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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | 室内氡与肺癌关系研究显示文摘目的 直接调查居室水平氡浓度对居民肺癌危险度的影响 ,并与由矿工受照结果推导的结论相比较。方法 在甘肃省平凉、庆阳两地区进行病例 对照研究。该地区居民稳定而室内氡水平较高。肺癌病例必须是在 1994年 1月至 1998年 4月期间诊断 ,年龄在 30~ 75岁之间 ,居住在平凉和庆阳两地区的居民。根据人口调查资料随机选取对照 ,对照要在年龄、性别、地区方面与病例相匹配。在过去 5~ 30年期间 ,凡住过两年以上的房间都布放了氡探测器。氡测量涵盖了 77%的照射周期。结果 病例居室的平均氡浓度为 2 30 4Bq m3 (n =76 8) ,对照为 2 2 2 2Bq m3 (n =16 5 9)。居民肺癌危险度随室内氡水平的增高有所上升 (P <0 0 0 1)。根据线性模型 ,对全部研究个体而言 ,在 10 0Bq m3 情况下 ,附加比值比 (EOR)为 0 19(95 %CI:0 0 5 ,0 47)。对测量涵盖了 10 0 %照射周期的个体 ,为 0 31(95 %CI:0 10 ,0 81)。在对照射的不确定度进行调整后 ,估算值可增加70 %。结论 研究结果证明室内水平氡照射会增加肺癌危险度 。 | 王作元 Lubin JH 王陇德 张守志 Boice JD Jr 崔宏星 张淑蓉 Conrath SC 夏英 尚兵 Brenner A 雷苏文 Metayer KC 曹吉生 Chen KW 雷淑杰 Kleinerman RA | 2002 | 中华放射医学与防护杂志2002，22，3： | 28 |
| 3 | 微小RNA-1和微小RNA-29b对急性心肌梗死后不良心室重塑的诊断和预后价值显示文摘已知微小RNA(microRNAs,miRs)在急性心肌梗死(acute myocardial infarction,AMI)临床前期模型中可发挥纤维化和抗纤维化作用。为了评估miR-1,miR-21,miR-29b和miR-92a能否作为患者发生AMI后不良心室重塑(adverse ventricular remodeling,AVR)的循环生物标志物, | 刘莉 叶鹏 Grabmaier U Clauss S Gross L Klier I Franz WM Steinbeck G Wakili R Theiss HD Brenner C | 2017 | 中华高血压杂志2017，25，7： | 17 |
| 4 | Relationship Between Degree of Starch Gelatinization and Quality Attributes of Parboiled Rice During Steaming显示文摘Paddy rice samples were parboiled by soaking at 65 °C for 180 min and steaming at 96 °C for 2–10 min, and then dried to achieve the final moisture content of 11% ± 1%. The degree of starch gelatinization(DSG) and several quality attributes(head rice yield(HRY), color value and hardness) of parboiled rice were measured. Results showed that DSG(46.8%–77.9%), color value(18.08–19.04) and hardness(118.6–219.2 N) all increased following steaming. In contrast, the HRY increased(64.8%–67.1%) for steaming times between 2–4 min but decreased(67.1%–65.0%) for steaming times between 4–10 min. Linear relations between DSG and color value(R^2 = 0.87), and DSG and hardness(R^2 = 0.88) were observed. The suitable DSG of parboiled rice leading to the highest HRY was found to be 62.5%, obtained following 4 min of steaming. | Ebrahim TAGHINEZHAD Mohammad Hadi KHOSHTAGHAZA Saeid MINAEI Toru SUZUKI Tom BRENNER | 2016 | Rice science2016，23，6： | 15 |
| 5 | Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?显示文摘Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of death in critically ill patients. It is the most common condition with high mortality in intensive care units. The complexity of the septic syndrome comprises immunological aspects- i.e.,sepsis induced immunosuppression- but is not restricted to this fact in modern concepts. So far, exact mechanisms and variables determining outcome and mortality stay unclear. Since there is no typical risk profile, early diagnosis and risk stratification remain difficult, which hinders rapid and effective treatment initiation. Due to the heterogeneous nature of sepsis, potential therapy options should be adapted to the individual. Biomarkers like C-reactive protein and procalcitonin are routinely used as complementary tools in clinical decision-making. Beyond the acute phase proteins, a wide bunch of promising substances and non-laboratory tools with potential diagnostic and prognostic value is under intensive investigation. So far, clinical decision just based on biomarker assessment is not yet feasible. However, biomarkers should be considered as a complementary approach. | Dubravka Kojic Benedikt H Siegler Florian Uhle Christoph Lichtenstern Peter P Nawroth Markus A Weigand Stefan Hofer Thorsten Brenner | 2015 | World Journal of Experimental Medicine2015，5，2： | 14 |
| 6 | Colorectal cancer显示文摘 | Hermann Brenner Matthias Kloor Christian Peter Pox | 2013 | The Lancet2013，，： | 8 |
| 7 | Interactions Between the Intestinal Microbiome and Liver Diseases显示文摘 | Bernd Schnabl David A. Brenner | 2014 | Gastroenterology2014，，： | 7 |
| 8 | 吸烟环境与肺癌关系研究显示文摘目的 找出在非吸烟人群中肺癌与吸烟环境暴露(ETS)之间的关系。方法 用流行病学方法在甘肃进行人群病例—对照研究。研究对象包括有233名肺癌患者(200名女性和33名男性)和521名对照(407名女性和114名男性)。结果 暴露在ETS中的人员,比值比(OR)为1.19(95%置信限0.7~2.0),且随暴露量增加有显著增高趋势(P<0.05)。对无暴露、暴露量<10包-年、暴露量为10~19包-年和暴露量≥20包-年的人员,OR值分别为1.00,1.04,1.13和1.51。未成年期(≤18岁)的ETS暴露具有附加危险度。在对成年期受到的ETS暴露进行调整后,未成年期受ETS暴露,OR值为1.52(95%置信限1.1~2.2),且随未成年期暴露量包-年数的增加有显著增加趋势(P<0.01)。对未成年期无暴露、暴露量<10包-年、10~19包-年和≥20年-年的未成年暴露人员,OR值分别为1.00,1.43,1.81和2.95。在对未成年期ETS暴露调整后,发现成年期ETS暴露不会产生附加危险度。成年期受ETS暴露人员,OR值为0.90(95%置信限0~1.4)。结论 未成年期(18岁以下)非吸烟人员受ETS暴露,肺癌相对危险度明显增大。吸烟成年人对与其生活在一起的未成年人的影响要比预期的大。 | 王陇德 Jay Lubin 张淑蓉 Catherine Metayer 夏英 Alina Brenner 尚兵 王作元 Ruth A.Kleinerman | 2002 | 中国预防医学杂志2002，3，1： | 6 |
| 9 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 10 | Immunotherapy against cancer-related viruses显示文摘世界范围的约 12% 所有癌症与病毒的感染被联系。迄今为止,八个病毒被显示了贡献人的癌症的发展,包括 Epstein-Barr 病毒(EBV ) ,肝炎 B 和 C 病毒,和人的乳突淋瘤病毒,在其它之中。这些 DNA 和 RNA 病毒通过不同机制生产 oncogenic 效果。首先,病毒可以通过他们表示的基因导致宿主细胞生长和幸存的持续混乱,或可以在宿主细胞导致 DNA 损坏反应,接着,增加它招待染色体不稳定性。第二,他们可以导致长期的发炎和在主人房间赞成 oncogenic 过程的发展的第二等的织物损坏。病毒相似 HIV 能通过有免疫力的抑制为癌症开发创造更容许的环境,但是我们将在这评论集中于以前的二机制。不同于不能把感染的房间与非感染的房间区分开来的传统的癌症治疗,免疫疗法特别地被装备指向联系病毒的恶意。与有免疫力的反应联系的指向并且工作的机制能被利用由种痘阻止病毒的感染,并且能也被用来在癌症建立前治疗感染。在使用免疫系统根除的成功由联系病毒的肿瘤房间的选择识别建立了恶意当前被报导。例如,产生病毒特定的 T 房间显示出的前 vivo 的采纳转移的众多的临床的试用与联系 EBV 的恶意在病人甚至为确定的肿瘤受益。在另外的联系病毒的肿瘤的另外的研究也被开始了,在这评论,我们为联系病毒的恶意描述免疫疗法的当前的地位并且讨论未来前景。 | Haruko Tashiro Malcolm K Brenner | 2017 | Cell Research2017，27，1： | 4 |
| 11 | Biosorption potential of cerium ions using Spirulina biomass显示文摘Two types of cyanobacteria of the genus Arthrospira(commonly known as Spirulina) were tested for biosorption of cerium(III) ions from aqueous solutions. An endemic type(ES) found in the northern Negev desert, Israel, and a commercial powder(CS) were used in this study. Biosorption was evaluated as a function of p H, contact time, initial metal concentration, number of sorption-desorption cycles, and salt concentration. The optimum p H range for biosorption was found to be 5.0–5.5. The kinetic characteristics of both Spirulina types were found to be highly compatible with a pseudo-second order kinetic model. The adsorption isotherms of both types were found to be well-suited to Langmuir and Freundlich adsorption isotherms. Maximum biosorption uptakes, according to the Langmuir model, were 18.1 and 38.2 mg/g, for ES and CS, respectively. Sodium chloride concentrations of up to 5 g/L had a minor effect on cerium biosorption. Desorption efficiency was found to be greater than 97% with 0.1 mol/L HNO_3 after three sorption-desorption cycles, without significant loss in the biosorption capacity. The results indicated the feasibility of cerium recovery from industrial wastes using Spirulina biomass. | David Sadovsky Asher Brenner Boaz Astrachan Boaz Asaf Raphael Gonen | 2016 | Journal of Rare Earths2016，34，6： | 4 |
| 12 | Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-Analysis显示文摘 | Ulrike Peters Shuo Jiao Fredrick R. Schumacher Carolyn M. Hutter Aaron K. Aragaki John A. Baron Sonja I. Berndt Stéphane Bézieau Hermann Brenner Katja Butterbach Bette J. Caan Peter T. Campbell Christopher S. Carlson Graham Casey Andrew T. Chan Jenny Chan | 2012 | Gastroenterology2012，，： | 4 |
| 13 | Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice显示文摘 | Kouichi Miura Yuzo Kodama Sayaka Inokuchi Bernd Schnabl Tomonori Aoyama Hirohide Ohnishi Jerrold M. Olefsky David A. Brenner Ekihiro Seki | 2010 | Gastroenterology2010，，1： | 3 |
| 14 | Efficacy of a Nationwide Screening Colonoscopy Program for Colorectal Cancer显示文摘 | Christian P. Pox Lutz Altenhofen Hermann Brenner Arno Theilmeier Dominik Von Stillfried Wolff Schmiegel | 2012 | Gastroenterology2012，，7： | 3 |
| 15 | Unsteady CFD simulations of a pump in part load conditions using scale-adaptive simulation显示文摘 | A. Lucius G. Brenner | 2010 | International Journal of Heat and Fluid Flow2010，，6： | 3 |
| 16 | Knowledge-enabled customer relationship management: integrating customer relationship management and knowledge management concepts[1]显示文摘 | Henning Gebert Malte Geib Lutz Kolbe Walter Brenner | 2003 | Journal of Knowledge Management2003，，5： | 3 |
| 17 | Incidence of chronic atrophic gastritis: systematic review and meta-analysis of follow-up studies显示文摘 | Mariam Abdullahi Adamu Melanie Nicole Weck Lei Gao Hermann Brenner | 2010 | European Journal of Epidemiology2010，，7： | 3 |
| 18 | 云南中部杞麓湖地区晚更新世——全新世植被研究显示文摘根据植被及C^14资料,本文将杞麓湖水下沉积物分为6个花粉带,其沉积年代及气候如下: 1.11.00--9.40m(水下沉积物深度,下同)松—油杉、冷杉、云杉、铁杉—栎针阔叶混交林带。气候冷湿。距今约3000—15000年,晚更新世(大理冰期最盛期)。 2.9.40—7.OOm 稀疏松-栎林带。气候干凉。距今约15000-12350年,晚更新世晚期(大理冰期冰后期)。 3.7.00-4.80m 松-油杉-栎、榆针阔叶林繁盛带。气候温暖。距今约12350-9500年,早全新世(前北方期-北方期)。 4.4.80-3.OOm 松-柏-栋、桦针阔叶林继续繁盛带。气候暖湿。距今约9500-5500年,中全新世(大西洋期-亚北方期) 5.3.00--0.84m 松-油杉-栎,以针叶树为主的针阔叶林带。气候温凉略干。距今约5000-1600年,晚全新世(亚大西洋期)。 6.0.84--O.OOm 稀疏松林。约1600年至今。本带森林面积迅速减小,可能由于人类的生产和生活活动所致,尚有待进一步研究。 | 龙瑞华 李百福 Mark Brenner 宋学良 | 1991 | 云南地质1991，10，1： | 3 |
| 19 | Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: Summary of a symposium显示文摘 | Vishnudutt Purohit J. Christian Bode Christiane Bode David A. Brenner Mashkoor A. Choudhry Frank Hamilton Y. James Kang Ali Keshavarzian Radhakrishna Rao R. Balfour Sartor Christine Swanson Jerrold R. Turner | 2008 | Alcohol2008，，5： | 3 |
| 20 | Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease显示文摘 | Kouichi Miura Ekihiro Seki Hirohide Ohnishi David A. Brenner Ian Nicholas Crispe | 2011 | Gastroenterology Research and Practice2011，，： | 3 |
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