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| 1 | Analysis of in vivo patterns of caspase 3 gene expression in primary hepatocellular carcinoma and its relationship to p21^(WAF1) expression and hepatic apoptosis显示文摘AIM To detect the expression of caspase 3gene in primary human hepatocellular carcinoma(HCC)and investigate its relationship to p21WAF1gene expression and HCC apoptosis.METHODS In situ hybridization was employedto determine caspase 3 and p21WAF1expression inHCC.In situ end-labeling was used to detecthepatocytic apoptosis in HCC.RESULTS Twenty-one of 39(53.8%)cases ofHCC were found to express caspase 3transcripts,while 45.2% of HCC failed toexpress caspase 3.Non-cancerous adjacent livertissues showed more positive caspase 3(87.5%,7/8)as compared with HCC(P<0.05).The expression of caspase 3 is correlated withHCC differentiation,72.2%(13/18)ofmoderately to highly differentiated HCC showedcaspase 3 transcripts positive,while only 38.1%of poorly differentiated HCC harbored caspase 3transcripts(P<0.05).No relationship wasfound between caspase 3 expression and tumorsize or grade or metastasis,although 52.5%(5/8)of HCC with metastasis were caspase 3positive and a little higher than that with nometastasis(51.6%,P>0.05).Expression of caspase 3 alone did not affect the apoptosisindex(AI)of HCC.The AI was 7.12%o in caspase3-positive tumors(n=21),while in caspase 3-negative cases(n=18)6.59%0(P>0.05).Expression of caspase 3 clearly segregated withp21WAF1positive tumors as compared withp21WAF1-negative cases(16 of 23,69.6% versus5 of 16,31.3%)with statistical significance(P=0.017).In the cases with positive caspase 3and negative p21WAF1,the Al was found slightlyhigher,but with no statistical significance,thanthat with expression of p21WAF1and caspase 3(7.21‰ vs 6.98‰,P>0.05).CONCLUSION Loss of caspase 3 expressionmay contribute to HCC carcinogenesis,althoughthe expression of caspase 3 does not correlatewell with cell apoptosis in HCC.p21WAF1may bemerely one of the inhibitors which can reducecaspase 3 mediated cell apoptosis in HCCs. | Bao Hua Sun Jun Zhang Bao JǜWang Xi Ping Zhao You Kun Wang Zhi Qun Yu Dong Liang Yang Lian Jie Hao Department of Clinical Immunology,Tongji Hospital,Tongji Medical University,Wuhan 430030,Hubei Province,China | 2000 | World Journal of Gastroenterology2000，6，3： | 65 |
| 2 | The genome-wide mutational landscape of pituitary adenomas显示文摘 | Zhi-Jian Song Zachary J Reitman Zeng-Yi Ma Jian-Hua Chen Qi-Lin Zhang Xue-Fei Shou Chuan-Xin Huang Yong-Fei Wang Shi-Qi Li Ying Mao Lian-g-Fu Zhou Bao-Feng Lian Hai Yan Yong-Yong Shi Yao Zhao | 2016 | Cell Research2016，26，11： | 5 |
| 3 | Plasmacytoid dendritic cells of different origins have distinct characteristics and function: studies of lymphoid progenitors versus myeloid progenitors 显示文摘 | Yang G X Lian Z X Kikuchi K Moritoki Y Ansari A A Liu Y J | 2006 | Immunol2006，175，： | 1 |
| 4 | Synthesis of titanium(Ⅳ)complexes with Schiff bases ligand and their catalytic activities for polymerization of ethylene and etyrene显示文摘 | Yong L Huang J L Lian B | 2001 | Chin J Chem2001，19，4： | 1 |
| 5 | Estrogen receptor alpha genotype is associated with a reduced prevalence of radiographic hip osteoarthritis in elderly Caucasian women1显示文摘 | LIAN K LUI L ZMUDA J M | 2007 | Osteoarthrtis Cartilage2007，15，8： | 1 |
| 6 | Electrogenerated chemiluminescence biosensor for glucose based on poty (Luminol-aniline) nanowires composite modified electrode 显示文摘 | Li G Lian J Zheng X | 2010 | Biosensors and Bioelectronics2010，26，： | 1 |
| 7 | Electroless Ni-P deposition plus zinc phosphate coating on AZ 91D magnesium alloy显示文摘 | Lian J S Li G Y Niu L Y | 2006 | Surface and Coatings Technology2006，20，10： | 1 |
| 8 | A cellular gene up-regulated by hepatitis B virus-encoded X antigen promotes hepatocellular growth and suriva显示文摘 | Lian Z Liu J Pan J | 2001 | J Hepatology2001，34，： | 1 |
| 9 | A study of orthonormal multiwavelets显示文摘 | CHUI C K LIAN J A | 1996 | Appl Numer Math1996，20，2： | 1 |
| 10 | Analysis and architecture design of block-coding engine for EBCOT in JPEG2000显示文摘 | C J Lian K F Chen H H Chen | 2003 | IEEE Transactions on Circuits and System for Video Technology2003，13，3： | 1 |
| 11 | Design and optical performance research of multi-phase diffractive microlens arrays显示文摘 | KONG L B YI X J LIAN K | 2004 | J Micromech Microeng2004，14，8： | 1 |
| 12 | Graphene segregated on Ni surfaces and transferred to insulators显示文摘 | Yu Q Lian J Siriponglert S | 2008 | Applied Physics Letters2008，93，11： | 1 |
| 13 | Discrete particle simulation ofagglomerate impact coalescence 显示文摘 | Lian G Thomtont C Adams M J | 1998 | Chemical Engineering Science(S0009-2509)1998，53，19： | 1 |
| 14 | Visible-light photocatalytic activity of nitrogen-doped TiO2thin film prepared by pulsed laser deposition 显示文摘 | Zhao L Jiang Q Lian J S | 2008 | Applied Surface Science2008，254，15： | 1 |
| 15 | Immunosuppression involving soluble CD83 induces tolerogenic dendritic cells that prevent cardiac al- lograft rejection 显示文摘 | Ge W Arp J Lian D | 2010 | Transplant2010，90，11： | 1 |
| 16 | Forming limit diagram of sheet metal in the negative minor strain region显示文摘 | LIAN J BAUDELCT B | | 0，，： | 1 |
| 17 | Appl Surf Sci显示文摘 | Chen X M Li G Y Lian J S | 2008 | 255(5): 23222008，255，5： | 1 |
| 18 | Orbit induced spin squeezing in a spin-orbit coupled Bose-Einstein condensate]显示文摘 | LIAN Jinling YU Lixian LIANG J Q | 2013 | Sci Rep2013，3，1： | 1 |
| 19 | High corrosion-resistance nanocrystalline Ni coating on AZ91D magnesium alloy显示文摘 | LIAN J S HE J G | 2006 | Surf Coat Technol2006，200，1819： | 1 |
| 20 | Electroless Ni- P Plating on AZ91D Magnesium Alloy from Sulfate Solution 显示文摘 | Gu S D Lian J S Li G Y | 2005 | Journal of Alloys and Compounds2005，，： | 1 |
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