|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 激光干涉气液两相流测量图像自动辨读方法的研究显示文摘在能源、化工、炼油、制药、机械制造等领域中广泛存在着气液颗粒两相流的测量问题,因此气液两相流测量技术一直是国内外的重点研究课题。该文将介绍一种气液两相流测量的新技术一激光干涉气液两相流测量技术(ILIDS),它具有提取两相流参数全、测量精度高和测量区域较大等优 点。该技术利用高干涉性片状激光束照射气液两相流,粒子将激光以折射和反射的方式散射,用高速数码相机(120万象素)收集并汇聚散射光成像,折射光与反射光之间因存在相位差会在汇聚成像系统的失焦平面上形成干涉条纹图,图中包含粒子的粒径和空间信息。利用作者开发的图像处理软件对两相流干涉图像进行数据处理,自动高速提取两相流信息,将处理结果与人工辨读比较,有效粒子信息提取率高于90%,粒子定位及粒径计算误差小于5%。实验证明本图像处理技术具有工业在线测量的潜力。 | 浦世亮 浦兴国 袁镇福 岑可法 Loic MEES Denis LEBRUN | 2004 | 中国电机工程学报2004，24，2： | 14 |
| 2 | 源于近端股骨间充质干细胞免疫抑制作用的研究显示文摘目的探讨源于成人近端股骨的间充质干细胞(MSC)是否具有免疫抑制功能,为临床移植物抗宿主病的防治寻找理想的细胞储备库。方法从全髋关节置换术患者的近端股骨中分离并培养MSC,将不同数量的细胞直接或以Transwell法加入混合淋巴细胞反应(MLR)中,检测MSC对外周血淋巴细胞(PBL)增殖水平的影响。以ELISA法及抗体中和法探讨细胞因子TGFβ1在MSC免疫调节中的作用。结果3×103、1×104、3×104、1×105个源于近端股骨的MSC对PBL增殖的抑制率分别为62%±18%、38%±4%、31%±16%、28%±12%,与采自髂骨骨髓穿刺物MSC的抑制作用相比差异无统计学意义(均P>0.05),后者对PBL的增殖抑制率为58%±12%、37%±8%、28%±6%、27%±6%;以0.2μm的微孔膜对MSC与MLR进行分隔,3×104及1×104个MSC对PBL的增殖抑制率为36%±8%和53%±12%;在ELISA实验中,MSC单独培养,MSC与MLR直接接触,或经Transwell共培养的这3种上清中转化生长因子(TGF)β1的表达水平差异无统计学意义,加入浓度递增的TGFβ1抗体不能逆转MSC对PBL增殖的抑制作用。结论源于近端股骨的MSC具有一定的免疫抑制功能,除TGFβ1外其他可溶性因子可能介导这一作用。 | 张翼鷟 Loic Fouillard Alain Chapel Morad Bensidhoum Christelle Mazurier Aish Nasef Sandrine Bouchet Manuel Lopez Dominique Thierry Norbert Cclaucle Gorin 达万明 | 2005 | 中华医学杂志2005，85，39： | 11 |
| 3 | 妊娠期盆底肌肉功能训练显示文摘 | 王晓光 Loic Dabbadie 王小辉 | 2008 | 中国实用妇科与产科杂志2008，24，8： | 10 |
| 4 | Formal verification of synchronous data-flow program transformations toward certified compilers显示文摘翻译确认被 Pnueli 等在 90 年代发明。作为一种技术到正式验证代码发电机的正确性。而非证明代码生成器或用尽一切地限制它,翻译验证程序试图证实程序转变保存语义。在这个工作,我们采用这条途径正式证实钟语义和数据依赖在信号编译器的编译期间被保存。翻译确认从起始的阶段为每个编译阶段被实现直到可执行的代码被产生的最近的阶段,由证明在编译器的每个阶段的转变保存语义。我们作为分别地被称为钟模型和同步依赖图(SDG ) 的一阶的公式代表钟语义,一个程序的数据依赖和它的转变对应物。我们然后分别地介绍表示钟语义和依赖的保藏的钟精炼和依赖精炼关系,作为钟模型和 SDG 上的一种关系。我们的验证程序不要求编译器,也不任何重写源程序的任何乐器学或修正。 | Van Chan NGO Jean-Pierre TALPIN Thierry GAUTIER Paul Le GUERNIC Loic BESNARD | 2013 | Frontiers of Computer Science2013，7，5： | 7 |
| 5 | What lessons can be learned from y T cell-based cancer immunotherapy trials?显示文摘 | Jean-Jacques Fournie Helene Sicard Mary Poupot Christine Bezombes Amandine Blanc Franqois-Romagne Loic Ysebaert Guy Laurent | 2013 | Cellular & Molecular Immunology2013，10，1： | 7 |
| 6 | 均匀球形液滴二阶和五阶彩虹的重建及应用显示文摘从理论和实验两方面研究了不同温度下球形液滴的彩虹强度分布及在粒度测量中的应用。研究结果表明折射率为 1.33附近液滴在 117°~ 134°散射角范围内的散射强度分布不是单一的二阶彩虹强度分布 ,而是二阶和五阶彩虹的干涉强度分布。基于散射强度频谱特点 ,提出了一种从干涉强度谱中重建二阶和五阶彩虹强度分布的方法 :逆快速傅里叶变换 (IFFT)。利用洛伦兹米理论 (LMT)模拟计算了温度为 2 0℃和 80℃下水粒子二阶彩虹的高频结构与粒子直径的关系 ,获得了经验公式。该关系式可用来测量确定温度下均匀水粒子直径。还利用激光彩虹测试系统测量了水柱二阶彩虹角度范围内的散射强度分布。上述理论研究结果与实验结果进行了比较 ,两者吻合得很好。基于上述研究 ,可以从单一阵列探测器获取的彩虹信号提取不同阶次彩虹分布 ,用于液滴多参量的反演测量。 | 姜会芬 韩香娥 任宽芳 潘凤艳 MEES Loic | 2004 | 光学学报2004，24，11： | 6 |
| 7 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 8 | 基于三维多物理场强耦合模型的超导磁悬浮振动特性显示文摘高温超导磁悬浮具有无源自稳定、节能、环保等优点,是未来轨道交通(如真空管道交通)发展的主要技术模式之一.针对目前关于高温超导磁悬浮振动特性理论建模研究的不足,本文基于三维电磁-热-力多物理场强耦合模型提出了高温超导磁悬浮振动特性模拟方法,建立了相关的理论模型.该理论模型可预测任意结构的高温超导磁悬浮系统在典型外界激励(如横风、地震、轨道不平顺等)作用下的振动响应特性,研究各种典型外界激励下系统的振动行为特征、失稳发生的临界条件及其对系统悬浮稳定性的影响规律,为高温超导磁悬浮技术在轨道交通、电磁发射等领域应用的可行性及安全性提供一定的科学判据. | 杨文姣 马光同 Loic Queval 李刚 叶常青 邓钰科 | 2019 | 科学通报2019，64，31： | 5 |
| 9 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 10 | Risk of ventricular arrhythmia in patients with myocardial infarction and non-obstructive coronary arteries and normal ejection fraction显示文摘AIM To assess the arrhythmic determinants and prognosis of patients presenting with myocardial infarction and nonobstructive coronary arteries(MINOCA)with normal ejection fraction(EF).METHODS This is an observational analysis of 131 MINOCA patients with normal EF.Three cardiac magnetic resonance(CMR)diagnosis classes were recognized according to the late gadolinium enhancement(LGE)pattern:Myocardial infarction(MI)(n=34),myocarditis(n=47),and'no LGE'(n=50).Ventricular events occurring during hospitalization were recorded and the entire population was followed-up at 1 year.RESULTS Ventricular arrhythmia was observed in 18(13.8%)patients during hospitalization.The'no LGE'patients experienced fewer ventricular events than the MI and myocarditis patients[4.0%vs 26.5%and 14.9%,respectively(P=0.013)].There was no significant difference between the MI and myocarditis groups.On multivariate analysis,LGE transmural extent[OR=1.52(1.08-2.15),P=0.017]and ST-segment elevation[OR=4.65(1.61-13.40),P=0.004]were independent predictors of ventricular arrhythmic events,irrespective of the diagnosis class.Finally,no patient experienced sudden cardiac death or ventricular arrhythmia recurrence at 1-year.CONCLUSION MINOCA patients with normal EF presented no 1-year cardiovascular events,irrespective of the CMR diagnosis class.LGE transmural extent and ST segment elevation at admission are risk markers of ventricular arrhythmia during hospitalization. | Loic Bière Marjorie Niro Hervé Pouliquen Jean-Baptiste Gourraud Fabrice Prunier Alain Furber Vincent Probst | 2017 | World Journal of Cardiology2017，9，3： | 3 |
| 11 | Association of gene variants with susceptibility to type 2 diabetes among Omanis显示文摘AIM:To investigate the association of 10 known common gene variants with susceptibility to type 2diabetes mellitus(T2D)among Omanis.METHODS:Using case-control design,a total of992 diabetic patients and 294 normoglycemic Omani Arabs were genotyped,by an allelic discrimination assay-by-design TaqMan method on fast real time polymerase chain reaction system,for the following gene variants:KCNJ11(rs5219),TCF7L2(rs7903146),CDKAL1(rs10946398),CDKN2A/B(rs10811661),FTO(rs9939609 and rs8050136),IGF2BP2(rs4402960),SLC30A8(rs13266634)CAPN10(rs3792267)and HHEX(rs1111875).T2D patients were recruited from the Diabetes Clinic(n=243)and inpatients(n=749)at Sultan Qaboos Univesity Hospital(SQUH),Muscat,Oman.Adult control participants(n=294)were volunteers from the community and from those visiting Family Medicine Clinic at SQU,for regular medical checkup.The difficulty in recruiting Omani participants with no family history of diabetes was the main reason behind the small number of control participants in this study.Almost all volunteers questioned had a relativewith diabetes mellitus.Inspite of the small number of normoglycemic controls in this study,this sample was sufficient for detection of genes and loci for common alleles influencing T2D with an odds ratio of≥1.3reaching at least 80%power.Data was collected from June 2010 to February 2012.RESULTS:Using binary logistic regression analysis,four gene variants showed significant association with T2D risk:KCNJ11(rs5219,P=5.8×10^(-6),OR=1.74),TCF7L2(rs7903146,P=0.001,OR=1.46),CDKAL1(rs10946398,P=0.002,OR=1.44)and CDKN2A/B(rs10811661,P=0.020,OR=1.40).The fixation index analysis of these four gene variants indicated significant genetic differentiation between diabetics and controls{[KCNJ11(rs5219),P<0.001],[TCF7L2(rs7903146),P<0.001],[CDKAL1(rs10946398),P<0.05],[CDKN2A/B(rs10811661),P<0.05]}.The highest genotype variation%between diabetics and controls was found at KCNJ11(2.07%)and TCF7L2(1.62%).This study was not able to detect an association of T2D risk with gene variants of IGF2BP2(rs4402960),SLC30A8(rs13266634),CAPN10(rs3792267)and HHEX(rs1111875).Moreover,no association was found between FTO gene variants(rs9939609 and rs8050136)and T2D risk.However,T2D risk was found to be significantly associated with obesity(P=0.002,OR=2.22);and with the Waist-to-Hip ratio(n=532,P=1.9×10^(-7),OR=2.4),[among males(n=234,P=1.2×10^(-4),OR=2.0)and females(n=298,P=0.001,OR=6.3)].CONCLUSION:Results confirmed the association of KCNJ11(rs5219),TCF7L2(rs7903146),CDKAL1(rs10946398)and CDKN2A/B(rs10811661)gene variants with susceptibility to T2D among Omani Arabs. | Sawsan Al-Sinani Nicolas Woodhouse Ali Al-Mamari Omaima Al-Shafie Mohammed Al-Shafaee Said Al-Yahyaee Mohammed Hassan Deepali Jaju Khamis Al-Hashmi Mohammed Al-Abri Khalid Al-Rassadi Syed Rizvi Yengo Loic Philippe Froguel Riad Bayoumi | 2015 | World Journal of Diabetes2015，6，2： | 3 |
| 12 | PACCRETA : Clinical situations at high risk of Placenta ACCRETA /Percreta: impact of diagnostic methods and management on maternal morbidity显示文摘 | Gilles Kayem Catherine Deneux‐Tharaux Loic Sentilhes | 2013 | Acta Obstet Gynecol Scand2013，，： | 2 |
| 13 | 三维曲率属性:一种新的地震解释方法显示文摘本文介绍了一种计算体积曲率的新方法,及其在基本断裂参数构造闭合度和品质评估中的应用。 | 常伟(译) Pascal Klein Loic Richard Huw James | 2008 | 国外石油动态2008，，15： | 2 |
| 14 | A review of processing of Cu/C base plate composites for interfacial control and improved properties显示文摘The increase in both power and packing densities in power electronic devices has led to an increase in the market demand for effective heat-dissipating materials with a high thermal conductivity and thermal expansion coefficient compatible with chip materials while still ensuring the reliability of the power modules.Metal matrix composites,especially copper matrix composites,containing carbon fibers,carbon nanofibers,or diamond are considered very promising as the next generation of thermalmanagement materials in power electronic packages.These composites exhibit enhanced thermal properties,as compared to pure copper,combined with lower density.This paper presents powder metallurgy and hot uniaxial pressing fabrication techniques for copper/carbon composite materials which promise to be efficient heat-dissipation materials for power electronic modules.Thermal analyses clearly indicate that interfacial treatments are required in these composites to achieve high thermal and thermomechanical properties.Control of interfaces(through a novel reinforcement surface treatment,the addition of a carbide-forming element inside the copper powders,and processing methods),when selected carefully and processed properly,will form the right chemical/mechanical bonding between copper and carbon,enhancing all of the desired thermal and thermomechanical properties while minimizing the deleterious effects.This paper outlines a variety of methods and interfacial materials that achieve these goals. | Jean-François Silvain Jean-Marc Heintz Amélie Veillere Loic Constantin Yong Feng Lu | 2020 | International Journal of Extreme Manufacturing2020，2，1： | 2 |
| 15 | Focus-tunable microscope for imaging small neuronal processes in freely moving animals显示文摘Miniature single-photon microscopes have been widely used to image neuronal assemblies in the brain of freely moving animals over the last decade. However,these systems have important limitations for imaging in-depth fine neuronal structures. We present a subcellular imaging single-photon device that uses an electrically tunable liquid crystal lens to enable a motion-free depth scan in the search of such structures. Our miniaturized microscope is compact (10 mm×17 mm×12 mm) and lightweight (≈1.4 g),with a fast acquisition rate (30–50 frames per second),high magnification (8.7×),and high resolution (1.4μm) that allow imaging of calcium activity of fine neuronal processes in deep brain regions during a wide range of behavioral tasks of freely moving mice. | ARUTYUN BAGRAMYAN LOIC TABOURIN ALI RASTQAR NARGES KARIMI FRéDéRIC BRETZNER TIGRAN GALSTIAN | 2021 | Photonics Research2021，9，7： | 2 |
| 16 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 17 | Relationships between native tree species and soil properties in the indigenous forest fragments of the Eastern Arc Mountains of the Taita Hills, Kenya显示文摘The relationship between soil properties and spatial distribution of native woody species was studied in three Taita Hills forest fragments which, although degraded, are ranked among 34 biodiversity hotspots of the world due to their high biodiversity of both plant and animal species. This relationship was assessed by using Spearman correlation and principal component analyses (PCA). The results of these analyses should be useful in instituting forest restoration programs that are crucial for the forests. Both the soil and vegetation studied were sampled from 17 subplots in the natural forest fragments of Ngangao (120 ha), Chawia (86 ha) and Mbololo (185 ha). The soil variables measured were: pH, texture, soil nutrients of C, N, Ca, P, K, Mg and Na. In total 36 native tree species from 13 families were identified from the three forest fragments. Ordination results show that axis 1 accounted for 35% and axis 2 for 25% of the total variation in species composition, indicating that the structure of vegetation is related to two major environmental gradients. The correlation analyses of species and soil properties showed that Na and clay particles were the most important determinants of species distribution; pH and soil variables such as C, N, Ca and P also played minor roles. Unexpectedly, some species (e.g. Psychotria petitii) showed positive relationships with Na attributed to possible substitution for K. Relationships with P were both positive (e.g. Craibia zimmermannii) and negative (e.g. Albizia gummifera) with some species, attributable to pH levels. An ANOVA for soil variables showed that there were differences in the Ca content in Mbololo (due to the parent material) and P in Ngangao where a special relationship was observed between some of the species. The presence of gaps accounted for the distribution of seedlings but not for the saplings, whose distribution responded more to factors similar to those to which mature trees respond. Soil-species relationships that were established may be utilized along with soil analyses when choosing native species for restoration. | Loice Mildred Akinyi OMORO Raija LAIHO Michael STARR Petri K.E.PELLIKKA | 2011 | Forestry Studies in China2011，13，3： | 2 |
| 18 | Single-Dose mucosal immunization with biodegradable micropatricles containing a schistosoma mansoni antigen显示文摘 | Benoit B Marie-ange B Loic D | 1999 | Inefction and Immunity1999，，： | 2 |
| 19 | 珠江下游颗粒沟链藻Aulacoseira granulata (Ehrenberg) Simonsen及形态相近种赫组基沟链藻Aulacoseira herzogii (Lemmerman) Simonsen的形态学研究显示文摘采用扫描电镜(SEM)技术,对采自珠江下游的沟链藻属2个物种颗粒沟链藻Aulacoseira granulata(Ehrenberg)Simonsen和赫组基沟链藻A.herzogii(Lemmerman)Simonsen的形态特征进行了观察和描述,并与其他相近种的形态异同点进行了比较分析。 | 李维薇 孙金辉 王超 Loic Tudesque | 2018 | 植物科学学报2018，36，2： | 2 |
| 20 | Duodenal intraepithelial T lymphocytes in patients with functional dyspepsia显示文摘AIM: To quantify the intraepithelial lymphocytes (IELs) and to document the membrane expression of CD4, CD8, TCRγδ and adhesion and/or activation-associated molecules (CD103, CD28, CD44, CD69, HLA-DR, CD95/ Fas) in the duodenal mucosa of patients with functional dyspepsia (FD) in order to provide arguments for an immunological process in FD. METHODS: Twenty-six FD patients according to Rome Ⅱ criteria (20 were H pylori negative) were studied and compared to 12 healthy adults. IELs were isolated from five duodenal biopsy samples, then quantified by microscopy and flow cytometry while the membrane phenotypes were determined by cytofluorometry. RESULTS: Duodenal histological examination was normal. In H pylori negative patients, the number of IELs was not different from that in healthy controls. Median percentage expression of CD4, CD8, or TCRγδ and CD103, CD44, CD28, CD69 on CD3+ IELs, among the adhesion/activation associated molecules tested, was not different from that in healthy controls. In contrast, the median percentage expression of CD95/ Fas [22 (9-65) vs 45 (19-88), P = 0.03] and HLA- DR expressing CD3+ IELs [4 (0-30) vs 13 (4-42), P = 0.04] was significantly lower in the H pylori negative FD group than in healthy controls, respectively. The number of IELs was significantly greater in H pylori positive FD patients than in healthy controls [median ratiofor 100 enterocytes 27.5 (6.7-62.5) vs 10.8 (3-33.3), P = 0.02] due to a higher number of CD8+ CD3+ IELs. CONCLUSION: In H pylori negative FD patients, the phenotypic characterization of IELs suggests that we cannot exclude a role of IELs in FD. | Gilles Gargala Stéphane Lecleire Arnaud Franois Serge Jacquot Pierre Déchelotte Jean Jacques Ballet Loic Favennec Philippe Ducrotté | 2007 | World Journal of Gastroenterology2007，13，16： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员