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| 1 | Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and coronary artery disease显示文摘Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2(11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls(P = 0.024): female subjects(DM and controls) had 50.9% higher baseline 11dhTxB2 than males(P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM(71.7%) and controls(75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders(ASA 'resistant') in DM than in controls(14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome(ACS) patients was 28.6 and 28.7%, in spite of a significant(81.6%) inhibition of urinary 11dhTxB2(P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources. | Luis R Lopez Kirk E Guyer Ignacio Garcia De La Torre Kelly R Pitts Eiji Matsuura Paul RJ Ames | 2014 | World Journal of Diabetes2014，5，2： | 13 |
| 2 | How to Make Capsules Containing Rejuvenators for Their Use in Asphalt Concrete显示文摘Rejuvenators are products designed to restore original properties to oxidized asphalt binders by restoring the original ratio of asphaltenes to maltenes. But,for a rejuvenator to be successful,it must penetrate the pavement surface. Besides,application of a rejuvenator will also reduce the skid resistance of the pavement. To solve this,these rejuvenators can be encapsulated and mixed in asphalt concrete. Once the stress in the capsules reaches a certain threshold,the particles break and the rejuvenator is released,giving back the original properties of the pavement. The objective of this paper is to show how these capsules behave and define the most appropriate testing methods to find their effect on asphalt concrete. For this,two different types of rejuvenators will be encapsulated and their effect on the properties of the capsules investigated. Besides,the release mechanisms of the capsules will be unravelled. | GARCIA A SCHLANGEN E VAN DE VEN M F C | 2010 | 武汉理工大学学报2010，32，17： | 7 |
| 3 | Postpartum depression:A systematic review of the genetics involved显示文摘Postpartum depression is one of the most prevalent psychopathologies. Its prevalence is estimated to be between 10% and 15%. Despite its multifactorial etiology, it is known that genetics play an important role in the genesis of this disorder. This paper reviews epidemiological evidence supporting the role of genetics in postpartum depression(PPD). The main objectives of this review are to determine which genes and polymorphisms are associated with PPD and discuss how this association may occur. In addition, this paper explores whether these genes are somehow related to or even the same as those linked to Major Depression(MD). To identify gaps in the current knowledge that require investigation, a systematic review was conducted in the electronic databases Pub Med, LILACS and Sci ELO using the index terms 'postpartum depression' and 'genetics'. Literature searches for articles in peerreviewed journals were made until April 2014. PPD was indexed 56 times with genetics. The inclusion criteria were articles in Portuguese, Spanish or English that were available by institutional means or sent by authors upon request; this search resulted in 20 papers. Genes and polymorphisms traditionally related to MD, which are those involved in the serotonin, catecholamine, brain-derived neurotrophic factor and tryptophan metabolism, have been the most studied, and some have been related to PPD. The results are conflicting and some depend on epigenetics, which makes the data incipient. Further studies are required to determine the genes that are involved in PPD and establish the nature of the relationship between these genes and PPD. | Tiago Castro e Couto Mayra Yara Martins Brancaglion António Alvim-Soares Lafaiete Moreira Frederico Duarte Garcia Rodrigo Nicolato Humberto Corrêa Regina Amélia Lopes P Aguiar Henrique Vitor Leite | 2015 | World Journal of Psychiatry2015，5，1： | 5 |
| 4 | 非运动症状负担、情绪和步态障碍是导致帕金森病非痴呆患者生活质量下降的最重要因素显示文摘帕金森病存在多种运动和非运动症状表现,其中非运动症状对于帕金森病患者生活质量的影响更为严重。改善帕金森病非运动症状,有助于提高患者的生活质量。既往帕金森病非运动症状研究多为单中心小样本研究,所涉及的非运动症状类型较为局限,无法全面反映非运动症状对帕金森病患者生活质量的影响。为此,该研究通过分析COPPADIS-2015研究队列来关注帕金森病患者非运动症状对其生活质量的影响。该队列是西班牙全国范围内为期5年的多中心综合观察性随访队列研究。 | 张煜(编译) Santos Garcia D de Deus Fonticoba T Suarez Castro E | 2020 | 中华医学杂志2020，100，27： | 3 |
| 5 | Evaluation of heavy metal availability in polluted soils by two sequential extraction procedures using factor analysis显示文摘 | I Maiz I Arambarri R Garcia E Millán | 2000 | Environmental Pollution2000，，1： | 2 |
| 6 | Highly sensitive and specific microRNA expression profiling using BeadArray technology显示文摘 | CHEN Jing LOZACH J GARCIA E W | 2008 | Nucleic Acids Res2008，36，14： | 1 |
| 7 | Postprocessing the Galerkin method : a novel approach, to approximate inertial manifolds 显示文摘 | Garcia - Archilla B Novo J Titi E S | 1998 | SIAM Journal on Numerical Analysis1998，35，： | 1 |
| 8 | Reaction synthesized Al2O3-based intermetalic composites显示文摘 | GARCIA D E BRUHN J | 1998 | Acta Mater1998，46，7： | 1 |
| 9 | Cloning and optimization of a nitrilase for the synthesis of (3S)-3-cyano-5-methyl hexanoic acid显示文摘 | Feng J Garcia E | 2006 | J Mol Catal B:Enzymatic2006，41，34： | 1 |
| 10 | Sebaceous trichofolliculoma显示文摘 | Garcia e Silva L | 1982 | Med Cutan Ibero Lat Am1982，10，1： | 1 |
| 11 | Highly sensitive and specific microRNA expression profiling using Bead Array technology显示文摘 | Chen J Lozach J Garcia E W | 2008 | Nucleic Acids Res2008，36，14： | 1 |
| 12 | Differential adhesion of major surface proteins la and lb of the chrlichial cattle pathogen Anaplasma marginale to bovine erythrecytes and tick cells显示文摘 | DELA FUENTE J GARCIA -GARCIA J C BLOUIN E F | 2001 | Im J Parasitol2001，31，2： | 1 |
| 13 | Trans-fissural or transsulcal approach versus combined stereotaetic-microsurgieal approach 显示文摘 | Garcia Sola R Pulido P Kusak E | 1991 | Acta Neuroehir Suppl (Wien)1991，52，： | 1 |
| 14 | Non-toxic alternative compounds for marine antifouling paints显示文摘 | Stupak M E Garcia M T Perez M C | 2003 | International Biodeterioration & Biodegradation2003，52，1： | 1 |
| 15 | Determination of sulfur release and its kinetics in rapid pyrolysis of coal显示文摘 | Garcia L F Hampartsoumian E Williams A | 1995 | Fuel1995，74，7： | 1 |
| 16 | Lipid addition toimprove barrier properties of edible starch-based films and coatings显示文摘 | GARCIA M A MARTINO M N ZARITZKY N E | 2000 | Food Chemistry and Toxicology2000，65，6： | 1 |
| 17 | Photocatalytic degradation of organic compounds in aqueous systems by transition metal doped polycrystalline TiO2 显示文摘 | DI PAOLA A GARCIA - L6PEZ E IKEDA S | 2002 | Catalysis Today2002，75，： | 1 |
| 18 | Palygorskite as a feasible amendment to stabilize heavily metal polluted soils显示文摘 | ALVAREZ-AYUSO E GARCIA SANCHEZ A | 2003 | Environ Pollut2003，125，3： | 1 |
| 19 | Tuning the performance of room temperat urephosphorescence sensing materials for oxygen using factorial designs显示文摘 | Badia R Garcia M E Diaz | 2000 | A nal Lett2000，33，2： | 1 |
| 20 | Theory for laserinduced ultrafast phase transitions in carbon显示文摘 | Jeschke H O Garcia M E Bennemann K H | 1999 | Applied Physics A1999，69，： | 1 |
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