglyceridemia >150 mg% 是独立地与发炎的高等级的存在联系的唯一的因素(或 = 1.6;95% CI:1.3-22.7, P = 0.02 ) ,当任何一个都没与先进纤维变性被联系时。甘油三酸酯层次与煽动性的等级断然相关(r = 0.412;P = 0.003 ) 。结论:在诺思印第安人病人的 NAFLD 是年轻超重男性,其中大多数是抵抗的胰岛素的疾病,他们趋于在表示有温和组织学的疾病。 | Kaushal Madan Yogesh Batra S Datta Gupta Bal Chander K D Anand Rajan M S Tewatia S K Panda S K Acharya | 2006 | World Journal of Gastroenterology2006，12，21： | 7 |
| 7 | Prediction of vibrations from underground trains on Beijing metro line 15显示文摘The impact of vibrations due to underground trains on Beijing metro line 15 on sensitive equipment in the Institute of Microelectronics of Tsinghua University was discussed to propose a viable solution to mitigate the vibrations.Using the state-of-the-art three-dimensional coupled periodic finite element-boundary element(FE-BE) method,the dynamic track-tunnel-soil interaction model for metro line 15 was used to predict vibrations in the free field at a train speed of 80 km/h.Three types of tracks(direct fixation fasteners,floating slab track and floating ladder track) on the Beijing metro network were considered in the model. For each track,the acceleration response in the free field was obtained.The numerical results show that the influence of vibrations from underground trains on sensitive equipment depends on the track types.At frequencies above 10 Hz,the floating slab track with a natural frequency of 7 Hz can be effective to attenuate the vibrations. | 丁德云 刘维宁 GUPTA S LOMBAERT G DEGRANDE G | 2010 | Journal of Central South University2010，17，5： | 6 |
| 8 | CT patterns of nodal disease in pediatric chest tuberculosis显示文摘AIM:To highlight various patterns of nodal involvement and post treatment changes in pediatric chest tuberculosis based on contrast enhanced computed tomography(CECT) scans of chest.METHODS:This was a retrospective study consisting of 91 patients aged less than 17 years,who attended Paediatrics OPD of All India Institute of Medical Sciences with clinically diagnosed tuberculosis or with chest radiographs suggestive of chest tuberculosis.These patients had an initial chest radiograph as well as CECT of the chest and follow up imaging after 6 mo,and in some cases 9 mo,of completion of anti-tubercular treatment(ATT).CECT of these patients was reviewed for the location and extent of nodal involvement along with determination of site,size,enhancement pattern and calcification.RESULTS:Enlargement of mediastinal or hilar lymph nodes was found in 88/91 patients(96.7%),with the most common locations being paratracheal(84.1%),and subcarinal(76.1%).The most common pattern of enhancement was found to be inhomogenous.The nodes were conglomerate in 56.8% and discrete in 43.2%.In addition,perinodal fat was obscured in 84.1% of patients.In the post-treatment scan,there was 87.4% reduction in the size of the nodes.All nodes post-treatment were discrete and homogenous with perinodal fat present.Calcification was found both pre-and post-treatment,but there was an increase in incidence after treatment(41.7%).There was hence a reduction in size,change in enhancement pattern,and appearance of perinodal fat with treatment.CONCLUSION:Tubercular nodes have varied appearance and enhancement pattern.Conglomeration and obscuration of perinodal fat suggest activity.In residual nodes decision to continue ATT requires clinical correlation. | Amar Mukund Rashmi Khurana Ashu S Bhalla Arun K Gupta Sushil K Kabra | 2011 | World Journal of Radiology2011，3，1： | 5 |
| 9 | Diagnostic efficacy of Ziehl-Neelsen method against fluorescent microscopy in detection of acid fast bacilli显示文摘Objective:To investigate the application of Ziehl-Neelsen(Z-N) and fluorescent microscopy in detection of acid fast bacilli(AFB).Methods:Duplicate smears were prepared from 260 sputum samples and stained with Z-N and fluorescent staining(FS) methods.The efficiency of both methods in primary diagnosis of tuberculosis were evaluated.Results:The smears were positive for AFB in 15(5.77%) samples by Z-N staining method and in 16(6.15%) samples by FS method.The sensitivity and specificity of Z-N staining method against FS method were 93.75% and 100%respectively.Conclusions:Though lesser cost-effective than Z-N,FS method is a more sensitive and better case finding tool in detection of AFB. | Soham Gupta Vishnu Prasad Shenoy Indira Bairy Muralidharan S | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，4： | 3 |
| 10 | 聚辛烯与硫磺交联剂对橡胶沥青性能改善作用研究显示文摘为评价聚辛烯与硫磺双掺对橡胶沥青性能的改善作用,制备不同掺量双掺改性橡胶沥青,采用黏度和DSR等试验测试其使用性能。结果表明:黏度对双掺改性橡胶沥青高温性能区分度较针入度和软化点好;双掺能使橡胶沥青高温性能明显改善,且降低其应力敏感性,但也增强了温度敏感性;聚辛烯与0.1%硫磺双掺能改善橡胶沥青低温性能,同时双掺能增强橡胶沥青弹性恢复和储存稳定性,其中弹性恢复随两者掺量的增加逐渐提高,储存稳定性则在1.0%聚辛烯掺量下效果较好;考虑综合性能,推荐的聚辛烯与硫磺掺量分别为1.0%和0.1%。 | 李平 翟龙 刘豪斌 刘连国 彭卓祥(译) Padhan R K Gupta A A Mohanta C S | 2018 | 中外公路2018，38，5： | 3 |
| 11 | Plasma cathepsin L:A prognostic marker for pancreatic cancer显示文摘AIM:To assess the prognostic significance of cathepsin L,a cysteine protease that degrades the peri-tumoral tissue,in patients with pancreatic cancer.METHODS:Plasma samples from 127 pancreatic cancer patients were analyzed for cathepsin L levels by ELISA.Out of these patients,25 underwent surgeryand their paraffin-embedded tissue was analyzed for cathepsin L expression by immunohistochemistry.Survival of patients and clinicopathological parameters was correlated with cathepsin L expression in plasma and tissue using appropriate statistical analysis.RESULTS:The mean(±SD)cathepsin L in plasma samples of pancreatic cancer patients was 5.98±2.5ng/m L that was significantly higher compared to the levels in healthy controls(3.83±0.45)or chronic pancreatitis patients(3.97±1.06).Using ROC curve,a cut-off level of 5.0 ng/m L was decided for survival analysis.Elevated plasma levels of cathepsin L were found to be associated with poor prognosis(P=0.01)in multivariate analysis.The plasma levels of the protease decreased after surgery.Though no significant correlation was seen between plasma and tissue expression of this protease,a trend did emerge that high cathepsin L expression in tissue correlated with its high levels in plasma.CONCLUSION:Cathepsin L levels in plasma of pancreatic cancer patients may be used as a potential prognostic marker for the disease. | Nidhi Singh Prasenjit Das Surabhi Gupta Vikas Sachdev Siddhartha Srivasatava Siddhartha Datta Gupta Ravindra Mohan Pandey Peush Sahni Shyam S Chauhan Anoop Saraya | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 12 | Genetic mapping of 66 new microsatellite(SSR)loci in bread wheat显示文摘 | Gupta P K Balyan H S Edwards K J | 2002 | Theor Appl Genet2002，105，： | 2 |
| 13 | Lens aldose reductase inhibiting potential of some indigenous plants显示文摘 | N Halder S Joshi S.K Gupta | 2003 | Journal of Ethnopharmacology2003，，1： | 2 |
| 14 | 有胰 divisum 的 Choledochocele : 在磁性的回声 cholangiopancreatography 上诊断的稀罕同现显示文摘 We report a case of a 42-year-old male with symptomatic choledochocele and incidental pancreas divisum diagnosed with magnetic resonance cholangiopancreatography (MRCP). Small choledochocele is rare congenital malformation associated with non-specific symptoms and a delay in diagnosis. The coexistence of choledochocele and pancreas divisum is extremely rare with only two case reports published in literature. In both cases MRCP failed to diagnose any biliary or pancreatic abnormality. This case suggests that the patients with recurrent abdominal pain and pancreas divisum should not be presumed to be suffering from pancreatitis. Careful evaluated for additional anomalies in the biliary tree should be sought for refractory symptoms. MRCP is a useful one-stop-shop for diagnosing pancreatic and biliary ductal anomalies. | Yashwant Patidar Nitesh Agarwal Shailesh Gupta Ankur Arora Amar Mukund S Rajesh | 2013 | World Journal of Radiology2013，5，7： | 2 |
| 15 | APACHE II score is superior to SOFA , CTP and MELD in predicting the short‐term mortality in patients with acute‐on‐chronic liver failure ( ACLF )显示文摘 | Ajay Duseja Narendra S Choudhary Sachin Gupta Radha Krishan Dhiman Yogesh Chawla | 2013 | Journal of Digestive Diseases2013，，9： | 2 |
| 16 | Cardiac papillary fibroelastoma:The need for a timely diagnosis显示文摘Cardiac papillary fibroelastomas(CPFs) are the second most common primary cardiac tumors and the most common cardiac valvular tumors. Although they are histologically benign and usually asymptomatic, CPFs can lead to serious and life-threatening complications like myocardial infarction, stroke, pulmonary embolus, cardiac arrest etc. CPFs represent a rare entity in clinical medicine and literature regarding their management is limited. We report two cases which illustrate such complications arising from undiagnosed CPFs on the aortic valve. We further stress on the importance of identifying CPFs early so that they can be managed appropriately based on recommendations from the available literature. | Srikanth Yandrapalli Bella Mehta Pratik Mondal Tanush Gupta Pallavi Khattar John Fallon Randy Goldberg Sachin Sule Wilbert S Aronow | 2017 | World Journal of Clinical Cases2017，5，1： | 2 |
| 17 | Increased apoptosis of T cell subsets in aging humans: altered expression of Fas(CD95), Fas ligand, Bcl-2, and Bax显示文摘 | Aggarwal S Gupta S | 1998 | Immunol1998，160，4： | 2 |
| 18 | Burner geometry effects on combustion and NOX emission characteristics using a variable geometry swirl combustor显示文摘 | Gupta A K Ramavajjala M S Chomiak J | 1991 | Journal of Propulsion1991，7，4： | 2 |
| 19 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 20 | Evaluation of mannitol effect in patients with acute hepatic failure and acute-on-chronic liver failure using conventional MRI,diffusion tensor imaging and in-vivo proton MR spectroscopy显示文摘AIM:To evaluate the effect of an intravenous bolus of mannitol in altering brain metabolites, brain water content, brain parenchyma volume, cerebrospinal fluid (CSF) volume and clinical signs in controls and in patients with acute liver failure (ALF) and acute-on-chronic liver failure (ACLF), by comparing changes in conventional magnetic resonance imaging (MRI), in vivo proton magnetic resonance spectroscopy (PMRS) and diffusion tensor imaging (DTI) before and after its infusion.METHODS: Five patients each with ALF and ACLF in grade 3 or 4 hepatic encephalopathy and with clinical signs of raised intracranial pressure were studied along with five healthy volunteers. After baseline MRI, an intravenous bolus of 20% mannitol solution was given over 10 min in controls as well as in patients with ALF and ACLF. Repeat MRI for the same position was acquired 30 min after completing the mannitol injection. RESULTS: No statistically significant difference was observed between controls and patients with ALF and ACLF in metabolite ratios, DTI metrics and brain volume or CSF volume following 45 min of mannitol infusion. There was no change in clinical status at the end of post-mannitol imaging. CONCLUSION: The osmotic effect of mannitol did not result in significant reduction of brain water content, alteration in metabolite ratios or any change in the clinical status of these patients during or within 45 min of mannitol infusion. | Vivek A Saraswat Sona Saksena Kavindra Nath Pranav Mandal Jitesh Singh M Albert Thomas Ramkishore S Rathore Rakesh K Gupta | 2008 | World Journal of Gastroenterology2008，14，26： | 2 |
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